Clinical trials: in Afghanistan
Procedural Pain
A Combined 2% Lidocaine Anesthetic Technique for Mandibular Molar Procedures Without Inferior Alveolar Nerve Block
This prospective single-arm pilot study evaluated the clinical effectiveness of a combined local anesthetic technique using 2% lidocaine with 1:100,000 epinephrine for dental procedures involving mandibular molars.
- Trial name
- NCT07771452
- Testing
- Lidocaine 2% with 1:100 000 epinephrine
- Where
- Afghanistan
- Volunteers
- 60 people
- Sponsor
- Herat University
Cost of ICU, Out of Pocket Expenses
ICU-related Out of Pocket Expenses (ICOPE)
The ICU-related Out-of-Pocket Expenses (ICOPE) study is a multinational, prospective observational study conducted in African and Asian countries to quantify ICU-related out-of-pocket expenditures and catastrophic health…
- Trial name
- ICOPE (NCT07439692)
- Where
- 44 sites in Afghanistan, Bangladesh and 10 more
- Volunteers
- 354 people
- Sponsor
- Nat Intensive Care Surveillance - MORU
Type II Diabetes Mellitus, Efficacy, Self
Real World Safety & Efficacy Experience of Empagliflozin With or Without Metformin in T2DM Patients - EASE Study
Study Objective To evaluate the safety and tolerability of Empagliflozin with or without metformin in patients with Type II Diabetes Mellitus in the Pakistani population.
- Conditions
- Type II Diabetes Mellitus, Efficacy, Self, Safety Issues
- Trial name
- EASE (NCT05164263)
- Testing
- Empagliflozin
- Where
- 6 sites in Afghanistan, Kenya and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Getz Pharma
Diabetes Type 2, Type II Diabetes Mellitus
Engagement of coMmunity Through Participatory Learning and Action for cOntrol and preVEntion of Type II Diabetes and Its Risk Factors
This project aims to adapt, implement, and evaluate PLA based intervention in Rural Kabul, Afghanistan for TIIDM prevention and control.
- Trial name
- EMPOWER-D-Afg (NCT07350694)
- Testing
- PLA
- Where
- Afghanistan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- HealthNet Transcultural Psychosocial Organization
Wound Healing
Rationale for New Topical Anthroponotic Cutaneous Leishmaniasis (ACL) Treatment in Kabul
The aim of the randomized double blind trial with 134 patients presenting old world cutaneous leishmaniasis is: to evaluate the clinical efficacy of electro-thermo-cauterisation (ETC) followed by moist wound treatment versus ETC…
- Trial name
- rtt-ACL (NCT00947362)
- Testing
- Electro-thermo-coagulation, DAC N-055, saline
- Where
- Afghanistan
- Volunteers
- 134 people
- Sponsor
- Waisenmedizin e. V. Promoting Access to Essential Medicine
Depression and Suicide Ideation, Anxiety
Culturally Adapted Psychological Support for Conflict-Affected Afghans: Study Protocol on Mental Health & Violence
This pilot study examines the feasibility and acceptability of a culturally adapted psychological intervention-Problem Management Plus with Emotional Processing (PM+ EP)-for young Afghans aged 16-30 experiencing high…
- Conditions
- Depression and Suicide Ideation, Anxiety, PTSD
- Trial name
- NCT06980441
- Testing
- Problem Management Plus with Emotional Processing module
- Where
- Afghanistan
- Volunteers
- 60 people
- Sponsor
- Peace of Mind Association (PoMA)
Moderate Respiratory Distress, Severe Respiratory Distress
High Flow Nasal Oxygen Therapy an Implementation Study in Pediatric Wards
The purpose of this study is to prospectively evaluate the process of implementing HFNO in several MSF projects, varying according to geographical and programmatic contexts, population, health structures, human resources, and…
- Trial name
- HFNO (NCT06715423)
- Where
- Afghanistan
- Volunteers
- 960 people
- Sponsor
- Epicentre
Parenting
ECD Newborn Parenting Education Program
Early childhood development: specifically the first 1000 days of life are of crucial importance. It sets the trajectory for the future and transgenerational health.
- Trial name
- NCT06572254
- Testing
- Early Childhood Development Newborn Parenting Education Program
- Where
- 2 sites in Afghanistan, Pakistan
- Volunteers
- 400 people
- Sponsor
- Aga Khan University
Stunting, Malnutrition, Child
Effectiveness of SNF and SBCC to Prevent Stunting Among Children in Afghanistan: a Quasi-experimental Study
Over the years, there has been some progress made in reducing stunting in Afghanistan, the prevalence remains high with half of the provinces experiencing rates above the WHO alert threshold.
