Clinical trials: sponsored by Icahn School of Medicine at Mount Sinai
Abnormal Uterine Bleeding, Analgesia
Combined Ketorolac and Lidocaine Paracervical Block for Office Hysteroscopy
A randomized double-blind placebo controlled trial comparing the effect of a combined ketorolac and lidocaine paracervical block with a standard lidocaine paracervical block on procedure related pain with office hysteroscopies.
- Conditions
- Abnormal Uterine Bleeding, Analgesia, Paracervical Block
- Trial name
- NCT06653400
- Testing
- paracervical block, Lidocaine, ketorolac
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Opioid Use Disorder, Substance Use Disorder
Neurofeedback During Naturalistic Stimuli to Reduce Craving in Heroin Addiction
Support groups are an important component of addiction treatment, where individuals at more stable stages of their recovery help others by sharing personal experiences.
- Conditions
- Opioid Use Disorder, Substance Use Disorder, Heroin Use Disorder
- Trial name
- NCT07344233
- Testing
- Real-time fMRI Neurofeedback
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Parkinson Disease (PD), Type 1 Gaucher Disease
Parkinson's Disease in Type 1 Gaucher Disease
Parkinson's disease (PD) is an age-related movement disorder with a complex pathophysiology. Among the risk factors for PD, variants in beta-glucocerebrosidase (encoded by the gene GBA1) represent one of the most significant…
- Trial name
- NCT07886879
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Inflammatory Bowel Disease (IBD)
Translating Scientific Evidence Into Practice Using Digital Medicine and Electronic Patient Reported Outcomes
Delivery of healthcare has been traditionally limited to in-person visits or hospitalizations, while patients spend the majority of their time at home or work. Digital Medicine (e.g.
- Trial name
- NCT04345393
- Testing
- Digital Transformation Network (DTN) Program
- Where
- 4 sites in United States
- Volunteers
- 659 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Major Depressive Disorder
Invasive Decoding and Stimulation of Altered Reward Computations in Depression Patients
Novel invasive neurostimulation stimulation strategies through neurosurgical interventions are emerging as a promising therapeutical strategy for major depressive disorder.
- Trial name
- NCT05239780
- Testing
- Brain stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Polypharmacy
Improving Medication Management in World Trade Center Responders
By 2030, the majority of World Trade Center (WTC) rescue and recovery workers (responders) will be aged 65 and over and at risk for aging-related conditions and consequences including the concurrent use of five or more…
- Trial name
- NCT07022990
- Testing
- Educational brochure for deprescribing
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Colorectal Neoplasms, Breast Neoplasms
Increasing Breast and Colorectal Cancer Screening in the Community
The goal of the proposed study is to conduct a pilot randomized controlled trial (RCT) of Chi gung, a community-based intervention using peer education and tailored navigation to simultaneously improve colorectal (CRC) and breast…
- Trial name
- NCT07748377
- Testing
- Chi gung: Stay Well, Live Well
- Where
- 7 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Obstructive Pulmonary Disease
Comprehensive Patient-Centered Home-based Care Coaching for COPD Self-management
The Icahn School of Medicine at Mount Sinai will conduct a randomized controlled trial of a self-management support intervention for predominantly minoritized and low-income adults with chronic obstructive pulmonary disease…
- Trial name
- SAMBA COPD (NCT06634810)
- Testing
- Self-Management Support, COPD Education
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Atopic Dermatitis, Alopecia Areata
Treatment of Atopic Dermatitis and Alopecia Areata With Abrocitinib in Individuals With Down Syndrome
This is a single-center, open-label, basket phase 2b trial that will enroll Down Syndrome (DS) participants with at least one inflammatory skin condition (Atopic Dermatitis (AD) and/or Alopecia Areata (AA)).
- Trial name
- NCT07242638
- Testing
- Abrocitinib
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cesarean Delivery
BUprenorphine Versus Morphine for Postcesarean Analgesia (BUMP)
In this study the researchers are randomizing pregnant patients coming for elective cesarean delivery to receive either intrathecal buprenorphine or morphine for their analgesia.
