Clinical trials: Type 1 Diabetes Mellitus With Hypoglycemia
Type 1 Diabetes, Organ Transplantation
Islet Cell Transplantation in Patients With Type I Diabetes With Previous Kidney Transplantation
This single center phase 2 clinical trial, is designed for confirming the efficacy and safety of sequential islet allotransplantation with steroid free immunosuppression in patients with previous kidney transplantation.
- Conditions
- Type 1 Diabetes, Organ Transplantation, Immunosuppression
- Trial name
- NCT01123187
- Testing
- islet transplantation
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Lille
Hypoglycemia, Diabetes Mellitus, Type 1
A Trial to Compare the Efficacy and Safety of 2 Different Batches of Subcutaneous Dasiglucagon in Patients With T1DM
A randomized, double-blind, crossover trial to compare the efficacy and safety of 2 different batches of subcutaneous dasiglucagon in patients with type 1 diabetes mellitus (T1DM)
- Trial name
- NCT03895697
- Testing
- dasiglucagon
- Where
- Canada
- Volunteers
- 92 people
- Sponsor
- Zealand Pharma
Nurse's Role, Diabetes Mellitus
Nurse Coaching the Effect of on Glycemic Control, Fear of Hypoglycemia and Risk Perception in Adults With Type 1 Diabetes.
Because of the unforeseen rate of increase in case numbers, the high rates of mortality and morbidity, and the increased socio economic load it causes, diabetes has become the most discussed chronic and widespread metabolic…
- Conditions
- Nurse's Role, Diabetes Mellitus, Hypoglycemia
- Trial name
- NCT05870280
- Testing
- nurse coaching
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Tuğba Bilgehan
Type 1 Diabetes, Diabetes Mellitus
Therapeutic Education in Very Young Children With Diabetes Mellitus
DIAB-EDUC tests in a group of young diabetic patients (less than 6 years old) a specific educational tool in order to assess its impact on glycemic control, quality of life, knowledge about the disease and its daily management…
- Trial name
- DIAB-EDUC (NCT01354288)
- Testing
- Educational tool
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Type 1
Management of Glycemia Following a Pizza Meal
Glycemia following pizza consumption is typically managed with a dual wave insulin bolus. This study evaluated the effect of a simple bolus on glycemia following consumption of traditionally prepared pizzas with long (22 hours)…
- Trial name
- NCT03748251
- Testing
- the patients ate a pizza that fermented for 8 hours, the patients ate a pizza that fermented for 24 hours
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Campania Luigi Vanvitelli
Type 1 Diabetes Mellitus, Fear of Hypoglycemia
Fear of Hypoglycemia in Children and Adolecents With Type 1 Diabetes
Acute symptoms of hypoglycemia influence all aspects of every day life and reduce quality of life of children and adolescents with type 1 diabetes and their parents.
- Trial name
- NCT04454827
- Where
- Slovenia
- Volunteers
- 316 people
- Sponsor
- University of Ljubljana, Faculty of Medicine
Diabetes Mellitus
First Clinical Evaluation of a Novel Glucose Non-invasive Sensor Technology in Patients With Type 1 Diabetes
The primary aim of this clinical study is to find signal characteristics of VOCs detected by Sokru device during fasting, insulin injection and after glucose intake and to find the association with blood glucose variation in…
- Trial name
- VAARA (NCT05771090)
- Testing
- Sokru device
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- DCB Research AG
Type 1 Diabetes, Hypoglycemia
Glycemic Effects of Morning Only, Evening Only or Twice Daily Insulin Glargine in Patients With Type 1 Diabetes
This research is a prospective, randomized, cross-over study that is being done to compare the effect of morning only, evening only and twice daily insulin glargine (Lantus®) on hypoglycemia (blood glucose level <70 mg/dL) as…
- Trial name
- NCT00869414
- Testing
- Evening only administration of insulin glargine, Morning only administration of insulin glargine, split dose insulin glargine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Johns Hopkins University
Diabetes Mellitus, Type 1
Evaluation of the EarEEG System for Detection of Hypoglycaemia-induced Changes in the EEG in Subjects With Type 1 Diabetes
The EarEEG system is a novel non-invasive, unobstructed and discrete method for recording EEG in which the signal is recorded using dry-contact electrodes embedded on a customised ear piece.
- Trial name
- NCT03022058
- Testing
- Ear-EEG system
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Odense University Hospital
Type 1 Diabetes, Hypoglycemia
Islet Allotransplantation With Steroid Free Immunosuppression
The restoration of endogenous insulin secretion carries significant hopes for shifting the paradigm of life long exogenous insulin therapy in selected groups of patients with type 1 diabetes(T1D).
