Clinical trials: sponsored by Vanderbilt University Medical Center
Autonomic Failure, Pure Autonomic Failure
Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure
The purpose of this study is to learn more about the effects of midodrine and droxidopa, two medications used for the treatment of orthostatic hypotension (low blood pressure on standing), on the veins of the abdomen of patients…
- Conditions
- Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy, Parkinson Disease
- Trial name
- NCT02897063
- Testing
- Droxidopa, Midodrine
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus
Multicenter Assessment of the Pancreas in Type 1 Diabetes
The overall goal of this research is to develop and validate standard operating procedures (SOP) to assess the human pancreas in individuals with type 1 diabetes (T1D) and other forms of diabetes using advanced, quantitative…
- Trial name
- MAP-T1D (NCT03585153)
- Testing
- Non-contrast magnetic resonance imaging
- Where
- 5 sites in United States, Australia
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Hiv
Healer-initiated HIV Counseling and Testing Versus Standard of Care in Rural South Africa
South Africa has made progress towards their 95-95-95 goals, yet a substantial proportion of the population do not test regularly.
- Trial name
- NCT06483854
- Testing
- HIV counseling and testing from a traditional health practitioner
- Where
- South Africa
- Volunteers
- 230,907 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Supine Hypertension, Autonomic Failure
Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure
Many persons with autonomic failure often have high blood pressure when lying down (supine hypertension). This study is exploring the impact of decreased venous return to the heart (achieved by raising the head of the bed) to…
- Trial name
- NCT04502225
- Testing
- Tilt, Elevated trunk, Tilt - In home
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Vanderbilt University Medical Center
Intradialytic Hypotension
Prevention of Intradialytic Hypotension by Inhibiting Bradykinin B2 Receptor
Currently, there is no medication available to adequately treat patients undergoing hemodialysis who are suffering from intradialytic hypotension (IDH).
- Trial name
- NCT05834777
- Testing
- Icatibant
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Vanderbilt University Medical Center
Dysphagia
Non-invasive Markers of Esophageal Function in Adults
The investigator proposes to study electrical activity reflective of esophageal motility in adults noninvasively by the use of multichannel electroesophagogram (EESG) and magnetoesophagogram (MESG) recordings.
- Trial name
- NCT04074356
- Testing
- Clinical measure questionnaires, EESG, MESG
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Microbial Colonization, Eye Diseases
Assessment of the Ocular Microbiome in Health and Disease
The objective of this application is to illustrate the core constituents of the ocular surface microbiome, describe factors that promote colonization, and assess the ocular microbiome's role in the health of the anterior segment.
- Conditions
- Microbial Colonization, Eye Diseases, Ophthalmopathy
- Trial name
- NCT05414994
- Testing
- Eye swab
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Type 1 Diabetes
Sleep Coach for Adolescents With Type 1 Diabetes
The goal of this work is to conduct a randomized trial evaluating the effects of a behavioral intervention to increase sleep duration and quality for adolescents with type 1 diabetes (T1D).
- Trial name
- NCT06516614
- Testing
- Sleep Coach, Diabetes Education
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Vanderbilt University Medical Center
Immunization; Infection|Transplantation Infection|Influenza, Influenza
High vs. Standard Dose Influenza Vaccines in Lung Transplant (Repeater)
This will be a follow-up study to the "Comparison of High Dose vs. Standard Dose Influenza Vaccine in Lung Allograft Recipient" study (DMID Protocol Number 22-0014) at Vanderbilt University Medical Center.
- Trial name
- NCT07192458
- Testing
- Fluzone High Dose Inactivated Influenza Vaccine, Fluzone Standard Dose Inactivated Influenza Vaccine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Aging, Depression
Cognitive Enhancement in Recurrent Depression (The COG-D-R Study)
The goal of this clinical trial is to learn if a combination of non-drug treatments works to benefit memory, thinking, and brain functioning in older individuals with recurrent depression.
- Conditions
- Aging, Depression, Cognitive Symptoms
- Trial name
- NCT07527273
- Testing
- Depression Cognitive Training, Non-Specific Cognitive Training, tDCS (active stimulation)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Vanderbilt University Medical Center
Delirium, Critical Illness
Goal-Directed Sedation in Mechanically Ventilated Infants and Children
Ventilated pediatric patients are frequently over-sedated and the majority suffer from delirium, a form of acute brain dysfunction that is an independent predictor of increased risk of dying, length of stay, and costs.
