Clinical trials: open to volunteers, in Pakistan
Inherited Eye Disease
Clinical and Molecular Studies in Families With Inherited Eye Disease
Background: Genes are the basic units of heredity. When genes are changed, certain cells don t work like they should. Researchers want to try to better understand the genetic conditions that are linked with inherited eye…
- Trial name
- NCT02771236
- Where
- 10 sites in United States, China and 6 more
- Volunteers
- 5,000 people
- Sponsor
- National Eye Institute (NEI)
Tuberculosis (TB)
Optimal Treatment Duration for Radiographically Apparent, Bacteriologically Unconfirmed TB, Identified Through Active Case Finding (RADIO-TB Trial)
People living in high TB burden communities who undergo active case finding for TB may have chest X-ray changes suggestive of TB but their sputum test can be negative for the TB bacteria or they are unable to provide a sputum…
- Trial name
- RADIO-TB (NCT07163143)
- Testing
- Isoniazid (H), Rifampicin (R), Pyrazinamide (Z)
- Where
- 4 sites in Pakistan, South Africa and 1 more
- Volunteers
- 784 people
- Sponsor
- University College, London
Healthy Participants
Comparative Study of Effects of Neuromuscular Warmup vs Conventional Warmup in Recreational Gym Population
Impaired balance or insufficient strength may increase the risk of musculoskeletal injuries among recreational enthusiasts. Warm-up protocols are an essential component of exercise preparation, aiming to enhance performance and…
- Trial name
- NMWU YBT CMJ (NCT07340021)
- Testing
- NM Warm-up, Conventional Warm-up
- Where
- 2 sites in Pakistan
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Lahore University of Biological and Applied Sciences
Perforated Duodenal Ulcer
Comparison of Open vs Laparoscopic Repair of Perforated Duodenal Ulcer
This randomized controlled trial aims to compare open and laparoscopic repair of perforated duodenal ulcer in terms of postoperative outcomes.
- Trial name
- NCT07893951
- Testing
- Laparoscopic Repair of Perforated Duodenal Ulcer, Open Repair of Perforated Duodenal Ulcer
- Where
- Pakistan
- Volunteers
- 134 people
- Sponsor
- Allied Hospital Faisalabad
Focus of the Study is Smoking Cessation and Prevention, Smoking Prevention
Effectiveness Of Project EX: A Classroom-Based Smoking Prevention And Cessation Intervention Program
The goal of this intervention is to learn if Project EX helps in prevention and cessation of smoking in adolescents. The main question it aims to answer is: 1.
- Trial name
- NCT07895784
- Testing
- Project EX
- Where
- Pakistan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Karachi
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
PRISM Trial: Partial Breast Versus Whole Breast Radiation in Early Breast Cancer
Breast-conserving surgery followed by radiotherapy is a standard treatment for women with early-stage breast cancer. Whole breast irradiation (WBI) is the current standard approach, but partial breast irradiation (PBI), which…
- Trial name
- PRISM (NCT07811635)
- Testing
- Ultra-Hypofractionated Partial Breast Irradiation, Ultra-Hypofractionated Whole Breast Irradiation
- Where
- 3 sites in Pakistan, Saudi Arabia and 1 more
- Volunteers
- 100 people
- Sponsor
- Jinnah Postgraduate Medical Centre
Computer Vision Syndrome
Comparative Effects of Exercises on Pain, Cervical Proprioception, Neck Disability and Visual Performance in Patients With Computer Vision Syndrome.
This study aims to compare the effectiveness of cervical sensorimotor training and oculomotor training in patients with Computer Vision Syndrome (CVS).
- Trial name
- NCT07892040
- Testing
- Cervical Sensorimotor Training, Occulomotor Training
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- University of Management and Technology Lahore
Back Pain
Comparative Effects of Soft Tissue Mobilization and Pressure Therapy With and Without Dynamic Cupping on on Pain and Disability in Patients With Thoracic Back Pain.
This study aims to compare the sequential effects of Instrument-Assisted Soft Tissue Mobilization (IASTM) and Transverse Oscillatory Pressure (TOP), with and without Directional Dynamic Cupping, in patients with thoracic back…
- Trial name
- NCT07892066
- Testing
- Instrument assisted soft tissue (IASTM), Transvers oscillatory pressure (TOP), Instrument assisted soft tissue (IASTM), Transvers oscillatory pressure (TOP) and Directional dynamic cupping
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- University of Management and Technology Lahore
Low Back Pain
Effects of Motor Control Exercises With and Without Pressure Biofeedback in Recurrent Low Back Pain (MCE)
This study aims to compare the effects of Motor Control Exercises (MCE) with and without Pressure Biofeedback-Guided Training in patients with recurrent low back pain.
- Trial name
- yes (NCT07892079)
- Testing
- Motor Control Exercise with Pressure Biofeedback-Guided Training, Motor Control Exercise
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- University of Management and Technology Lahore
Text Neck Syndrome
Effects of Progressive Neck Motor Control Exercises With and Without Conventional Therapy in Text Neck Syndrome.(PNMCE-TNS)
This study aims to compare the effects of Progressive Neck Motor Control Exercises (PNMCE) with and without conventional physiotherapy in patients with Text Neck Syndrome.
