Clinical trials: vNOTES
Salpingectomy
vNOTES Transvaginal Endoscopic Surgery Versus Laparoscopy
The feasibility and safety of laparoscopy are no longer to be demonstrated, especially in the field of gynecology, but this technique often causes post-operative pain.
- Trial name
- NOTRANDO (NCT04324034)
- Testing
- vNOTES, laparoscopy
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Uterine Myoma, Surgery, Laparoscopic
Safety and Efficacy of Using a Novel Full Visual Access Platform System in Transvaginal Hysterectomy
The modified vNOTES hysterectomy was accomplished and validated for efficacy and safety using a multi-access vaginal confinement instrument with a fully visualised vaginal access platform.
- Trial name
- NCT06658145
- Testing
- Vnotes surgery using fully visualised surgical instruments, Vnotes surgery using traditional surgical instruments
- Where
- China
- Volunteers
- 94 people
- Sponsor
- China-Japan Friendship Hospital
Leiomyoma, Uterine, Benign Gynecological Disease
Deep Neuromuscular Blockade and a Low-Residue Diet for the Surgical Field in vNOTES Hysterectomy
vNOTES (vaginal natural orifice transluminal endoscopic surgery) hysterectomy is performed entirely through the vagina, with no abdominal incision.
- Conditions
- Leiomyoma, Uterine, Benign Gynecological Disease, Abnormal Uterine Bleeding (AUB), Uterine Prolapse
- Trial name
- vNOTES_NMBDIET (NCT07730970)
- Testing
- Deep Neuromuscular Blockade (NMB), Standard (moderate) neuromuscular blockade, Preoperative low-residue diet
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Pelvic Organ Prolapse
Unilateral Versus Bilateral High Uterosacral Ligament Suspension Following vNOTES Hysterectomy for Apical Pelvic Organ Prolapse: A Prospective Study
This study aims to compare unilateral and bilateral high uterosacral ligament suspension techniques performed following vaginal hysterectomy in patients with pelvic organ prolapse.
- Trial name
- HUSLS (NCT07552337)
- Testing
- High Uterosacral Ligament Suspension
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Minimally Invasive Surgery
RCT on 3 Types of Hysterectomy
A randomized controlled trial comparing the vaginal, vNOTES ( vaginal natural orifice transluminal surgery) or laparoscopic approach for hysterectomy in women with benign gynaecological disease
- Trial name
- VANOLAH (NCT05971875)
- Testing
- vNOTES vs Vaginal Hysterectomy, vNOTES vs Laparoscopic Hysterectomy
- Where
- 2 sites in Croatia, Sweden
- Volunteers
- 1,000 people
- Sponsor
- Dr Jan Baekelandt, MD
Gynecologic Surgery
TUbal LIgation Per Differents Endoscopic Routes and Sexuality (TULIPES)
The goal of this clinical trial is compare the quality of sexual life at 6 months after tubal ligation, depending on whether it was performed by abdominal laparoscopy or by vNOTES, on the basis of a non-inferiority hypothesis.
- Trial name
- TULIPES (NCT05910385)
- Testing
- laparoscopy, vnotes
- Where
- 2 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Clermont-Ferrand
Vaginal Prolapse
0050-19-RMB CTIL - VNOTES Compared to VH for Vaginal Apex Prolapse
VNOTES (Transvaginal natural orifice transluminal endoscopic surgery) is a relatively new surgery for Hysterectomy and Uterosacral ligament suspension to treat Vaginal prolapse.
- Trial name
- NCT04078802
- Testing
- VNOTES/VH
- Volunteers
- 60 people
- Sponsor
- Rambam Health Care Campus
Hysterectomy
vNOTES vs Laparoscopic Hysterectomy: Randomized Trial on Pain and Recovery"
This study is a prospective, randomized controlled trial comparing two different minimally invasive hysterectomy techniques: vaginal natural orifice transluminal endoscopic surgery (vNOTES) and conventional total laparoscopic…
- Trial name
- VNOTES-TLH (NCT07306507)
- Testing
- vNOTES Hysterectomy, Total Laparoscopic Hysterectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Pelvic Organ Prolapse
Comparison of V-NOTES and Laparoscopic Mesh-Free Sacrocolpopexy Techniques
This study aims to compare the surgical outcomes, safety profiles, and patient satisfaction between two minimally invasive techniques for pelvic organ prolapse repair: Vaginal Natural Orifice Transluminal Endoscopic Surgery…
- Trial name
- vnotes (NCT07082023)
- Testing
- V-NOTES Mesh-Free Sacrocolpopexy, Laparoscopic Mesh-Free Sacrocolpopexy
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Havva Betül Bacak
Pain, Inflammatory, Pain Management
Reduced-pressure Pneumoperitoneum and Intraperitoneal Saline Washout to Alleviate Pain Following vNOTES Hysterectomy
vNOTES, initially employed for cholecystectomy, appendectomy, and nephrectomy, made its debut in the field of gynecologic surgery in 2012.
- Trial name
- Vnotes (NCT06944015)
- Testing
- normal saline
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Erzincan Military Hospital
Enlarged Uterus, Adenomyosis
Comparing the Efficacy of TU-LESS and vNOTES for Hysterectomy of Enlarged Uterus
Enlarged uterus is frequently encountered in clinical practice, and its incidence due to conditions such as adenomyosis, uterine fibroids, and other gynecological disorders has steadily increased over the years statistically.
