Clinical trials: Weaning Mechanical Ventilation
Respiratory Insufficiency
Preventive Versus Curative Treatment of Fluid Overload
Fluid overload is associated with a poor prognosis in critically ill patients, especially during weaning from mechanical ventilation as it may promote weaning induced pulmonary edema.
- Trial name
- PCT-Fluid (NCT04050007)
- Testing
- Preventive initiation of fluid removal, Curative initiation of fluid removal
- Where
- France
- Volunteers
- 410 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mechanical Ventilation Complication, Pulmonary Edema
Systolic Function and Weaning-induced Pulmonary Edema (SystoWean Study)
The purpose of this study is to determine if the left and right ventricular systolic function is involved in the development of weaning failure related to weaning-induced pulmonary edema.
- Trial name
- SystoWean (NCT05226247)
- Testing
- Spontaneous breathing trial
- Where
- 3 sites in France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Respiratory Failure, Functional Performance
Correlations Among Functional Performance, Muscle Strength and Weaning Rate in Mechanically Ventilated Patients
To assess the correlations among the physical functional performance, muscle strength, respiratory muscle strength and the ventilator weaning rate.
- Conditions
- Respiratory Failure, Functional Performance, Physical Therapy
- Trial name
- NCT03894293
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Diaphragm Injury, Weaning Failure
The Validity of Maximal Diaphragm Thickening Fraction to Measure Diaphragm Function in Mechanically Ventilated Patients
This study is designed to determine whether maximal diaphragm thickening fraction measured by ultrasound during volitional maximal inspiratory efforts is a valid measure of diaphragm function in mechanically ventilated patients.
- Conditions
- Diaphragm Injury, Weaning Failure, Mechanical Ventilation Complication
- Trial name
- SNIFF III (NCT03129217)
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- University Health Network, Toronto
Mechanical Ventilation Complication, Weaning Failure
Preventing Failed Extubations
More than 300,00 people in the United States experience acute respiratory failure and require mechanical ventilation every year.
- Trial name
- PreFIX (NCT06301867)
- Testing
- Plateau Pressure
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Duke University
Weaning Failure, Mechanical Ventilation
Weaning With Tracheostomy - an Observational Study on Patient-centered Outcomes
Background: It is largely undocumented how long it takes to wean from invasive mechanical ventilation (IMV) with tracheostomy and to what extend these patients suffer from dyspnea or discomfort and how often sputum retention…
- Conditions
- Weaning Failure, Mechanical Ventilation, Patient-centered Care
- Trial name
- Wean-Trach (NCT05906888)
- Where
- 13 sites in Netherlands
- Volunteers
- 156 people
- Sponsor
- Henrik Endeman
Acute Respiratory Failure, Mechanical Ventilation Complication
Evaluation of Regional Ventilation Distribution Using Electrical Impedance Tomography During Weaning From Mechanical Ventilation
The goal of this physiological cross-over clinical trial is to evaluate the effect of different clinically used weaning trials on regional mechanical ventilation in a population of patients undergoing weaning from mechanical…
- Conditions
- Acute Respiratory Failure, Mechanical Ventilation Complication, Ventilator-Induced Lung Injury, Weaning Failure
- Trial name
- WEAN-EIT (NCT05726513)
- Testing
- Weaning trial - Low support, high Positive end-expiratory pressure, Weaning trial - Low support, zero positive end-expiratory pressure, Weaning trial - Zero support, zero positive end-expiratory pressure
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università degli Studi di Ferrara
Adult Patients Ventilated More Than 48 h, Stable Respiratory and Hemodynamic Conditions for SBT
Nasal Humidified High Flow Oxygen During Weaning From Mechanical Ventilation : Ultrasonography Study
This is a prospective, randomized clinical multicentric study in ICU (Intensive Care University)during weaning from mechanical ventilation.
- Conditions
- Adult Patients Ventilated More Than 48 h, Stable Respiratory and Hemodynamic Conditions for SBT, Consent of Patients, Arterial Line
- Trial name
- HiFloLUS (NCT01702779)
- Testing
- mechanical ventilation
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Weaning from Mechanical Ventilation
Impact of Gamma-OH on Sleep in ICU Patients
The Main objective of the trial is to assess sleep quality with Gamma-OH® in patients difficult to wean from mechanical ventilation in the ICU.
- Trial name
- GO-SLEEP (NCT04224246)
- Testing
- Gamma Hydroxybutyrate
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Poitiers University Hospital
Critical Illness
Specialized Treatment, Rehabilitation and Outcome in Patients With Prolonged Critical Illness
This prospective observational study aims to describe the outcome for patients with persistent or chronic critical illness treated at Remeo, a clinic specialized for patients in need of prolonged intensive care and intensive care…
- Trial name
- CritillPro (NCT04247607)
- Where
- Sweden
- Volunteers
- 250 people
- Sponsor
- Remeo AB
Mechanical Ventilator Weaning, Respiratory Muscle Training
Muscle Recruitment During Neck Flexion and Inspiratory Muscle Training
Respiratory muscle dysfunction is highly prevalent in patients with prolonged weaning from mechanical ventilation and is strongly associated with weaning failure.
