Find a clinical trial
Breast Cancer, Breast Cancer Female
Resistance and Aerobic Exercise for Prevention in Women With Dense Breasts (REP-D)
The goal of this study is to learn more about how exercise might lower the risk of developing breast cancer in women with dense breast tissue by studying changes that occur in breast tissue and blood as a result of participating…
- Trial name
- NCT06322888
- Testing
- Exercise Training Program
- Where
- 2 sites in United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Menopause, Obesity
Effects of SlimTrack® Platform on Diet Adherence, Anthropometry and Arterial Stiffness in Postmenopausal Women
Introduction:The weight gain expected in the postmenopausal period has deleterious effects on the physical and mental health of the female population.
- Conditions
- Menopause, Obesity, Overweight
- Trial name
- SlimTrack (NCT06497946)
- Testing
- SlimTrack Plataform, Diet prescription
- Where
- Brazil
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Geographic Atrophy
Adaptive Optics Scanning Light Ophthalmoscopy (AOSLO) and Microperimetry (MP) Sub-study
This research sub-study is to evaluate if combining images from Optical Coherence Tomography (OCT) scans with Adaptive Optics Scanning Light Ophthalmoscopy (AOSLO) and Microperimetry (MP) could show a link between structural…
- Trial name
- NCT07747662
- Testing
- Adaptive Optics Scanning Light Ophthalmoscopy, Microperimetry, Optical Coherence Tomography
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Wisconsin, Madison
Male
2D:4D Ratio vs Semen Parameters
The aim of this study evaluate the relationship between sperm count and the second-to-fourth digit ratio (2D:4D) in male patients.
- Trial name
- NCT07894263
- Testing
- Group 1
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Suleyman Demirel University
Chronic Myelomonocytic Leukemia (CMML)
Cobimetinib in Newly Diagnosed or HMA-treated CMML Patients With RAS Pathway Mutations
This is an open-label, nonrandomized phase 2 trial to assess the efficacy of cobimetinib in RAS pathway activated CMML. All eligible patients will be treated daily with cobimetinib in 28-day cycles.
- Trial name
- CONCERTO (NCT04409639)
- Testing
- Cobimetinib
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Utah
XLA, CVID
Immune Regulation in Patients With Common Variable Immunodeficiency and Related Inborn Errors of Immunity (IEI)
This study aims to understand the causes and progression of Common Variable Immunodeficiency (CVID) and related inborn errors of immunity (IEI).
- Conditions
- XLA, CVID, Yao Syndrome, Blau Syndrome
- Trial name
- NCT00001244
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Prostate Cancer
Real World Prostate Cancer Registry
Prostate cancer is the most common cancer diagnosed in men in the USA with 268,490 cases diagnosed in 2022 constituting 27% of male cancers and 34,500 deaths (11%) occurred in same year.1 Prostate cancer is a very heterogeneous…
- Trial name
- RWPCR (NCT06355336)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Cincinnati Cancer Advisors
Postprandial Glucose, GI Tolerance
A Crossover Study Evaluating the Postprandial Glycemic Response of Three Sweeteners in a Mixed Meal Setting
This study is using a double-blind, randomize crossover evaluating the impact of three different sweeteners on postprandial glycemic response in a mixed meal setting.
- Trial name
- NCT07895628
- Testing
- LOAM Fiber-based Sweetener, Sugar, Stevia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- LOAM Science
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, MASH - Metabolic Dysfunction-Associated Steatohepatitis
Exercise for an Aging Liver (EXALIVER)
The goal of this clinical trial is to learn how physical exercise affects liver health in adults with metabolic dysfunction-associated steatotic liver disease (MASLD) or at-risk metabolic dysfunction-associated steatohepatitis…
- Conditions
- MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, MASH - Metabolic Dysfunction-Associated Steatohepatitis, Liver Fibrosis/NASH
- Trial name
- EXALIVER (NCT07467512)
- Testing
- Exercise, Usual Care
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Vestibular Schwannoma, Facial Nerve Paralysis
Steroids for Facial Nerve Function Protection in Post-surgical Vestibular Schwannoma Patients
The purpose of this study is to evaluate the efficacy and safety of steroids treatment compared with placebo in preserving facial nerve function after craniotomy in patients with vestibular schwannoma who have not received…
- Trial name
- SAF-NRVS (NCT07116811)
- Testing
- Steroids therapy
- Where
- China
- Volunteers
- 364 people
- Sponsor
- Beijing Tiantan Hospital
Dysphagia, Eosinophilic Esophagitis
The Esophageal String Test as a Diagnostic Screening Tool for Eosinophilic Esophagitis Among Africans With Dysphagia in Mali and the United States
Background: Eosinophilic esophagitis (EoE) is a disease that causes inflammation in the esophagus. The esophagus is the tube that moves food from the mouth to the stomach.
