Drug UseGAME-OvBLOCNCT05609864
Drug Wastage : Observational Study in the Operating Rooms of France
An observational study of Drug Use, run by Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer at 83 sites in 4 countries.
Trial summary
Environmental awareness is leading medical field to question its responsibility and possibilities for action. Drug residues can have a major environmental impact as per their bioaccumulation, toxicity and persistence characteristics, depending on where they are discarded. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Drug Use
- What is being tested?
- Quantification of injectable drugs wastage
- Type of treatment
- Injection or infusion
- How many people
- 3,763 participants
- Where
- 83 sitesin 4 countries
- Study dates
- 6 Apr 2023to 20 Jul 2023
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: All patients who will need an anesthesia act in operating room during a 24 hours period
Who may be able to join
- All patients who will need an anesthesia act in operating room during a 24 hours period
Who cannot join
- Patient opposition to participate in the study or parents opposition if the patient is a child or patient family opposition if the patient is not capable of being informed
Trial locations and contacts
83 sites in 4 countries.
83 sites in 4 countries
France80 sites
CHU d'Amiens
Amiens, Somme, 80054
Clinique Victor Pauchet
Amiens, Somme, 80090
Centre Hospitalier de l'Agglomération Montargoise
Amilly, Loiret, 45200
CHU d'Angers
Angers, Maine-et-Loire, 49100
Hôpital privé Arras les Bonnettes
Arras, Pas-de-Calais, 62000
Centre Hospitalier Henri Mondor
Aurillac, Cantal, 15000
Hôpital Privé de la Chataigneraie
Beaumont, Val d'Oise, 63110
Hôpital NOVO - Site de Beaumont-sur-Oise
Beaumont-sur-Oise, Val d'Oise, 95260
CHU Jean Minjoz
Besançon, Doubs, 25000
Clinique Aguilera
Biarritz, Pyrénées-Atlantiques, 64200
CHU de Bordeaux - Groupe hospitalier Pellegrin
Bordeaux, Gironde, 33000
HIA Clermont Tonnerre
Brest, Finistère, 29240
CHRU de Brest
Brest, Finistère, 29609
Centre Hospitalier de Brive-la-Gaillarde
Brive-la-Gaillarde, Corrèze, 19100
Hôpital mère-enfant (HCL)
Bron, Rhône, 69500
CHU de Caen
Caen, Calvados, 14000
Centre Hospitalier de Cannes
Cannes, Alpes-Maritimes, 06400
Centre Hospitalier Intercommunal Castres-Mazamet
Castres, Tarn
Hôpital NOVO - Site de Pontoise
Cergy-Pontoise, Val d'Oise, 90079
Centre Hospitalier de Charleville-Mézières
Charleville-Mézières, Ardennes, 08000
HIA Percy Clamart
Clamart, Hauts-de-Seine, 92141
CHU de Clermont-Ferrand
Clermont-Ferrand, Puy-de-Dôme, 63000
Clinique de la Plaine Santé
Clermont-Ferrand, Puy-de-Dôme, 63000
Centre hospitalier Sud Francilien
Corbeil-Essonnes, Essonne, 91106
Clinique des Cèdres
Cornebarrieu, Haute-Garonne, 31700
Centre Hospitalier de Dax
Dax, Landes, 40100
CHU de Dijon
Dijon, Côte d'Or, 21000
CHU de Grenoble
Grenoble, Isère, 38100
Centre Hospitalier Départemental de Vendée
La Roche-sur-Yon, Vendée, 85000
Groupe Hospitalier Littoral Atlantique
La Rochelle, Charente-Maritime, 17019
Centre Hospitalier d'Arcachon
La Teste-de-Buch, Gironde, 33260
Hôpital Marie Lannelongue
Le Plessis-Robinson, Hauts-de-Seine, 92350
Centre Hospitalier Emile Roux
Le Puy-en-Velay, Haute-Loire, 43012
Centre Hospitalier de Lens
Lens, Pas-de-Calais, 62300
Centre Oscar Lambret
Lille, Nord, 59000
