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Advanced Neuroendocrine NeoplasmPhase 2NCT04776876

Retifanlimab (INCMGA00012) and Telotristat Ethyl for the Treatment of Advanced Neuroendocrine Tumors and Carcinoid Syndrome

A Phase 2 study testing Retifanlimab and Telotristat Ethyl in people with Advanced Neuroendocrine Neoplasm and Carcinoid Syndrome, run by M.D. Anderson Cancer Center.

Withdrawn

Withdrawn. The study stopped before anyone enrolled.

Official record
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Trial summary

This phase II trial studies the effect of retifanlimab and telotristat ethyl in treating patients with neuroendocrine tumors that have spread to other places in the body (advanced) and carcinoid syndrome. Retifanlimab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Read more about this study

Who is it for?
Ages 18 years and older
What is being tested?
Retifanlimab and Telotristat Ethyl
Type of treatment
Injection or infusion
Could I receive a placebo?
No, everyone receives an active treatment
How many people
0 participants
Where
No sites listed yet
Study dates
1 Mar 2021to 2 Sep 2021
Phase
Phase 2
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Grade 1, 2, or 3 (or described as low grade, intermediate grade, well differentiated, or moderately differentiated) neuroendocrine tumor, according to reviewing pathologist or documented interpretation of report by the investigator
  • Progressive disease over the preceding 12 months
  • Prior therapy with any number of anticancer therapies, but a somatostatin analogue (such as octreotide, lanreotide, or pasireotide) must be one of the prior therapies
  • Carcinoid syndrome, as documented by the investigator
  • Patients using a somatostatin analogue for symptom control must be on stable doses for 56 days prior to enrollment
  • Signed informed consent form
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  • Age >= 18 years
  • Ability to comply with the study protocol, in the investigator's judgment
  • Measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1
  • Previously irradiated lesions can be considered as measurable disease only if progressive disease has been unequivocally documented at that site since radiation
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
  • Absolute neutrophil count >= 1,500/mm^3 without granulocyte colony-stimulating factor support (obtained within 28 days prior to initiation of study treatment)
  • Lymphocyte count >= 500/mm^3 (obtained within 28 days prior to initiation of study treatment)
  • Platelet count >= 100,000/mm^3 without transfusion (obtained within 28 days prior to initiation of study treatment)
  • White blood cell count >= 2,500/mm^3 (obtained within 28 days prior to initiation of study treatment)
  • Hemoglobin >= 9.0 g/dL (obtained within 28 days prior to initiation of study treatment)
  • Patients may be transfused to meet this criterion
  • Aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase =< 2.5 x upper limit of normal (ULN) (obtained within 28 days prior to initiation of study treatment), with the following exceptions:
  • Patients with documented liver metastases: AST and ALT =< 5 x ULN
  • Patients with documented liver or bone metastases: alkaline phosphatase =< 5 x ULN
  • Serum bilirubin =< 1.5 x ULN (obtained within 28 days prior to initiation of study treatment) with the following exception:
  • Patients with known Gilbert disease: serum bilirubin level =< 3 x ULN
  • Serum creatinine =< 1.5 x ULN (obtained within 28 days prior to initiation of study treatment)
  • Serum albumin >= 2.5 g/dL (obtained within 28 days prior to initiation of study treatment)
  • For patients not receiving therapeutic anticoagulation: international normalized ratio (INR) or activated partial thromboplastin time (aPTT) =< 1.5 x ULN (obtained within 28 days prior to initiation of study treatment)
  • For patients receiving therapeutic anticoagulation: stable anticoagulant regimen
  • For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use a barrier contraceptive method with a failure rate of < 1% per year during the treatment period and for 6 months after the last dose of study treatment
  • For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use a contraceptive method with a failure rate of < 1% per year during the treatment period and for 6 months after the last dose of study treatment
  • A woman is considered to be of childbearing potential if she is postmenarcheal, has not reached a postmenopausal state (>= 12 continuous months of amenorrhea with no identified cause other than menopause), and has not undergone surgical sterilization (removal of ovaries and/or uterus)
  • Examples of contraceptive methods with a failure rate of < 1% per year include bilateral tubal ligation, male sterilization, hormonal contraceptives that inhibit ovulation, hormone-releasing intrauterine devices, and copper intrauterine devices
  • The reliability of sexual abstinence should be evaluated in relation to the duration of the clinical trial and the preferred and usual lifestyle of the patient. Periodic abstinence (e.g., calendar, ovulation, symptothermal, or postovulation methods) and withdrawal are not acceptable methods of contraception