- Conditions
- Delirium, Critical Illness, Sedation Complication, Executive Dysfunction
- Trial name
- mini-MENDS (NCT04801589)
- Testing
- Dexmedetomidine, Midazolam
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- Vanderbilt University Medical Center
Post Intensive Care Syndrome
Addressing Post-Intensive Care Syndrome Among Survivors of COVID (APICS-COVID)
This study will assess the relationship between early unmet needs after hospital discharge and subsequent clinical outcomes among survivors of acute respiratory failure.
- Trial name
- APICS (NCT03738774)
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- Vanderbilt University Medical Center
Postoperative Nausea, Postoperative Vomiting
Advancing Strategies to Optimize the PerIopeRativE Management of PostOperative Nausea and Vomiting (ASPIRE-PONV) Trial
The goal of this prospective, unblinded, pragmatic and repeated crossover trial is to learn if clinical decision support alerts will impact postoperative nausea and vomiting (PONV) prophylaxis and reduce PONV rates in adult…
- Trial name
- ASPIRE-PONV (NCT07152249)
- Testing
- AW-D Clinical Decision Support Tool
- Where
- United States
- Volunteers
- 19,480 people
- Sponsor
- Vanderbilt University Medical Center
Postural Tachycardia Syndrome
Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)
The investigators will test whether an intravenous infusion of saline (salt water) will improve the exercise capacity in patients with postural tachycardia syndrome (POTS).
- Trial name
- NCT01000350
- Testing
- Saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Postural Tachycardia Syndrome
POTS NET mRNA Functional Correlation With NET Activity
DNA Acetylation can be responsible for significant down-regulation of transcription of the Norepinephrine Transporter (NET). NET is an important clearance transporter that removes norepinephrine (NE) from sympathetic neuronal…
- Trial name
- NCT03218761
- Testing
- NET mRNA level, Plasma catechols, Urine Catechols
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Ehlers-Danlos Syndrome, Anesthesia, Local
Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers
Local anesthetic resistance is commonly reported by patients with EDS. However, there are no objective data on the occurrence of local anesthetic resistance in EDS patients and in healthy volunteers.
- Trial name
- NCT04036305
- Testing
- 0.9% Sodium Chloride Injection, Lidocaine Injection 2%, Bupivacaine Injection 0.5%
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Pulmonary Hypertension
Activity Monitoring in Pulmonary Hypertension
This is a prospective, longitudinal, observational study of free-living activity trackers and patient reported outcomes to test the hypothesis that daily activity will have stronger prognostic value than 6MWD in patients with…
- Trial name
- NCT04101630
- Testing
- Activity Monitoring
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Vanderbilt University Medical Center
Pain, Post Operative Analgesia
The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery
The goal of this single-center, pragmatic, randomized, blinded, placebo-controlled trial is to evaluate the impact of intravenous (IV) lidocaine within the existing Enhanced Recovery After Surgery (ERAS)program on outcomes in…
- Conditions
- Pain, Post Operative Analgesia, Opioid Consumption, Postoperative
- Trial name
- IMPALA ERAS (NCT07224711)
- Testing
- Lidocaine HCl 0.8% in D5W, Dextrose 5% in water
- Where
- United States
- Volunteers
- 2,290 people
- Sponsor
- Vanderbilt University Medical Center
Bilateral Sensorineural Hearing Loss
Effect of Donepezil on Speech Recognition in Cochlear Implant Users
Hearing loss is a major cause of disability that affects over 48 million Americans. There are currently no medications used to treat sensorineural hearing loss.
- Trial name
- NCT05438264
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University Medical Center
Dysphagia, Critical Illness
Optimizing Dysphagia Treatment Delivery in Acute Care: A Hybrid Efficacy Implementation Trial
This research study is investigating the efficacy and implementation of expiratory muscle strength training (EMST), standard of care dysphagia treatment, and intensive dysphagia treatment in critically ill adults in the acute…
- Trial name
- NCT07736105
- Testing
- Expiratory muscle strength training (EMST), Standard of Care Dysphagia Treatment, Intensive Dysphagia Treatment
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Vanderbilt University Medical Center