- Trial name
- NCT07786012
- Testing
- buprenorphine, morphine
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Traumatic Brain Injury
Evaluation of the Abbott i-STAT TBI Biomarker Test
According to the Centers for Disease Control and Prevention, approximately 200,000 hospitalizations occurred in 2020 related to Traumatic Brain Injury (TBI), which does not include many TBIs treated only in emergency departments…
- Trial name
- NCT06766435
- Testing
- i-STAT TBI Test
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Misophonia
Transcranial Magnetic Stimulation in Misophonia
The purpose of the project is to assess the efficacy of parietal transcranial magnetic stimulation in misophonia. N=60 participants will undergo two transcranial magnetic stimulation sessions: one inhibitory and another…
- Trial name
- NCT06960083
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
HPV-related Lower Genital Tract Neoplasias, HPV-related Anal Neoplasias
Screening Women With Prior HPV for Anal Neoplasia
The goal of this single arm trial is to prospectively evaluate screening methods for anal cancer precursors in HIV uninfected women with a history of lower genital tract neoplasias and cancers.
- Conditions
- HPV-related Lower Genital Tract Neoplasias, HPV-related Anal Neoplasias, Early Stage Lower Genital Tract Cancers
- Trial name
- SWAN (NCT05217940)
- Testing
- Diagnostic tests for anal cancer screening
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Postpartum Recovery
Delivering Empowering Conversations About Obstetric Regional Anesthesia for Underserved Minorities
Racial and ethnic disparities in obstetric anesthesia care remains persistent despite studies documenting its existence and calling for action.
- Trial name
- DECORUM (NCT05260242)
- Testing
- Disparities Conversation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Advanced Heart Failure, Advanced Non-Colorectal Gastointestinal Cancer
Tier - Palliative Care For Patients With Advanced Heart Failure or Cancer
TIER-PC is an adaptive model of delivering palliative care that provides the right level of care to the right patients at the right time.
- Conditions
- Advanced Heart Failure, Advanced Non-Colorectal Gastointestinal Cancer, Advanced Lung Cancer
- Trial name
- TIER-PC (NCT06228209)
- Testing
- Tier-Palliative Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Lumbar Spine Pathology, Elective Spine Surgery
Neurocognitive and Genomic Predictors of Persistent Pain and Opioid Misuse After Spine Surgery
Having spine surgery and recovery is a vulnerable period when opioid naive patients may transition into long-term use of opioids, and when previously opioid tolerant patients may be at risk to continue towards long-term opioid…
- Trial name
- NCT06288256
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Back Pain
Behavioral and Cognitive Predictors of Persistent Pain and Opioid Misuse in Chronic Pain
Chronic lower back pain (CLBP) affects approximately 20% of the global population. The study objective is to determine if impulsivity, inhibitory control, drug choice, and/or cognitive distortions predict opioid misuse and…
- Trial name
- NCT06288282
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Metastatic Breast Cancer, Stage IV Breast Cancer AJCC V7
Enhancing Access to Supportive Services for Women of Color With Metastatic Breast Cancer
Black and Latina women experience disparities in supportive and palliative care access and outcomes. The goal of the proposed pilot study is to evaluate the feasibility and acceptability of a community navigator delivered…
- Trial name
- ACCESS (NCT06405828)
- Testing
- ACCESS Supportive Care, Phone sessions
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Prostate Cancer
Feasibility of Timesaving When Using Histolog Confocal Laser Endomicroscopy for Margin Assessment in Prostatectomy Specimen
This study investigates a new, faster way to find cancer cells on the surface of the prostate during radical prostatectomy surgery.
- Trial name
- IMARHGIN (NCT07141121)
- Testing
- Histolog Scan
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cocaine Use Disorder, Cocaine Dependence
Transcranial Direct Current Stimulation (tDCS) for Treatment of Substance Use Disorder
The researchers will test whether cognitively enhanced transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex can reduce craving in inpatients with cocaine use disorder or opioid use disorder.
- Conditions
- Cocaine Use Disorder, Cocaine Dependence, Substance Use Disorder (SUD), Opioid Use Disorder
- Trial name
- NCT07318480
- Testing
- Transcranial Direct Current Stimulator (tDCS), Cognitive Reappraisal Training
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Icahn School of Medicine at Mount Sinai