Clinical trials: sponsored by Icahn School of Medicine at Mount Sinai
Multiple Sclerosis, Neuromyelitis Optica
Longitudinal Cortical Demyelination in Multiple Sclerosis and Related Disorders
In this protocol, a combination of MRI, blood, and cerebrospinal fluid (CSF) analysis will be used to understand the natural history, underlying immunologic mechanisms, and clinical implications of central nervous system (CNS)…
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica, Demyelinating Autoimmune Diseases, CNS
- Trial name
- NCT05982925
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Caregiver Burden, Caregiver Burnout
A Study of Meaning-Centered Psychotherapy for Caregivers to People With Cancer
Participants will complete 1 set of questionnaires about 2 weeks before beginning their Meaning-Centered Psychotherapy for Caregivers/MCP-C or standard Supportive Psychotherapy for Caregivers/SP-C sessions.
- Conditions
- Caregiver Burden, Caregiver Burnout, Caregiver Stress Syndrome
- Trial name
- NCT06307535
- Testing
- Meaning-Centered Psychotherapy for Caregivers, Supportive Psychotherapy for Caregivers
- Where
- 8 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Airway Disease, Interstitial Lung Disease
WTC Chest CT Imaging Archive
Dr. Rafael E de la Hoz and colleagues have performed standardized and computer-assisted readings of all chest CT scans received by WTC workers and volunteers at the Mount Sinai Medical Center between 2003 and 2016.
- Conditions
- Chronic Airway Disease, Interstitial Lung Disease, Lung Cancer
- Trial name
- NCT03295279
- Where
- United States
- Volunteers
- 2,122 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Labor
Impact of Prophylactic Ephedrine on Fetal Heart Tracing and Uterine Tetanic Contraction After CSE
Labor analgesia is an important component of the care of laboring patients. A known side effect of combined spinal and epidural anesthesia (a type of labor analgesia) is an increased incidence of category II fetal heart rate…
- Trial name
- NCT05873218
- Testing
- Ephedrine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Thrombosis
Antithrombotic Activities of Sotagliflozin vs. Empagliflozin
The availability of Sodium-glucose cotransporter-2 inhibitors (SGLT2-i) has dramatically altered the management of heart failure (HF) patients, independently of their ejection fraction and glycemic status.
- Trial name
- SOTATHROMBUS (NCT06618976)
- Testing
- Sotagliflozin, Empagliflozin
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Major Depressive Disorder
Neutralizing Interleukin (IL)-6
The proposed study aims to establish the feasibility and safety of subcutaneous tocilizumab, a monoclonal antibody (mAb) against interleukin (IL)-6 receptor, in adults with Major Depressive Disorder (MDD) and evidence of…
- Trial name
- NCT07493317
- Testing
- Tocilizumab
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Liver Lesion
Gadopiclenol vs Gadoxetate MRI for Liver Lesions
The overall purpose of this study is to establish noninferiority of gadopiclenol MRI compared to gadoxetate MRI in terms of image quality and lesion detection/conspicuity in patients undergoing clinically indicated liver MRI in a…
- Trial name
- NCT06596616
- Testing
- Radiology, Gadopiclenol
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Metabolic Dysfunction-associated Steatotic Liver Disease
Guerbet Liver Fibrosis
The goal of this study is to assess the value of liver dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and texture analysis post gadopiclenol for liver fibrosis staging, in comparison with MR elastography, T1…
- Trial name
- NCT06703450
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Breast Cancer, Metastasis
Abemaciclib in Combination With Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer
This is an open label multicenter, Phase IB/II Study of Abemaciclib in Combination with Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer
- Trial name
- NCT05095207
- Testing
- Abemaciclib, Bicalutamide
- Where
- 3 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Intestinal Failure
The LIFT-ECHO Last Mile Project
This is a multi-site research study to evaluate the efficacy and effectiveness of the LIFT-ECHO program to improve clinical outcomes in patients and improve patient reported quality of life (PRQOL).