- Trial name
- NCT04581993
- Testing
- Super Cereal - wheat soya blend with sugar, Lipid-based nutrient supplement-medium quantity (LNS-MQ), Social and behavior change communication (SBCC)
- Where
- Afghanistan
- Volunteers
- 33,100 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Wound Dehiscence, Incision
Pediatric Post-operative Abdominal Wound Dehiscence in Association With Midline vs Other Incisions: A Prospective Cohort Study
This study is designed to see different abdominal incisions complication among neonates, infants and children and to find risk factors for developing wound dehiscence
- Trial name
- NCT05963477
- Testing
- laparatomy
- Where
- Afghanistan
- Volunteers
- 270 people
- Sponsor
- French Medical Institute for Mothers and Children
Severe Acute Respiratory Syndrome Coronavirus 2
Treatment Of CORONAVIRUS DISEASE 2019 (COVID-19) With Anti-Sars-CoV-2 Convalescent Plasma (ASCoV2CP)
This treatment protocol is designed to provide convalescent plasma as a therapeutic option for patients diagnosed with and hospitalized for COVID-19 with symptoms ranging from mild to life-threatening.
- Trial name
- NCT04360486
- Testing
- Anti-Sars-CoV-2 Convalescent Plasma
- Where
- 38 sites in United States, Afghanistan and 6 more
- Sponsor
- U.S. Army Medical Research and Development Command
Malaria, Fever
Cluster Randomised Trial of Malaria RDTs Used by CHWs in Afghanistan
Malaria is a common, but decreasing, cause of fever in endemic areas. The use of rapid diagnostic tests could improve treatment of malaria at the local community level. Deployment of these tests is, however, a considerable cost.
- Conditions
- Malaria, Fever, Acute Febrile Illness, Pneumonia
- Trial name
- NCT01403350
- Testing
- Malaria Rapid Diagnostic test
- Where
- 3 sites in Afghanistan
- Volunteers
- 2,421 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Depressive Symptoms, Anxiety
Transdiagnostic Treatment for Emotional Disorders
Background and study aims Depression is more prevalent in younger populations. The age of first onset of depression has become younger, yet many adolescents with depressive symptoms remain untreated.
- Conditions
- Depressive Symptoms, Anxiety, Emotional Problem
- Trial name
- UP (NCT04498949)
- Testing
- UP, Treatment as usual
- Where
- Afghanistan
- Volunteers
- 170 people
- Sponsor
- Mohamad hasan yousefi
Prevalence of Elevated Blood Pressure in Type-2 Diabetics
Prevalence of Hypertension in Type-2 Diabetes Mellitus
Cardiovascular disease is the most prevalent cause of morbidity and mortality in diabetic patients. Hypertension has been confirmed as a major risk factor for cardiovascular disease, which is frequently associated with diabetes…
- Trial name
- NCT05266885
- Where
- Afghanistan
- Volunteers
- 322 people
- Sponsor
- Kabul University of Medical Sciences
Incarcerated Inguinal Hernia
Incarcerated Right Inguinal Hernia Containing Sigmoid Colon: An Unusual Case Report
Incarcerated inguinal hernia is an irreducible but the blood supply to the contained part is intact, but developing towards strangulation. Here the lumen of the portion of colon occupying a hernia sac is blocked with faeces.
- Trial name
- NCT05251350
- Testing
- surgery
- Where
- Afghanistan
- Volunteers
- 2,717 people
- Sponsor
- Ahmadullah Danish
Coronavirus Disease 2019
Expanded Access Remdesivir (RDV; GS-5734™)
Disease caused by 2019 Novel Coronavirus also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Trial name
- NCT04302766
- Testing
- Remdesivir
- Where
- 22 sites in United States, Afghanistan and 6 more
- Sponsor
- U.S. Army Medical Research and Development Command
Prevalence of Cervical Extension of the Thymus
Prevalence of Cervical Extension of the Thymus in Children
This prospective, observational study included all pediatric patients who were referred to the radiology department for neck ultrasonography between August-October 2018.
- Trial name
- CET (NCT05228977)
- Where
- 2 sites in Afghanistan
- Volunteers
- 220 people
- Sponsor
- Kabul University of Medical Sciences
The Study Was Aimed to Assessing the Clinical Profile of Acute Abdomen and Their Frequency According to Age and Sex
A Retrospective Case Series Study for Acute Abdomen in General Surgery Ward
The acute abdomen is a clinical situation in which an acute an change in the condition of intra-abdominal organ, commonly attached to inflammation or infection need urgent and correct diagnosis .
- Trial name
- NCT05088200
- Testing
- surgery
- Where
- Afghanistan
- Volunteers
- 118 people
- Sponsor
- Ahmadullah Danish
Uncomplicated P. Falciparum Malaria
SPK Study in Afghanistan
In Afghanistan, studies over the past 15 years have shown a high degree of Plasmodium falciparum resistance to chloroquine. In 2003 the high failure rate of chloroquine against falciparum malaria led the national malaria…
- Trial name
- NCT01707199
- Testing
- Artesunate + Sulphadoxine-pyrimethamine
- Where
- Afghanistan
- Volunteers
- 83 people
- Sponsor
- University of Oxford
Vivax Malaria
G6PD Assessment Before Primaquine for Radical Treatment of Vivax Malaria
This will be a single-arm observational cohort study. Malaria patients with Plasmodium vivax and meeting study inclusion criteria, who give consent to be enrolled in the study, will have their G6PD status measured by the…
- Trial name
- GAP (NCT02876549)
- Testing
- Chloroquine, Primaquine 0.25 mg/kg/day, Primaquine 0.75 mg/kg weekly
- Where
- Afghanistan
- Volunteers
- 1,000 people
- Sponsor
- University of Oxford