Clinical trials: Propofol
Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Abdominal
Effect of Remimazolam Versus Propofol Total Intravenous Anesthesia on Intraoperative Hemodynamic Stability in Patients Undergoing Thoracic or Abdominal Endovascular Aortic Repair
The purpose of this study is to compare two intravenous anesthetics, remimazolam and propofol, for their effects on intraoperative hemodynamic stability in patients undergoing thoracic or abdominal endovascular aortic repair.
- Conditions
- Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Abdominal, Intraoperative Hypotension, Hemodynamic Instability During Anesthesia
- Trial name
- NCT07806006
- Testing
- Remimazolam Besylate, propofol
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Traumatic Brain Injuries
Impact of Dexmedetomidine Versus Propofol on Intracranial Pressure in Adult Traumatic Brain Injury Patients: Randomized Controlled Double-Blind Trial
To investigate whether dexmedetomidine or propofol is more effective in controlling intracranial pressure (ICP) (assessed via optic nerve sheath diameter "ONSD" as a primary outcome) and which is more effective in suppressing…
- Trial name
- NCT07807579
- Testing
- Propofol, Dexmedetomidine
- Volunteers
- 80 people
- Sponsor
- Assiut University
Treatment Resistant Depression
Neural and Antidepressant Effects of Propofol
This study will compare the antidepressant effects of propofol at two different doses while measuring potential treatment-related biomarkers.
- Trial name
- NCT03684447
- Testing
- Propofol
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Utah
Intracranial Tumors
The Effect of Ciprofol Versus Propofol Anesthesia on Postoperative Neurological Complications
Postoperative delirium and postoperative ischemic stroke are common neurological complications in clinical practice. The incidence of these complications is further increased in patients undergoing neurosurgical procedures.
- Trial name
- NCT07805876
- Testing
- Ciprofo, Propofol
- Where
- China
- Volunteers
- 434 people
- Sponsor
- Beijing Tiantan Hospital
Colonoscopy Procedures, Sedation
Effects of Low-Dose Ketamine Added to Propofol Sedation During Colonoscopy
"This prospective observational study aims to evaluate the effects of adding low-dose ketamine (0.25 mg/kg) to standard propofol sedation on hemodynamic stability, sedation depth, and recovery times in adult patients undergoing…
- Trial name
- NCT07809230
- Testing
- Propofol group, Propofol + Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ankara Etlik City Hospital
Esophageal Cancer
Total Intravenous Anesthesia and Recurrence Free Survival
The investigators propose to compare recurrence-free survival in patients having potentially curative (Stages 1-3) surgery for esophageal cancer who will be randomly assigned to propofol-based total intravenous anesthesia or…
- Trial name
- NCT04513808
- Testing
- Propofol-based total intravenous anesthesia, Sevoflurane intravenous anesthesia
- Where
- China
- Volunteers
- 1,614 people
- Sponsor
- The Cleveland Clinic
Surgery-Complications, Anesthesia Complication
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major…
- Conditions
- Surgery-Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia
- Trial name
- THRIVE (NCT05991453)
- Testing
- Anesthetic technique Propofol TIVA, Anesthetic technique inhaled agent
- Where
- 24 sites in United States
- Volunteers
- 13,000 people
- Sponsor
- Washington University School of Medicine
Postoperative Sleep
Remimazolam for Postoperative Sleep in Elderly Patients
Postoperative sleep disturbance (PSD) is highly prevalent in elderly patients undergoing laparoscopic radical resection of colorectal cancer.
- Trial name
- NCT07740343
- Testing
- Remimazolam, propofol
- Where
- China
- Volunteers
- 84 people
- Sponsor
- General Hospital of Ningxia Medical University
Emergence Delirium, Anesthesia
Comparing the Efficacy of Propofol and Dexmedetomidine in Prevention of Emergence Agitation After Sevoflurane Anesthesia in Children
This is a clinical study for comparing the efficacy of two drugs i.e propofol and dexmedetomidine in prevention of a group of post operative abnormal behaviours that can occur after sevoflurane anesthesia in children and we will…
- Trial name
- NCT07799311
- Testing
- propofol 1mg/kg, Dexmedetomidine
- Where
- Pakistan
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Brain Neoplasms, Delirium - Postoperative
Ciprofol, Propofol and Sevoflurane for Postoperative Delirium in Elderly Brain Tumor Patients
This study will compare three anesthesia medicines used to put people into a deep sleep during surgery: ciprofol, propofol, and sevoflurane. All three are commonly used for general anesthesia, but they work in different ways.
