Clinical trials: in Guadeloupe
Ventilator-Associated Pneumonia (VAP)
Immediate Versus Substantiated Antibiotic Therapy in Suspected Non-Severe Ventilator-Associated Pneumonia
Ventilator-associated pneumonia is the leading nosocomial infection in the intensive care units, and is associated with prolonged mechanical ventilation and overuse of antibiotics.
- Trial name
- POSTPONE (NCT06743529)
- Testing
- control group, Conservative strategy
- Where
- 42 sites in France, Guadeloupe
- Volunteers
- 686 people
- Sponsor
- Nantes University Hospital
Tobacco Addiction
Interventional Study on Smoking Reduction in Psychiatry
The smoking rate among people with mental disorders is higher than in the general population. Greater exposure to the harmful effects of tobacco partly explains the major inequality in life expectancy observed among people with…
- Trial name
- TABAPSY (NCT06926153)
- Testing
- TABAPSY, Usual Care
- Where
- 22 sites in France, Guadeloupe and 1 more
- Volunteers
- 6,500 people
- Sponsor
- GCS-CCOMS
Sickle Cell Disease, Venous Thromboembolism
Comparison of Thrombin Generation, Platelet Activation and Aggregation Profiles in Patients With Sickle Cell Disease Depending on Their SS or SC Genotype (DrepAgreg)
Sickle cell disease (SCD) is characterized by chronic hemolytic anemia, painful crises called vaso-occlusive crises (VOC) and chronic inflammation.
- Trial name
- DrepAgreg (NCT07852442)
- Where
- 2 sites in France, Guadeloupe
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Zika Virus Infection on Fetus and Child During the Pregnancy
Zika Virus Infection's Neonatal and Pediatric Consequences in French Department of America
The Zika epidemic has spread into the three French Overseas Departments in the Caribbean (DFAs). It is therefore urgent to set up tools to collect clinical and paraclinical data for the evaluation of potential complications due…
- Trial name
- ZIKA-DFA-BB (NCT02810210)
- Testing
- fundus examination, Head ultrasound
- Where
- 6 sites in France, French Guiana and 2 more
- Volunteers
- 1,180 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Morbid Obesity, Chronic Kidney Disease (Stage 3-4)
Metabolic Status and Risk of Chronic Kidney Disease in French Overseas Populations With Morbid Obesity (OBECAMcohort).
Morbid obesity is defined by a body mass index (BMI) ≥ 40 kg/m2 or > 35 if there is at least one comorbidity (hypertension, diabetes, hypercholesterolemia, joint pain, obstructive sleep apnea syndrome, etc.) Morbid obesity…
- Trial name
- OBECAMcohort (NCT07830030)
- Where
- Guadeloupe
- Volunteers
- 480 people
- Sponsor
- Clinique
Shock
The Prevalence of the Aortic to Radial Pressure Gradient in States of Shock, Outside the Context of Cardiac Surgery, a Prospective Study
First described in cardiac surgery, the aortic to radial pressure gradient (ATRAP) is the cause of an underestimation of the aortic pressure with a measure assumed with a radial catheter, and he can concert 1 of 3rd patients.
- Trial name
- PARECHOC (NCT06460519)
- Testing
- Non-invasive blood pressure measurements
- Where
- 9 sites in France, Guadeloupe
- Volunteers
- 180 people
- Sponsor
- Hospices Civils de Lyon
Cardiac Arrest
Targeted Temperature Management at 33°C Versus Controlled Normothermia for In-hospital Cardiac Arrest
The IH-TTM trial is designed to determine whether survival with a favorable neurological outcome is improved by induced hypothermia at 33°C in comatose critically ill patients admitted after resuscitated in-hospital cardiac…
- Trial name
- IH-TTM (NCT07086703)
- Testing
- Induced hypothermia at 33°C, Control normothermia
- Where
- 31 sites in Belgium, France and 1 more
- Volunteers
- 788 people
- Sponsor
- Nantes University Hospital
Critical Illness, Shock
Impact of Early Low-Calorie Low-Protein Versus Standard Feeding on Outcomes of Ventilated Adults With Shock
Among critically ill patients requiring mechanical ventilation and catecholamines for shock, nearly 40% to 50% die, and functional recovery is often delayed in survivors.
- Conditions
- Critical Illness, Shock, Mechanical Ventilation, Critical Illness Myopathy
- Trial name
- NUTRIREA3 (NCT03573739)
- Testing
- low-calorie low-protein, standard-calorie/standard-protein
- Where
- 59 sites in France, Guadeloupe
- Volunteers
- 3,044 people
- Sponsor
- Nantes University Hospital
Red Blood Cell Disorder
Pathophysiological Explorations of Red Blood Cells
GR-Ex is a program labelled by Labex (Laboratory of Excellence) by the French Ministry of Higher Education and Research. This program aims to develop the means to improve knowledge in the physiology and pathologies of…
- Trial name
- GR-Ex (NCT03541525)
- Testing
- Biological sampling
- Where
- 25 sites in Benin, France and 1 more
- Volunteers
- 3,750 people, healthy volunteers welcome
- Sponsor
- Imagine Institute
Vaso-Occlusive Pain Episode in Sickle Cell Disease
Lidocaine for Opioid Sparing in Vaso-occlusive Crisis of Sickle Cell Disease
The purpose of the study is to determine whether adding lidocaine to standard of care in pain management during severe vaso-occlusive crisis has an effect on the cumulative opioid consumption expressed as morphine milligram…
- Trial name
- LidoVOC (NCT07274254)
- Testing
- Lidocain, Standard of care
- Where
- 12 sites in France, Guadeloupe
- Volunteers
- 104 people
- Sponsor
- Nantes University Hospital
Gene Mutation-Related Cancer, Genetic Predisposition
COsegregation of VARiants in Panel of Genes
The aim of the COVAR project is to achieve reliable classification of as many variants of interest as possible from the French OncoGenetics Database (FrOG, https://frog-db.fr/) in order to use them for the genetic counseling.
