Clinical trials: Vaginal Discharge
Vaginal Discharge, Perineum; Rupture
Efficacy and Safety of the Application of Local Anaesthetic in Spray to Repair of 1st- 2nd Perineal Lacerations
Randomized controlled trial aimed at evaluating the efficacy and safety of the use of a local anesthetic spray, commonly used in clinical practice as off-label, during the suturing of perineal lacerations in post-partum…
- Conditions
- Vaginal Discharge, Perineum; Rupture, Analgesia
- Trial name
- LISPRAY (NCT05201313)
- Testing
- Lidocaine Hydrochloride, Mepivacaine Injection
- Where
- Italy
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Dysmenorrhea
A Study to Evaluate the Effect of Contraceptive Vaginal Rings on Primary Dysmenorrhea (P08257/MK-8175A/MK-8342B-057)
The study investigates four vaginal ring groups with respect to relief of primary dysmenorrhea, and should identify at least one vaginal ring that shows clinically relevant treatment efficacy in relief of primary dysmenorrhea.
- Trial name
- NCT01670656
- Testing
- Nomegestrol acetate contraceptive vaginal ring (NOMAC-CVR), Etonogestrel containing contraceptive vaginal ring (ENG-CVR), Ibuprofen
- Volunteers
- 439 people
- Sponsor
- Organon and Co
Vaginitis and Vulvovaginitis
Clinical Investigation To Evaluate Cerviron Ovules® in Symptomatic Vaginitis
CYRON is a Prospective, Open-Label, Pilot, Multicentric Clinical Investigation to Evaluate the Performance and Safety of Cerviron Ovules® in the Local Treatment of Non-Specific or Endogenous, Symptomatic Vaginitis.
- Trial name
- NCT04735705
- Testing
- Cerviron
- Where
- 2 sites in Romania
- Volunteers
- 50 people
- Sponsor
- Perfect Care Distribution
Gynecologic Cancer
Evaluation of a Brachytherapy Discharge Education Program to Improve Patient Care
Although brachytherapy is an effective treatment modality for gynecological cancer, a significant proportion of patients develop late treatment-related vaginal toxicity, negatively impacting their quality of life and limiting…
- Trial name
- BrachDEP (NCT04707937)
- Testing
- Online education, Regular standard of care education
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Placental Bleeding
Placental Drainage Versus no Placental Drainage After Vaginal Delivery in the Management of Third Stage of Labour
In this randomized controlled study, 222 pregnant women who admitted to Zeynep Kamil Women and Children's Health Training and Research Hospital from December 2016 and July 2017 were included.
- Trial name
- NCT03542292
- Testing
- placental drainage
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Bacterial Vaginoses
Evaluate the Safety of a Single Oral Dose of Solosec™ (Secnidazole) 2g for the Treatment of Adolescent Girls With BV
A multi-center, open-label study to evaluate the treatment of one oral dose of 2g Solosec™ (Secnidazole) in adolescent girls with BV
- Trial name
- NCT03937869
- Testing
- Secnidazole
- Where
- 9 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lupin Research Inc
BACTERIAL VAGINOSIS, Signs and Symptoms to be Evaluated and Recorded Include
A Multi-center, Double-blind, Randomized Study, Comparing Clindamycin Phosphate Vaginal Cream 2% (Watson Laboratories, Inc.) to Clindesse® (Ther-Rx™, Clindamyin Phosphate Vaginal Cream 2%) and Both Active Treatments to a Placebo Control in the Treatment of Bacterial Vaginosis in Non-pregnant Women
A multi-center, double-blind, randomized, placebo controlled, parallel-group study, comparing Clindamycin phosphate vaginal cream 2% (Watson Laboratories, Inc.) to Clindesse® (Ther-Rx™, Clindamyin Phosphate Vaginal Cream 2%) and…
- Conditions
- BACTERIAL VAGINOSIS, Signs and Symptoms to be Evaluated and Recorded Include, Vaginal Discharge Color, Odor, and Consistency, Vulvovaginal Itching and Irritation (Subjective) Absent, Mild, Moderate, or Severe
- Trial name
- NCT02210689
- Testing
- clindamycin phosphate vaginal cream 2%
- Where
- 18 sites in United States, Dominican Republic and 1 more
- Volunteers
- 604 people
- Sponsor
- Actavis Inc.
Cervical Lesion, Vaginal Bleeding
RWE Study in the Treatment of Cervical Lesions of Various Etiology
The aim of the study was to assess the post-market performance and tolerability of Cerviron® ovules in the treatment and management of cervical lesions of different etiologies.
- Trial name
- NCT05668806
- Testing
- Cerviron
- Where
- 15 sites in Romania
- Volunteers
- 345 people
- Sponsor
- Perfect Care Distribution
Bacterial Vaginosis, Vaginal Discharge
Study of How Bacterial Vaginosis and Its Treatment Affects Cervical and Vaginal Tissue
This is a research study to determine whether bacterial vaginosis (BV) changes the cervico-vaginal tissue (skin covering the cervix and vagina) and makes women at higher risk for getting HIV (Human Immunodeficiency Virus).
- Trial name
- CONRADBV (NCT01347632)
- Testing
- Metronidazole
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- CONRAD
Vaginal Discharge, Postcoital Vaginal Changes
In-Clinic Assessment of Vaginal Mucosal Safety Following Repetitive Use of the Livi Device
The goal of this clinical trial is to learn if the Livi postcoital tampon device is safe for repetitive use in sexually active women aged 18 years and older.
