Clinical trials: sponsored by University of British Columbia
OSA COPD Overlap Syndrome
Comparing Two Types of Breathing Support in People With COPD, High Carbon Dioxide Levels, and Sleep Apnea
This pilot study compares two positive airway pressure strategies for patients with both COPD and obstructive sleep apnea (overlap syndrome) who retain excess carbon dioxide.
- Trial name
- PAVE-OVS (NCT07891962)
- Testing
- Bilevel
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Bipolar Disorder (BD), Quality of Life (QOL)
Evaluating the PolarUs App in People With Bipolar Disorder
Our team recently pilot tested a new mobile app, PolarUs, co-designed with people who live with bipolar disorder (BD), to support BD self-management and quality of life (QoL) measurement.
- Trial name
- NCT07890805
- Testing
- PolarUs Mobile App
- Where
- Canada
- Volunteers
- 504 people
- Sponsor
- University of British Columbia
Perimenopause, Subjective Cognitive Complaints
Exercise in Perimenopause to Improve Cognitive Health
Perimenopause is now considered a possible risk factor for dementia and may contribute to the fact that 2/3 of those living with Alzheimer's disease are females.
- Trial name
- EPIC (NCT07272174)
- Testing
- Progressive Resistance Training, Balance, Flexibility, and Tone Exercises
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Spinal Cord Injury, Spinal Cord Injury at C5-C7 Level
Nerve Transfer Surgery to Restore Upper-limb Function After Cervical Spinal Cord Injury
The goal of this prospective, open-label cohort study is to assess functional outcomes in individuals with cervical spinal cord injury who have undergone nerve transfer surgery to restore upper limb function.
- Conditions
- Spinal Cord Injury, Spinal Cord Injury at C5-C7 Level, SCI - Spinal Cord Injury, Upper Extremity Paralysis
- Trial name
- NCT05638191
- Testing
- Nerve transfer surgery
- Where
- 4 sites in Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation (AF)
Optimal PharmacoTherapy and Invasive Management of Atrial Fibrillation in Patients With Heart Failure
Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardiovascular epidemics, individually impairing quality of life and cardiac performance, as well as increasing the risk of hospitalisation and mortality.
- Trial name
- OPTIMal AF-HF (NCT07238452)
- Testing
- Pulmonary Vein Isolation, Pharmacological Rate Control
- Volunteers
- 1,050 people
- Sponsor
- University of British Columbia
Urinary Incontinence
Synthetic Versus Autologous Sling For Stress Incontinence
This is a multi-centre randomized controlled trial comparing mid-urethral synthetic mesh sling or tension-free vaginal tape (TVT) and autologous fascia sling (AFS) in elderly patients with stress predominant urinary incontinence.
- Trial name
- SASSI (NCT07276295)
- Testing
- autologous fascia sling, tension-free vaginal tape
- Where
- 7 sites in Canada
- Volunteers
- 232 people
- Sponsor
- University of British Columbia
SCI - Spinal Cord Injury
Cardiocentric Inotropic Optimization in Spinal Cord Injury
The first hours-to-day following acute traumatic cervical SCI represent a critical period of time to optimize hemodynamic management. After a spinal cord injury, cardiovascular function is affected.
- Trial name
- CARDIO-SCI (NCT07871643)
- Testing
- Dobutamine crossover
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of British Columbia
Healthy Adult
Ivabradine for Heart Rate Reduction During Exercise in Healthy Adults
During exercise, working muscles require more oxygen. The heart meets this demand in two ways: by beating faster (heart rate) and by pumping more blood with each beat (stroke volume).
- Trial name
- NCT07717710
- Testing
- Ivabradine (single oral dose)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy Participants
Rate of Tranexamic Acid Administration on Blood Pressure (RateTXA) Study.
Tranexamic acid is a well-established treatment for post-partum hemorrhage. This study aims to examine the effect of tranexamic acid administration rates on blood pressure changes over 1 minute compared to 10 minutes in healthy…
- Trial name
- RateTXA (NCT06356948)
- Testing
- Tranexamic Acid (TXA)
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Shared Decision Making, Cesarean Section
Shared Decision-Making During Anesthesia Consent for Elective Cesarean Delivery
Shared decision-making (SDM) is the accepted ethical and legal standard for informed consent, but it is not known how it operates in anesthesia consent for cesarean delivery.