- Trial name
- Yes (NCT07892131)
- Testing
- Progressive Neck Motor Control Exercises, Progressive Neck Motor Control Exercises and Conventional Therapy
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- University of Management and Technology Lahore
Knee Osteoarthritis
Effects of Low-Load Blood Flow Restriction Resistance Training With and Without Hip Abductor Strengthening in Patients With Knee Osteoarthritis.(BFR)
This study aims to compare the effects of low-load Blood Flow Restriction (BFR) resistance training with and without hip abductor strengthening in patients with knee osteoarthritis.
- Trial name
- yes (NCT07892144)
- Testing
- Hip Abductor Strength Training followed by Low-Load BFR Resistance Training, Low-Load Blood Flow Restriction (BFR) Resistance Training
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- University of Management and Technology Lahore
Gingivitis
Effectiveness of Oil Pulling Using Oils in Comparison With Mouthwash for Gingivitis
The goal of this clinical trial is to learn if daily oil pulling with coconut oil or sesame oil works as effectively as a standard mouthwash to treat gum swelling and redness (gingivitis) in adults aged 18 to 55 years.
- Trial name
- NCT07892235
- Testing
- virgin coconut oil (VCO), Sesame Oil, 0.2% Chlorhexidine Digluconate Mouthwash
- Where
- Pakistan
- Volunteers
- 45 people
- Sponsor
- Bahria University
Arthritis, Fibromyalgia
Wearable Biofeedback Devices for Remote Physiotherapy and Rehabilitation
This study evaluates the effectiveness of wearable biofeedback devices in improving pain, mobility, and rehabilitation outcomes in elderly patients with arthritis and fibromyalgia in Karachi, Pakistan.
- Conditions
- Arthritis, Fibromyalgia, Chronic Pain
- Trial name
- NCT06960330
- Testing
- Wearable Biofeedback + Virtual Physiotherapy, Standard Physiotherapy Exercises
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- University of Karachi
Acne Vulgaris
Comparison of Topical Clascoterone 1% Cream Versus Adapalene 0.1% Cream in the Treatment of Mild-to-Moderate Acne Vulgaris
This study will compare the effectiveness and safety of topical clascoterone 1% cream and adapalene 0.1% cream in patients with mild-to-moderate acne vulgaris.
- Trial name
- NCT07883538
- Testing
- Clascoterone 1% cream, Adapalene 0.1% cream
- Where
- Pakistan
- Volunteers
- 130 people
- Sponsor
- Pak Emirates Military Hospital
Neonatal Sepsis, Neutropenia
G-CSF In Neonatal Sepsis With Neutropenia
This study will evaluate whether adding G-CSF to standard treatment improves outcomes in newborns (0-28 days) with sepsis and neutropenia.
- Trial name
- NCT07888829
- Testing
- Granulocyte-colony stimulating factor (G-CSF), Standard Sepsis Management
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- University of Health Sciences Lahore
Antenatal Care Model, Gestatiaonl Diabetes Mellitus
Effects Of Core Canister Training in Pregnant Women With History of Gestational Diabetes Mellitus
This randomized control trial aims to determine the effects of structured Core Canister Training on muscular thickness, lumbopelvic stability and pelvic floor function in pregnant women diagnosed with GDM
- Trial name
- NCT07889791
- Testing
- core canister training, traditional antenatal exercises
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Melasma
COMPARISON OF TOPICAL VITAMIN C VS NIACINAMIDE IN TREATMENT OF MELASMA
Melasma is a common acquired hyperpigmentation disorder that significantly affects quality of life. Various topical agents are used in its treatment, including Vitamin C and Niacinamide, both of which possess depigmenting…
- Trial name
- NCT07890571
- Testing
- Ascorbic acid, niacinamide
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Pak Emirates Military Hospital
Cerebral Venous Sinus Thrombosis
MENA Regional Endovascular Intervention for Venous Cerebral Venous Sinus Thrombosis
REVIVE-CVST is a multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) trial evaluating whether early endovascular thrombectomy (EVT) combined with standard anticoagulation improves outcomes compared to…
- Trial name
- REVIVE-CVST (NCT07548346)
- Testing
- Endovascular Thrombectomy, Anticoagulation Therapy
- Where
- 14 sites in Egypt, Jordan and 6 more
- Volunteers
- 440 people
- Sponsor
- Middle East North Africa Stroke and Interventional Neurotherapies Organization
Beta-Thalassemia, Thalassemia
Combination Therapy With Danazol, Prednisolone, and Thalidomide for Thalidomide-Refractory Transfusion-Dependent β-Thalassemia
This study will compare two treatments for children with beta-thalassemia who need regular blood transfusions and have not responded well to thalidomide. One group will continue thalidomide alone.
- Trial name
- NCT07884773
- Testing
- Thalidomide, Danazol, Prednisolone
- Where
- Pakistan
- Volunteers
- 172 people
- Sponsor
- Khyber Medical University Peshawar
Stroke
Effectiveness of Epley Maneuver Versus Semont Maneuver on Dizziness and Balance in Stroke Survivors With Posterior Canal BPPV
This randomized controlled trial aims to compare the effectiveness of the Epley maneuver and the Semont maneuver in reducing dizziness and improving balance in stroke survivors diagnosed with posterior canal benign paroxysmal…
- Trial name
- NCT07887191
- Testing
- Epley Maneuver, Semont Maneuver
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Ibadat International University, Islamabad