- Trial name
- NCT07799623
- Testing
- Ciprofol, Propofol, Sevoflurane
- Where
- China
- Volunteers
- 381 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Laparoscopic Hepatectomy
The Effect of Remimazolam Versus Propofol on Postoperative Extubation Time
This clinical trial aims to help us understand how two drugs, Propofol and Remazoloam, affect when researchers remove a Participants' breathing tube after liver surgery (laparoscopic liver resection).The main research questions…
- Trial name
- NCT07611344
- Testing
- Remimazolam, propofol
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Xuyu Zhang
Balanced Anesthesia for Minimally Invasive Cardiac Valve Surgery
Propofol-Dexmedetomine Adjunction in Balanced Anesthesia for Minimally Invasive Cardiac Valve Surgery :Effect on Anesthetic Consumption ,Perioperative Outcomes,and Early Recovery
Propofol-Dexmedetomidine Adjunction in Balanced Anesthesia for Minimally Invasive Cardiac Valve Surgery: Effects on Anesthetic Consumption, perioperative outcomes, and Early Recovery
- Trial name
- NCT07798089
- Testing
- Propofol (Astra-Zeneca), propofol and dexmetomidine
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Postoperative Cognitive Dysfunction (POCD), Controlled Hypotension for Nasal Surgeries
Comparison of Desflurane, Sevoflurane, and Total Intravenous Anesthesia in Ear Surgery Under Controlled Hypotension
This randomized prospective study aimed to compare desflurane, sevoflurane, and total intravenous anesthesia methods in patients undergoing elective ear surgery under controlled hypotension, with a particular focus on…
- Trial name
- POCD-ENT (NCT07792759)
- Testing
- Desflurane, Sevoflurane, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Depression
Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Stage II
The investigators hypothesize that brief behavioral therapy and targeted propofol infusion in depressed geriatric patients will augment subsequent slow wave sleep and improve clinical and cognitive outcomes.
- Trial name
- SWIPED II (NCT06867549)
- Testing
- Propofol, Electroencephalography (EEG), Brief Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine
Intraoperative Hypotension, Hepatectomy
Remimazolam Versus Propofol for Maintenance of Anaesthesia During Major Hepatectomy Under Low Central Venous Pressure
The goal of this clinical trial is to learn whether remimazolam helps prevent low blood pressure better than propofol during major liver surgery in adults.
- Trial name
- NCT07789275
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Intracranial Pressure Change, Optic Nerve Diameter
VIMA vs TIVA and ONSD in Laparoscopic Cholecystectomy
This study compared two commonly used general anesthesia techniques in adults undergoing elective laparoscopic gallbladder surgery.
- Trial name
- NCT07786740
- Testing
- Propofol (Astra-Zeneca), Remifentanil, Sevofluorane
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bagcilar Training and Research Hospital
Coronary Artery Disease, Postoperative Complications
Intraoperative Targeted Versus Liberal Blood Pressure Management in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
The goal of this clinical trial is to learn whether two approaches to anesthesia and blood pressure management can improve care for adults having off-pump coronary artery bypass grafting (OPCAB).
- Trial name
- NCT07787364
- Testing
- Targeted Blood Pressure Management, Liberal Blood Pressure Management, Remimazolam
- Volunteers
- 416 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Myocardial Injury
Effects of Remimazolam on Postoperative Myocardial Injury
This study is designed as a prospective, double-blind, randomized controlled trial to investigate the effect of remimazolam on intraoperative cardiac output (CO) in elderly patients undergoing general anesthesia, and to evaluate…
- Trial name
- NCT07725185
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Affiliated Hospital of Jiaxing University
Peritoneal Neoplasms, Postoperative Recovery
Remimazolam Versus Propofol for Early Recovery After Cytoreductive Surgery
The REPAIR Trial is a single-center, prospective, randomized, parallel-group superiority trial enrolling 320 adults scheduled for elective cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy…
- Trial name
- REPAIR (NCT07785557)
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Propofol Injection Pain
Arm Elevation for Prevention of Propofol Injection Pain
The purpose of this research is to determine whether a simple technique, temporarily raising the arm during the injection of propofol (a commonly used medication for anesthesia), can reduce the pain that some people experience…
- Trial name
- NCT07785674
- Testing
- Passive arm elevation, Normal saline, Lidocaine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mayo Clinic