- Trial name
- NCT07094308
- Testing
- Learn Intestinal Failure Tele-ECHO Program, Standard of Care
- Where
- 5 sites in United States, United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Resilience, Psychological, Burnout, Psychological
Building Community Resilience Program
Established in 2021, NYCEAL consists of approximately 40 organizational partners and 120 Community Health Workers (CHWs). Over the next four years (2024-2028), NYCEAL will work with this network to implement the following…
- Conditions
- Resilience, Psychological, Burnout, Psychological, Stress, Psychological
- Trial name
- BCR (NCT06771167)
- Testing
- Building Community Resilience Program (BCR)
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Anorexia Nervosa
Metabolic Diet for Relapse Prevention in Anorexia Nervosa
This is an interventional study that will test the safety, tolerability, and efficacy of the Metabolic Diet, which was designed as a treatment for women with anorexia nervosa to remain weight-stable after they have been restored…
- Trial name
- NCT05197309
- Testing
- Metabolic Diet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Age Related Macular Degeneration
A Snapshot Adaptive Optics and Hyperspectral Autofluorescence Fundus Camera for Age-Related Macular Degeneration (AMD)
This study proposes to use a new instrument (AO-OCT/AF: adaptive optics - optical coherence tomography/autofluorescence) combined with a data processing method to image the retinal pigment epithelium (RPE) of the eye in normal…
- Trial name
- NCT03963817
- Testing
- adaptive optics AO-OCT/AF instrument
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Schizophrenia and Related Disorders
Social Isolation and Aging in Schizophrenia
Individuals diagnosed with schizophrenia and related psychotic disorders (SZ) exhibit a markedly elevated risk of premature mortality, with a 10-20-year shorter lifespan relative to the general population.
- Trial name
- SIAS (NCT07419321)
- Where
- 4 sites in United States, Netherlands and 2 more
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Bulimia Nervosa
Changes in Inhibition and Valuation After Eating
An impaired ability to exert control has been implicated in bulimia nervosa (BN), but this impairment may not represent a stable trait or be the most effective focus for treatment.
- Trial name
- NCT05995496
- Testing
- Fasting state, Fed state, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Bulimia Nervosa
Self-Control in Bulimia Nervosa
This study examines the influence of acute fasting and eating on self-control in adult females with and without bulimia nervosa (BN).
- Trial name
- NCT04409457
- Testing
- fasting state, fed state, magnetic resonance imaging
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Voice Disorders
Immersive Virtual Reality Meditation in Voice Therapy
This study aims to explore the feasibility of incorporating regular guided meditations via immersive virtual reality (IVR) at the start of voice therapy sessions to facilitate better learning and retention of treatment.
- Trial name
- NCT07176013
- Testing
- Voice therapy, Meditation, Virtual Reality
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Circadian Disruption
Evaluation of Circadian OS Technology on Melatonin Suppression
Primary Objective: Evaluate how the Circadian OS iPad-based light intervention suppresses melatonin. This small pilot study is designed to validate the Circadian OS technology by testing physiological response using melatonin…
- Trial name
- NCT07095270
- Testing
- Circadian OS software
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Crohns Disease, Pregnancy
Pregnant Women With and Without Crohns Disease to Explore the Role of Plastics and Toxins in Intestinal Inflammation
The PLANET Study aims to determine the impact of microplastics on intestinal inflammation and gut microbiome in order to understand the role of this pollutant on the risk of developing inflammatory bowel disease (IBD) as well as…
- Conditions
- Crohns Disease, Pregnancy, Inflammatory Bowel Disease
- Trial name
- PLANET (NCT06001450)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Myalgic Encephalomyelitis, Chronic Fatigue Syndrome
Cardiovascular Analysis of PEM
The purpose of this study is to examine cardiopulmonary function in Chronic Fatigue Syndrome (CFS) patients and determine how it relates to the common symptom of Post-exertional malaise (PEM).
- Trial name
- NCT04740736
- Testing
- Saline Infusion
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai