Clinical trials: Treatment Adverse Effect
Anemia, Breast Cancer
Epoetin Alfa in Treating Anemia in Patients Who Are Receiving Chemotherapy
RATIONALE: Epoetin alfa may stimulate red blood cell production and treat anemia in patients with cancer who are receiving chemotherapy.
- Conditions
- Anemia, Breast Cancer, Chronic Myeloproliferative Disorders, Drug/Agent Toxicity by Tissue/Organ
- Trial name
- NCT00003600
- Testing
- epoetin alfa
- Where
- 21 sites in United States, Canada
- Volunteers
- 344 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Cardiotoxicity
Effect of Trimetazidine on Radiotherapy-induced Heart Damage.
This is a randomized controlled trial. 80 patients with thoracic radiotherapy will be included. Participants will be randomly divided into experimental group or control group.
- Trial name
- NCT04939857
- Testing
- Trimetazidine
- Volunteers
- 80 people
- Sponsor
- Peking University Third Hospital
Hepatitis, Toxic
Cholestatic Drug-induced Liver Injury
Cholestatic drug-induced liver injury (DILI) is the severe form of DILI with a grave outcome. Drug-metabolizing enzymes play an important role in the metabolism of drugs.
- Trial name
- DILI (NCT01141322)
- Testing
- Ursodeoxycholic Acid
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Bronchiectasis
Bacterial Load Guided Therapy for Severe Bronchiectasis Exacerbations
From the British Thoracic Guidelines1 and a PUBMED search there are no randomised controlled trials exploring optimum antibiotic duration for chest infections.
- Trial name
- BLTBrIV (NCT02047773)
- Testing
- Duration, Colomycin, Meropenem
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Edinburgh
Drug/Agent Toxicity by Tissue/Organ, Lymphoma
Dexamethasone Followed by Denileukin Diftitox in Treating Patients With Persistent or Recurrent T-Cell Lymphoma
RATIONALE: Denileukin diftitox may be able to deliver cancer-killing substances directly to T-cell lymphoma cells. Dexamethasone may decrease the side effects of denileukin diftitox.
- Trial name
- NCT00006345
- Testing
- denileukin diftitox, dexamethasone
- Where
- 11 sites in United States
- Sponsor
- Ligand Pharmaceuticals
Breast Cancer, Radio Dermatitis
Photobiomodulation in Radiodermatitis in People With Breast Cancer
Most breast cancer patients undergoing radiotherapy develop radiodermatitis, making it one of the most prevalent adverse events during cancer treatment.
- Trial name
- NCT06990165
- Testing
- Photobiomodulation
- Where
- 2 sites in Brazil
- Volunteers
- 148 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Glaucoma
This Study Examines Whether Personality Traits Influence the Frequency or Severity of Ocular Adverse Effects Reported by Patients Using Glaucoma Medications. The Findings May Identify Patients at Greater Risk of Intolerance and Support More Personalized Treatment and Counselling.
The goal of this observational study is to learn whether personality traits are related to eye side effects from glaucoma medications in adults who currently use or previously used these medications.
- Trial name
- Adverse Events (NCT07739784)
- Testing
- No Interventions
- Where
- Canada
- Volunteers
- 352 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Toxic Epidermal Necrolysis, Stevens-Johnson Syndrome
Study to Evaluate the Use of Palifermin to Treat Toxic Epidermal Necrolysis
To test the ability of palifermin (a recombinant human keratinocyte growth factor) to decrease mucocutaneous injury and to promote epithelial repair in Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome-Toxic Epidermal…
- Trial name
- NCT02037347
- Testing
- Palifermin
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Brett King
Pulmonary Disease, Chronic Obstructive, Adverse Effect of Glucocorticoids and Synthetic Analogues
Reduction of Corticosteroid Use in Outpatient Treatment of Exacerbated COPD
Background Chronic obstructive pulmonary disease (COPD) is a major public health issue with no curative treatment. In Switzerland estimated 5-7% of the total population are suffering from this chronic disease.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Adverse Effect of Glucocorticoids and Synthetic Analogues, Disease Exacerbation
- Trial name
- RECUT (NCT02386735)
- Testing
- Prednisone
- Where
- Switzerland
- Volunteers
- 133 people
- Sponsor
- Prof. Dr. Jörg Leuppi
Cardiovascular Disease, High Cardiovascular Risk
A Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group study in overweight and obese subjects with cardiovascular (CV) disease and/or multiple CV risk factors.
- Conditions
- Cardiovascular Disease, High Cardiovascular Risk, Obesity, Overweight
- Trial name
- CAMELLIA-TIMI (NCT02019264)
- Testing
- Lorcaserin hydrochloride
- Where
- 499 sites in United States, Australia and 6 more
- Volunteers
- 14,673 people
- Sponsor
- Eisai Inc.
Breast Cancer, Cardiotoxicity
Cardiotoxicity Prevention in Breast Cancer Patients Treated With Anthracyclines and/or Trastuzumab
The aim of the study is to analyze the protective impact on the cardiac damage of beta blockers and ACE inhibitors for breast cancer patients treated with anthracyclines-based chemotherapy with or without trastuzumab.
- Trial name
- SAFE (NCT02236806)
- Testing
- Bisoprolol, Ramipril
- Where
- Italy
- Volunteers
- 262 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Anterior Cruciate Ligament (ACL) Reconstruction
Subdermal Implant-bioabsorbable Oxandrolone Pellet For Rehabilitation Following Anterior Cruciate Ligament (ACL) Surgical Reconstruction
Rehabilitation of knee stability and function after anterior cruciate ligament (ACL) reconstruction is slow and costly. The use of anabolic steroids, such as oxandrolone, may aid in the recovery of muscle mass and strength, as…
- Trial name
- IMOX (NCT06974526)
- Testing
- Oxandrolone
- Where
- 6 sites in Brazil
- Volunteers
- 96 people
- Sponsor
- Science Valley Research Institute
Adverse Effect
Phenylephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia
The purpose of this study is to investigate the suitable infusion dose of phenylephrine for prophylaxis against postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean section.
- Trial name
- NCT04576663
- Testing
- Normal saline, Phenylephrine
- Volunteers
- 95 people
- Sponsor
- General Hospital of Ningxia Medical University
Hot Weather; Adverse Effect, Kidney Dysfunction
Renal Considerations in the Heat Stress Recommendations
An epidemic of chronic kidney disease is occurring in laborers who undertake physical work outdoors in hot conditions. The reason for this is unknown, but may be related to kidney dysfunction caused by increases in body…
- Conditions
- Hot Weather; Adverse Effect, Kidney Dysfunction, Kidney Injury, Hyperthermia
- Trial name
- Aim1 (NCT04767347)
- Testing
- 23.0°C WBGT - Fixed Work Rate, 25.5°C WBGT - Fixed Work Rate, 27.5°C WBGT - Fixed Work Rate
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Indiana University
Lung Cancer
Design and Evaluation of a Novel Methodology for SABR for Lung Cancer
Aims: To increase the number of patients that benefit from Stereotactic Ablative Radiotherapy (SABR) for lung cancer using new treatment methods that reduce the amount of non-cancer tissue receiving a high radiation dose without…
- Trial name
- NCT04928755
- Volunteers
- 30 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Implant Complication, Implant Infection
Local Antibiotics for Breast Implants
The BREAST-AB Trial is a multi-center, randomized, double blind, placebo-controlled trial investigating the efficacy of local application of gentamicin, vancomycin and cefazolin in decreasing all-cause implant explantation after…
- Conditions
- Implant Complication, Implant Infection, Implant Site Infection, Implant Capsular Contracture
- Trial name
- BREAST-AB (NCT04731025)
- Testing
- Gentamicin, Cefazolin and Vancomycin
- Where
- 8 sites in Denmark
- Volunteers
- 1,003 people, healthy volunteers welcome
- Sponsor
- Mikkel Herly
Advanced Neuroendocrine Neoplasm, Carcinoid Syndrome
Retifanlimab (INCMGA00012) and Telotristat Ethyl for the Treatment of Advanced Neuroendocrine Tumors and Carcinoid Syndrome
This phase II trial studies the effect of retifanlimab and telotristat ethyl in treating patients with neuroendocrine tumors that have spread to other places in the body (advanced) and carcinoid syndrome.
- Trial name
- NCT04776876
- Testing
- Retifanlimab, Telotristat Ethyl
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer Survivorship, Breast Cancer
Development and Validation of a Personalized Digital Healthcare Model for Managing Side Effects in Breast Cancer Survivors
The ultimate goal of this research and development is to develop personalized digital healthcare technologies and self-management strategies based on self-assessment results and evidence, for breast cancer survivors who require…
- Conditions
- Breast Cancer Survivorship, Breast Cancer, Digital Health
- Trial name
- NCT06729684
- Testing
- digital health (application and smartwatch)
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Samsung Medical Center
Complications; Cesarean Section, Anesthesia; Adverse Effect, Spinal and Epidural
Non-invasive Cardiac Output Monitoring in Obstetric Patients
The investigators hypothesize that continuously measuring stroke volume (SV) and cardiac output (CO) will 1) reveal hemodynamic instability in a timely manner and alert the physician promptly, 2) provide information for the…
- Trial name
- NCT01516697
- Testing
- experimental, Control
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Artificial Intelligent, Cardiotoxicity
Smart Home Care of Cloud Base ECG on the Cardiotoxicity Prevention on the Cancer Patients.
Thoracic malignancy is the most commonly diagnosed cancer worldwide.1,2 The incidence of thoracic malignancy has decreased in North America, but not in Asia, where it continues to show an increasing trend.
- Conditions
- Artificial Intelligent, Cardiotoxicity, Cardiac Monitor, Cancer Treatment
- Trial name
- AI (NCT04885088)
- Testing
- Wisdom bracelet
- Volunteers
- 400 people
- Sponsor
- Ju-Chi Liu
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