Clinical trials: open to volunteers, sponsored by Brigham and Women's Hospital
Infertility of Uterine Origin
Deceased Uterine Transplant in Absolute Uterine Infertility (AUIF)
Our study will explore the feasibility of initiating a deceased donor uterine transplant program in addition to the existing living donor IRB at BWH.
- Trial name
- NCT04026893
- Testing
- Uterine Transplant from Deceased Donor
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Stress
Photobiomodulation, Heart Rate Variability, and Acute Stress
Photobiomodulation (PBM) is a form of light therapy that uses red or near-infrared light to influence biological processes. In prior studies, PBM has been shown to improve various physiological functions, including tissue repair…
- Trial name
- NCT07475858
- Testing
- Vielight Vagus
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Genetics in Hypertension
Beta-2 Adrenergic Receptor Polymorphic Variants: An Endotype of Salt Sensitive Hypertension (Beta2AR).
All living things are made of building blocks called cells. Genes are the part of cells that contain the instructions which determine important things about you, like your height or hair color, and affect your health.
- Trial name
- Beta2AR (NCT07832942)
- Testing
- low sodium diet, high sodium diet, renal plasma flow
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Brigham and Women's Hospital
CPPD - Calcium Pyrophosphate Deposition Disease
Colchicine to Reduce Your SympToms And Lower Levels of Inflammation, Zeroing in on Effective CPPD Disease Treatment
The goal of this clinical trial is to learn if colchicine reduces levels of proteins indicating inflammation in the blood in individuals with calcium pyrophosphate deposition (CPPD) disease.
- Trial name
- CRYSTALLIZE (NCT06855433)
- Testing
- Colchicine Pill
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Brigham and Women's Hospital
Heart Failure, Beta-blocker
N-of-1 Trial to Promote Beta-Blocker Titration in Heart Failure
In this study we seek to understand whether N-of-1 trials using a crossover withdrawal/reversal design with 1-5 three-week periods can be used to identify the highest tolerated beta-blocker dose for patients with Heart Failure…
- Conditions
- Heart Failure, Beta-blocker, Older Adults
- Trial name
- NCT07489352
- Testing
- N-of-1 trials, Enhanced usual care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Cardiac Surgery
Nicotinamide Mononucleotide in Patients Undergoing Cardiac Surgery
The investigators will perform a phase 2a, randomized, double-blind, placebo-controlled clinical trial in adult patients undergoing elective cardiac surgery to investigate the effects of oral nicotinamide mononucleotide (NMN)…
- Trial name
- NCT07013591
- Testing
- MIB-626
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Brigham and Women's Hospital
Amputation
Training Independent Muscle Activation From a Common Source
In this study, the investigators are evaluating a new surgical technique that may allow participants to control their muscles in a new way after their amputation or revision surgery.
- Trial name
- NCT07831278
- Testing
- amputation or revision procedure with additional RPNI construction
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea, Sleep-disordered Breathing
Combination Upper-Airway Electrical and Pharmacological Stimulation for Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a common condition in which the airway repeatedly collapses during sleep, leading to poor sleep quality and reduced oxygen levels.
- Trial name
- NCT07577661
- Testing
- Combination device and drug: Unilateral hypoglossal nerve stimulation & atomoxetine-plus-oxybutynin (HGNS+AtoOxy), Unilateral hypoglossal nerve stimulation (HGNS), active comparator condition, Atomoxetine-plus-oxybutynin (80/5 mg) (AtoOxy), active comparator condition
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Brigham and Women's Hospital
Perinatal Depression, Post Partum Depression
Accelerated TMS for Perinatal Depression
We are studying a treatment for depression called accelerated Transcranial Magnetic Stimulation (TMS) among pregnant and postpartum individuals.
- Conditions
- Perinatal Depression, Post Partum Depression, Major Depressive Disorder
- Trial name
- PAiNT (NCT06968390)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Brigham and Women's Hospital
Opioid Consumption, Postoperative, Multimodal Analgesia
Assessing Suzetrigine for Pain Reduction Following Ureteroscopic Surgery
Urologic surgery has advanced with new technologies to allow less invasive management of common afflictions such as kidney stones, these procedures are notoriously painful as the ureter must be dilated to accommodate any…
- Conditions
- Opioid Consumption, Postoperative, Multimodal Analgesia, Ureteroscopy, Ureteral Stents
- Trial name
- NCT07654296
- Testing
- multimodal analgesia regimen without suzetrigine, Suzetrigine
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Brigham and Women's Hospital
Major Depressive Disorder (MDD)
Imaging- vs. Scalp-Targeted Accelerated TMS for Depression: The Number Needed to Scan Trial
Transcranial magnetic stimulation(TMS) is a non-invasive form of brain stimulation that is cleared by the United States Food and Drug Administration (FDA) for depression.
