Healthy AgingNCT06516146
Impact 360 for Healthy Agers
A study testing Exercise, Meditation and Diet in people with Healthy Aging, run by University of British Columbia at 1 site in Canada.
Trial summary
The Impact 360 study will evaluate the effects of a combined intervention of exercise, mindfulness, and nutrition on 8 key indicators of health and the mechanisms that drive these changes. 60 subjects aged 50 to 75 without a current diagnosis of a brain disorder will be recruited. Read more about this study
- Who is it for?
- Ages 50 to 75 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy Aging
- What is being tested?
- Exercise, Meditation and Diet
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteCanada
- Study dates
- 24 Jan 2024to 5 Jan 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 75 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Participants who are able to complete questionnaires and follow directions for interventions
- Have access to a smartphone that can support the Fitbit app
Who cannot join
- Any neurological disease/disorder diagnosis (Ex: Parkinson's Disease, Multiple Sclerosis, Traumatic Brain Injury, Brain lesion, Stroke, etc)
- Any chronic medical condition which would affect ability to participate in exercise
- Any contraindication for exercise based on the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) and medical clearance form
- Participants who were told by a medical doctor that they need to be medically supervised for exercise
- Montreal Cognitive Assessment (MoCA) scores <21/30
- Significant cognitive impairment, depression, or eating disorder
Show all 31Show fewer
- Any contraindication to MRI scanning; such as implanted metal clips or wires (see list below)
- Participants currently doing 180 minutes or more of moderate-vigorous intensity exercise per week AND either of the following:
- Completion of an Mindfulness-Based Stress Reduction course OR; Score >8/15 in the Mediterranean-Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay (MIND) Diet Questionnaire
- Significant or unstable cardiovascular or respiratory disease
- Severe/multiple head trauma(s)
- Subjects who are pregnant or breastfeeding
- Subjects with a history or major episodes of drug or alcohol abuse
- Chronic/acute bacterial/viral infection
- GI cancer
- Inflammatory bowel disease
- Individuals weighing > 400 lbs (limit of MRI machine)
- Artificial heart valve
- Brain aneurysm clip
- Electrical stimulator for nerves or bones
- Ear or eye implant
- Implanted drug infusion pump
- Coil, catheter, or filter in any blood vessel
- Orthopedic hardware (artificial joint, plate, screws)
- Other metallic prostheses
- Shrapnel, bullets, or other metal fragments
- Surgery or tattoos (including tattooed eyeliner) in the last six weeks
- Brain surgery
- Have a cardiac pacemaker, wires or defibrillator
- Have had an injury where a piece of metal lodged in the eye or orbit
- Have a ferromagnetic aneurysm clip
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Canada1 site, 1 recruiting
- Recruiting
University of British Colombia
Vancouver, British Columbia, V6T 1Z3
Madeleine Powell, (604) 822-8691, madeleine.powell@ubc.ca
Annie Kuan, (604) 827-0576, annie.kuan@ubc.ca
About this study
Official title: Impact 360 Study for Healthy Agers
The Impact 360 study will evaluate the effects of a combined intervention of exercise, mindfulness, and nutrition on 8 key indicators of health and the mechanisms that drive these changes. 60 subjects aged 50 to 75 without a current diagnosis of a brain disorder will be recruited. This study will follow a partial crossover design. All participants will receive the intervention. Participants randomized into the intervention group after their baseline screening will receive the 6-month intervention. Those randomized into the waitlist group will complete another assessment at the end of the 6-month care as usual phase before receiving the intervention.
Read the detailed description
Current research suggests that exercise, meditation, and nutrition have neuroprotective effects although there is still a lack of pharmacological therapies to prevent or slow down disease progression. The benefits of these individual interventions have been shown, but emerging evidence suggests that combined interventions are more powerful than isolated ones. The crucial next step is to study the impact of a multimodal program on brain health and to comprehensively examine underlying mechanisms.
