Clinical trials: Vertebral Fracture
Osteoporotic Fracture of Vertebra
Percutaneous Vertebral-disc Plasty for Thoracolumbar Very Severe Osteoporotic Vertebral Compression Fractures
Purpose: To compare the clinical outcomes and radiological parameters of patients undergoing percutaneous vertebroplasty (PVP) versus those undergoing percutaneous vertebral-disc plasty (PVDP) for back pain, segmental…
- Trial name
- NCT05519332
- Testing
- percutaneous vertebral-disc plasty
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jiawei Jiang
Denosumab Allergy, Zoledronic Acid Allergy
Denosumab vs Zoledronate After Vertebroplasty
Osteoporotic vertebral compression fracture (OVCF) patients had a proportion of secondary fractures after percutaneous vertebroplasty (PVP).
- Trial name
- NCT05598606
- Testing
- Denosumab Injection, Zoledronate
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Shenzhen People's Hospital
Compression Fracture of Thoracic Vertebral Body, Spinal Compression Fracture
Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures
The purpose of this study is to 1. Assess bone marrow edema within the VCF by use of a DE CT virtual noncalcium image compared with MR imaging as standard reference. 2.
- Trial name
- NCT01281826
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Cheng-Kung University Hospital
Hip Fracture, Vertebral Fracture
Norwegian Capture the Fracture Initiative
The main aim is to assess the effectiveness of introducing a standardized intervention program for treatment of patients with a fragility fracture as measured by changes in the fracture rates and the mortality.
- Conditions
- Hip Fracture, Vertebral Fracture, Other Low-trauma Fracture
- Trial name
- NoFRACT (NCT02536898)
- Testing
- Fracture Liaison Service, Current treatment
- Where
- 7 sites in Norway
- Volunteers
- 94,260 people
- Sponsor
- Oslo University Hospital
Burst Fracture
Thoracolumbar Burst Fracture Treated With Pedicle Screws: Radiographic Outcomes
The surgical results of thoracolumbar and lumbar burst fracture have been reported to be comparable between patients with and without fusion in a midterm follow-up.
- Trial name
- NCT01979198
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Vertebral Compression Fracture, Compression Fracture
STAND - Study of the AGN1 LOEP SV Kit Compared to PMMA in Patients With Vertebral Compression Fractures
This is a multicenter, single-blinded, randomized controlled clinical trial evaluating the safety and efficacy of the AGN1 LOEP SV Kit for the treatment of painful vertebral compression fragility fractures (VCFs).
- Conditions
- Vertebral Compression Fracture, Compression Fracture, Vertebral Compression
- Trial name
- NCT04835428
- Testing
- Treatment Group: AGN1 LOEP SV Kit, Control Group: PMMA bone cement
- Where
- 12 sites in United States
- Volunteers
- 408 people
- Sponsor
- AgNovos Healthcare, LLC
Kyphosis, Spinal Fractures
Intra-operative Assessment of the Intellirod LOADPRO Spinal Rod Strain Sensor for Use During Kyphotic Corrective Surgery
The LOADPRO Study is an intra-operative, non-significant risk (NSR) case series feasibility assessment of the Intellirod LOADPRO™ System measuring spinal rod strain in long spinal kyphotic corrective constructs.
- Trial name
- LOADPRO (NCT02768675)
- Testing
- LOADPRO
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Intellirod Spine
Osteoporosis
Addressing Vertebral Osteoporosis Incidentally Detected to Prevent Future Fractures
Osteoporosis is a common and progressive condition that leads to broken bones (fractures), which cause pain, disability, deformity, and even death.
- Trial name
- AVOID Fracture (NCT00388908)
- Testing
- Reminders and opinion leader generated guidelines +/- leaflets and counselling, Usual Care
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- University of Alberta
Osteoporosis
Trial to Evaluate Tibolone in the Treatment of Osteoporosis (P06468)
Tibolone 1.25 mg is an effective treatment for the prevention of osteoporosis and is expected to be effective in preventing fractures in osteoporotic women.
- Trial name
- LIFT (NCT00519857)
- Testing
- Tibolone
- Volunteers
- 4,534 people
- Sponsor
- Organon and Co
Osteoporotic Fractures, Spinal Fractures
Build Better Bones With Exercise
The long-term goal of our research team is to conduct a large multicentre study to evaluate whether tailored home exercise can prevent fractures in high-risk individuals.
