Acute Brain InjuriesNCT07496125
Retrospective Study on Ventilator Weaning Outcomes in Patients With Acute Brain Injury
An observational study of Acute Brain Injuries and Mechanical Ventilation, run by Southeast University, China at 1 site in China.
Trial summary
Invasive mechanical ventilation (IMV) is a life-saving supportive therapy for patients with acute brain injury, which accounted for nearly one-fifth of all mechanically ventilated patients in the intensive care unit (ICU). Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Acute Brain Injuries, Mechanical Ventilation
- How many people
- 0 participants
- Where
- 1 siteChina
- Study dates
- 1 Jan 2018to Mar 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients with ABI including traumatic brain injury (TBI), non-traumatic intracranial hemorrhage (ICH), subarachnoid aneurysmal hemorrhage (SAH), acute ischemic stroke (AIS), and central nervous system infection were eligible to this study, if they were ≥ 18 years old and underwent IMV for at least 24 hours
Who may be able to join
- Patients with ABI
- ≥ 18 years old
- underwent IMV for at least 24 hours
Who cannot join
- already tracheostomized
- concurrent of cervical spinal cord injury
- pregnant or lactation
- withdraw of life-sustaining treatment within the first 24 hours of ICU admission
Trial locations and contacts
1 site in 1 country.
China1 site
Department of Critical Care Medicine, Zhongda Hospital
Nanjing, Jiangsu, 210009
About this study
Official title: Weaning Outcomes in Patients With Acute Brain Injury Based on CDIC
Invasive mechanical ventilation (IMV) is a life-saving supportive therapy for patients with acute brain injury, which accounted for nearly one-fifth of all mechanically ventilated patients in the intensive care unit (ICU). However, prolonged exposure to IMV is consistently associated with an increased risk of ventilator-related complications and adverse outcomes. Accordingly, alongside the initiation of IMV, timely and safe liberation from ventilator should be considered. Nevertheless, data detailing the weaning process and its associated outcomes in mechanically ventilated patients with ABI remain scarce. To address this gap, the investigators conducted an observational study aimed at characterizing the ventilator weaning process and outcomes in patients with ABI receiving IMV, using the modified WIND classification.
- Conditions
- Acute Brain Injuries, Mechanical Ventilation
- Medical subject headings
- Brain Injuries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Classified by weaning outcomes | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
weaning outcome
The primary endpoint was the weaning outcome according to the modified WIND classification
Measured: day 90
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Mar 2026
- Study start1 Jan 2018
- Primary completion31 Dec 2025
- Study completionMar 2026 (estimated)
Why it stopped: major revision
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Acute Brain InjuriesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 0 participants (actual)
Sponsor and investigators
- Lead sponsor
- Southeast University, China
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ling Liu, Southeast University, China
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07496125
- Sponsor's protocol ID
- Retro WEAN ABI
- Status last verified
- Jun 2026
- First submitted
- 22 Mar 2026
- Last updated
- 8 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 8 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Weaning Outcomes in Patients With Acute Brain Injury Based on CDIC
- ClinicalTrials.gov ID
- NCT07496125
- Acronym / sponsor ID
- Retro WEAN ABI
- Conditions
- Acute Brain Injuries, Mechanical Ventilation
- Study type
- Observational
- Recruitment status
- WithdrawnReason stopped: major revision
- Enrolment
- 0 participants (actual)
- Lead sponsor
- Southeast University, ChinaUniversity, hospital or other
- Study start
- 1 Jan 2018 (actual)
- Primary completion
- 31 Dec 2025 (actual)
- Study completion
- Mar 2026 (estimated)
- First posted
- 27 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Invasive mechanical ventilation (IMV) is a life-saving supportive therapy for patients with acute brain injury, which accounted for nearly one-fifth of all mechanically ventilated patients in the intensive care unit (ICU). However, prolonged exposure to IMV is consistently associated with an increased risk of ventilator-related complications and adverse outcomes. Accordingly, alongside the initiation of IMV, timely and safe liberation from ventilator should be considered. Nevertheless, data detailing the weaning process and its associated outcomes in mechanically ventilated patients with ABI remain scarce. To address this gap, the investigators conducted an observational study aimed at characterizing the ventilator weaning process and outcomes in patients with ABI receiving IMV, using the modified WIND classification.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Classified by weaning outcomes | – | – |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients with ABI including traumatic brain injury (TBI), non-traumatic intracranial hemorrhage (ICH), subarachnoid aneurysmal hemorrhage (SAH), acute ischemic stroke (AIS), and central nervous system infection were eligible to this study, if they were ≥ 18 years old and underwent IMV for at least 24 hours
Key inclusion criteria (3 listed)
- Patients with ABI
- ≥ 18 years old
- underwent IMV for at least 24 hours
Key exclusion criteria (4 listed)
- already tracheostomized
- concurrent of cervical spinal cord injury
- pregnant or lactation
- withdraw of life-sustaining treatment within the first 24 hours of ICU admission
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
weaning outcome
Time frame: day 90
The primary endpoint was the weaning outcome according to the modified WIND classification
Results and safety
The study was withdrawn before enrolling participants, so there are no results.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Jun 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Acute Brain Injuries and Mechanical Ventilation, run by Southeast University, China at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: withdrawn, as of the sponsor's last update on 8 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was withdrawn before enrolling participants, so there are no results.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
weaning outcome (time frame: day 90). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Jun 2026.