The comprehensive assessment ("360 degree approach") will focus on 8 key areas of health: cognition, inflammation, microbiome diversity, sleep quality, neurological imaging markers, physical fitness, cardiovascular health, and social and mental well-being. This comprehensive assessment in this healthy aging cohort will serve two purposes: 1) Help us to understand the mechanisms behind the benefits of this multimodal intervention and how the interactive effects influence one's overall health and 2) to serve as a normative dataset for replication of this study in clinical populations (e.g. Parkinson's disease, Alzheimer's disease, stroke)
The objective of this study is to explore the effects of this combined intervention on overall health. The investigators aim to discover the mechanisms of action behind the benefits of this multimodal intervention. The investigators will assess the impact of the intervention on overall health using the following 8 key indicators of overall health: cognition, inflammation and biomarkers, gut microbiome diversity, sleep quality, Magnetic Resonance Imaging (MRI) neurological markers, cardiorespiratory fitness and physical health, cardiovascular disease risk factors, and emotional well-being.
- Conditions
- Healthy Aging
- Being tested
- Exercise, Meditation, Diet
- Keywords
- Exercise, Mindfulness, Microbiome, Well-Being
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ExerciseBehavioural
The intervention will involve online (via University of British Colombia (UBC) Zoom videoconferencing) 1-hour moderate to high intensity exercise classes 3 times a week for 6 months
MeditationBehavioural
The intervention will involve 15 minute guided mediation following exercise classes as well as mindfulness classes.
Mindfulness classes will consist of 1.5 hour Mindfulness Based Stress Reduction (MBSR) classes for the first 2 months, followed by 1 month of 1 hour bi-weekly discussions and practice, then MBSR 2.0 for months 4 and 5, and 1 hour bi-weekly discussions and practice for the remaining month of the intervention.
DietBehavioural
The intervention will involve biweekly 1-hour nutrition and cooking classes with a dietician.
| Study group | Role | What they receive |
|---|---|---|
| Exercise, Diet, Mindfulness | Experimental | The intervention group will start the intervention immediately following their baseline assessment. They will undergo another assessment after the 6 month intervention period. Receives: Behavioral: Exercise; Behavioral: Meditation; Behavioral: Diet |
| Waitlist Group | No intervention | Participants randomized into the waitlist group will undergo a baseline assessment, and will then be encouraged to continue their daily activities as usual for 6 months. Physical activity and sleep will be monitored during this time using wearable devices. Links to questionnaires will be emailed monthly. After the 6-month waitlist period, participants will undergo a second assessment prior to starting the intervention. The multimodal intervention will be 6-months in length, using the same measures of adherence, and will be followed by a final assessment. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cognition - NIH Toolbox Cognitive Battery
Cognition will be measured using the National Institutes of Health (NIH) Toolbox Cognitive battery (NIHTB-CB). Testing is done pre- and post-intervention to compare scores.
Measured: 6 Months
Cognition- Montreal Cognitive Assessment
Cognition will be measured using the Montreal Cognitive Assessment (MoCA). Testing is done pre- and post-intervention to compare scores.
Measured: 6 Months
Cognition- Parkinson's Disease Cognitive Rating Scale
Cognition will be measured using the Parkinson's Disease Cognitive Rating Scale (PD-CRS). Testing is done pre- and post-intervention to compare scores.
Measured: 6 Months
Inflammation and Biomarkers in Serum- High Sensitivity C-Reactive Protein
Systemic inflammation will be assessed by measuring concentrations of high sensitivity C-reactive protein (hs-CRP). Samples will be taken pre- and post-intervention to assess changes.
Measured: 6 Months
Inflammation and Biomarkers in Serum - Interleukin-1β
Systemic inflammation will be assessed by measuring concentrations of interleukin-1β (IL-1β). Samples will be taken pre- and post-intervention to assess changes.
Measured: 6 Months
Inflammation and Biomarkers in Serum - Interleukin-6
Systemic inflammation will be assessed by measuring concentrations of interleukin-6 (IL-6). Samples will be taken pre- and post-intervention to assess changes.