- Trial name
- NNS (NCT07043738)
- Testing
- Transcranial Magnetic Stimulation
- Volunteers
- 160 people
- Sponsor
- Brigham and Women's Hospital
Prostate Cancer Patients
AI Chatbot for Prostate Radiation Therapy Patient Education
This study will evaluate whether an artificial intelligence chatbot can help patients better understand radiation therapy for localized prostate cancer.
- Trial name
- NCT07719062
- Testing
- AI Educational Chatbot
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Life Style
Effect of Physical Activity Pattern on Cardiometabolic Health
The goal of this study is to understand the interaction between the circadian system and physical activity. Participants will: complete 2 inpatient stays perform moderate exercise be provided with identical meals have frequent…
- Trial name
- PACE (NCT05838508)
- Testing
- Exercise intervention
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea, Sleep Disordered Breathing
Combination Tonsillectomy and Hypoglossal Nerve Stimulation for OSA Patients With Lateral Pharyngeal Collapse
The goal of this clinical trial is to learn whether removing the tonsils at the time of hypoglossal nerve stimulation improves treatment of obstructive sleep apnea in adults whose airway collapses from the side of the upper…
- Trial name
- HGNS+T (NCT07724938)
- Testing
- Tonsillectomy, HGNS
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Brigham and Women's Hospital
Venous Thromboembolism, Cancer
Statins to Prevent Cancer Associated Blood Clots
Patients with cancer are at high risk for life-threatening venous thromboembolism (VTE) yet rarely receive anticoagulant prophylaxis due to bleeding risks.
- Conditions
- Venous Thromboembolism, Cancer, Cardiovascular Events
- Trial name
- STAT-CAT (NCT07303816)
- Testing
- Rosuvastatin
- Where
- 9 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- Brigham and Women's Hospital
Hematopoietic Stem Cell Transplant
Positive Psychology Intervention for Hematopoietic Stem Cell Transplantation Survivors
This randomized clinical trial is evaluating the impact of a positive psychology intervention (PATH) on anxiety symptoms, depression symptoms, and quality of life in survivors of hematopoietic stem cell transplant (HSCT) compared…
- Trial name
- PATH-4 (NCT06328127)
- Testing
- PATH
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- Brigham and Women's Hospital
Hematopoietic Stem Cell Transplantation
A Structured Peer Support Intervention for Patients Undergoing Hematopoietic Stem Cell Transplantation
This randomized clinical trial is evaluating the impact of a structured peer support intervention (STEPP) on psychological distress and quality of life among patients undergoing hematopoietic stem cell transplantation.
- Trial name
- STEPP-3 (NCT07774104)
- Testing
- STEPP, Minimally Enhanced Usual Care Control
- Where
- 3 sites in United States
- Volunteers
- 350 people
- Sponsor
- Brigham and Women's Hospital
Brain Cancer, Brain Metastases
Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases
The purpose of this study is to determine whether AGuIX (Activation and Guidance of Irradiation by X-ray) gadolinium-based nanoparticles make radiation work more effectively in the treatment of patients with brain metastases that…
- Conditions
- Brain Cancer, Brain Metastases, Melanoma, Lung Cancer
- Trial name
- NCT04899908
- Testing
- Stereotactic Radiation, AGuIX gadolinium-based nanoparticles
- Where
- 2 sites in United States
- Volunteers
- 134 people
- Sponsor
- Brigham and Women's Hospital
Brain Tumor
Treatment Response Assessment Maps to Delineate Necrosis From Tumor After Stereotactic Radiation in Brain Metastases
This research study is investigating the value of an imaging study of the brain called an MRI (which stands for magnetic resonance imaging), utilized in unique way, to delineate whether the tumor has recurred or whether radiation…
- Trial name
- NCT04033497
- Testing
- MRI
- Where
- 2 sites in United States
- Volunteers
- 101 people
- Sponsor
- Brigham and Women's Hospital
Diagnostic Errors
Achieving Diagnostic Excellence Through Prevention and Teamwork
This study seeks to link a group of hospitals to measure and share the rates of diagnostic errors, to understand underlying causes of diagnostic errors, and develop ways that hospitals, clinicians, and patients can work together…
- Trial name
- ADEPT (NCT05747755)
- Testing
- ADEPT Program
- Where
- 2 sites in United States
- Volunteers
- 7,200 people
- Sponsor
- Brigham and Women's Hospital