- Conditions
- Type 1 Diabetes, Hypoglycemia, Metabolic Diseases
- Trial name
- NCT00446264
- Testing
- islet transplantation, daclizumab - sirolimus - tacrolimus
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Lille
Blood Glucose Decrease During and After Defined Individual Exercise in T1DM
Exercise in Type 1 Diabetes Mellitus
Background: During and after exercise there is a twofold stimulation of glucose transporter type 4 in type 1 diabetes mellitus (T1DM) caused by an exogenous insulin injection and muscle contraction.
- Trial name
- ExT1DM (NCT02075567)
- Testing
- Experimental
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Hypoglycemia, Diabetes Mellitus, Type 1
Trial to Confirm the Clinical Efficacy and Safety of Dasiglucagon in the Treatment of Hypoglycemia in Subjects With T1DM
A randomized, double-blind, parallel-group trial to confirm the clinical efficacy and safety of dasiglucagon in the rescue treatment of hypoglycemia in subjects with type 1 diabetes mellitus (T1DM) compared to placebo
- Trial name
- NCT03688711
- Testing
- Dasiglucagon
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- Zealand Pharma
Type 1 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) for 12 Days in Adults With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT02846831
- Testing
- 12-day intervention with sensor-augmented pump therapy, 12-day intervention with single-hormone closed-loop strategy, Insulin pump
- Where
- 2 sites in Canada
- Volunteers
- 36 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Diabetes Mellitus, Type I
Study to Determine the Relationship Between Exercise and Hypoglycemia in Children With Type 1 Diabetes
The main purpose of this study is to find out how often low blood sugar (hypoglycemia) happens during the night after exercise in the late afternoon.
- Trial name
- NCT00109434
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Jaeb Center for Health Research
Type 1 Diabetes
Prevalence of Post Traumatic Stress Disorder Related to Diabetes Diagnosis or Severe Hypoglycaemia in Adult With Type 1 Diabetes
In France, the adult population living with diabetes in 2016 is estimated at more than 3.3 million patients treated. Type 1 diabetes (T1DM) represents 5.6% of diabetic patients (approximately 185,000 patients).
- Trial name
- NCT05662657
- Testing
- Diagnostic Test: PCL-S Questionnaire
- Where
- 2 sites in France
- Volunteers
- 297 people
- Sponsor
- Hospital St. Joseph, Marseille, France
Type 1 Diabetes Mellitus
Model Predictive Control (MPC) Artificial Pancreas vs. Sensor Augmented Pump (SAP)/Predictive Low Glucose Suspend (PLGS) With Different Food Choices in the Outpatient Setting
The objective of this randomized crossover clinical trial is to 1) assess the efficacy and safety of an automated insulin delivery (AID) system using a Model Predictive Control (MPC) algorithm versus sensor augmented pump therapy…
- Trial name
- NCT03767790
- Testing
- iAPS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sansum Diabetes Research Institute
Type 1 Diabetes, Hypoglycemia
Impact of MEnstruation on Glycemic Response and Exercise In Females With Type 1 Diabetes
The objectives of this study are to examine how sex hormones (use of hormonal birth control, menstrual cycle phase) impact glycemic control among women with type 1 diabetes (T1D), and to test adjustments to insulin dosing and…
- Conditions
- Type 1 Diabetes, Hypoglycemia, Hyperglycaemia Due to Type 1 Diabetes Mellitus, Menstruation Disturbances
- Trial name
- MERIT (NCT06297980)
- Testing
- Personalized modifications to treatment to address menstrual cycle effects on glycemia
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 1, Insulin Hypoglycemia
Effects of Frequency and Duration of Exercise in People With Type 1 Diabetes A Randomized Crossover Study
According to the Standards of Medical Care in Diabetes by the American Diabetes Association, people with diabetes should aim for 30 minutes of moderate-to-vigorous intensity aerobic exercise at least 5 days a week or a total of…
- Trial name
- NCT04089462
- Testing
- "Five sessions per period" - "Two sessions per period", "Two sessions per period" - "Five sessions per period"
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 1 Diabetes
Closed-loop Control of Postprandial Glucose Levels in Adults With Type 1 Diabetes
Postprandial meal glucose control with closed-loop systems (CLS) still needs some improvements. In the postprandial period, sensor delay in detecting blood glucose rise after a meal together with delays in insulin absorption…
- Trial name
- NCT02416765
- Testing
- 15-hour intervention, Insulin (Lispro, Aspart or guilisine), Glucagon (Eli Lilly)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 1 Diabetes Mellitus
Using Wearable Sensors To Understand Low Blood Sugar in Type 1 Diabetes
This is a single-site study using wearable sensor technology (CGM and smartwatch) to better explain low blood sugars in patients living with type 1 diabetes.
- Trial name
- Wear WOLF (NCT06727071)
- Testing
- Hyperglycemic clamp
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego