Clinical trials: sponsored by University of British Columbia
Small Airways Diseases, Vaping
The Canadian Lung Outcomes in Users of Vaping Devices Study
Vaping is increasingly popular with both adolescent and adult Canadians, but the long-term health impacts remain unknown. We believe that the tools we currently have to detect lung disease in people who vape may be insufficient…
- Conditions
- Small Airways Diseases, Vaping, Vaping Related Disorder, Vaping Teens
- Trial name
- CLOUD (NCT06819969)
- Where
- 8 sites in Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy Aging
Impact 360 for Healthy Agers
The Impact 360 study will evaluate the effects of a combined intervention of exercise, mindfulness, and nutrition on 8 key indicators of health and the mechanisms that drive these changes.
- Trial name
- NCT06516146
- Testing
- Exercise, Meditation, Diet
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Medical Education Assessment
AI vs Human Exam Assessment and Development (AHEAD Trial)
The Artificial Intelligence (AI) vs Human Exam Assessment and Development (AHEAD) Trial is a participant-blinded randomized controlled trial conducted among first-year medical students at the University of British Columbia.
- Trial name
- AHEAD (NCT07481162)
- Testing
- AI-generated MCQ examination, Human-generated MCQ examination
- Where
- Canada
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Asthma, Healthy
Effects of Salbutamol in Athletes and Implications for Screening and Sports
β2-Agonists, commonly used to treat asthma, have also been used by athletes to enhance performance, leading to their ban by the International Olympic Committee in 1972.
- Conditions
- Asthma, Healthy, Effect of Drug
- Trial name
- NCT07037511
- Testing
- Salbutamol
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy
Cannabis and Polysubstance Use: Response Inhibition and Stress Exposure
The purpose of this Phase I non-therapeutic trial is to examine the neurological effects of cannabis on stress reactivity and inhibition in healthy cannabis users.
- Trial name
- CAPU RISE (NCT05261321)
- Testing
- Cannabis oil with a high ratio of THC to CBD, Cannabis oil with a high ratio of CBD to THC
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Anemia, Pregnancy
Assessing Health System Readiness for Scaling Antenatal MMS in Cambodia
Malnutrition among pregnant women in low- and middle-income countries (LMICs) can cause micronutrient deficiencies that result in adverse maternal and neonatal health outcomes.
- Conditions
- Anemia, Pregnancy, Micronutrients, Supplement
- Trial name
- TIPS-Cambodia (NCT07400796)
- Testing
- Multiple micronutrient supplement (MMS) for pregnancy
- Where
- Cambodia
- Volunteers
- 710 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy Individuals
FIRE-Diet: Food as an Intervention to Reduce the Effects of Woodsmoke Exposure on Respiratory Health
Research suggests that consuming more fatty fish, fruits, and vegetables could potentially shield the lungs from the negative impacts of air pollution.
- Trial name
- FIRE-Diet-M (NCT06711614)
- Testing
- Intervention Diet, Control Diet
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Pregnancy Related
Methionine Requirements During Healthy Human Pregnancy
The current recommendations for dietary amino acid intake in pregnant women are based on calculations from requirements of adult men.
- Trial name
- NCT04326322
- Testing
- Methionine Intake
- Where
- Canada
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Homocystinuria
Proof of Concept Creatine Supplementation for Homocystinuria Study
Homocystinuria is a rare and inherited metabolic disorder, people with this condition don't have an enzyme needed to break down an amino acid called homocysteine.
- Trial name
- NCT06495567
- Testing
- Creatine, Dietary methionine tracer and protein intake
- Where
- Canada
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Menstrual Cycle
Leucine Requirements During the Menstrual Cycle
The existing guidelines for dietary amino acid intake for women are set the same as those established for men. These recommendations might not be appropriate for women, as they do not take into consideration important differences…
- Trial name
- NCT06533501
- Testing
- Dietary Leucine Intakes
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cerebral Blood Flow, Cerebral Blood Flow Regulation
The Role of Estrogen and Testosterone in Determining Brain Blood Flow and Metabolic Regulation in Humans
Due to historical exclusion of females from research, there are gaps in the understanding of female physiology, how it differs from males, and how sex-specific hormones contribute.