Who cannot join

  • Grade 3, poorly differentiated neuroendocrine carcinoma
  • Large cell or small cell histology
  • Treatment for the studied cancer within 28 days prior to initiation of study treatment
  • Treatment with investigational therapy within 28 days prior to initiation of study treatment
  • Palliative radiation therapy administered within 1 week of first dose of study treatment or radiation therapy in the thoracic region that is > 30 Gy within 6 months of the first dose of study treatment. Note: Participants must have recovered from all radiation-related toxicities, not require corticosteroids for this purpose, and not have had radiation pneumonitis
  • Toxicity of prior therapy that has not recovered to =< grade 1 or baseline (with the exception of any grade of alopecia and anemia not requiring transfusion support)
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  • Known hypersensitivity to another monoclonal antibody that cannot be controlled with standard measures (e.g., antihistamines and corticosteroids)
  • Known allergy or hypersensitivity to any component of the INCMGA00012 formulation
  • Known allergy or hypersensitivity to any component of the telotristat formulation
  • Active autoimmune disease requiring systemic immunosuppression in excess of physiologic maintenance doses of corticosteroids (> 10 mg/day of prednisone or equivalent)
  • Physiologic corticosteroid replacement therapy at doses > 10 mg/day of prednisone or equivalent for adrenal or pituitary insufficiency and in the absence of active autoimmune disease is permitted
  • Participants with asthma that requires intermittent use of bronchodilators, inhaled steroids, or local steroid injections may participate
  • Brief courses of corticosteroids for prophylaxis (e.g., contrast dye allergy) or study treatment-related standard premedication are permitted
  • Participants using topical, ocular, intra-articular, or intranasal steroids (with minimal systemic absorption) may participate
  • Prior allogeneic stem cell or solid organ transplantation
  • Evidence of interstitial lung disease, history of interstitial lung disease, or active, noninfectious pneumonitis
  • Positive human immunodeficiency virus (HIV) test at screening with CD4+ T-cell count < 350 cells/mcL
  • Known HIV infection and opportunistic infection within the past 12 months
  • Active hepatitis B virus (HBV) infection (chronic or acute), defined as having a positive hepatitis B surface antigen (HBsAg) test at screening
  • Patients with a past or resolved HBV infection, defined as having a negative HBsAg test and a positive total hepatitis B core antibody (HBcAb) test and negative HBV deoxyribonucleic acid (DNA) test at screening, are eligible for the study
  • Active hepatitis C virus (HCV) infection, defined as having a positive HCV antibody test followed by a positive HCV ribonucleic acid (RNA) test at screening
  • The HCV RNA test will be performed only for patients who have a positive HCV antibody test
  • Known diagnosis of active tuberculosis
  • Treatment with therapeutic oral or IV antibiotics within 7 days prior to initiation of study treatment
  • Patients receiving prophylactic antibiotics (e.g., to prevent a urinary tract infection or chronic obstructive pulmonary disease exacerbation) are eligible for the study
  • Treatment with a live, attenuated vaccine within 4 weeks prior to initiation of study treatment, or anticipation of need for such a vaccine during the course of the study, or up to 5 months following the anticipated last dose of INCMGA00012
  • Malignancies other than the disease under study within 3 years prior to cycle 1, day 1, with the exception of those with a negligible risk of metastasis or death and with expected curative outcome (such as adequately treated carcinoma in situ of the cervix, basal or squamous cell skin cancer, or ductal carcinoma in situ treated surgically with curative intent) or undergoing active surveillance per standard-of-care management (e.g., chronic lymphocytic leukemia Rai stage 0)
  • Any other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding that contraindicates the use of an investigational drug, may affect the interpretation of the results, or may render the patient at high risk from treatment complications
  • Prior treatment with CD137 agonists or immune checkpoint blockade therapies, including anti-CTLA-4, anti-PD-1, and anti-PD-L1 therapeutic antibodies
  • Treatment with systemic immunostimulatory agents (including, but not limited to, interferon and interleukin 2) within 4 weeks or five half-lives of the drug (whichever is longer) prior to initiation of study treatment
  • Treatment with systemic immunosuppressive medication (including, but not limited to, corticosteroids, cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-TNF-alpha agents) within 2 weeks prior to initiation of study treatment, or anticipation of need for systemic immunosuppressive medication during the course of the study, with the following exceptions:
  • Patients who received low-dose immunosuppressant medication are eligible for the study
  • Patients who received mineralocorticoids (e.g., fludrocortisone), corticosteroids for chronic obstructive pulmonary disease or asthma, or low-dose corticosteroids for orthostatic hypotension or adrenal insufficiency are eligible for the study
  • Pregnant or breastfeeding, or intending to become pregnant during the study
  • Women of childbearing potential must have a negative serum pregnancy test result within 14 days prior to initiation of study treatment

About this study

Official title: A Phase II, Open-Label, Single-Arm Study of INCMGA00012 and Telotristat Ethyl in Patients With Advanced Neuroendocrine Tumors and Carcinoid Syndrome

This phase II trial studies the effect of retifanlimab and telotristat ethyl in treating patients with neuroendocrine tumors that have spread to other places in the body (advanced) and carcinoid syndrome. Retifanlimab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Telotristat ethyl is a drug used to reduce side effects of carcinoid syndrome. Giving retifanlimab and telotristat ethyl may help to control neuroendocrine tumors in patients who also have carcinoid syndrome.

