Clinical trials: sponsored by Duke University
Talaromycosis
Liposomal Amphotericin B and Flucytosine Antifungal Strategy for Talaromycosis (LAmB-FAST)
LAmB-FAST is a factorial randomized controlled trial simultaneously testing two interventions in one trial. LAmB-FAST seeks to inform treatment guidelines on the induction and maintenance therapy of HIV-associated talaromycosis…
- Trial name
- LAmB-FAST (NCT06525389)
- Testing
- Liposomal Amphotericin B (LAmB), Flucytosine (5FC), Deoxycholate Amphotericin B (DAmB)
- Where
- 5 sites in United States, Vietnam
- Volunteers
- 428 people
- Sponsor
- Duke University
Retinopathy of Prematurity (ROP)
Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care
Retinopathy of prematurity (ROP) is a disorder of development of the retina and its vasculature that can impact vision in vulnerable preterm neonates for a lifetime.
- Trial name
- (BabySTEPS3) (NCT07738874)
- Testing
- Ultra-widefield Optical Coherence Tomography (UWF-OCT), Wide-field ophthalmic imaging system
- Where
- 2 sites in United States
- Volunteers
- 175 people
- Sponsor
- Duke University
Delayed Graft Function
TxAccess and Dd-cfDNA for Improved Care of Patients With Delayed Graft Function
This is a prospective multicenter nonrandomized pragmatic hybrid effectiveness-implementation study to test the effectiveness of TxAccess in improving time to renal recovery and immunologic outcomes in patients with delayed graft…
- Trial name
- NCT07825688
- Testing
- TxAccess, Donor-Derived Cell-Free DNA (dd-cfDNA)
- Volunteers
- 450 people
- Sponsor
- Duke University
Newly Diagnosed Glioblastoma
Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and Relatlimab
GIANT is an open-label, multi-center, randomized, perioperative (neoadjuvant followed by adjuvant), phase 2 trial with a safety lead-in phase to investigate the feasibility, safety and tolerability, and establish the biological…
- Trial name
- GIANT (NCT06816927)
- Testing
- Nivolumab, Relatlimab, TMZ
- Where
- 4 sites in United States, Australia
- Volunteers
- 92 people
- Sponsor
- Duke University
Old Age, Mobility Limitation
RIC (Remote Ischemic Conditioning) in Older Individuals
The purpose of this study is to examine the feasibility and acceptability of a technique called remote ischemic conditioning (RIC) that aims to improve muscle strength, muscle mass, exercise tolerance, resilience (i.e.
- Conditions
- Old Age, Mobility Limitation, Debility
- Trial name
- NCT06476288
- Testing
- Low-intensity resistance exercise training, High-Dose Remote ischemic conditioning (RIC), Low-Dose Remote ischemic conditioning (RIC)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Duke University
Idiopathic Intracranial Hypertension (IIH)
Tirzepatide in Idiopathic Intracranial Hypertension Trial
This will be a randomized, double-blind, parallel, placebo-controlled trial of 60 participants. The primary analysis will be a statistical comparison of the estimates of the mean difference in the 12-month change in intracranial…
- Trial name
- TIIHT (NCT07191873)
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Breast Mass
Spot Compression Ultrasound Compared to Traditional Breast Ultrasound
The purpose of this study is to determine the efficacy of targeted breast ultrasound ("ultrasound in the grid") performed concurrently with diagnostic mammogram during breast compression with an open mammogram paddle in lesion…
- Trial name
- NCT07471672
- Testing
- Targeted ultrasound in the grid
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Kidney Transplant
Tailored mHealth Coaching and Social Resource Support in Kidney Transplantation
The purpose of this study is to learn if a mobile app, personalized coaching, and assistance from social workers can help improve outcomes for kidney transplant patients.
- Trial name
- NCT07815782
- Testing
- mHealth app plus personalized coaching, Social work support
- Where
- United States
- Volunteers
- 339 people
- Sponsor
- Duke University
Glaucoma, Glaucoma, Suspect
Automated Applanation Tonometry
Goldmann Applanation Tonometry (GAT) is considered the clinical gold standard for eye pressure measurements and yet it is known to be a subjective measurement with limited repeatability and limited portability.
- Trial name
- NCT05235321
- Testing
- Standard GAT, Fixed force GAT, Upright applanating prototype
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Duke University
Heart Failure, Diastolic
External Body Pressure in Heart Failure With Preserved Ejection Fraction
The primary objective of the study is to test the impact of positive and negative body pressure on exercise capacity, symptoms, blood volume distribution and central cardiac hemodynamics in patients with heart failure and…
- Trial name
- NCT05764564
- Testing
- Positive or negative pressure
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Duke University
Hepatic Encephalopathy
Deprescribing Proton Pump Inhibitors to Reduce Post-TIPS Hepatic Encephalopathy
A total of 40 patients taking proton pump inhibitors (PPIs) who undergo transjugular intrahepatic portosystemic shunt (TIPS) creation as part of routine clinical care will be randomized in 1:1 fashion to either continue or…
- Trial name
- NCT05070351
- Testing
- PPI deprescribing
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Duke University
Epilepsy
Health Literacy Project
Evaluating changes in knowledge, attitude, and practices (KAP) related to epilepsy and its treatment as a result of an educational intervention among adolescents with epilepsy to determine if improved KAP about epilepsy results…
- Trial name
- NCT06634901
- Testing
- Health Literacy Educational Session- Comparator, Health Literacy Educational Session
- Where
- 2 sites in Uganda
- Volunteers
- 60 people
- Sponsor
- Duke University
Atrial Fibrillation
Shared Decision Making to Address Racial Disparities in Oral Anticoagulation in NVAF
The study is a pilot analysis using a decision on the risk and benefits of oral anticoagulation for stroke reduction for patients with non-valvular atrial fibrillation.
- Trial name
- NCT04956978
- Testing
- Patient Decision Support Tool
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Duke University
Menstrual Dysfunction
Stress and Menstrual Health
The goal of this experimental study is to determine how stressors that do not directly impact energy state or energy demands (hereafter called "non-energetic stressors") affect reproductive health in pre-menopausal women.
- Trial name
- NCT07566260
- Testing
- Heat stress, Sleep stress, Exercise stress
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Duke University
Opioid Use Disorder, Digital Health Intervention
Pilot Testing of the emPath Platform to Improve Medication for Opioid Use Disorder (MOUD) Linkage and Retention Among Adults With Opioid Use Disorder in Durham, North Carolina
This pilot study will evaluate the emPath digital platform, a platform designed to improve access to and retention in low-barrier telemedicine for delivery of medication for opioid use disorder (MOUD) among adults with opioid use…
- Conditions
- Opioid Use Disorder, Digital Health Intervention, Telemedicine, Outreach Intervention
- Trial name
- NCT07810322
- Testing
- emPath Intervention
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Duke University
HER2+ Metastatic Breast Cancer (MBC)
Patient Navigation for HER2+ Metastatic Breast Cancer Patients Treated With Tucatinib
The goal of this study is to test a novel nurse-delivered patient navigation program for women with HER2+ metastatic breast cancer (mBC) receiving tucatinib, trastuzumab, and capecitabine.
- Trial name
- NCT06983691
- Testing
- Patient Navigation Program
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Duke University
Chronic Kidney Diseases, Dialysis
Dialysis Geriatric Care Model
The objectives of this study are to refine the dialysis care model with key stakeholder input and conduct a pilot randomized controlled trial (RCT) to obtain evidence critical to inform a definitive RCT.
- Conditions
- Chronic Kidney Diseases, Dialysis, Geriatric
- Trial name
- NCT05793138
- Testing
- Geriatric Care Model, Usual Care
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Duke University
Large Tumor, Palliative Radiotherapy
Lattice Radiotherapy for Adults With Large Tumors
The purpose of this study is to ask whether using a specialized radiation therapy technique called Lattice Radiation Therapy (LRT) can shrink large tumors when given with palliative radiation therapy.
- Trial name
- LRT (NCT07647679)
- Testing
- Lattice Radiation Therapy (LRT)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
IPMN, IPMN, Pancreatic
The Prevention of Progression to Pancreatic Cancer Trial (The 3P-C Trial)
This is a multi-center randomized double-blind placebo controlled trial of patients with high-risk intraductal papillary mucinous neoplasms (IPMNs) of the pancreas.
- Trial name
- NCT04207944
- Testing
- Sulindac 400 MG
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Duke University
ASCVD, Hyperlipidemia
Duke Cardiometabolic Prevention Clinic's Impact on High-risk Cardiovascular Patients With Uncontrolled Risk Factors
This project is studying whether a team-based specialty clinic can help people with type 2 diabetes and heart disease better manage their blood pressure and cholesterol.
- Conditions
- ASCVD, Hyperlipidemia, Hypertension
- Trial name
- DUKE PREVENT (NCT07117695)
- Testing
- Referral to the Duke Cardiometabolic Prevention Clinic
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Duke University