Clinical trials: gene expression analysis
Multiple Myeloma (MM)
A Clinical Trial Evaluating the Safety Tolerability, Radiation Absorption Dose, Distribution, PET Imaging and Histological Expression of 68Ga-NOTA-SCH001 in Patients With Multiple Myeloma
Multiple myeloma is the second most common hematologic malignancy in adults, and no curative treatment currently exists. With the development of monoclonal antibodies for tumor therapy, identifying tumor-specific biomarkers has…
- Trial name
- NCT06925958
- Testing
- Flow cytometry
- Volunteers
- 15 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Adult Acute Lymphoblastic Leukemia
Description and Prognostic Evaluation of Four Biological Parameters of Blast Cells in Adult Acute Lymphoblastic Leukemia
Adult acute lymphoblastic leukemia treatment approaches relie on risk stratification, including cytogenetics. We want to study at diagnosis several blast cells parameters on frozen samples of GRAALL protocols enrolled patients…
- Trial name
- NCT00188084
- Testing
- DNA Index, S-Phase%, CD45 expression
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Angers
Estrogen Excess, Varicose Veins
Estrogen Receptors and Chronic Venous Disease
Chronic Venous Disease (CVD) is a very common problem affecting western adult population. To date the pathophysiology of CVD development encloses several theories such as the role of extracellular matrix (ECM) components…
- Trial name
- ERCVD (NCT02558426)
- Testing
- Venous Surgery
- Volunteers
- 40 people
- Sponsor
- University of Catanzaro
Cervical Intraepithelial Neoplasia Grade 1 (CIN 1)
Diagnostic and Prognostic Value of p16INK4a Expression in Low Grade Squamous Intraepithelial Lesions of the Cervix.
P16INK4a has recently been described as a surrogate marker for HR-HPV associated squamous and glandular intraepithelial lesions of the cervix.
- Trial name
- NCT00343213
- Testing
- colposcopy
- Where
- 3 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Male Infertility, Heart Valve Disease
Warfarin Effects on Male Fertility After Cardiac Surgery
Young male patients undergoing cardiac surgery may require oral anticoagulation with warfarin either lifelong, such as after mechanical valve replacement, or for a limited postoperative period, for example following valve repair…
- Trial name
- NCT07330869
- Testing
- Semen analysis, sperm DNA fragmentation and hormonal evaluation
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Città di Lecce Hospital, GVM Care & Research
Disorder of Consciousness, Consciousness, Loss of
SeeMe: An Automated Tool to Detect Early Recovery After Brain Injury
Early prediction of outcomes after acute brain injury (ABI) remains a major unsolved problem. Presently, physicians make predictions using clinical examination, traditional scoring systems, and statistical models.
- Conditions
- Disorder of Consciousness, Consciousness, Loss of, Trauma, Brain, Traumatic Brain Injury
- Trial name
- NCT06083441
- Testing
- SeeMe, Coma Recovery Scale-Revised (CRS-R)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Pneumonia, Bacterial, Ventilator Associated Pneumonia
MASTERMIND-Pneumonia Study (Also Known as Pneumonia Direct Pilot)
The MASTERMIND-Pneumonia Study (also known as Pneumonia Direct Pilot Study) is designed to assess whether combining molecular diagnostics for bacteria and AMR markers with host-response profiling improves agreement and predictive…
- Trial name
- PDP (NCT06181669)
- Testing
- Pathogen and Host Directed testing
- Where
- 4 sites in United States
- Volunteers
- 173 people
- Sponsor
- Duke University
Breast Cancer
Gene Expression Following Short Term Exposure to Neoadjuvant Endocrine Therapy in Invasive Breast Cancer
The purpose of this pilot study is to see if taking anastrozole (Arimidex) for 10 days causes changes in breast cancer cells. Anastrozole (Arimidex) is a drug used in the treatment of a type of breast cancer that depends on…
- Trial name
- NCT00588003
- Testing
- anastrozole
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Prostate Cancer
Isotretinoin, Interferon Alfa-2b, Docetaxel, and Estramustine in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to Hormone Therapy
RATIONALE: Isotretinoin may help prostate cancer cells become more like normal cells, and to grow and spread more slowly. Interferon alfa-2b may interfere with the growth of tumor cells.
- Trial name
- NCT00176527
- Testing
- recombinant interferon alfa-2b, docetaxel, estramustine phosphate sodium
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Leukemia
Biomarkers in DNA Samples From Patients With Chronic Lymphocytic Leukemia Previously Treated With Fludarabine-Based Therapy
RATIONALE: Studying samples of DNA in the laboratory from patients who received fludarabine-based treatment may help doctors learn more about the effects of fludarabine on cells.
- Trial name
- NCT01145469
- Testing
- DNA analysis, gene expression analysis, polymorphism analysis
- Volunteers
- 225 people
- Sponsor
- Eastern Cooperative Oncology Group
Systemic Lupus Erythematosus (SLE)
miR-101-3p and Autotaxin in SLE Patients
Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting multiple organs and characterized by heterogeneous clinical manifestations.
- Trial name
- NCT07252141
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eman Mohamed Shawky
Myelodysplastic Syndromes
Sterile Inflammation and Molecular Aberrations in MDS
The objective of this study is the description of the possible association between genetic mutation/aberration profiles, inflammatory tonus and clinical phenotype based on PROMs and HRQoL.
- Trial name
- InflamGen (NCT04313231)
- Testing
- Next Generation Sequencing, Tumorimmunological examinations - multiplex assays/quantitative polymerase chain reaction, flow cytometry
- Where
- Austria
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Astrocytoma, Glioblastoma
First-in Cancer-Type Phase I Study of FT536 for Recurrent WHO Grade 4 Astrocytoma
This is a single center, first-in cancer-type phase I clinical trial of FT536 for adult patients with recurrent WHO Grade 4 astrocytoma, irrespective of IDH-mutational status, for which a standard of care repeat craniotomy for…
- Conditions
- Astrocytoma, Glioblastoma, Progressive Disease
- Trial name
- NCT07560865
- Testing
- FT536, Biopsy/ Intratumoral Injection/ Gross Tumor Resection, Blood/ Cerebrospinal Fluid/ Tumor Pathology
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Metastatic/Locally Advanced Small-Cell Lung Cancer, Metastatic/Locally Advanced Poorly Differentiated NEC
Study Investigating Tarlatamab (AMG 757) in Patients With Metastatic/Locally Advanced Small-Cell Lung Cancer (SCLC) and Other Poorly Differentiated Neuroendocrine Carcinomas (NECs), With Biomarker Analysis to Characterize Response/Resistance (UNLOCK TARLATAMAB)
UNLOCK TARLATAMAB is an open-label, single arm, multicenter, phase 2 platform study that aims to evaluate the mechanisms of action and resistance to tarlatamab in metastatic/locally advanced Small-Cell Lung Cancer (SCLC) with any…
- Trial name
- NCT07016230
- Testing
- Tarlatamab
- Where
- 3 sites in France
- Volunteers
- 40 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Breast Cancer
Correlation of Genomic Variation in Enzymes Responsible for Metabolism of Capecitabine With Drug Metabolism
The goal of this clinical research study is to find out how gene expression (as well as how often this expression occurs) in patients with breast cancer affects how Xeloda® (capecitabine) is cleared (passed through the urine)…
- Trial name
- NCT00960544
- Testing
- Capecitabine
- Sponsor
- M.D. Anderson Cancer Center
Leukemia, Myelodysplastic Syndromes
Clofarabine and High-Dose Melphalan Followed by Donor Stem Cell Transplant in Patients With Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, or Myelodysplastic Syndromes
RATIONALE: Giving chemotherapy, such as clofarabine and melphalan, before a donor stem cell transplant helps stop the growth of cancer or abnormal cells.
- Trial name
- NCT00641030
- Testing
- clofarabine, melphalan, gene expression analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center
Urothelial Carcinoma, Breast Cancer
Clinical Application of PET Imaging Targeting Nectin-4 in Malignant Tumors
This study is a diagnostic study. Patients and healthy volunteers with clinically suspected or confirmed urothelial carcinoma, breast cancer, lung carcinoma and other malignant tumors with high expression of Nectin-4 will be…
- Conditions
- Urothelial Carcinoma, Breast Cancer, Lung Carcinoma
- Trial name
- NCT06994078
- Testing
- 68Ga-NOTA-Nectin-4 antibody fragment
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Complete and Accurate Statistical Data of 60 Patients, CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately
Analysis of the Effect of Donor CYP3A5 Gene Polymorphism on Early Tacrolimus Concentration and Postoperative Acute Renal Injury After Liver Transplantation
Tacrolimus is the most commonly used immunosuppressant for preventing and treating rejection after liver transplantation. However, its treatment window is narrow, the pharmacokinetic individual differences are large, routine dose…
- Conditions
- Complete and Accurate Statistical Data of 60 Patients, CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately, Postoperative Tacrolimus Concentrations Were Accurately Recorded in 60 Patients, According to the Diagnosis and Grading Criteria of Acute Kidney Injury, the Cases and Grading of Postoperative Acute Kidney Injury in 60 Patients Were Counted
- Trial name
- NCT06319391
- Testing
- CYP3A5*1*、CYP3A5*1*3, CYP3A5*3*3
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ziqiang Li
Melanoma (Skin)
Sorafenib and Isolated Limb Infusion of Melphalan in Treating Patients With Stage III Melanoma of the Arm or Leg
RATIONALE: Sorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00565968
- Testing
- melphalan, sorafenib tosylate, gene expression analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Atopic Dermatitis, Psoriasis
Comparison of Cathelicidin Expression in Skin and Saliva in Patients With Atopic Dermatitis and Psoriasis
Cathelicidins are small proteins in the human body that protect against infection. The purpose of this study is to determine if the amount of cathelicidins and other small proteins found in saliva can predict the amount of these…
- Trial name
- NCT00407979
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)