- Conditions
- Cerebral Blood Flow, Cerebral Blood Flow Regulation, Sex Differences, Exercise
- Trial name
- NCT07212712
- Testing
- GnRH antagonist, Estradiol (E2), Testosterone
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
HPV, Human Papilloma Virus
A Study of Reduced Dosing of the Nonavalent HPV Vaccine in Women Living With HIV
There are very little data on human papillomavirus (HPV) vaccination among the 18 million women living with HIV (WLWH) globally, who constitute a population most vulnerable to HPV and the resultant cervical cancer.
- Conditions
- HPV, Human Papilloma Virus, Human Immunodeficiency Virus
- Trial name
- NOVA-HIV (NCT05495906)
- Testing
- Nonavalent HPV vaccine
- Where
- 10 sites in Canada
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Metabolic Dysfunction-Associated Steatotic Liver Disease
Ultrasound Liver Imaging for Classification of Metabolic Dysfunction-associated Steatotic Liver Disease
Tissue elasticity and viscosity correlate with pathology. These tissue properties are typically evaluated subjectively using palpation.
- Trial name
- NCT07373769
- Testing
- Ultrasound and magentic resonance imaging
- Where
- Canada
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Muscle Hypertrophy, Muscular Strength
Determining the Effect of Shoulder Flexion Angle on Latissimus Dorsi and Forearm Flexor Hypertrophy
The goal of this clinical trial is to learn the effect of training a muscle at a longer or shorter muscle length during resistance exercise in young and healthy adults.
- Trial name
- LPDLR (NCT07360236)
- Testing
- LAT PULLDOWN and LAT ROW training sessions, Maximal isotonic strength testing (1RM), Isokinetic strength testing (1080 Quantum)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Inflammatory Bowel Diseases, Crohn Disease
Predicting IBD Treatment Outcomes With Gut Microbiome Analysis
The goal of this prospective observational study is to determine if specific microbiome signatures can predict therapeutic responses in adult patients with Crohn's disease (CD), a form of inflammatory bowel disease (IBD), living…
- Trial name
- OPTIMIST (NCT06453720)
- Testing
- Colonoscopy
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Obstructive Apnea, Sleep Apnea Syndrome, Obstructive
Pilot Study of Negative Pressure Neck Therapy (NPNT)
Obstructive sleep apnea (OSA) is a serious, chronic sleep-related breathing disease in which the upper airway repeatedly collapses during sleep, leading to intermittent oxygen deprivation.
- Conditions
- Obstructive Apnea, Sleep Apnea Syndrome, Obstructive, Sleep Disorder (Disorder)
- Trial name
- NCT07301567
- Testing
- Negative Pressure Neck Therapy (NPNT)
- Where
- 2 sites in Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Histamine, Exercise
Histamines and Central Hemodynamics
When we exercise, more blood flow goes to our muscles, challenging our blood vessels. Following exercise, blood flow remains elevated and seems to be the reason for many of the positive cardiovascular benefits that occur with…
- Trial name
- NCT07285031
- Testing
- Diphenhydramine hydrochloride, Exercise Bout
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Fracture, Lengthening; Leg
Pediatric Orthopaedic Implant Safety & Efficacy
Implant devices are important tools - their use is essential across a number of orthopaedic indications, including hip conditions, trauma and limb deformity.
- Conditions
- Fracture, Lengthening; Leg, Orthopedic Disorder, Deformity of Limb
- Trial name
- Global POISE (NCT05361980)
- Testing
- Pediatric orthopaedic implant
- Where
- Canada
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Pregnancy
Tryptophan Requirements During Pregnancy
Pregnancy is an important period of life where there is an increased need for nutrients including protein and amino acids from food.
- Trial name
- NCT06519071
- Testing
- Tryptophan Intake
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Lactation, Breastfeeding, Exclusive
Lysine Requirements During Lactation
The study aims to establish lysine requirements using the indicator amino acid oxidation (IAAO) method in women exclusively breastfeeding a single infant aged 3-4 months, and how maternal lysine needs change once infant…
- Conditions
- Lactation, Breastfeeding, Exclusive, Breastfeeding
- Trial name
- NCT06366204
- Testing
- Dietary Lysine Intakes
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of British Columbia