- Trial name
- NCT07445958
- Testing
- Livi Postcoital Tampon Device
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Bacterial Vaginosis
Trial of Trimosan Gel Effect on Pessary-associated Bacterial Vaginosis
The primary objective of this prospective, randomized, controlled study is to assess the effect of Trimo-San vaginal gel on the rate of bacterial vaginosis in women who use pessaries.
- Trial name
- TBVAP (NCT01471457)
- Testing
- Trimo-San gel
- Where
- 2 sites in United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Healthy, Vaginal Discharge
Vaginal and Oral Microbiome Crosstalk
To study the vaginal and oral microbiome by swab samples. On selected cases, also papa smear will be studied.
- Trial name
- NCT02898818
- Testing
- vaginal and oral swab sample, questionnaire, papa smear
- Where
- Finland
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Trichomonas Infection
A Phase 3 Study of Solosec® for the Treatment of Trichomoniasis
This is a Phase 3, multi-center, prospective, randomized, placebo-controlled, delayed treatment, double-blind, study to evaluate the effectiveness, and safety of a single, oral dose of Solosec® containing 2 grams of secnidazole…
- Trial name
- NCT03935217
- Testing
- Secnidazole
- Where
- 11 sites in United States
- Volunteers
- 147 people
- Sponsor
- Lupin Research Inc
Relieves Vaginal Dryness / Improves Self-Lubrication, Improves Strength & Elasticity of Vagina (Aka Collagen and Elastin)
A Clinical Trial to Evaluate the Effects of the NeuEve Dryness Treatment Kit on Vaginal Health, Comfort, and Quality of Life in Postmenopausal Women
This is a decentralized, single-group, open-label clinical trial evaluating a 12-week regimen of the NeuEve Dryness Treatment Kit (comprising Feminine Moisture Support oral softgels, Bone Support oral capsules, NeuEve Salve…
- Conditions
- Relieves Vaginal Dryness / Improves Self-Lubrication, Improves Strength & Elasticity of Vagina (Aka Collagen and Elastin), Improves Vaginal Wall Thickness, Reduces Pain During Sex
- Trial name
- NCT07893795
- Testing
- Intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- NeuEve
Menopause Related Conditions, Postmenopausal Symptoms
Use of J3 Bioscience Lubricating Intravaginal Ring VR101 to Relieve the Symptoms of Vaginal Dryness
This investigation is designed to demonstrate the safety and efficacy of the VR101 lubricating intravaginal ring (IVR) in treating the symptoms of vaginal dryness.
- Trial name
- NCT03150407
- Testing
- VR101 Device (Efficacy), VR101 Device (Safety)
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- J3 Bioscience, Inc.
Vaginal Odor
Efficacy of (WaterWorks®)Douching Device for Elimination of Perceived Vaginal Odor Not Caused by BV or Vaginitis
Comparing the new Stainless Steel WaterWorks® douching device to a commercially available douching device using just water for safety and efficacy of odor abatement.
- Trial name
- NCT00417365
- Testing
- WaterWorks Douching Device
- Where
- 7 sites in United States
- Volunteers
- 100 people
- Sponsor
- Abbott Research Group
Vaginal Infection, Vaginal Discharge
Evaluation of a Postcoital Sponge on Self-Reported Vaginal Health Parameters
LiviWell has developed a product designed for postcoital semen absorption. Previous studies have demonstrated the product rapidly absorbs semen, and leads to less symptoms of postcoital vaginal microbiome disruption such as…
- Conditions
- Vaginal Infection, Vaginal Discharge, Vaginosis, Sexual Dysfunction
- Trial name
- NCT06530186
- Testing
- LiviWell Postcoital Vaginal Insert
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Atrophy of Vagina, Vaginal Ulceration
Vaginal Creams to Reduce Vaginal Erosion in Pessary Users
To compare the use of Estrace ® vaginal cream against a placebo vaginal cream in reducing symptomatic vaginal discharge and vaginal erosion in patients who are using the Gellhorn or Ring with support pessaries.
- Conditions
- Atrophy of Vagina, Vaginal Ulceration, Vaginitis
- Trial name
- NCT02316249
- Testing
- Estradiol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
Delivery Uterine
Comparison Between 25 µg Vaginal Misoprostol vs Slow Release Pessary PGE2
For about 10% of pregnancies, it is necessary to induce delivery for medical reasons. Prostaglandins alone can be used to perform cervical ripening in cases of immature cervix.
- Trial name
- CYTOPRO (NCT01765881)
- Testing
- Misoprostol, Dinoprostone
- Where
- 4 sites in France
- Volunteers
- 1,700 people
- Sponsor
- University Hospital, Toulouse
Vaginal Discharge, Dyspareunia
Evaluation of a Novel Female Hygiene Device for Postcoital Discomfort
Previous research has shown that semen deposition in the vagina after intercourse leads to dripping, discomfort, and vaginal odor.
- Conditions
- Vaginal Discharge, Dyspareunia, Female Sexual Dysfunction, Vaginitis
- Trial name
- NCT04885556
- Testing
- Tampon-like device for absorption of sexual fluids
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System