CHU de Lille - Institut coeur poumon
Lille, Nord, 59000
CHU de Lille - Hôpital Huriez
Lille, Nord, 59037
CHU de Lille - Hôpital Jeanne de Flandre
Lille, Nord, 59037
CHU de Lille - Hôpital Roger Salengro
Lille, Nord, 59037
CHU de Limoges
Limoges, Haute Vienne, 87042
Groupe Hospitalier Bretagne Sud
Lorient, Morbihan, 56322
Hôpital Edouard Herriot
Lyon, Rhône, 69003
Centre Léon Bérard
Lyon, Rhône, 69008
Clinique de la Sauvegarde
Lyon, Rhône, 69009
Hôpital La Timone (AP-HM)
Marseille, Bouches-du-Rhône, 13005
Hôpital Nord (AP-HM)
Marseille, Bouches-du-Rhône, 13015
CHU de Nîmes
Nîmes, Gard, 30900
Clinique de l'Archette
Olivet, Loiret, 45160
Hôpital Lariboisière (AP-HP)
Paris, 75010
Hôpital Saint Louis (AP-HP)
Paris, 75010
Hôpital Trousseau (AP-HP)
Paris, 75012
Hôpital La Pitié-Salpêtrière
Paris, 75013
Hôpital Européen Georges Pompidou
Paris, 75015
Groupe Hospitalier Diaconesses Croix Saint Simon
Paris, 75020
Hôpital Tenon (AP-HP)
Paris, 75020
Institut mutualiste Montsouris
Paris, 75674
Centre Hospitalier de Pau
Pau, Pyrénées-Atlantiques, 64046
CHU de Bordeaux, Groupe Sud
Pessac, Gironde, 33600
Clinique mutualiste de Pessac
Pessac, Gironde, 33600
Centre Hospitalier de Cornouailles
Quimper, Finistère, 29000
Clinique la Croix du Sud
Quint-Fonsegrives, Haute-Garonne, 31130
Institut Godinot
Reims, Marne, 51100
CHU de Rennes - Pontchaillou
Rennes, Ille-et-Vilaine, 35033
CHU de Rennes - Hôpital Sud
Rennes, Ille-et-Vilaine, 35200
Clinique mutualiste La Sagesse
Rennes, Ille-et-Vilaine, 44345
Centre Hospitalier Jacques Puel
Rodez, Aveyron, 12000
CHU de Rouen
Rouen, Seine-Maritime, 76000
CHU de la Réunion
Saint-Denis, La Réunion, 97400
Clinique de l'Union
Saint-Jean, Haute-Garonne, 31240
CHU de Strasbourg - IHU
Strasbourg, Bas-Rhin, 67000
Sainte-Anne Military Teaching Hospital
Toulon, Var, 83000
Centre Hospitalier Intercommunal Toulon - La Seyne sur Mer
Toulon, Var, 83100
CHU de Toulouse - Hôpital Rangueil
Toulouse, Haute-Garonne, 31400
Hôpital Nord Franche-Comté
Trévenans, Territoire De Belfort, 90400
Centre Hospitalier de Valence
Valence, Drôme, 26000
Institut de Cancérologie de Lorraine
Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54519
Hôpital Robert Schuman-Groupe UNEOS
Vantoux, Vaucluse, 57070
Institut Gustave Roussy
Villejuif, Val-de-Marne, 94805
Hôpital Paul Brousse (AP-HP)
Villejuif, 94800
Centre Hospitalier Intercommunal de Villeneuve Saint Georges
Villeneuve-Saint-Georges, Val-de-Marne, 94190
Mayotte1 site
Centre Hospitalier de Mayotte
Mamoudzou, 97600
About this study
Environmental awareness is leading medical field to question its responsibility and possibilities for action.
Drug residues can have a major environmental impact as per their bioaccumulation, toxicity and persistence characteristics, depending on where they are discarded. In France, drug residues should be disposed of by incineration, but in practice this is not systematic. Moreover, data on drug wastage in the operating rooms by anesthesia department are rare.
The GAME-OvBLOC observational study aim to evaluate drug wastage in the operating rooms by anesthesia department in France and to propose ways of improving health care practices.
Read the detailed description
Observational study with data collection over a 24-hour business day. Data collected refer to healthcare team's practices and patients.