Measured: 6 Months
Inflammation and Biomarkers in Serum - Tumour Necrosis Factor Alpha
Systemic inflammation will be assessed by measuring concentrations of Tumour Necrosis Factor Alpha (TNFa). Samples will be taken pre- and post-intervention to assess changes.
Measured: 6 Months
Inflammation and Biomarkers in Serum - Interleukin-8
Systemic inflammation will be assessed by measuring concentrations of interleukin-8 (IL-8). Samples will be taken pre- and post-intervention to assess changes.
Measured: 6 Months
Inflammation and Biomarkers in Serum - Interleukin-10
Systemic inflammation will be assessed by measuring concentrations of interleukin-10 (IL-10). Samples will be taken pre- and post-intervention to assess changes.
Measured: 6 Months
Inflammation and Biomarkers in Serum - Interleukin-18
Systemic inflammation will be assessed by measuring concentrations of interleukin-18 (IL-18). Samples will be taken pre- and post-intervention to assess changes.
Measured: 6 Months
Inflammation and Biomarkers in Serum - Calprotectin
Systemic inflammation will be assessed by measuring concentrations of calprotectin. Samples will be taken pre- and post-intervention to assess changes.
Measured: 6 Months
Inflammation and Biomarkers in Serum - cortisol
Systemic inflammation will be assessed by measuring concentrations of cortisol. Samples will be taken pre- and post-intervention to assess changes.
Measured: 6 Months
Microbiome Diversity
Stool samples will be analyzed for gut microbiome composition by shallow shotgun metagenome sequencing. Samples will be taken pre- and post-intervention to assess changes.
Measured: 6 Months
Sleep Efficiency
Sleep efficiency (total sleep time/time spent in bed) will be measured through a wearable device with an accelerometer. This device will also measure other components of sleep quality such as sleep onset latency, total sleep time and wake after sleep onset.
Measured: 6 Months
Pittsburgh Sleep Quality Index
The Pittsburgh Sleep Quality Index will be used to collect subjective sleep quality data on a monthly basis.
Measured: 6 Months
Total Grey Matter Volume
Total grey matter volume will be measured using an MRI. Testing is done pre- and post-intervention to compares scores.
Measured: 6 Months
Hippocampal Volume
Hippocampal volume will be measured using an MRI. Testing is done pre- and post-intervention to compares scores.
Measured: 6 Months
White matter hyperintensities volume
White matter hyperintensities volume will be measured using an MRI. Testing is done pre- and post-intervention to compares scores.
Measured: 6 Months
Myelin Water
Myelin water imaging will be collected using resting state functional MRI. Testing is done pre- and post-intervention to compares scores.
Measured: 6 Months
Functional MRI
A flanker task will be administered during the MRI to examine selective attention, inhibitory function, and executive control. Testing is done pre- and post-intervention to compares scores.
Measured: 6 Months
Maximal oxygen consumption (VO2 Max)
Predicted maximal oxygen consumption will be measured using a six-minute walk test. Testing is done pre- and post-intervention to compares scores.
Measured: 6 Months
Heart Rate Recovery
Heart rate recovery will be measured using a three-minute step test. Testing is done pre- and post-intervention to compares scores.
Measured: 6 Months
Berg Balance Assessment
A Berg Balance Assessment will be used to measure participants balance. Testing is done pre- and post-intervention to compares scores.
Measured: 6 Months
Dynamic Gate Index
The Dynamic Gait Index will be used to measure participants gait. Testing is done pre- and post-intervention to compares scores.
Measured: 6 Months
Timed Up and Go Test
The Dynamic Gait Index will be used to measure participants gait. Testing is done pre- and post-intervention to compares scores.
Measured: 6 Months
30 Second Sit to Stand Test
Functional lower extremity strength with be assessed using the 30 second sit to stand test. Testing is done pre- and post-intervention to compare scores.
Measured: 6 Months
Dual-Energy X-Ray Absorptiometry (DEXA)
Body composition, such as body fat and muscle mass, will be measured using Dual-energy X-ray Absorptiometry. Testing is done pre- and post-intervention to compare scores.
