Clinical trials: Vascular Dilation
Aging, Vascular Stiffness
Acetate and Age-associated Arterial Dysfunction
Cardiovascular diseases are the leading cause of morbidity and mortality and contribute most to healthcare costs in the U.S. Age is the strongest cardiovascular disease risk factor, with >90% of all deaths from cardiovascular…
- Conditions
- Aging, Vascular Stiffness, Vascular Dilation
- Trial name
- NCT05424263
- Testing
- Calcium Acetate Oral Solution, Calcium Carbonate Oral Suspension
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Endothelial Function of Saphenous Vein Grafts
Investigation of Endothelium in Saphenous Vein Grafts
This is a single center prospective study of 30 patients undergoing elective heart bypass surgery (CABG) with at least two vein grafts from the leg (SVG).
- Trial name
- NCT01510821
- Testing
- Use of Maquet Vasoshield Pressure-limiting syringe on SVG, Use of non-regulated syringe on SVG
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Erectile Dysfunction, Arterial Hypertension
Correlation Study of Vascular Parameters in Hypertensive Men With Erectile Dysfunction
The purpose of the study is to assess the correlation of FMD of brachial artery and carotid intima media thickness with ED severity and clinical response to vardenafil in hypertensive men.
- Conditions
- Erectile Dysfunction, Arterial Hypertension, Endothelial Dysfunction
- Trial name
- NCT01084187
- Testing
- Vardenafil
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital Universitario Pedro Ernesto
Copd, Hypertension, Pulmonary
Lung Hyperinflation and Response to Pulmonary Vasodilator Therapy
The goal of this retrospective observational study is to evaluate if lung distension disorders can be a predictive factor of bad response to vasodilator therapy in patients with pulmonary hypertension (PH) associated with chronic…
- Conditions
- Copd, Hypertension, Pulmonary, Hyperdistention
- Trial name
- NCT06613321
- Testing
- Respiratory function tests before introduction of vasodilator therapy, 3 month follow up evaluation of response to treatment.
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Central Hospital, Nancy, France
Cardiovascular Diseases, Cardiovascular Risk Factor
The Effect of Antioxidants on Skin Blood Flow During Local Heating
The goal of this study is to examine possible mechanisms of impaired vasodilaton in obese and Black/African American men and women as possible links to the elevated prevalence of cardiovascular dysfunction and disease.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Vasodilation
- Trial name
- NCT03680638
- Testing
- Control (Lactated Ringer's), Tempol, Apocynin
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Non-Alcoholic Fatty Liver Disease
The Effect of Coenzyme Q10 on Endothelial, Vascular and Myocardial Function
Non-alcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular risk. The aim of this study is to investigate the effects of coenzyme Q10 (CoQ10) on endothelial, vascular and myocardial function in patients…
- Trial name
- NCT05941910
- Testing
- Q10
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Attikon Hospital
Peripheral Vascular Disease
Study of Safety and Tolerability of UNIFUZOL (Solution for Infusions) in Healthy Volunteers
Unifusol (R) is a solution of arginine sodium succinate for intravenous infusions. Its effects include vasodilation, protection of inner layer of blood vessels and improvement of blood viscosity.
- Trial name
- NCT03028285
- Testing
- arginine sodium succinate
- Where
- 2 sites in Russia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company
Pre Diabetes, Vascular Stiffness
Dietary Exchanges With Avocado and Mango in Pre-diabetes
The research is designed as a randomized, 2-arm, parallel, controlled, human clinical trial to investigate the effects of avocado and mango consumption for 8 weeks on indices of macro- and micro- vascular function in individuals…
- Conditions
- Pre Diabetes, Vascular Stiffness, Vascular Dilation, Cognitive Change
- Trial name
- AVMa (NCT05353790)
- Testing
- Meals + snacks: control, Meals + snacks: Avocado mango
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Coronary Disease
Randomized Trial of Coronary Angioplasty for de Novo Lesions in sMall vesSElS With Drug Eluting Balloon.
Significant lesions in small coronary arteries are frequently found (35%-50%) in patients with coronary artery disease. Independently of the type of coronary angioplasty the restenosis and the need for repeat revascularization…
- Trial name
- RAMSES (NCT01722799)
- Testing
- Drug elluting Balloon (DEB), Drug elluting coronary stent (DES)
- Where
- Spain
- Volunteers
- 97 people
- Sponsor
- Andres Iñiguez Romo, MD, PhD
Coronary Artery Disease
The Nordic Bifurcation Study III
Should we, or should we not, perform dilatation of the side branch through the main vessel stent, if there is acceptable blood flow in the side branch?
