Clinical trials: Propofol
Anesthesia, Hemodynamic Instability
Anesthesia Induction with the Target-controlled Infusion of Propofol in High-risk Patients
The purpose of this study is to compare the risk of hypotension following induction of anesthesia in high-risk patients (American Society of Anesthesiologists risk scores III and IV) using target-controlled infusion (TCI) of…
- Trial name
- NCT06535230
- Testing
- Manual anesthesia induction, Anesthesia induction with Target controlled infusions (TCI), Hemodynamic monitoring with pressure recording analytical method (PRAM)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Acibadem University
Induction of Anaesthesia, Age
Onset Time of Thiopental Versus Propofol in the Elderly
This study is aimed at increasing the safety of the use of anaesthesia in an elderly population (> 60 years). Patients with decreased physiological reserve, including all elderly patients, have an increased risk of getting an…
- Trial name
- NCT00965107
- Testing
- Thiopental, Propofol
- Where
- 2 sites in Denmark
- Volunteers
- 78 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Adrenal Suppression, Hemodynamic Instability
THe Comparison of Target Controlled Infusion of Propofol or Etomidate at General Anesthesia in Geriatric Patients
Compare the efficacy and safety of closed-loop target controlled infusion of propofol or etomidate at general anesthesia in geriatric patients
- Trial name
- NCT02111265
- Testing
- Remifentanil, Cisatracurium, Sufentanil
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Intra-abdominal Hypertension
Effect of Sedation on Intra-abdominal Pressure
The purpose of this study is to evaluate the effect of deepening of sedation on intra-abdominal pressure in mechanically ventilated adult patients with intra-abdominal hypertension.
- Trial name
- NCT02944292
- Testing
- Deepening of sedation, Propofol
- Where
- Estonia
- Volunteers
- 40 people
- Sponsor
- Tartu University Hospital
Cirrhosis
Propofol Versus Midazolam for Upper Endoscopy in Cirrhotic Patients
Upper GI endoscopy is often performed in patients with chronic liver disease to screen for esophageal and gastric varices. The purpose of this study is to compare propofol to midazolam for sedation in patients with chronic liver…
- Trial name
- NCT01141036
- Testing
- propofol, Midazolam
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Ziv Hospital
Fraily, Abdominal Surgery
Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.
This is a bicentric, prospective, non-pharmacological, randomized study designed to compare the efficacy and safety of awake neuraxial anesthesia with sedation versus general anesthesia in frail patients undergoing elective major…
- Conditions
- Fraily, Abdominal Surgery, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- SAFE-AWARENESS (NCT07486336)
- Testing
- Neuraxial anesthesia, General Anesthesia, avoidance of GABAergic-drugs strategy
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Ente Ospedaliero Ospedali Galliera
Transcervical Resection of Endometrium, Transcervical Resection of Fibroids
Comparing Two Types of Sedation to Gynaecological Patients
The primary endpoint is to investigate the difference in pain between patients who receive deep sedation with spontaneous breathing versus patients who receive general anesthesia.
- Conditions
- Transcervical Resection of Endometrium, Transcervical Resection of Fibroids, Transcervical Resection of Polyp
- Trial name
- NCT01412632
- Testing
- Remifentanil, propofol and citanest
- Where
- Denmark
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Depression
Comparison of Thiopental and Propofol as Anaesteticum During ECT
Electroconvulsive therapy is the most effective treatment in severe depression and the effect is related to the generalized seizure induced by the treatment. General anesthesia is used during the treatment.
- Trial name
- NCT00379886
- Testing
- Propofol Thiopental
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Anesthesia, Craniotomy
Anesthesiological Strategies in Elective Craniotomy
This protocol, NeuroMorfeo, aims to assess equivalence between volatile and intravenous anesthetics for neurosurgical procedures.
- Conditions
- Anesthesia, Craniotomy, Neurosurgery
- Trial name
- Neuromorfeo (NCT00741351)
- Testing
- Sevoflurane + Fentanyl, Sevoflurane + Remifentanyl, Propofol + Remifentanyl
- Where
- 15 sites in Italy
- Volunteers
- 411 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Female Sexual Dysfunction
Female Sexual Dysfunction Assessment and Managment of Vaginismus
The study aims at : 1. The extent female sexual dysfunction problem in community through questionnaire . 2. Compare effectiveness of two treatment options for vaginismus .
- Trial name
- NCT06755099
- Testing
- Botox, Radiofrequency
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Restlessness, Pain
Effects of Dexmedetomidine on Stress Response and Postoperative Analgesia
Dexmedetomidine is a highly selective α2 adrenoreceptor agonist approved by the US FDA for short-term postoperative sedation and analgesia.It can also reduce the stress response without respiratory depression.
