Clinical trials: open to volunteers, sponsored by Vanderbilt University Medical Center
Idiopathic Pulmonary Arterial Hypertension, Heritable Pulmonary Arterial Hypertension
Hormonal, Metabolic, and Signaling Interactions in PAH
Our hypothesis is that optimal treatment of the dysfunctional metabolic pathways which underlie PAH will improve pulmonary vascular function and consequences of the disease.
- Conditions
- Idiopathic Pulmonary Arterial Hypertension, Heritable Pulmonary Arterial Hypertension, Scleroderma Associated Pulmonary Arterial Hypertension, Appetite Suppressant Associate PAH
- Trial name
- NCT01884051
- Where
- United States
- Volunteers
- 1,899 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Post-operative Pain, DIEP Flap Breast Reconstruction
Suzetrigine Post DIEP
This research study is being conducted to see whether adding suzetrigine (Journavx), an FDA-approved non-opioid pain medication, to the standard Enhanced Recovery After Surgery (ERAS) pain management protocol can improve pain…
- Conditions
- Post-operative Pain, DIEP Flap Breast Reconstruction, DIEP Flap, Opioid
- Trial name
- NCT07839715
- Testing
- Suzetrigine Group
- Volunteers
- 198 people
- Sponsor
- Vanderbilt University Medical Center
Cochlear Implant, Cochlear Implant Users
Patient-Oriented Research to Optimize Cochlear Implant Outcomes
The rationale is that only through understanding how individual Cochlear Implant (CI) patients respond to interventions investigators further develop precision-medicine approaches to optimize outcomes.
- Conditions
- Cochlear Implant, Cochlear Implant Users, Cochlear Implant Recipients, Cochlear Implant Listeners
- Trial name
- NCT07678879
- Testing
- AC Group, CA group
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Obesity and Obesity-related Medical Conditions, Bariatric Surgery
Transition to Ambulatory Bariatric Surgery (TABS) Trial
This study will compare same day discharge and at least one night stay in the hospital after bariatric surgery. Patients undergoing bariatric surgery will be randomized (i.e. have an equal chance of either plan) to either group.
- Trial name
- TABS (NCT07011628)
- Testing
- Same Day Discharge
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Vanderbilt University Medical Center
Childhood Obesity
The Dose Trial: Dose Intensity of Behavioral Interventions for Childhood Obesity
The research team is recruiting 900 children between the ages 5-17 with obesity from Tennessee and Louisiana. The team is assigning children and their caregivers by chance to one of five groups.
- Trial name
- NCT06654323
- Testing
- Intensive Behavioral Lifestyle Modification
- Where
- 2 sites in United States
- Volunteers
- 900 people
- Sponsor
- Vanderbilt University Medical Center
Dysphagia, Heart Transplant Recipients
Respiratory Strength Training in Heart Transplant Recipients
This research study is investigating whether completing breathing exercises before surgery helps heart transplant patients recover after surgery.
- Trial name
- NCT06190171
- Testing
- Active respiratory muscle strength training
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Vanderbilt University Medical Center
Acute Uncomplicated Diverticulitis
APLAUD Trial (Antibiotics vs PLacebo for Acute Uncomplicated Diverticulitis)
The goal of this clinical trial is to determine whether antibiotics improve recovery from acute uncomplicated diverticulitis (AUD) in racially and ethnically diverse United States clinical practice.
- Trial name
- NCT07492134
- Testing
- Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet, Metronidazole, Cefuroxime
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Acute Respiratory Failure
Hyperangulated Versus Standard Geometry Laryngoscope Blade Trial
The Hyperangulated versus Standard Geometry Laryngoscope Blade (ANGLE) Trial is a multi-center, non-blinded, parallel-group, randomized clinical trial evaluating the effect of use of a hyperangulated video laryngoscope blade…
- Trial name
- ANGLE (NCT07223762)
- Testing
- Hyperangulated video laryngoscope blade, Standard geometry video laryngoscope blade
- Where
- 19 sites in United States
- Volunteers
- 2,500 people
- Sponsor
- Vanderbilt University Medical Center
Tremor, Essential Tremor
Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor
The purpose of this study is to determine the changes in quality of life and degree of tremor for patients with essential tremor or Parkinsonian tremor who are treated by stereotactic radiosurgery (SRS).
- Conditions
- Tremor, Essential Tremor, Parkinson Disease, Radiosurgery
- Trial name
- NCT01734122
- Testing
- Questionnaires / Observational Assessments
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Critical Illness, Intensive Care Medicine
VoiceLove: An App-Based COMMunication Tool Designed to Address DeliriUm and Improve Family ENgagement and PatIent/Family SatisfaCtion in CriticAlly Ill PaTiEnts (COMMUNICATE)
VoiceLove is a phone application allowing family and patients to share information in a secure platform. This project will compare the VoiceLove app to usual care to learn about whether VoiceLove improves patient-family…
- Trial name
- COMMUNICATE (NCT06923462)
- Testing
- Communication Application
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Stroke, Stroke Acute
Individual vs Co-Treatment in Acute Stroke Rehabilitation and Evaluation
This is a single center, pragmatic, randomized trial comparing the effectiveness of two commonly used approaches (co-treatment and individual treatment) in acute care rehabilitation.