- Conditions
- Drug Use
- Being tested
- Quantification of injectable drugs wastage
- Keywords
- Drug wastage, Green Anesthesia, Environmental sustainability, Injectable drugs, Eco-design of care, Operating Room
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Quantification of injectable drugs wastageOther
Drugs are prescribed at discretion of physicians. For each patient who have anesthesia in the operating room, all labelled syringes having contained drugs (name + dilution) are collected and analyzed.
| Study group | Role | What they receive |
|---|---|---|
| Injectable drugs | Patient's data and data relating to prepared/administrated/discarded injectable drugs will be collected during 24 hours in the operating rooms by anesthesia department Receives: Other: Quantification of injectable drugs wastage |
What is being measured
The primary outcome is the main question the study is designed to answer.
Ratio of overall wastage in milliliter (mL) of prepared and discarded injectable drugs, to overall volume in milliliter (mL) of prepared injectable drugs
Wastage is defined as : any prepared and unused drug that remains in syringe
Measured: 24 hours
Secondary outcomes (7)
Reason for discarding drug residues
The reason of waste full syringe will be noticed : 1/ prepared in advance and not used ; 2/ prescription change ; 3/ preparation error ; 4/ other reason
Measured: 24 hours
Describe drug wastage for each kind of surgery/anesthesia
Drug wastage according to type of surgery and anaesthesia
Measured: 24 hours
Drug residues discarding process
Questionnaire on nursing practices on the choice of waste disposal circuits according to drugs
Measured: 24 hours
Cost of overall injectable drugs wastage
Estimated cost of drug residues will be evaluated for each drug by the following formula :
volume of discarded injectable drugs x theoretical price
Measured: 24 hours
Describe drug wastage for each age group
Drug wastage according to the following age groups : adult (≥18 years old) and pediatrics (< 1 year old, 1-5 years old, ≥ 6 years old)
Measured: 24 hours
Describe waste and environmental impact of used plastic syringes
Number and volume of used syringes, use of pre-filled syringes, refilling of syringes and multi-patient use.
Environmental impact is indirectly assessed by type of plastic used and the transport distance from the production site to France.
Measured: 24 hours
Use of alternative to injectable drugs
Alternatives : local anaesthesia and anaesthetic gases
Measured: 24 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Nov 2022
- Study start6 Apr 2023
- Primary completion20 Jul 2023
- Study completion20 Jul 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Drug UseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 3,763 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
- Sponsor type
- University, hospital or other
- Collaborators
- Sainte-Anne Military Teaching Hospital
- Responsible party
- Sponsor
- Investigators
- Erwan D'Aranda, MD, Study director, Sainte-Anne Military Teaching Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05609864
- Sponsor's protocol ID
- 2023-CHITS-001
- Acronym
- GAME-OvBLOC
- Status last verified
- Jul 2026
- First submitted
- 2 Nov 2022
- Last updated
- 7 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
McGain F, Muret J, Lawson C, Sherman JD. Environmental sustainability in anaesthesia and critical care. Br J Anaesth. 2020 Nov;125(5):680-692. doi: 10.1016/j.bja.2020.06.055. Epub 2020 Aug 12.
PubMed 32798068Barbariol F, Deana C, Lucchese F, Cataldi G, Bassi F, Bove T, Vetrugno L, De Monte A. Evaluation of Drug Wastage in the Operating Rooms and Intensive Care Units of a Regional Health Service. Anesth Analg. 2021 May 1;132(5):1450-1456. doi: 10.1213/ANE.0000000000005457.
PubMed 33667211Mankes RF. Propofol wastage in anesthesia. Anesth Analg. 2012 May;114(5):1091-2. doi: 10.1213/ANE.0b013e31824ea491. Epub 2012 Mar 13.
PubMed 22415537Ramstrom H, Martini S, Borgendahl J, Agerstrand M, Larfars G, Ovesjo ML. Pharmaceuticals and Environment: a web-based decision support for considering environmental aspects of medicines in use. Eur J Clin Pharmacol. 2020 Aug;76(8):1151-1160. doi: 10.1007/s00228-020-02885-1. Epub 2020 May 9.
PubMed 32388641