Clinical trials: open to volunteers, sponsored by Icahn School of Medicine at Mount Sinai
Asymptomatic Hypertension
Innovative Approaches to Hypertension Management in High-Risk Emergency Department Populations
This single-center, single-arm quasi-experimental study will assess the feasibility and acceptability of a community health worker (CHW)-led intervention to address social determinants of health (SDOH) among emergency department…
- Trial name
- aHTN-Manage (NCT07539597)
- Testing
- Community Health Worker engagement
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Acute Kidney Failure, Acute Kidney Insufficiency
Kidney Precision Medicine Project
Acute kidney injury (AKI) and chronic kidney disease (CKD) impose a significant global health burden. Yet, no effective therapies currently exist for AKI, and only a few are available for CKD.
- Conditions
- Acute Kidney Failure, Acute Kidney Insufficiency, Acute Renal Failure, Acute Renal Injury
- Trial name
- KPMP (NCT04334707)
- Testing
- Kidney Biopsy, MRI, Retina Scan
- Where
- 13 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Breast Cancer, Metastasis
Abemaciclib in Combination With Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer
This is an open label multicenter, Phase IB/II Study of Abemaciclib in Combination with Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer
- Trial name
- NCT05095207
- Testing
- Abemaciclib, Bicalutamide
- Where
- 3 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Thyroid, PD-1
Correlation Vitamin D Level to Endocrine Autoimmune Toxicity Due to Immune Checkpoint Inhibitors
The purpose of this research study is to see if the amount of vitamin D in ones blood makes it more or less likely to develop thyroid gland toxicity when being treated with immunotherapy that blocks the activity of proteins…
- Conditions
- Thyroid, PD-1, Cancer
- Trial name
- NCT04615988
- Testing
- blood draw and questionnaire completion, questionnaire completion, blood collection
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Ulcerative Colitis
Heart Rate Variability (HRV) Biofeedback to Treat Ulcerative Colitis
This is a prospective interventional study exploring the modifiability of physiological metrics, namely Heart Rate Variability (HRV), using a 5-week standardized HRV biofeedback intervention in subjects with symptomatic…
- Trial name
- NCT05892159
- Testing
- HRV biofeedback
- Volunteers
- 23 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Long Covid, Post-treatment Lyme Disease Syndrome
Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This will be a pilot multi-arm clinical trial investigating the feasibility of Lumbrokinase (LK) as an intervention in three clinical cohorts: Long Covid (LC) Post-treatment Lyme disease syndrome (PTLDS) Myalgic…
- Conditions
- Long Covid, Post-treatment Lyme Disease Syndrome, Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
- Trial name
- NCT06511050
- Testing
- Lumbrokinase
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Long Covid
Antiviral Clinical Trial for Long Covid-19
The trial will test if two repurposed HIV antivirals can reduce symptom burden in adult participants with Long Covid compared to placebo. Viral infection and viral reactivation have been documented in Long Covid.
- Trial name
- NCT06511063
- Testing
- tenofovir disoproxil/emtricitabine, Selzentry
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cerebral Palsy
Paired Non-invasive VNS in Adolescent Cerebral Palsy Rehabilitation
This is an open-label safety and feasibility trial evaluating the use of paired non-invasive vagus nerve stimulation (VNS) and upper extremity (UE) rehabilitation in the motor impairment reduction of adolescent patients with…
- Trial name
- NCT07394608
- Testing
- Non-invasive taVNS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Intestinal Failure
The LIFT-ECHO Last Mile Project
This is a multi-site research study to evaluate the efficacy and effectiveness of the LIFT-ECHO program to improve clinical outcomes in patients and improve patient reported quality of life (PRQOL).