- Conditions
- Shared Decision Making, Cesarean Section, Anesthesia, Obstetrical, Informed Consent
- Trial name
- SDM-Consent (NCT07858084)
- Testing
- Observation of anesthesia consent encounter and postpartum questionnaire
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- University of British Columbia
Healthy Adult Male, Healthy Adult Females
Investigating Sex Differences in Mitochondrial Function and Leg Blood Flow During Exercise
This study will compare mitochondrial function and leg blood flow during exercise in healthy endurance-trained females and males aged 19-35.
- Trial name
- MITOP (NCT07866651)
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Patient Satisfaction, Virtual Reality
Virtual Reality to Improve Satisfaction in Hysteroscopy Patients
This study aims to investigate whether viewing an immersive virtual reality (VR) image through a VR headset during elective hysteroscopy under Registered Nurse (RN) led sedation with fentanyl and midazolam plus local anesthesia…
- Conditions
- Patient Satisfaction, Virtual Reality, Hysteroscopy
- Trial name
- VIP (NCT04862598)
- Testing
- Oculus Virtual Reality
- Where
- Canada
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cesarean Delivery, Urinary Catheterization
Duration of Urinary Catheterization Following Cesarean Deliveries Under Neuraxial Anesthesia
In cesarean deliveries, urinary catheters are often used to help empty the bladder while patients have limited mobility. These catheters typically stay in during early recovery because certain pain medications can make it hard…
- Trial name
- DUCC (NCT06881849)
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Nicotine Dependence
Effects of Psilocybin on Craving in Nicotine Dependence
This pilot study will examine how a single 25 mg dose of psilocybin affects nicotine craving in people with nicotine dependence.
- Trial name
- SCANS-PSIL (NCT07852832)
- Testing
- Psilocybin (drug)
- Volunteers
- 3 people
- Sponsor
- University of British Columbia
Cerebral Palsy
Feasibility of a Robot-Guided Active Play Intervention for Children With Cerebral Palsy
Cerebral palsy can make it difficult for children and adolescents to participate consistently in enjoyable physical activity. This study will examine whether a small humanoid robot called NAO can deliver a short, story-based…
- Trial name
- REACT (NCT07842328)
- Testing
- Humanoid Robot-Guided Active Play Intervention
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Opioid-use Disorder
Evaluating Buprenorphine/Naloxone Microdosing vs. Standard Dosing in Emergency Departments
This is a multi-centre, open-label RCT at four Emergency Departments (EDs) in British Columbia and Alberta. The purpose of the current study is to compare the effectiveness of buprenorphine/naloxone microdosing and standard…
- Trial name
- NCT04893525
- Testing
- Buprenorphine/naloxone
- Where
- 6 sites in Canada
- Volunteers
- 658 people
- Sponsor
- University of British Columbia
Traumatic Spinal Cord Haemorrhage
Characterizing Hemorrhage in Acute Spinal Cord Injury With MRI
The study is designed to determine whether hemorrhage within the injured spinal cord is influenced by mean arterial pressure (MAP) augmentation with vasopressors and by venous thromboembolism (VTE) prophylaxis with anticoagulants…
- Trial name
- CHASM (NCT04758377)
- Testing
- Magnetic resonance imaging (MRI)
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of British Columbia
Spinal Cord Injuries
"UroMonitor Trial" in Spinal Cord Injury.
This study aims to determine if a non-functioning UroMonitor device can be safely inserted, monitored, and removed in patients with SCI.
- Trial name
- NCT04800523
- Testing
- UroMonitor System
- Where
- Canada
- Sponsor
- University of British Columbia
Acute Spinal Cord Injury, Spinal Cord Injuries
Optical Monitoring With Near-Infrared Spectroscopy for Spinal Cord Injury Trial
The study involves the 'first-in-human' evaluation of a novel optical sensor which uses near-infrared spectroscopy (NIRS) technology to assess oxygenation and hemodynamics of the injured spinal cord.
- Trial name
- NCT04811235
- Testing
- Near Infra-Red Spectroscopy (NIRS) Sensor
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of British Columbia
Acute Spinal Cord Injury, Acute Spinal Paralysis
"SCRIBBLE" Spinal Cord Injury Blood Biomarker Longitudinal Evaluation
Prospective, single center study designed to assess blood biomarkers for classifying injury severity and predict neurologic recovery in traumatic spinal cord injured (SCI) patients.
- Conditions
- Acute Spinal Cord Injury, Acute Spinal Paralysis, Spinal Cord Injuries, Trauma, Spinal Cord
- Trial name
- SCRIBBLE (NCT05244408)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of British Columbia