Clinical trials: sponsored by Nanjing First Hospital, Nanjing Medical University
Performance Verification
Clinical Application Research Plan for Fully Automated Sample Processing System
By utilizing the fully automated sample processing system from Xiamen U-Medical Instruments Co., Ltd. (compatible with the Wan200+/Wan600+ fully automatic chemiluminescent immunoassay systems and the Wan BC2800 fully automatic…
- Trial name
- NCT07921979
- Testing
- performance verification
- Volunteers
- 2,900 people
- Sponsor
- BangShun He
Performance Verification
Clinical Application Research of the Fully Automatic Biochemical System
By applying the fully automatic biochemical analysis system, samples such as serum, plasma, urine or other body fluids are tested.
- Trial name
- NCT07921992
- Testing
- performance verification
- Volunteers
- 2,900 people
- Sponsor
- BangShun He
Helicobacter Infection
Keverprazan-Minocycline Dual Therapy of Different Durations Versus Bismuth Quadruple Therapy for Helicobacter Pylori Eradication.
This study aims to compare the efficacy and safety of keverprazan-minocycline dual therapy versus bismuth-based quadruple therapy for Helicobacter pylori eradication, focusing on eradication rates, patient adherence, and the…
- Trial name
- NCT07904429
- Testing
- Minocycline, Keverprazan, Amoxicillin
- Where
- China
- Volunteers
- 612 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Performance Verification
Clinical Application Research Plan for Fully Automated Chemiluminescent Immunoassay Reagents
For the remaining serum, plasma, urine or other body fluid samples from clinical tests, chemiluminescence immunoassay reagents are used (covering eleven types of markers such as infectious diseases, tumors, hormones, thyroid…
- Trial name
- NCT07918820
- Testing
- performance verification
- Volunteers
- 2,800 people
- Sponsor
- BangShun He
Squamous Cell Non-small Cell Lung Cancer
Neoadjuvant Therapy of Sintilimab Combined With Chemotherapy for Resectable Squamous Cell NSCLC（neoSCORE Ⅱ）
This is a Phase 3, prospective, randomized, open-label, multi-center study that assesses the efficacy and safety of neoadjuvant therapy with different cycles of sintilimab combined with chemotherapy for Resectable Squamous Cell…
- Trial name
- neoSCORE Ⅱ (NCT05429463)
- Testing
- Sintilimab, Carboplatin, Albumin-Bound Paclitaxel
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Medullary Thyroid Carcinoma, Small Cell Lung Cancer ( SCLC )
68Ga-labeled Cholecystokinin Receptor (CCK2R) Targeted Molecular Probes in Early Tumor Diagnosis
Evaluate the safety of the novel radioactive nuclide-labeled cholecystokinin receptor (CCK2R) targeted molecular probe, 68Ga-YQ-CC05, in clinical application, and verify its effectiveness in tumor diagnosis.
- Conditions
- Medullary Thyroid Carcinoma, Small Cell Lung Cancer ( SCLC ), Gastric Adenocarcinoma
- Trial name
- NCT07914764
- Testing
- Intravenous injection of 68Ga-YQ-CC05 for PET-CT examination
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Gastric Cancer, Postoperative Delirium
Remimazolam for Reducing Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Gastrectomy
This prospective, single-center, randomized, participant- and outcome assessor-blinded, parallel-group controlled trial evaluated whether remimazolam-based anesthesia reduced postoperative delirium (POD) and improved…
- Trial name
- NCT07351474
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 170 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
D2 Gastrectomy With or Without Para-Aortic Lymph Node Dissection After Chemoimmunotherapy for Gastric Cancer
Some patients with gastric cancer have enlarged para-aortic lymph nodes, also called No. 16 lymph nodes, at diagnosis. After standard chemoimmunotherapy, these lymph nodes may shrink to less than 10 mm on imaging, but it is…
- Trial name
- PAN-SELECT (NCT07912606)
- Testing
- Gastrectomy with D2 lymphadenectomy plus para-aortic lymph node dissection, Gastrectomy with standard D2 lymphadenectomy
- Where
- China
- Volunteers
- 32 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Colorectal Adenoma, Cholecystectomy
Cholecystectomy, Biliary Diseases, and Colorectal Adenoma Risk: A Real-World Retrospective Study
This study is a retrospective real-world study based on the electronic medical record database of Nanjing First Hospital. By integrating data from the hospital information system, ultrasound system, endoscopy system, pathology…
- Conditions
- Colorectal Adenoma, Cholecystectomy, Biliary Tract Diseases
- Trial name
- NCT07908576
- Testing
- No intervention. This is an observational study.
- Volunteers
- 8,450 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
ST Elevation Myocardial Infarction
Efficacy and Safety of a Half-dose Bolus of r-SAK Prior to Primary PCI in ST-elevation Myocardial Infarction
As an effective treatment for acute ST-segment elevation myocardial infarction (STEMI), early reperfusion may reduce the infarct size and improve the prognosis of patients.