- Trial name
- COVAR (NCT01689584)
- Testing
- salivary kit
- Where
- 62 sites in France, Guadeloupe and 3 more
- Volunteers
- 11,000 people
- Sponsor
- Institut Curie
HIV Infections
Study Among People Living With HIV and Their Health Professionals of Associated Factors of Resilience to Self-stigma
This study is perform to study the effect of psychological and psychosocial factors associated with resilience to the self-stigmatization of people living with HIV
- Trial name
- RESILSTIGMA (NCT05149001)
- Where
- 43 sites in France, Guadeloupe and 1 more
- Volunteers
- 667 people
- Sponsor
- University Hospital, Clermont-Ferrand
Contraception Behavior
SAPLAI : Assessing the faiSAbility of a Peer-to-peer Contraceptive Education Program on Social Networks Aimed at 15- to 19-year-old High School Students in GuAdeloupe and La RéunIon
The goal of this clinical trial is to evaluate the feasibility of a contraception education program delivered by peers via social networks to high school students.
- Trial name
- SAPLAI (NCT06943209)
- Testing
- Creation of a contraception education program and post on social networks for high school students, Education program, Survey and questionnaires
- Where
- 2 sites in Guadeloupe, Reunion
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Hepatitis E
Prevalence of Hepatitis E During Follow-up Liver and Kidney Transplant Patients in Guadeloupe, French West Indies
Hepatitis E is well known to be a common cause of severe hepatitis on organ-transplanted people. However, several studies also show a risk of transition to a chronic state.
- Trial name
- KARU-HEP (NCT07729202)
- Testing
- Liver and Kidney transplanted patients
- Where
- Guadeloupe
- Volunteers
- 95 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Drug Use
Drug Wastage : Observational Study in the Operating Rooms of France
Environmental awareness is leading medical field to question its responsibility and possibilities for action. Drug residues can have a major environmental impact as per their bioaccumulation, toxicity and persistence…
- Trial name
- GAME-OvBLOC (NCT05609864)
- Testing
- Quantification of injectable drugs wastage
- Where
- 83 sites in France, Guadeloupe and 2 more
- Volunteers
- 3,763 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Mental Disorder, Psychosocial Rehabilitation
CapExchange: A Pilot Feasibility Study of a Capacity-Exchange Programme for Mental Health Recovery
CapExchange is a psychosocial rehabilitation programme based on reciprocal exchange of capacities and services between service users and their community environment, grounded in the concepts of circular mutuality and micro-social…
- Trial name
- CapExchange (NCT07620418)
- Testing
- CapExchange
- Where
- Guadeloupe
- Volunteers
- 15 people
- Sponsor
- EPSM de la Guadeloupe
Sickle Cell Crisis
Evaluation of the Efficacy of Intra-nasal Sufentanil for Analgesia of Vaso-occlusive Crisis in Sickle-cell Adults.
The analgesic treatment for vaso-occlusive crisis (VOC) in sickle-cell patients is an emergency. The reference treatment is morphine, which requires a venous way sometimes difficult to obtain in these patients.
- Trial name
- DREPSUFINDOL (NCT04076748)
- Testing
- Sufentanil, EMONO
- Where
- 8 sites in France, French Guiana and 1 more
- Volunteers
- 115 people
- Sponsor
- University Hospital, Bordeaux
Thyroid and Parathyroid Surgery
Analysis of Chlordecone Tissue Concentrations in Patients Treated for Thyroid Surgery at Guadeloupe University Hospital
Chlordecone, an organochlorine pesticide used in the French Caribbean for several decades, is recognized as an endocrine disruptor.
- Trial name
- COTICHLO (NCT07611994)
- Testing
- Blood and thyroid tissue collection
- Where
- Guadeloupe
- Volunteers
- 69 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Liver Abscess, Pyogenic
Pyogenic Liver Abcess in Guadeloupe
Liver abscesses are infections of the liver parenchyma, most often bacterial, occurring via the biliary tract, bloodstream, or by direct spread. Although rare, they are serious, with a mortality rate of around 15%.
- Trial name
- PYG (NCT07579104)
- Where
- Guadeloupe
- Volunteers
- 58 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Endometriosis
Impact of Microbiome in Endometriosis Development
Endometriosis is a chronic disease, of which the pathophysiology is still unknown. Several theories exist, the one of menstrual blood flow has been retained until now but does not fully explain it.
- Trial name
- ENDOBIOME (NCT07576361)
- Where
- Guadeloupe
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe