Clinical trials: Weaning Failure
Respiratory Failure
Weaning Children From Mechanical Ventilation:Computer-driven System Versus Usual Care
The purpose of this study is to determine whether a computer-driven system (Smartcare/PS) decreases weaning duration from mechanical ventilation when compared to usual care in children.
- Trial name
- NCT00678912
- Testing
- Smartcare/PS
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- St. Justine's Hospital
Obesity, Respiratory Failure
Wean Obese Study : Determination of the Optimal Spontaneous Breathing Trial for Obese Patient
The decision to extubate a patient after acute respiratory failure is based on clinical observation and measurement of pulmonary mechanics. Current extubation criteria(tidal volume, respiratory frequency...) lack of specificity.
- Conditions
- Obesity, Respiratory Failure, PSV 7cmH2O PEEP 7cmH2O, PSV 7 cmH2O PEEP 0 cmH20
- Trial name
- NCT01616901
- Testing
- Spontaneous breathing trial
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Montpellier
Mechanical Ventilation, Weaning From Mechanical Ventilation
Temporal Change in Parasternal Thickening Fraction as a Predictor for Weaning
optimal time to liberate from mechanical ventilation is highly prioritized since improper extubation time lead to serious consequences
- Conditions
- Mechanical Ventilation, Weaning From Mechanical Ventilation, Weaning Failure
- Trial name
- NCT07083128
- Testing
- Parasternal intercostal thickening
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Cairo University
Weaning Failure, Pulmonary Collapse
Lung Volume Preservation During Extubation
Introduction: At present, the best spontaneous breathing trial (SBT) during weaning from mechanical ventilation is a 30-min test with pressure support (PSV) 8 cmH2O without positive end-expiratory pressure (PEEP).
- Trial name
- NCT05526053
- Testing
- Lung volume preservation
- Where
- Spain
- Volunteers
- 1,753 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Heart Failure With Reduced Ejection Fraction, Heart Rhythm Disorder
Withdrawal of Treatment for Heart Failure Patients With Recovery From Tachycardia-induced Cardiomyopathy
New onset heart failure (HF) is observed in up to 25% of patients with incident atrial fibrillation or flutter (AF). Current guidelines suggest that both conditions (AF \& HF) be addressed with guideline directed medical therapy…
- Trial name
- WEAN-HF (NCT06128980)
- Testing
- GDMT
- Where
- Denmark
- Volunteers
- 348 people
- Sponsor
- Herlev and Gentofte Hospital
Tracheostomy, ICU
Determinants of Successful Decannulation in Difficult-to-wean Patients
The factors of success of decannulation are not well known in the literature and the decision to decannulate is mainly based on clinical judgment.
- Conditions
- Tracheostomy, ICU, Weaning Failure
- Trial name
- DESCATRON (NCT04841889)
- Testing
- Associated factors with decannulation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hopital Forcilles
Weaning Failure
Can High Intensity Inspiratory Muscle Training Improve Inspiratory Muscle Strength and Accelerate Weaning in Medical Patients With Difficulty on Weaning?
Introduction: It has been described that invasive mechanical ventilation leads to diaphragm weakness. The inspiratory muscle weakness is related with a difficult and prolonged weaning as well as longer duration of mechanical…
- Trial name
- NCT04347317
- Testing
- Low Intensity IMT, High Intensity IMT
- Where
- 2 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Respiratory Failure
Multicenter, Multinational, Follow-Up Clinical Trial of the Performance of RESPINOR DXT to Identify Patients at Increased Risk of Weaning Failure
The study will be a multicenter, multinational, prospective single arm blinded non-interventional follow-up study (from DXT-CS-005) to validate RESPINOR DXT's performance to identify patients at increased risk of weaning failure…
- Trial name
- DE-RISK WF II (NCT05580185)
- Testing
- RESPINOR DXT
- Where
- 8 sites in France, Norway
- Volunteers
- 145 people
- Sponsor
- Respinor AS
Respiratory Failure With Hypoxia
Non Invasive and Invasive Ventilation Post Extubation
Patients and methods: It is a prospective double blind study done on total 300 patients. Admitted with respiratory failure ARDS due to severe lung contusion. All of them selected to be ventilated for one week or more.
- Trial name
- NCT04402320
- Testing
- Midazolam, ventilator
- Where
- Saudi Arabia
- Volunteers
- 300 people
- Sponsor
- King Abdul Aziz Specialist Hospital
Prematurity, Apnea
Caffeine to Reduce Mechanical Ventilation in Preterm Infants
Most premature infants require mechanical ventilation for prolonged periods of time and a significant proportion of them develop Bronchopulmonary Dysplasia (BPD).
- Conditions
- Prematurity, Apnea, Respiratory Failure
- Trial name
- NCT01751724
- Testing
- Caffeine citrate, Normal saline
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Miami
Respiratory Failure, Functional Performance
Correlations Among Functional Performance, Muscle Strength and Weaning Rate in Mechanically Ventilated Patients
To assess the correlations among the physical functional performance, muscle strength, respiratory muscle strength and the ventilator weaning rate.
- Conditions
- Respiratory Failure, Functional Performance, Physical Therapy
- Trial name
- NCT03894293
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Mechanical Ventilation Weaning From Mechanical Ventilation Extubation Failure Critical Illness
Delta Pocc During Spontaneous Breathing Trial to Predict Extubation Failure in Mechanically Ventilated Adults (DELTA-EXT)
This prospective observational single-center study will evaluate whether dynamic respiratory stress estimated by delta airway occlusion pressure deflection (Delta Pocc) during a standardized spontaneous breathing trial can…
- Trial name
- DELTA-EXT (NCT07634783)
- Testing
- Delta Pocc Measurement During Spontaneous Breathing Trial
- Where
- Argentina
- Volunteers
- 120 people
- Sponsor
- Sanatorio Parque, Argentina
Weaning Failure
Changes of Weaning Parameter in Weaning Failure Patient After Tracheostomy as a Predictor of Subsequent Weaning
Weaning from mechanical ventilator is an essential element in the care of critically ill intubated patients receiving mechanical ventilation.
- Trial name
- NCT01312142
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Intubation in Intensive Care Units
Predictors of Airway Extubation/Weaning Failure
Airway management in intensive care unit (ICU) patients is challenging. Benefit risk ratio of extubation has to be daily assessed in intubated patients.
- Trial name
- Free-Rea (NCT02450669)
- Where
- France
- Volunteers
- 417 people
- Sponsor
- University Hospital, Montpellier
Weaning Failure, Weaning-induced Pulmonary Edema
Incidence and Risk Factors of Weaning-induced Cardiac Dysfunction: Results From a Multicenter, Observational Study
During weaning from mechanical ventilation, the shift from positive to negative pressure ventilation may be responsible for a cardiac dysfunction that can lead to the development of pulmonary oedema (weaning-induced pulmonary…
- Conditions
- Weaning Failure, Weaning-induced Pulmonary Edema, Spontaneous Breathing Trial
- Trial name
- WIPO (NCT05318261)
- Testing
- Spontaneous breathing trial
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Bicetre Hospital
Adults With Cardiopulmonary Disease at Risk of Prolonged Weaning From Mechanical Ventilation
Neurally Adjusted Ventilatory Assist in Adults at Risk of Delayed Weaning From Mechanical Ventilation
Many patients admitted to intensive care have heart or lung problems. Patients with these conditions often require longer durations of support from breathing machines.
- Trial name
- RESTUS (NCT01826890)
- Testing
- NAVA Technology
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- King's College Hospital NHS Trust
Mechanical Ventilator Weaning, Predictive Value of Tests
ICU Predictive Score of WEaning Success in Patients At Risk of Extubation Failure
Observational study in two medical-surgical intensive care units of the Clermont-Ferrand University Hospital to develop a composite score for prediction of 72h-extubation failure in patients at risk of extubation failure.
- Conditions
- Mechanical Ventilator Weaning, Predictive Value of Tests, Ventilator Weaning, Airway Extubation
- Trial name
- I-SWEAR (NCT05114551)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Clermont-Ferrand
Mechanical Ventilator Weaning, Mechanical Ventilation
Use of a Physiotherapy Assessment to Predict Extubation Failure in Mechanically Ventilated Patients: the EPIC Assessment
"Weaning from mechanical ventilation is a crucial step in the intensive care unit. Several factors complicate weaning and increase the risk of failure.
- Trial name
- PREDEXTUB (NCT06450678)
- Where
- France
- Volunteers
- 330 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilator Weaning, Respiration, Artificial
Time Course of Neuro-ventilatory Efficiency During a Spontaneous Breathing Training
The TONES trial aims to evaluate the neuroventilatory efficiency (NVE = tidal volume / peak voltage of diaphragm contraction) measured during a zero-assist manoeuvre (ZAM, i.e. with PEEP but without pressure support).
- Conditions
- Ventilator Weaning, Respiration, Artificial, Respiratory Muscles, Respiratory Failure
- Trial name
- TONES (NCT05380687)
- Testing
- Inspiratory hold, Expiratory hold, Ultrasound of respiratory muscles
- Where
- Belgium
- Volunteers
- 1 people
- Sponsor
- University Hospital, Antwerp
Ventilator Weaning, Weaning Failure
Voices of Patients' Relatives to Support Weaning From Mechanical Ventilation
Patients with severe brain injuries, such as ischemic stroke and intracranial hemorrhage, frequently require mechanical ventilation. Weaning of stroke patients is complicated by impaired consciousness and respiratory drive.
- Conditions
- Ventilator Weaning, Weaning Failure, Brain Injuries
- Trial name
- VOICE-WEANING (NCT03795623)
- Testing
- Voice-Weaning
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- University of Erlangen-Nürnberg Medical School