Measured: 6-Months
Physical Activity Levels
Physical activity levels will be measured through a wearable device to help ensure adherence and effectiveness of the exercise intervention. Data will be collected throughout the study.
Measured: 6 Months
Heart Rate
Heart rate will be measured through a wearable device to help ensure adherence and effectiveness of the exercise intervention. Data will be collected throughout the study.
Measured: 6 Months
Fried Frailty Index
Physical frailty will be assessed using the fried frailty index. Testing is done pre- and post-intervention to compares scores.
Measured: 6 Months
Blood Pressure
Blood pressure will be measured pre- and post-intervention to compares scores.
Measured: 6 Months
Weight
Weight will be measured pre- and post-intervention to compares scores.
Measured: 6 Months
Framingham Risk Score
Cardiovascular health will be assessed using the Framingham Risk Score. This score includes measurements of age, total cholesterol, smoking status, HDL level, diabetes status, systolic blood pressure and treatment status. Testing is done pre- and post-intervention to compares scores.
Measured: 6 Months
NIH Toolbox- Emotional Battery
Social, emotional, and mental well-being will be evaluated using the NIH Toolbox-Emotional Battery. Testing is done pre- and post-intervention to compares scores.
Measured: 6 Months
World Health Organization (WHO) Quality of Life Questionnaire
Quality of life will be evaluated using the World Health Organization (WHO) Quality of Life Questionnaire. Testing is done pre- and post-intervention to compares scores.
Measured: 6 Months
Freiburg Mindfulness Inventory
Questionnaires related to mindfulness will be administered throughout the study at monthly intervals.
Measured: 6 Months
Mindful Attention Awareness Scale
Questionnaires related to mindfulness will be administered throughout the study at monthly intervals.
Measured: 6 Months
Multidimensional Assessment of Interoceptive Awareness
Questionnaires related to mindfulness will be administered throughout the study at monthly intervals.
Measured: 6 Months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Jul 2024
- Study start24 Jan 2024
- Primary completion20 Feb 2027 (estimated)
- Study completion5 Jan 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy AgingStudies of the same condition, open and under way.
- More trials run by University of British ColumbiaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Adults 50-75 years of age without a diagnosis of a neurodegenerative condition, will be recruited and screened for eligibility. Sixty participants will be randomly assigned to the waitlist group or the intervention group and will be striated into cohorts blocks. Each cohort block will start the intervention at the same time and will participate in the intervention together. This will allow for social interaction, engagement with their peers, and hopefully encouraging better adherence.
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of British Columbia
- Sponsor type
- University, hospital or other
- Collaborators
- The Jack and Darlene Poole Foundation
- Responsible party
- Principal investigator, Silke Cresswell, University of British Columbia
- Investigators
- Silke Appel-Cresswell, MD, FRCPC, Principal investigator, University of British Colombia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06516146
- Sponsor's protocol ID
- H21-01750
- Status last verified
- Feb 2026
- First submitted
- 3 May 2024
- Last updated
- 23 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 23 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact 360 Study for Healthy Agers
- ClinicalTrials.gov ID
- NCT06516146
- Acronym / sponsor ID
- H21-01750
- Conditions
- Healthy Aging
- Keywords
- Exercise, Mindfulness, Microbiome, Well-Being
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- University of British ColumbiaUniversity, hospital or other
- Collaborators
- The Jack and Darlene Poole Foundation
- Study start
- 24 Jan 2024 (actual)
- Primary completion
- 20 Feb 2027 (estimated)
- Study completion
- 5 Jan 2028 (estimated)
- First posted
- 23 Jul 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The Impact 360 study will evaluate the effects of a combined intervention of exercise, mindfulness, and nutrition on 8 key indicators of health and the mechanisms that drive these changes. 60 subjects aged 50 to 75 without a current diagnosis of a brain disorder will be recruited. This study will follow a partial crossover design. All participants will receive the intervention. Participants randomized into the intervention group after their baseline screening will receive the 6-month intervention. Those randomized into the waitlist group will complete another assessment at the end of the 6-month care as usual phase before receiving the intervention.