- Trial name
- FLEX (NCT05710432)
- Testing
- Quasi-Isometric Neck Flexion, Inspiratory Muscle Training
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
Respiratory Failure, Respiration, Artificial
Proportional Assisted Ventilation and Pressure Support Ventilation in Adult Patients With Prolonged Ventilation
A prospective randomized controlled trial was conducted to collect patients with prolonged mechanical ventilation. Patients were randomly assigned to receive PAV+ or PSV as weaning mode.
- Trial name
- NCT04140682
- Testing
- PAV+ mode, PSV mode
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Ventilator Weaning
Echocardiographic Detection of Extravascular Lung Water Increase During Weaning From Mechanical Ventilation
Switching from positive airway pressure ventilation to spontaneous ventilation during weaning from mechanical ventilation, pulmonary edema may occur and in this case, doppler echocardiographic (U/S) indices of cardiac dysfunction…
- Trial name
- ECHOBAG (NCT02412202)
- Testing
- Monitoring of pulmonary oedema induced by weaning from mechanical ventilation
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of Thessaly
Airway Extubation, Weaning Mechanical Ventilation
One-Hour Positive Pressure Ventilation After a Pressure Support Spontaneous Breathing Trial
This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to…
- Conditions
- Airway Extubation, Weaning Mechanical Ventilation, Extubation Failure
- Trial name
- NCT07324460
- Testing
- One-hour positive pressure ventilation, Immediate extubation
- Volunteers
- 4,000 people
- Sponsor
- Hospital do Coracao
Weaning Mechanical Ventilation, Mechanical Power
Evaluation of Mechanical Power and Ventilator Parameters to Predict Weaning Success in the Intensive Care Unit
The goal of this prospective observational study is to evaluate whether ventilator-based respiratory parameters can predict weaning success in adult intensive care unit (ICU) patients who are mechanically ventilated.
- Conditions
- Weaning Mechanical Ventilation, Mechanical Power, Negative Inspiratory Force, Airway Occlusion Pressure
- Trial name
- NCT07268989
- Testing
- Mechanical power
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Anıl Berkay Balıtatlı
Acute Brain Injuries, Mechanical Ventilation
Retrospective Study on Ventilator Weaning Outcomes in Patients With Acute Brain Injury
Invasive mechanical ventilation (IMV) is a life-saving supportive therapy for patients with acute brain injury, which accounted for nearly one-fifth of all mechanically ventilated patients in the intensive care unit (ICU).
- Trial name
- NCT07496125
- Where
- China
- Sponsor
- Southeast University, China
Acute Respiratory Failure
High Flow During Weaning From Mechanical Ventilation
Detection and relief of dyspnea in mechanically ventilated patients is a priority. Optimization of mechanical ventilation settings is unfortunately often insufficient to relieve dyspnea in patients entering the weaning process.
- Trial name
- FLOWEAN (NCT05577221)
- Testing
- High Flow Nasal Air
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Left Ventricular Diastolic Dysfunction, Weaning Failure
Left Ventricular Diastolic Dysfunction as a Predictor of Weaning Failure From Mechanical Ventilation
Both premature and delayed extubation prolong the duration of mechanical ventilation and the intensive care unit (ICU) length of stay and increase morbidity and mortality.
- Conditions
- Left Ventricular Diastolic Dysfunction, Weaning Failure, Mechanical Ventilation Complication, Diaphragmatic Disorder
- Trial name
- NCT04703387
- Testing
- transthoracic echocardiography
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tanta University
Acute Respiratory Distress Syndrome
Thorathic Fluid Content as an Early Predictor of Weaning From Mechanical Ventilation in Acute Respiratory Distress Syndrome
Thorathic fluid content measurement using indirect cardiometry is required for prediction of Weaning from mechanical ventilation in cases of acute respiratory distress syndrome and its value in sucsess Weaning
- Trial name
- NCT06233448
- Testing
- Indirect cardiometry
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Diaphragm, Diaphragm Disease
Diaphragmatic Ultrasound and Weaning After Lung Transplant.
The prevalence and adverse effect of diaphragm dysfunction (DD) after bilateral-lung transplant (LT) are still unclear, despite a well-known negative impact on weaning and outcome in other cohorts of critically ill and surgical…
- Conditions
- Diaphragm, Diaphragm Disease, Diaphragm Issues, Weakness, Muscle
- Trial name
- NCT05670327
- Testing
- Diaphragmatic ultrasound assessment
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- University of Padova