- Trial name
- NCT07094308
- Testing
- Learn Intestinal Failure Tele-ECHO Program, Standard of Care
- Where
- 5 sites in United States, United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Resilience, Psychological, Burnout, Psychological
Building Community Resilience Program
Established in 2021, NYCEAL consists of approximately 40 organizational partners and 120 Community Health Workers (CHWs). Over the next four years (2024-2028), NYCEAL will work with this network to implement the following…
- Conditions
- Resilience, Psychological, Burnout, Psychological, Stress, Psychological
- Trial name
- BCR (NCT06771167)
- Testing
- Building Community Resilience Program (BCR)
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Anorexia Nervosa
Metabolic Diet for Relapse Prevention in Anorexia Nervosa
This is an interventional study that will test the safety, tolerability, and efficacy of the Metabolic Diet, which was designed as a treatment for women with anorexia nervosa to remain weight-stable after they have been restored…
- Trial name
- NCT05197309
- Testing
- Metabolic Diet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Prostatic Neoplasms, Prostate Cancer
Diagnostic Utility of rhPSMA-7.3 (18F) PET/CT in Men With Prostate Cancer on Active Surveillance
This investigator-initiated, prospective study evaluates the diagnostic utility of rhPSMA-7.3 (¹⁸F) PET/CT (flotufolastat F18, marketed as POSLUMA®) in men with biopsy-proven, low-risk or favorable intermediate-risk prostate…
- Conditions
- Prostatic Neoplasms, Prostate Cancer, Prostate Adenocarcinoma
- Trial name
- NCT07285057
- Testing
- rhPSMA-7.3 (18F) PET/CT Imaging (Flotufolastat F18, POSLUMA®), Flotufolastat F18
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Schizophrenia and Related Disorders
Social Isolation and Aging in Schizophrenia
Individuals diagnosed with schizophrenia and related psychotic disorders (SZ) exhibit a markedly elevated risk of premature mortality, with a 10-20-year shorter lifespan relative to the general population.
- Trial name
- SIAS (NCT07419321)
- Where
- 4 sites in United States, Netherlands and 2 more
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Immunological Disease, Autoimmune Diseases
Biologics And Clinical Immunology Cohort at Sinai
The study team plans to establish a bioregistry of patients receiving biologic therapy as part of their standard treatment at the Mount Sinai Therapeutic Infusion Center and affiliated practices.
- Conditions
- Immunological Disease, Autoimmune Diseases, Primary Immune Deficiency
- Trial name
- BACICS (NCT04784364)
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Mal de Débarquement Syndrome
DevRobust Treatment for Mal de Débarquement Syndrome
Mal de Débarquement Syndrome (MdDS) is an under-recognized balance disorder, which is manifested by persistent false sensations of oscillatory self-motion (rocking/swaying) and/or pulling in a specific direction (gravitational…
- Trial name
- NCT05460520
- Testing
- VOR Readaptation, VOR Habituation, Visual Motion Desensitization
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Bulimia Nervosa
Changes in Inhibition and Valuation After Eating
An impaired ability to exert control has been implicated in bulimia nervosa (BN), but this impairment may not represent a stable trait or be the most effective focus for treatment.
- Trial name
- NCT05995496
- Testing
- Fasting state, Fed state, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pancreas Cancer, Pancreatitis
Pancreas Registry and High Risk Registry
The purpose of this study is to establish a registry of patients with pancreatic diseases. Patients included in the registry may include those with: pancreatic cancer, precancerous lesions of the pancreas, inflammatory lesions of…
- Conditions
- Pancreas Cancer, Pancreatitis, Chronic Pancreatitis, Pancreatic Cyst
- Trial name
- NCT02775461
- Where
- 2 sites in United States
- Volunteers
- 1,368 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Voice Disorders
Immersive Virtual Reality Meditation in Voice Therapy
This study aims to explore the feasibility of incorporating regular guided meditations via immersive virtual reality (IVR) at the start of voice therapy sessions to facilitate better learning and retention of treatment.
- Trial name
- NCT07176013
- Testing
- Voice therapy, Meditation, Virtual Reality
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Bulimia Nervosa
Neurofeedback During Eating for Bulimia Nervosa
The purpose of this study is to examine the effects of noninvasive prefrontal cortex (PFC) neurofeedback during eating in women with bulimia nervosa (BN) using a wearable brain imaging device, functional near-infrared…
- Trial name
- NCT05614024
- Testing
- Real fNIRS Neurofeedback
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Clinical High Risk for Psychosis (CHR)
Telehealth Cognitive Behavioral Therapy for Youth at Risk for Psychosis
This study aims to evaluate the feasibility and effectiveness of telehealth interventions for individuals at clinical high risk for psychosis (CHR).
- Trial name
- NCT05968560
- Testing
- CBT Skills Group for CHR Youth, Individual CBT sessions, CBT Skills Group for Families
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Icahn School of Medicine at Mount Sinai