Detailed description
Current research suggests that exercise, meditation, and nutrition have neuroprotective effects although there is still a lack of pharmacological therapies to prevent or slow down disease progression. The benefits of these individual interventions have been shown, but emerging evidence suggests that combined interventions are more powerful than isolated ones. The crucial next step is to study the impact of a multimodal program on brain health and to comprehensively examine underlying mechanisms.
The comprehensive assessment ("360 degree approach") will focus on 8 key areas of health: cognition, inflammation, microbiome diversity, sleep quality, neurological imaging markers, physical fitness, cardiovascular health, and social and mental well-being. This comprehensive assessment in this healthy aging cohort will serve two purposes: 1) Help us to understand the mechanisms behind the benefits of this multimodal intervention and how the interactive effects influence one's overall health and 2) to serve as a normative dataset for replication of this study in clinical populations (e.g. Parkinson's disease, Alzheimer's disease, stroke)
The objective of this study is to explore the effects of this combined intervention on overall health. The investigators aim to discover the mechanisms of action behind the benefits of this multimodal intervention. The investigators will assess the impact of the intervention on overall health using the following 8 key indicators of overall health: cognition, inflammation and biomarkers, gut microbiome diversity, sleep quality, Magnetic Resonance Imaging (MRI) neurological markers, cardiorespiratory fitness and physical health, cardiovascular disease risk factors, and emotional well-being.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Adults 50-75 years of age without a diagnosis of a neurodegenerative condition, will be recruited and screened for eligibility. Sixty participants will be randomly assigned to the waitlist group or the intervention group and will be striated into cohorts blocks. Each cohort block will start the intervention at the same time and will participate in the intervention together. This will allow for social interaction, engagement with their peers, and hopefully encouraging better adherence.
| Arm | Type | Receives |
|---|---|---|
| Exercise, Diet, Mindfulness | Experimental | Behavioral: Exercise, Behavioral: Meditation, Behavioral: DietThe intervention group will start the intervention immediately following their baseline assessment. They will undergo another assessment after the 6 month intervention period. |
| Waitlist Group | No intervention | –Participants randomized into the waitlist group will undergo a baseline assessment, and will then be encouraged to continue their daily activities as usual for 6 months. Physical activity and sleep will be monitored during this time using wearable devices. Links to questionnaires will be emailed monthly. After the 6-month waitlist period, participants will undergo a second assessment prior to starting the intervention. The multimodal intervention will be 6-months in length, using the same measures of adherence, and will be followed by a final assessment. |
Who may qualify
- Ages
- 50 to 75 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Participants who are able to complete questionnaires and follow directions for interventions
- Have access to a smartphone that can support the Fitbit app
Key exclusion criteria (31 listed)
- Any neurological disease/disorder diagnosis (Ex: Parkinson's Disease, Multiple Sclerosis, Traumatic Brain Injury, Brain lesion, Stroke, etc)
- Any chronic medical condition which would affect ability to participate in exercise
- Any contraindication for exercise based on the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) and medical clearance form
- Participants who were told by a medical doctor that they need to be medically supervised for exercise
- Montreal Cognitive Assessment (MoCA) scores <21/30
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ExerciseThe intervention will involve online (via University of British Colombia (UBC) Zoom videoconferencing) 1-hour moderate to high intensity exercise classes 3 times a week for 6 months | Behavioural | Exercise, Diet, Mindfulness |
| MeditationThe intervention will involve 15 minute guided mediation following exercise classes as well as mindfulness classes. Mindfulness classes will consist of 1.5 hour Mindfulness Based Stress Reduction (MBSR) classes for the first 2 months, followed by 1 month of 1 hour bi-weekly discussions and practice, then MBSR 2.0 for months 4 and 5, and 1 hour bi-weekly discussions and practice for the remaining month of the intervention. | Behavioural | Exercise, Diet, Mindfulness |
| DietThe intervention will involve biweekly 1-hour nutrition and cooking classes with a dietician. | Behavioural | Exercise, Diet, Mindfulness |
Primary outcome
Cognition - NIH Toolbox Cognitive Battery
Time frame: 6 Months
Cognition will be measured using the National Institutes of Health (NIH) Toolbox Cognitive battery (NIHTB-CB). Testing is done pre- and post-intervention to compare scores.
Cognition- Montreal Cognitive Assessment
Time frame: 6 Months
Cognition will be measured using the Montreal Cognitive Assessment (MoCA). Testing is done pre- and post-intervention to compare scores.
Cognition- Parkinson's Disease Cognitive Rating Scale
Time frame: 6 Months
Cognition will be measured using the Parkinson's Disease Cognitive Rating Scale (PD-CRS). Testing is done pre- and post-intervention to compare scores.
Inflammation and Biomarkers in Serum- High Sensitivity C-Reactive Protein
Time frame: 6 Months
Systemic inflammation will be assessed by measuring concentrations of high sensitivity C-reactive protein (hs-CRP). Samples will be taken pre- and post-intervention to assess changes.
Inflammation and Biomarkers in Serum - Interleukin-1β
Time frame: 6 Months
Systemic inflammation will be assessed by measuring concentrations of interleukin-1β (IL-1β). Samples will be taken pre- and post-intervention to assess changes.
Inflammation and Biomarkers in Serum - Interleukin-6
Time frame: 6 Months
Systemic inflammation will be assessed by measuring concentrations of interleukin-6 (IL-6). Samples will be taken pre- and post-intervention to assess changes.
Inflammation and Biomarkers in Serum - Tumour Necrosis Factor Alpha
Time frame: 6 Months
Systemic inflammation will be assessed by measuring concentrations of Tumour Necrosis Factor Alpha (TNFa). Samples will be taken pre- and post-intervention to assess changes.
Inflammation and Biomarkers in Serum - Interleukin-8
Time frame: 6 Months
Systemic inflammation will be assessed by measuring concentrations of interleukin-8 (IL-8). Samples will be taken pre- and post-intervention to assess changes.
Inflammation and Biomarkers in Serum - Interleukin-10
Time frame: 6 Months
Systemic inflammation will be assessed by measuring concentrations of interleukin-10 (IL-10). Samples will be taken pre- and post-intervention to assess changes.
Inflammation and Biomarkers in Serum - Interleukin-18
Time frame: 6 Months
Systemic inflammation will be assessed by measuring concentrations of interleukin-18 (IL-18). Samples will be taken pre- and post-intervention to assess changes.
Inflammation and Biomarkers in Serum - Calprotectin
Time frame: 6 Months
Systemic inflammation will be assessed by measuring concentrations of calprotectin. Samples will be taken pre- and post-intervention to assess changes.
Inflammation and Biomarkers in Serum - cortisol
Time frame: 6 Months
Systemic inflammation will be assessed by measuring concentrations of cortisol. Samples will be taken pre- and post-intervention to assess changes.
Microbiome Diversity
Time frame: 6 Months
Stool samples will be analyzed for gut microbiome composition by shallow shotgun metagenome sequencing. Samples will be taken pre- and post-intervention to assess changes.
Sleep Efficiency
Time frame: 6 Months
Sleep efficiency (total sleep time/time spent in bed) will be measured through a wearable device with an accelerometer. This device will also measure other components of sleep quality such as sleep onset latency, total sleep time and wake after sleep onset.
Pittsburgh Sleep Quality Index
Time frame: 6 Months
The Pittsburgh Sleep Quality Index will be used to collect subjective sleep quality data on a monthly basis.
Total Grey Matter Volume
Time frame: 6 Months
Total grey matter volume will be measured using an MRI. Testing is done pre- and post-intervention to compares scores.
Hippocampal Volume
Time frame: 6 Months
Hippocampal volume will be measured using an MRI. Testing is done pre- and post-intervention to compares scores.
White matter hyperintensities volume
Time frame: 6 Months
White matter hyperintensities volume will be measured using an MRI. Testing is done pre- and post-intervention to compares scores.