- Trial name
- B3E (NCT01761084)
- Testing
- Exercise and behaviour change strategies
- Where
- Canada
- Volunteers
- 141 people
- Sponsor
- University of Waterloo
Vertebral Fracture
Early Percutaneous Vertebroplasty Versus Standard Conservative Treatment in Thoracolumbar Vertebral Fractures
The aim of this study is to evaluate the efficacy of carrying out early vertebroplasty procedure, compared to the standard conservative treatment (corset), in order to prevent residual deformations that could occur in…
- Trial name
- AGIL11 (NCT03617094)
- Testing
- Early percutaneous vertebroplasty (EPV), Standard Conservative treatment (CT)
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Grenoble
Vertebral Fracture
Anesthesia Methods on Percutaneous Kyphoplasty
The aim of this research is to examine the effects of the anesthesia method and preoperative characteristics on postoperative results and complications in patients who underwent percutaneous kyphoplasty (PKP).
- Trial name
- NCT05526794
- Testing
- Analgesic consumption
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Postoperative Pain, Spine Deformity
Intraoperative Placement of Superficial Erector Spinae Plane Block; A New Approach in Spine Surgery
Major spine surgery causes severe postoperative pain. The primary objective of this randomized controlled study is to compare the effect of ultrasound (US)-guided superficial erector spinae plane (ESP) block on 48-hour…
- Conditions
- Postoperative Pain, Spine Deformity, Spine Injury, Spine Fracture
- Trial name
- NCT05244031
- Testing
- superficial erector spina plane block, Standard (opioid-based) analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Osteoporosis, Vertebral Fracture
Effectiveness of Physiotherapy for Osteoporotic Spinal Fracture
The aim of this pilot study was to determine the effect of physiotherapy on impairments and health-related quality of life in people with a painful osteoporotic spinal fracture.
- Trial name
- NCT00638768
- Testing
- Physiotherapy
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- University of Melbourne
Osteoporosis, Osteoporotic Fracture of Vertebra
Development and Evaluation of an Exercise Intervention for Prevention of Vertebral Osteoporosis and Deformity in Postmenopausal Women
Osteoporotic fractures of the vertebrae (bones in the back) cause substantial pain and disability. Exercise could help to prevent these fractures by increasing bone strength and improving posture.
- Conditions
- Osteoporosis, Osteoporotic Fracture of Vertebra, Postural, Thoracic Kyphosis
- Trial name
- NCT04660825
- Testing
- A resistance band exercise programme, Control
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Osteoporosis
Analgesic Effects of the Gastrolith, in Osteoporotic Patients Suffering From Recent Skeletal Pain Caused by Vertebral Fractures
This study aims to evaluate the safety and analgesic effect (efficacy) of Gastrolith powder (GASP) on skeletal pain caused by osteoporotic vertebral compression fractures (OVCF) versus placebo, primarily as assessed by the…
- Trial name
- NCT01482858
- Testing
- Gastrolith
- Where
- 5 sites in Israel
- Sponsor
- Amorphical Ltd.
Osteoporotic Vertebral Compression Fracture
Denosumab and Osteoporotic Vertebral Compression Fracture
This study aimed to investigate the effect of denosumab on bone mineral density(BMD), bone turnover markers(BTMs), functional status, secondary fracture rate, and adverse effects in osteoporotic vertebral compression fracture…
- Trial name
- NCT05058443
- Testing
- Denosumab 60 mg/ml [Prolia]
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shenzhen People's Hospital
Cancer, Spinal Fractures
CAFE Study - Cancer Patient Fracture Evaluation
The primary objective of this study is to evaluate the safety and effectiveness of balloon kyphoplasty treatment for painful, acute, vertebral compression fractures (VCFs) as compared to standard non-surgical therapy in patients…
- Trial name
- CAFE (NCT00211237)
- Testing
- Balloon Kyphoplasty, Non Surgical Management
- Where
- 20 sites in United States, Australia and 6 more
- Volunteers
- 134 people
- Sponsor
- Medtronic Spine LLC
Spinal Metastases
Quantitative MRI for Functional Assessment Following SBRT for Spinal Metastases
The purpose of this study is to determine if quantitative magnetic resonance imaging (qMRI) can objectively measure changes in the tumor/vertebral body and adjacent spinal cord following stereotactic body radiation therapy (SBRT)…
- Trial name
- NCT04248543
- Testing
- qMRI with Gadoteridol contrast agent
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Vertebral Compression Fracture, Myeloma
The Value of Systematic Biopsies During Vertebroplasty for the Treatment of Osteoporotic Vertebral Fractures
Background : Vertebral fracture is the most common complication of osteoporosis. Vertebroplasty is a widespread treatment modality for osteoporotic vertebral fractures, providing consolidation, rapid pain relief and preventing…
- Conditions
- Vertebral Compression Fracture, Myeloma, Bone Metastases, Malignant Bone Tumour
- Trial name
- NCT06153576
- Where
- France
- Volunteers
- 1,120 people
- Sponsor
- Centre Hospitalier Universitaire de Nice