- Trial name
- ICARE (NCT07411534)
- Testing
- Co-treatment, Individual Treatment
- Where
- United States
- Volunteers
- 567 people
- Sponsor
- Vanderbilt University Medical Center
Acute Respiratory Failure
Tube Size Randomized Trial During Emergency Tracheal Intubation
The BREATHE trial is a parallel-group, pragmatic, randomized clinical trial comparing the effectiveness of smaller versus larger endotracheal tubes for mechanical ventilation of critically ill adults at 7 geographically diverse…
- Trial name
- BREATHE (NCT06939361)
- Testing
- Smaller endotracheal tube, Larger endotracheal tube
- Where
- 7 sites in United States
- Volunteers
- 3,180 people
- Sponsor
- Vanderbilt University Medical Center
Postoperative Bleeding, Skin Cancer Face
Tranexamic Acid in Nasal Mohs Reconstruction
This study will be a prospective randomized control trial to evaluate the effects of subcutaneously administered TXA among patients undergoing nasal Mohs reconstruction with local flaps at VUMC.
- Trial name
- NCT06057675
- Testing
- Treatment (tranexamic acid and 1% lidocaine with 1:100,000 epinephrine), Control (1% lidocaine with 1:100,000 epinephrine)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Glucose, Metabolism
Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells - Intensive Care Unit
The purpose of this study is to understand how cells of the immune system use the common sugar glucose during critical illness. Investigators will intravenously infuse a non-radioactive carbon-13 glucose tracer into adult…
- Conditions
- Glucose, Metabolism, Isotope Labeling, Immune System and Related Disorders
- Trial name
- TORCH-ICU (NCT07811180)
- Testing
- 13C6-Glucose
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt University Medical Center
Salt-sensitivity of Blood Pressure
Gut Microbiome, Metabolome, and SSBP
The goal of this interventional study is to learn if elevated Na+ alters the gut microbiota and is associated with altered metabolism, inflammation and salt sensitivity of blood pressure (SSBP).
- Trial name
- Gut-SSBP (NCT07790900)
- Testing
- Dietary sodium
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Valvular Heart Disease
Home-Based Cardiac Rehabilitation Using a Novel Mobile Health Exercise Regimen Following Transcatheter Heart Valve Interventions
The vast majority of cardiac rehabilitation eligible individuals do not participate in center based cardiac rehabilitation (CBCR).
- Trial name
- HOMERUNHITTER (NCT06077201)
- Testing
- HBCR hands-off, HBCR interactive
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Vanderbilt University Medical Center
Alzheimer Disease, Early Onset, Dementia
Cholinergic Deep Brain Stimulation for Alzheimer's Disease
This project will investigate the potential of Deep Brain Stimulation to improve cognitive abilities and counteract the effects of Alzheimer's disease.
- Conditions
- Alzheimer Disease, Early Onset, Dementia, Alzheimer Disease
- Trial name
- NCT05882344
- Testing
- Device Implantation- Boston Scientific, VERCISE GENUS™ system, DBS Stimulation - Boston Scientific, VERCISE GENUS™ system
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Vanderbilt University Medical Center
Respiratory Failure, Mechanical Ventilation
Mode of Ventilation During Critical Illness at Multiple Centers
The goal of this clinical trial is to learn whether the choice of ventilator mode for patients on breathing machines in the intensive care unit affects their survival and recovery.
- Conditions
- Respiratory Failure, Mechanical Ventilation, Critical Illness
- Trial name
- MODEM (NCT07313956)
- Testing
- Volume control, Pressure control, Adaptive pressure control
- Where
- 4 sites in United States
- Volunteers
- 4,785 people
- Sponsor
- Vanderbilt University Medical Center
Type 2 Diabetes Mellitus (T2DM), Sarcopenia
HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide
This randomized, double-blind, placebo-controlled trial will evaluate whether daily calcium beta-hydroxy-beta-methylbutyrate (calcium-HMB) plus vitamin D3 preserves muscle mass, physical function, and resting metabolism in adults…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Sarcopenia, Obesity, Muscle Loss
- Trial name
- PRESERVE-HMB (NCT07760948)
- Testing
- Calcium-HMB Plus Vitamin D3
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Vanderbilt University Medical Center
Microtia, Dysbiosis
Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT
Among people living with HIV, heavy drinking increases the risk of heart disease and death. Studies suggest that alcohol changes the number and kind of bacteria in your gut and these changes increase the risk of heart disease and…
- Conditions
- Microtia, Dysbiosis, Alcohol Drinking, HIV Infections
- Trial name
- META HIV CVD (NCT05288790)
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Vanderbilt University Medical Center