Myelin Water
Time frame: 6 Months
Myelin water imaging will be collected using resting state functional MRI. Testing is done pre- and post-intervention to compares scores.
Functional MRI
Time frame: 6 Months
A flanker task will be administered during the MRI to examine selective attention, inhibitory function, and executive control. Testing is done pre- and post-intervention to compares scores.
Maximal oxygen consumption (VO2 Max)
Time frame: 6 Months
Predicted maximal oxygen consumption will be measured using a six-minute walk test. Testing is done pre- and post-intervention to compares scores.
Heart Rate Recovery
Time frame: 6 Months
Heart rate recovery will be measured using a three-minute step test. Testing is done pre- and post-intervention to compares scores.
Berg Balance Assessment
Time frame: 6 Months
A Berg Balance Assessment will be used to measure participants balance. Testing is done pre- and post-intervention to compares scores.
Dynamic Gate Index
Time frame: 6 Months
The Dynamic Gait Index will be used to measure participants gait. Testing is done pre- and post-intervention to compares scores.
Timed Up and Go Test
Time frame: 6 Months
The Dynamic Gait Index will be used to measure participants gait. Testing is done pre- and post-intervention to compares scores.
30 Second Sit to Stand Test
Time frame: 6 Months
Functional lower extremity strength with be assessed using the 30 second sit to stand test. Testing is done pre- and post-intervention to compare scores.
Dual-Energy X-Ray Absorptiometry (DEXA)
Time frame: 6-Months
Body composition, such as body fat and muscle mass, will be measured using Dual-energy X-ray Absorptiometry. Testing is done pre- and post-intervention to compare scores.
Physical Activity Levels
Time frame: 6 Months
Physical activity levels will be measured through a wearable device to help ensure adherence and effectiveness of the exercise intervention. Data will be collected throughout the study.
Heart Rate
Time frame: 6 Months
Heart rate will be measured through a wearable device to help ensure adherence and effectiveness of the exercise intervention. Data will be collected throughout the study.
Fried Frailty Index
Time frame: 6 Months
Physical frailty will be assessed using the fried frailty index. Testing is done pre- and post-intervention to compares scores.
Blood Pressure
Time frame: 6 Months
Blood pressure will be measured pre- and post-intervention to compares scores.
Weight
Time frame: 6 Months
Weight will be measured pre- and post-intervention to compares scores.
Framingham Risk Score
Time frame: 6 Months
Cardiovascular health will be assessed using the Framingham Risk Score. This score includes measurements of age, total cholesterol, smoking status, HDL level, diabetes status, systolic blood pressure and treatment status. Testing is done pre- and post-intervention to compares scores.
NIH Toolbox- Emotional Battery
Time frame: 6 Months
Social, emotional, and mental well-being will be evaluated using the NIH Toolbox-Emotional Battery. Testing is done pre- and post-intervention to compares scores.
World Health Organization (WHO) Quality of Life Questionnaire
Time frame: 6 Months
Quality of life will be evaluated using the World Health Organization (WHO) Quality of Life Questionnaire. Testing is done pre- and post-intervention to compares scores.
Freiburg Mindfulness Inventory
Time frame: 6 Months
Questionnaires related to mindfulness will be administered throughout the study at monthly intervals.
Mindful Attention Awareness Scale
Time frame: 6 Months
Questionnaires related to mindfulness will be administered throughout the study at monthly intervals.
Multidimensional Assessment of Interoceptive Awareness
Time frame: 6 Months
Questionnaires related to mindfulness will be administered throughout the study at monthly intervals.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Mar 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Silke Appel-Cresswell, MD, FRCPC principal investigator
University of British Colombia
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Exercise, Meditation and Diet in people with Healthy Aging, run by University of British Columbia at 1 site in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 31 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 23 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Jeffrey Kelly, MSc (6048274230, jeffrey.kelly@ubc.ca), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cognition - NIH Toolbox Cognitive Battery (time frame: 6 Months). The study lists 38 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Mar 2026.