- Trial name
- NCT01517932
- Testing
- dexmedetomidine
- Volunteers
- 60 people
- Sponsor
- Fang Luo
Hyperparathyroidism
Interaction Between Anaesthetics and Methylene Blue
We hypothesized that pre-treatment with methylene blue could potentiate the effects of general anaesthetic agents in patients undergoing parathyroidectomy
- Trial name
- NCT00513032
- Testing
- methylene blue
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- University Hospital, Geneva
Sedative, Hypnotic, or Anxiolytic Withdrawal, Airway Control
Sedation Compaired With Anesthesia With THRIVE in Endotracheal Intubation With Difficult Airways
To compare the difference in endotracheal intubation in participants with difficult airway between under general anesthesia by Transnasal Humidified Rapid-Insufflation Ventilatory Exchange and under traditional sedation by mask…
- Trial name
- NCT04924621
- Testing
- Respiratory Humidification Treatment Device, AIRVO 2 PT101AZ, Fisher & Paykel Healthcare, Inc., Mask ventilation, Midazolam(T group)
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking University
Sleep Apnea, Obstructive, Sleep Apnea
Comparison Between Natural Sleep Endoscopy and Drug-induced Sleep Endoscopy in Patients With Obstructive Sleep Apnea
Drug-induced sleep endoscopy (DISE) is the most used technique for identifying the obstruction site associated with obstructive sleep apnea (OSA).
- Conditions
- Sleep Apnea, Obstructive, Sleep Apnea, Sleep Apnea Syndromes, Apnea
- Trial name
- NCT04729478
- Testing
- Drug-induced sleep endoscopy, Natural sleep endoscopy
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- ethisch.comite@uza.be
Anesthesia, Intravenous, Laparotomy
TCI vs Manually Controlled Infusion of Propofol
Anesthesia records for patients anesthetized with target controlled infusion of propofol and remifentanil will be matched with patients anesthezied with manyally controlled infusion.
- Conditions
- Anesthesia, Intravenous, Laparotomy, Airway Extubation
- Trial name
- NCT04266535
- Testing
- Target controlled infusion
- Volunteers
- 40 people
- Sponsor
- Regional Hospital West Jutland
Haemodynamic Fluctuations During Off-pump CABG.
Atropine Effects in Anaesthesia With Sufentanil vs. Remifentanil
Induction of general anaesthesia with a combination of opiates and hypnotics often induces vasodilation resulting in several haemodynamic effects such as a decrease in blood pressure (MAP), heart rate (HR) and cardiac output…
- Trial name
- NCT01871935
- Testing
- Remifentanil, Sufentanil
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- University Medical Center Groningen
General Anesthesia, Geriatric Patient
Sevoflurane and Propofol Anesthesia on Postoperative Delirium
Delirium is defined as an acute onset and fluctuating course of mental status change with inattention and an altered level of consciousness.
- Trial name
- NCT01995214
- Testing
- Propofol, Sevoflurane
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Huazhong University of Science and Technology
Anesthesia, Cancer Recurrence
Effect of Propofol and Sevoflurane Anesthesia on HSP70 Expression in Tumor Cells
The goal of this clinical trial is to learn if sevoflurane-based inhalational anesthesia (s-IA) and propofol-based total intravenous anesthesia (p-TVA) have different effects on HSP70 expression in different types of tumour…
- Conditions
- Anesthesia, Cancer Recurrence, Cancer
- Trial name
- NCT06626711
- Testing
- Propofol, Sevoflurane
- Where
- Russia
- Volunteers
- 10 people
- Sponsor
- Saint Petersburg State University, Russia
Neuromuscular Blockade
Interaction of Volatile Anesthetics With Magnesium
Magnesium and volatiles anesthetics both have an effect on the neuromuscular transmission. The primary objective of the study is to quantify the effect of a perfusion of intravenous magnesium on neuromuscular transmission…
- Trial name
- Volmag (NCT05261516)
- Testing
- Magnesium Sulfate
- Where
- Switzerland
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Christoph Czarnetzki
PONV, Opioid Use
Opioid Free Versus Opioid Balanced Anesthesia
OPIOID FREE VERSUS OPIOID BALANCED ANAESTHESIA IN MIDDLE EAR SURGERY AIM OF THE WORK Primary aim: To compare between opioid and opioid free anaesthesia on post-operative nausea and vomiting in middle ear surgery Secondary aim…
- Trial name
- NCT03809949
- Testing
- Fentanyl Opioid anesthesia, Saline Nonopioid anesthesia
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- University of Alexandria
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