- Trial name
- NCT07027826
- Testing
- Esophageal string test
- Where
- 3 sites in United States, Mali
- Volunteers
- 70 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Unruptured Intracranial Aneurysms, Cerebrovascular Event
Efficacy and Safety of Methylprednisolone After Flow-Diverter Stent Implantation in Unruptured Intracranial Aneurysms
Study Title: Testing Methylprednisolone to Prevent Strokes After a Stent Procedure for Brain Aneurysms What is the purpose of this study? This study aims to find out if a short course of a steroid medicine called…
- Conditions
- Unruptured Intracranial Aneurysms, Cerebrovascular Event, Hemorrhagic Stroke, Methylprednisolone
- Trial name
- NCT07353749
- Testing
- Methylprednisolone (Injectable Form)
- Where
- China
- Volunteers
- 864 people
- Sponsor
- Duan Chuanzhi
Advanced Solid Tumors
NY-ESO-1 TCR-T Cells for NY-ESO-1 Positive Subjects With Advanced Solid Tumors
New York Esophageal Squamous Cell Carcinoma 1 (NY-ESO-1) is a cancer-testis antigen (CTA) which is expressed in various tumors. In TCR-T therapy, researchers take the blood of a certain patient, select T cells and insert genes…
- Trial name
- NCT05881525
- Testing
- TC-N201 cells, IL-2, Fludarabine
- Where
- China
- Volunteers
- 18 people
- Sponsor
- TCRCure Biopharma Ltd.
Non-Small Cell Lung Cancer (NSCLC)
U3-1402 in Metastatic or Unresectable Non-Small Cell Lung Cancer
This study was designed to evaluate safety and antitumor activity of HER3-DXd in two parts: Dose Escalation and Dose Expansion. In Dose Escalation, HER3-DXd was evaluated in participants with metastatic or unresectable NSCLC with…
- Trial name
- NCT03260491
- Testing
- HER3-DXd (FL-DP), HER3-DXd (CTM-1 Lyo-DP), HER3-DXd (CTM-3 Lyo-DP)
- Where
- 37 sites in United States, Japan and 4 more
- Volunteers
- 312 people
- Sponsor
- Daiichi Sankyo
Improve Facial Wrinkles
Clinical Trial Protocol for the Effectiveness and Safety of Radiofrequency Skin Therapy Equipment in Improving Facial Skin Wrinkles
Evaluate the clinical efficacy and safety of the radiofrequency skin therapy device (model specification: RFM-01) produced by ReFumei (Hunan) Technology Co., Ltd. for improving facial skin wrinkles
- Trial name
- NCT07894120
- Testing
- Radiofrequency skin therapy equipment developed and produced by ReFumei (Hunan) Technology Co., Ltd. improves facial wrinkles, The control group subjects used the radiofrequency therapy device produced by Israel Flyton Laser Co., Ltd. to improve facial wrinkles
- Where
- China
- Volunteers
- 278 people
- Sponsor
- Peking University Third Hospital
Postpartum, Trunk Muscle Endurance
Online-Delivered Core Stability Exercises in Postpartum Women
This study will examine a 12-week online core stability program for postpartum women, where participants will complete supervised sessions three times per week and will be compared with an education-only group.
- Conditions
- Postpartum, Trunk Muscle Endurance, Postural Stability
- Trial name
- NCT07560774
- Testing
- online core stability exercise group, an education-only control group
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- Prince Sattam Bin Abdulaziz University
Chronic Spontaneous Urticaria
A Study to Learn About Ritlecitinib for the Potential Treatment of Chronic Spontaneous Urticaria in Adults.
The purpose of the study is to learn about the safety and effects of the study medicine (called ritlecitinib) for the treatment of chronic spontaneous urticaria (CSU) that is not effectively treated by antihistamines which are…
- Trial name
- NCT07219615
- Testing
- Ritlecitinib 50 mg, Ritlecitinib 100 mg
- Where
- 77 sites in United States, Bulgaria and 8 more
- Volunteers
- 200 people
- Sponsor
- Pfizer
Relapsed or Refractory Large B-cell Lymphoma
Study Evaluating the Efficacy of KITE-753 Versus Axicabtagene Ciloleucel in Participants With Relapsed or Refractory Large B-Cell Lymphoma After First-Line Therapy
The goal of this clinical study is to compare the study drug KITE-753 versus axicabtagene ciloleucel (axi-cel) in adult participants with relapsed or refractory (r/r) large B-cell lymphoma (LBCL) after one prior line of therapy.
- Trial name
- NCT07479797
- Testing
- KITE-753, Axicabtagene Ciloleucel, Fludarabine
- Where
- 42 sites in United States, Australia and 7 more
- Volunteers
- 550 people
- Sponsor
- Kite, A Gilead Company
Prostate Cancer, Metastatic Castration-Resistant Prostate Cancer
A Study to Evaluate the Safety and Drug Levels of ASP5541 in Chinese Participants With Prostate Cancer
In this study, ASP5541 will be given to Chinese men with prostate cancer. It will be given together with prednisone and androgen deprivation therapy (ADT).
- Conditions
- Prostate Cancer, Metastatic Castration-Resistant Prostate Cancer, Metastatic Hormone Sensitive Prostate Cancer
- Trial name
- NCT07339267
- Testing
- ASP5541, Prednisone
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Breast Cancer
Phase I/II Study of Intrathecal/Ommaya T-DXd in HER2-Expressing Breast Cancer With Leptomeningeal/Brain Metastases
Multiple trials confirm systemic T-DXd efficacy in HER2+ breast cancer with leptomeningeal/brain metastases, yet median LM survival remains 3-4 months, highlighting unmet needs.
- Trial name
- INOVATE (NCT07134153)
- Testing
- T-DXd
- Where
- 2 sites in China
- Volunteers
- 139 people
- Sponsor
- Fudan University