- Conditions
- Enlarged Uterus, Adenomyosis, Uterine Fibroids (UF)
- Trial name
- NCT06663553
- Testing
- TU-LESS, vNOTES
- Where
- China
- Volunteers
- 210 people
- Sponsor
- West China Second University Hospital
Vaginal Hysterectomy, Postoperative Pain
Evaluating the Efficacy and Safety of Preoperative Administration of Duloxetine for Pain Management in Women Undergoing Hysterectomy Via Vaginal Route
Hysterectomy performed through the vaginal route (HVR) is the preferred method for women seeking hysterectomy to address uterine concerns such as premalignant conditions and fibroids.
- Conditions
- Vaginal Hysterectomy, Postoperative Pain, vNOTES
- Trial name
- NCT06429605
- Testing
- duloxetine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Erzincan Military Hospital
Salpingectomy
vNOTES Salpingo-oophorectomy or Bilateral Salpingectomy Compared With Laparoscopic.
Objective: To compare the vNOTES approach versus conventional laparoscopic approach used in elective Salpingo-oophorectomy surgery for benign disease or bilateral salpingectomy for sterilization.
- Trial name
- NCT05228938
- Testing
- VNOTES, laparoscopic
- Where
- Israel
- Volunteers
- 1 people
- Sponsor
- HaEmek Medical Center, Israel
Vaginal Vault Prolapse
Traditional Vaginal Surgery VS Autologous Tissue in Pelvic Floor Repair
The goal of this randomized, non blind, one center study is to compare the efficacy of vNOTES (vaginal natural orifice transluminal surgery) and traditional vaginal operation between the two groups by determining the risk of…
- Trial name
- PREFAP (NCT05628831)
- Testing
- vNOTES suspension with autologous tissue, Vaginal surgery
- Where
- Croatia
- Volunteers
- 56 people
- Sponsor
- General Hospital Zadar
Pelvic Organ Prolapse (POP), Postoperative Pain
Effect of Paracervical Block on Postoperative Pain After vNOTES Uterosacral Ligament Suspension
This study is a prospective, randomized, double-blind, placebo-controlled clinical trial designed to evaluate the effect of paracervical block on early postoperative pain after vaginal natural orifice transluminal endoscopic…
- Trial name
- vNOTES-PB (NCT07440576)
- Testing
- Bupivacaine, Normal Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Erkan Gol
Hysterectomy, Laparoscopy
Tolerance of the vNOTES Surgical Technique in Total Hysterectomy for Benign Lesion. Clinical Trial of Non-inferiority Compared to the Laparoscopic Technique.
During a first consultation with an indication of total hysterectomy for a benign lesion, we will study the patient's eligibility.
- Conditions
- Hysterectomy, Laparoscopy, vNOTES
- Trial name
- VLAP (NCT05031182)
- Testing
- Laparoscopy, vNOTES
- Where
- 2 sites in France
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Surgery, Gynecologic Disease
Study Evaluating the Success Rate of Outpatient Management of the Total Benign Hysterectomy by Transvaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) Compared to Each of the Two Laparoscopic Routes (Conventional and Robot-assisted).
Benign total hysterectomy is one of the most commonly performed gynecological surgery. Conventionally performed by a classical surgical approach, it is now provided routinely and for several years by laparoscopy and more recently…
- Trial name
- HYSTERAMBU (NCT06471049)
- Testing
- Benign Hysterectomy
- Where
- France
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Elsan
Hysterectomy, Hysterectomy, Benign Uterine Diseases
VNOTES and Vaginal Hysterectomy for Benign Indications
This study aimed to compare the surgical outcomes of Vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) and conventional vaginal hysterectomy (VH) for benign gynecological conditions.
- Conditions
- Hysterectomy, Hysterectomy, Benign Uterine Diseases, Hysterectomy, Vaginal
- Trial name
- NCT06776718
- Testing
- vNOTES, vaginal hysterectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Hysterectomy, Benign Uterine Diseases, Hysterectomy, Vaginal
Effect of Abdominal Ice Pack After vNOTES Hysterectomy
This randomized, controlled, open-label, parallel-group clinical trial is designed to investigate the efficacy of abdominal ice pack application as an adjunct to standard pain management following vNOTES (Vaginal Natural Orifice…
- Conditions
- Hysterectomy, Benign Uterine Diseases, Hysterectomy, Vaginal, vNOTES, Postoperative Pain Following Hysterectomy
- Trial name
- NCT07626684
- Testing
- Abdominal Ice Pack + ERAS
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Erzincan Military Hospital
Postoperative Pain, vNOTES
Does Intraperitoneal Washout Further Reduce Pain After Low-Pressure vNOTES Hysterectomy?
The evolution of minimally invasive gynecology has transitioned from traditional laparotomy to laparoscopy, and most recently, to vNOTES (Vaginal Natural Orifice Transluminal Endoscopic Surgery).
- Trial name
- Low-Pressure (NCT07467577)
- Testing
- warm saline
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Erzincan Military Hospital