- Trial name
- BIF III (NCT00914199)
- Testing
- Percutaneous coronary intervention (PCI)
- Where
- Denmark
- Volunteers
- 477 people
- Sponsor
- Evald Hoej Christiansen
Diabetic Retinopathy
Computer Detection of Diabetic Retinopathy Compared to Clinical Examination
The hypothesis is that computer detection of the severity of diabetic retinopathy including the presence of clinically significant macular edema is not inferior to the detection using a dilated eye examination by a…
- Trial name
- CDDR (NCT01625598)
- Testing
- Photography of the retina, Retinal photography
- Where
- 7 sites in United States
- Volunteers
- 600 people
- Sponsor
- Digital Diagnostics, Inc.
Improve Endothelial Function and Decrease Vascular Stenosis
Phosphodiesterase Type 5 Inhibition to Improve Endothelial Function and Vascular Remodeling in Chronic Kidney Disease and End Stage Renal Disease Patients Requiring New Arteriovenous Fistula
Patients with stage IV and V chronic kidney disease and end stage renal disease requiring hemodialysis at University of Alabama at Birmingham (UAB) Dialysis Clinics will be recruited from the UAB Vascular Access Clinic, which has…
- Trial name
- NCT02414204
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Alabama at Birmingham
Acute Coronary Syndrome, Angiographic Evidence if Coronary Aneurysms
The Italian Coronary Artery Aneurysm and Ectasia In Patients With Acute Coronary Syndrome
The ITACA study is a prospective, observational no profit registry enrolling patients with Acute Coronary Syndrome and angiographic evidence of coronary aneurysms and/or ectasia.
- Conditions
- Acute Coronary Syndrome, Angiographic Evidence if Coronary Aneurysms, Ectasia
- Trial name
- ITACA (NCT05051917)
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Federico II University
Vascular Diseases
Locally Applied Pressure-induced Vasodilatation
Measure microcirculatory responses after localized ischemia obtained by local application of pressure (laser speckle).
- Trial name
- LAV (NCT02861924)
- Testing
- microcirculatory responses
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Familial Hypercholesterolemia
Effect of APL180 on Endothelial Function in Familial Hypercholesterolemia Patients
This study will evaluate the effect of APL180 on endothelial function measured by forearm venous occlusion plethysmography in patients with familial hypercholesterolemia.
- Trial name
- NCT00751608
- Testing
- APL180
- Sponsor
- Novartis Pharmaceuticals
Peripheral Artery Disease
BIOTRONIK Dynetic-35 Stent for the Treatment of Peripheral Iliac Lesions
BIOTRONIK cobalt chromium balloon-expandable Dynetic-35 stent in association with Passeo-35 Xeo peripheral dilation catheter for the treatment of peripheral iliac lesions
- Trial name
- BIONETIC-I (NCT04830228)
- Testing
- Ballon expandable stent and PTA
- Where
- 15 sites in Austria, Belgium and 4 more
- Volunteers
- 160 people
- Sponsor
- Biotronik AG
Dyslipidemias, Hypertension
Cardiovascular Effects of Salvia Miltiorrhiza Extract (Danshen)
Rationale: Extracts of the plant Salvia miltiorrhiza (Danshen) have been used as traditional Chinese medicine in the treatment of cardiovascular diseases, such as angina pectoris and myocardial infarction.
- Conditions
- Dyslipidemias, Hypertension, Vasodilation, Oxidative Stress
- Trial name
- NCT01563770
- Testing
- Salvia miltiorrhiza extract
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Coronary Artery Disease
Effect of Garlic Tablet Some Indicators Related to Atherosclerosis
The purpose of this study is to determine whether garlic in adjunct to conventional medical treatment is effective in improving carotid intima media thickness (CIMT), Flow mediated dilation (FMD) and plasma lipid profile or…
- Trial name
- NCT01948453
- Testing
- Garlic
- Where
- Iran
- Volunteers
- 56 people
- Sponsor
- Shahid Beheshti University
Vascular Stiffness, Endothelial Dysfunction
Targeting Inflammation to Treat Cardiovascular Aging
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States with older age being a primary risk factor.
- Conditions
- Vascular Stiffness, Endothelial Dysfunction, Diastolic Dysfunction
- Trial name
- TIVA (NCT01775865)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
PERIPHERAL VASCULAR DISEASE
Study Comparing Two Methods of Expanding Stents Placed in Legs of Diabetics With Peripheral Vascular Disease
Despite recent advances in stent technology and its widespread application in the treatment of peripheral vascular disease (PVD), incidences of partial or complete blockage of stent lumen (in-stent restenosis) due to in growth of…
- Trial name
- COBRA (NCT00827853)
- Testing
- Conventional angioplasty balloon, cryoplasty balloon
- Where
- 4 sites in United States
- Volunteers
- 90 people
- Sponsor
- North Texas Veterans Healthcare System