- Trial name
- OPTIMA-6 (NCT05410925)
- Testing
- Recombinant staphylokinase
- Where
- 61 sites in China
- Volunteers
- 2,260 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
MAFLD
Liver Stiffness Changes by iLivTouch to Predict Liver-Related Events in MAFLD
This is an observational study (multicenter retrospective real-world cohort study). The purpose of this study is to assess the predictive performance of liver stiffness measurement (LSM, including baseline LSM1, current LSMC and…
- Trial name
- MAFLD (NCT07777198)
- Volunteers
- 2,303 people
- Sponsor
- Beijing Friendship Hospital
Moyamoya Disease
Clinical Evaluation of the Safety and Efficacy of "Buyan Huan Wu Tang" Combined With Atorvastatin in the Treatment of Atypical Pneumonia
Moyamoya disease, also known as "smoky vein disease," is a relatively rare chronic form of cerebral artery occlusion. The exact cause of this condition is currently unknown.
- Trial name
- NCT07906652
- Testing
- Atorvastatin, Replenishing Five Herbs Decoction
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Multiple Myeloma, Venous Thromboembolism (VTE)
Aspirin vs. Rivaroxaban for Thromboprophylaxis in Multiple Myeloma
The goal of this clinical trial is to compare the efficacy and safety of aspirin versus rivaroxaban for thromboprophylaxis in newly diagnosed multiple myeloma patients receiving immunomodulatory drug (IMiD)-based therapy.
- Trial name
- NCT07907211
- Testing
- Aspirin, Rivaroxaban
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chen Lijuan
Delirium - Postoperative
The Effect of Remimazolam Tosylate on the Incidence of Postoperative Delirium in Older Patients Undergoing Cardiac Surgery: A Prospective Randomized Controlled Trial
This study aims to compare the efficacy and safety of remimazolam tosylate and propofol for postoperative sedation in patients aged 65 years or older undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- NCT07908121
- Testing
- Remimazolam Tosylate, Propofol
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Gastric Adenocarcinoma, Esophagogastric Junction Adenocarcinoma
Lymph Node Dissection After Neoadjuvant Therapy for Gastric and EGJ Adenocarcinoma
This multicenter retrospective observational cohort study will evaluate approximately 2,000 adults with gastric or esophagogastric junction adenocarcinoma who received at least two cycles of neoadjuvant therapy followed by R0…
- Trial name
- NA-LND-GC (NCT07902596)
- Where
- 8 sites in China
- Volunteers
- 2,000 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Intrahepatic Cholangiocarcinoma (Icc), Neoadjuvant Therapy
Perioperative Retlirafusp Alfa(Anti-PD-L1/TGF-β Bifunctional Fusion Protein) Plus Famitinib and GEMOX-Based Hepatic Arterial Infusion Chemotherapy for Locally Advanced Intrahepatic Cholangiocarcinoma: A Multicenter, Single-Arm, Exploratory Phase II Trial
This is a multicenter, single-arm, exploratory clinical study for adults with locally advanced intrahepatic cholangiocarcinoma (ICC) that may be technically resectable but is difficult to remove directly by surgery.
- Trial name
- H-FROG (NCT07847710)
- Testing
- Retlirafusp alfa, Famitinib malate, Gemcitabine & oxaliplatin
- Where
- China
- Volunteers
- 81 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Breast Cancer
A Prospective, Phase II, Exploratory Study Protocol of a Chemotherapy Sensitivity-based Culmerciclib Combination Regimen in Neoadjuvant Therapy for HR+/HER2- Breast Cancer.
To explore the efficacy and safety of Culmerciclib combined with chemotherapy as neoadjuvant therapy for HR+/HER2- breast cancer patients who are insensitive to neoadjuvant TAC (docetaxel, doxorubicin, cyclophosphamide)…
- Trial name
- NCT07900516
- Testing
- Kumoxili, Docetaxel, Epirubicin
- Where
- China
- Volunteers
- 48 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Atrial Fibrillation (AF), Heart Failure
Mobile Clinic-Supported, Village Doctor-Led Screening and Integrated Care for Atrial Fibrillation and Heart Failure Comorbidity in Rural China (MOVE-AF HF)
AF and HF frequently coexist and are associated with poor clinical outcomes. In rural areas, limited access to echocardiography, NT-proBNP testing, and specialist care may hinder the early identification and appropriate…
- Trial name
- NCT07896863
- Testing
- Mobile Clinic-Supported, Village Doctor-Led Screening and Integrated Care Group, Routine Management Group
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Jiangsu Taizhou People's Hospital
Moyamoya Disease
Clinical Safety and Efficacy Evaluation of the Blood-cooling and Stasis-removing Formula as an Adjunct to Atorvastatin in the Treatment of Hemorrhagic Moyamoya Disease.
Moyamoya disease is a relatively rare chronic cerebrovascular disease, and its exact cause is currently unknown. This disease is characterized by the gradual narrowing or even blockage of important blood vessels in the brain (the…
- Trial name
- NCT07894640
- Testing
- Atorvastatin, Blood-cooling and Stasis-clearing Formula
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Depression, Anxiety
Postoperative Anxiety and Depression Among Chinese Elderly Patients
The goal of this observational study is to learn about the prevalence of postoperative anxiety and depression symptoms and identify the related risk factors in elderly patients aged 65 and older who undergo non-cardiac surgery in…
- Trial name
- NCT07532122
- Where
- China
- Volunteers
- 7,568 people
- Sponsor
- Chinese PLA General Hospital
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