Read the detailed description

PRIMARY OBJECTIVE:

  1. To evaluate the efficacy of retifanlimab (A12) + telotristat ethyl (TE).

SECONDARY OBJECTIVE:

  1. To evaluate the efficacy of A12 + TE.

SAFETY OBJECTIVES:

  1. To evaluate the safety of A12 + TE. II. To evaluate the safety of withholding concurrent somatostatin analogue in patients receiving A12 + TE.

EXPLORATORY BIOMARKER OBJECTIVE:

  1. To identify biomarkers that are predictive of response to A12 + TE (i.e., predictive biomarkers), are associated with progression to a more severe disease state (i.e., prognostic biomarkers), are associated with resistance to A12 + TE, are associated with susceptibility to developing adverse events, can provide evidence of study treatment activity, or can increase the knowledge and understanding of disease biology.

OUTLINE:

Patients receive retifanlimab intravenously (IV) over 30-60 minutes on day 1 and telotristat ethyl orally (PO) 3 times daily (TID) on days 1-28. Cycles repeat every 28 days for up to 2 years in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years.

Being tested
Retifanlimab, Telotristat Ethyl
Medical subject headings
Serotonin Syndrome

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • RetifanlimabBiological

    Also called INCMGA 0012, INCMGA-0012, INCMGA00012, INCMGA0012

    Given IV

  • Telotristat EthylDrug

    Given PO

Study groups in NCT04776876
Study groupRoleWhat they receive
Treatment (retifanlimab, telotristat ethyl)ExperimentalPatients receive retifanlimab IV over 30-60 minutes on day 1 and telotristat ethyl PO TID on days 1-28. Cycles repeat every 28 days for up to 2 years in the absence of disease progression or unacceptable toxicity.
Receives: Biological: Retifanlimab; Drug: Telotristat Ethyl

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Overall best response rate (partial response or complete response)

    Will estimate the best response rate and its 95% exact confidence interval using the Clopper and Pearson method.

    Measured: Up to 2 years

Secondary outcomes (6)

  1. Objective response

    Will be determined by an independent radiologist according to immune-modified RECIST.

    Measured: Up to 2 years

  2. Progression free survival

    Will be determined by an independent radiologist according to RECIST v1.1. Will be estimated using the Kaplan-Meier method. The log-rank test will be performed to test the difference in time-to-event distributions between patient groups. Cox proportional hazards model may be utilized to include multiple covariates in the time-to-event analysis.

    Measured: Time from enrollment to the first occurrence of disease progression or death from any cause, whichever occurs first, assessed up to 2 years

  3. Duration of response

    Will be determined by an independent radiologist according to RECIST v1.1. Will be estimated using the Kaplan-Meier method. The log-rank test will be performed to test the difference in time-to-event distributions between patient groups. Cox proportional hazards model may be utilized to include multiple covariates in the time-to-event analysis.

    Measured: Time from the first occurrence of a documented objective response to disease progression or death from any cause, whichever occurs first, assessed up to 2 years

  4. Disease control

    Will be determined by an independent radiologist according to RECIST v1.1.

    Measured: Up to 2 years

  5. Overall survival

    Will be estimated using the Kaplan-Meier method. The log-rank test will be performed to test the difference in time-to-event distributions between patient groups. Cox proportional hazards model may be utilized to include multiple covariates in the time-to-event analysis.

    Measured: Time from enrollment to death from any cause, assessed up to 2 years

  6. Occurrence and severity of adverse events

    Will be determined according to National Cancer Institute Common Terminology Criteria for Adverse Events, version 5.0. Toxicity data will be summarized by frequency tables.

    Measured: Up to 30 days post-intervention

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted2 Mar 2021
  2. Study start1 Mar 2021 (estimated)
  3. Primary completion2 Sep 2021
  4. Study completion2 Sep 2021

Why it stopped: The study will not be opening. Support was withdrawn.

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 2
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrolment
0 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT04776876
Sponsor's protocol ID
2020-0083
Other IDs
NCI-2021-00021, 2020-0083
Status last verified
Sep 2021
First submitted
8 Feb 2021
Last updated
29 Sep 2021
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No

Questions about this trial

What is this clinical trial studying?

A Phase 2 study testing Retifanlimab and Telotristat Ethyl in people with Advanced Neuroendocrine Neoplasm and Carcinoid Syndrome, run by M.D. Anderson Cancer Center.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 31 inclusion and 35 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: withdrawn, as of the sponsor's last update on 29 Sep 2021. Status can change between updates, so confirm with the study contact before making plans.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study was withdrawn before enrolling participants, so there are no results.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Overall best response rate (partial response or complete response) (time frame: Up to 2 years). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT04776876.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Sep 2021.

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