Clinical trials: sponsored by Brigham and Women's Hospital
Chronic Kidney Diseases
An Individuation Intervention to Reduce Socioeconomic Disparities in Chronic Kidney Disease Care
The goal of this clinical trial is to test whether an individuation intervention can improve the quality of chronic kidney disease (CKD) care for patients with low socioeconomic status (SES) and to understand the mechanisms…
- Trial name
- NCT07921342
- Testing
- Individuation + Implicit Bias Training, Implicit Bias Training Alone
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Brigham and Women's Hospital
Lupus Nephritis (LN)
Dapagliflozin in Active Lupus Nephritis
Lupus nephritis is a chronic and life-threatening autoimmune cause of kidney disease that predominately impacts young people and can lead to kidney failure.
- Trial name
- Dapa-Active LN (NCT07323524)
- Testing
- Dapagliflozin (10Mg Tab) along with standard medical therapy
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- Brigham and Women's Hospital
Skilled Nursing Facility, Rehabilitation
Skilled Nursing Facility Care at Home
We will perform a parallel-group multicenter patient-level randomized controlled evaluation of skilled nursing facility care at home.
- Trial name
- NCT06416670
- Testing
- Skilled nursing facility care at home
- Where
- 5 sites in United States
- Volunteers
- 244 people
- Sponsor
- Brigham and Women's Hospital
Medication Adherence
Personalized Routine and Habit Integration to Support Medication Management
The objective of this study is to test a multidisciplinary care team behavioral intervention to enhance medication adherence among older adults with multiple chronic conditions (MCC).
- Trial name
- PRISM (NCT07914452)
- Testing
- PRISM Arm, Enhanced Usual Care Arm
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Brigham and Women's Hospital
Cognition, Cardiometabolic Risk Factors
Trial of Pistachio Consumption in Older Adults
The goal of this study is to evaluate whether a pistachio-enriched diet leads to changes in cognitive function, cardiometabolic risk factors, and life satisfaction in older adults over a 6-month period.
- Conditions
- Cognition, Cardiometabolic Risk Factors, Life Satisfaction
- Trial name
- NCT06992544
- Testing
- Pistachio-enriched diet, Usual diet
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Primary Aldosteronism, Resistant Hypertension
Electronic Alert to Improve Testing For Primary Aldosteronism in Patients With Hypertension
Primary aldosteronism (PA) is common but rarely recognized cause of hypertension that carries excess cardiovascular and renal risk and has approved targeted treatments.
- Conditions
- Primary Aldosteronism, Resistant Hypertension, Secondary Hypertension, Hyperaldosteronism
- Trial name
- ALERT-PA (NCT05925569)
- Testing
- Best Practice Advisory Computerized Alert
- Where
- United States
- Volunteers
- 12,501 people
- Sponsor
- Brigham and Women's Hospital
Advanced Prostate Cancer, Metastatic Prostate Cancer
Pilot Study for Detection of PSMA-Low CRPC-NE Tumors With Fluciclovine PET/CT
This research study is studying a positron emission tomography (PET) agent called 18F-fluciclovine to evaluate how well 18F-fluciclovine-PET scans determine the extent of advanced prostate cancer that either has low…
- Conditions
- Advanced Prostate Cancer, Metastatic Prostate Cancer, Metastatic Prostate Neuroendocrine Carcinoma
- Trial name
- NCT06062745
- Testing
- 18F-fluciclovine, PET/CT
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Amputation
Magnetic Bead Tracking System and eOPRA Implant System With Bionic Prosthesis for Transtibial Amputees
The e-OPRA Implant System, is a further development of the OPRA (Osseointegrated Prostheses for the Rehabilitation of Amputees) Implant System.
- Trial name
- TTeOPRA+MB (NCT06391697)
- Testing
- eOPRA Implant System for Transtibial Amputees and Magnetic Bead Tracking System
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- Brigham and Women's Hospital
Migraine
Cocoa Extract for Migraine Trial
The goal of this clinical trial is to assess the feasibility of recruitment and adherence to a high-dose cocoa extract supplement in individuals diagnosed with migraine.
- Trial name
- CORAL (NCT06808230)
- Testing
- Cocoa extract
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Brigham and Women's Hospital
Metastatic Prostate Cancer, Hormone Sensitive Prostate Cancer
PSMAtrack-tracking Changes in PSMA-PET During Initial Therapy for Metastatic Hormone-sensitive Prostate Cancer
The goal of this clinical trial is to learn if serial PSMA-PET/CT scans can be used to monitor response to therapy in metastatic hormone sensitive prostate cancer and can be potentially used to optimize future treatment…
- Conditions
- Metastatic Prostate Cancer, Hormone Sensitive Prostate Cancer, Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
- Trial name
- NCT06479187
- Testing
- 18F-rhPSMA-7.3, PET/CT
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Type 2 Diabetes
Personalizing A1c Using Hematologic Indices and CGM for Accurate Diabetes Diagnosis
The goal of this observational study is to learn why some adults over the age of 65, have A1c tests that do not match up with their blood glucose levels, also known as 'A1c-glucose discordance'.
- Trial name
- PRECISE DM DX (NCT07111416)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Primary Sclerosing Cholangitis (PSC)
FEAST and HOPE: Redox PSC Pilot Study
The goal of this clinical trial is to test whether a type of cell death called disulfidptosis plays a role in primary sclerosing cholangitis (PSC) in adults aged 18 to 70.
- Trial name
- FEAST (NCT07898839)
- Testing
- N-Acetyl Cysteine (NAC), Alpha-Lipoic Acid (ALA), Nicotinamide Riboside (NR)
- Volunteers
- 15 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Hypoglossal Nerve Stimulation in Obstructive Sleep Apnea With Complete Concentric Collapse
This study examines how hypoglossal nerve stimulation affects breathing and sleep apnea in adults whose airway closes from all sides at the soft palate during sleep, a pattern called complete concentric collapse.
- Trial name
- NCT07898618
- Testing
- Inspire Hypoglossal Nerve Stimulation System
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Spinal Surgery for Lumbar Spinal Stenosis (LSS)
Activity Post Spinal Surgery Engagement Trial
Back pain can be disabling, limiting the ability to walk and to engage in physical activity. For patients with degenerative lumbar spinal stenosis, decompressive surgery often provides substantial pain relief and improved…
- Trial name
- ASSET (NCT07825480)
- Testing
- Wrist based activity tracker wear, Basic Study Activities, Telephonic Active Coaching (Motivational Interviewing) + Financial Incentives
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Brigham and Women's Hospital
Infant Development, Language Development
The Impact of Music Medicine on Preterm Brain Development and Behavior
The investigators are conducting a two-site randomized control trial with the aim of defining the impact of music (M) without or with parent voice (MPV) on very preterm infants' acute and cumulative stress, intranetwork…
- Conditions
- Infant Development, Language Development, Prematurity, Stress
- Trial name
- NCT06536296
- Testing
- Music, Music and parent voice, Standard Care
- Where
- 2 sites in United States
- Volunteers
- 243 people
- Sponsor
- Brigham and Women's Hospital
Preterm Birth Complication
Serial Brain MRI in Hospitalized Preterm Infants
The purpose of this research study is to use serial magnetic resonance imaging (MRI) to define the timing and factors associated with brain injury as well as the pattern of brain growth of very preterm infants during…
- Trial name
- NCT06052865
- Testing
- SENSE-plus: The Supporting and Enhancing NICU Sensory Experiences 2nd Edition (SENSE II) program, SENSE: The Supporting and Enhancing NICU Sensory Experiences 2nd Edition (SENSE II) program, Reference/ Standard of care
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Brigham and Women's Hospital
Pancreatic Ductal Adenocarcinoma (PDAC), Family History of Pancreas Cancer
Reach and Engagement of GENetic Education, Risk Assessment, and TEsting Feasibility Trial
This study will test a remote approach to help people who may be at higher risk for pancreatic cancer learn about and decide whether to get genetic testing and a blood test that looks for signs of several cancers (MCED testing).
- Conditions
- Pancreatic Ductal Adenocarcinoma (PDAC), Family History of Pancreas Cancer, Genetic Testing, Multi-cancer Early Detection
- Trial name
- REGENERATE (NCT07787156)
- Testing
- Telephone education session, Online educational materials
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Brigham and Women's Hospital
Multiple Chronic Conditions, Adverse Event
Real-time Symptom Monitoring Using ePROs to Prevent Adverse Events During Care Transitions
This study aims to predict and minimize post-discharge adverse events (AEs) during care transitions through early identification and escalation of patient-reported symptoms to inpatient and ambulatory clinicians by way of…
- Trial name
- NCT05282654
- Testing
- ePRO Application
- Where
- 2 sites in United States
- Volunteers
- 937 people
- Sponsor
- Brigham and Women's Hospital
Pulmonary Disease, Chronic Obstructive, Emphysema
Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is a long-term lung disease that is often caused by cigarette smoking. The purpose of this study is to evaluate whether certain genetic factors predispose some smokers to develop COPD…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Emphysema, Bronchitis, Chronic
- Trial name
- COPDGene (NCT00608764)
- Where
- 20 sites in United States
- Volunteers
- 10,718 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Chronic Obstructive Pulmonary Disease
Boston Early-Onset Chronic Obstructive Pulmonary Disease (COPD) Study
Chronic obstructive pulmonary disease (COPD) is often caused by cigarette smoking, but genetic predisposition also influences COPD susceptibility.
- Trial name
- NCT01177618
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Brigham and Women's Hospital
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