Clinical trials: Trauma
Urologic Diseases, Male Urogenital Diseases
Bioengineered Penile Tissue Constructs for Irreversibly Damaged Penile Corpora
The primary objective of this clinical trial is to evaluate the safety of autologous engineered corpora cavernosa + albuginea constructs for treatment of complex penile deformities.
- Conditions
- Urologic Diseases, Male Urogenital Diseases, Penile Diseases, Corpus Callosum Malformation
- Trial name
- NCT03463239
- Testing
- Autologous tissue engineered corpora
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Phantom Limb Pain After Amputation, Chronic Pain Due to Injury
Negative Pressure Wound Therapy as a Predictor of Persistent Pain After War-Related Trauma
War-related trauma frequently causes complex soft tissue injuries that require repeated surgical treatment and advanced wound management techniques such as Negative Pressure Wound Therapy (NPWT).
- Conditions
- Phantom Limb Pain After Amputation, Chronic Pain Due to Injury, Postoperative Pain, Trauma (Including Fractures)
- Trial name
- NPWT-Pain Stud (NCT07475897)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Acute Spinal Cord Injury (SCI), Spinal Cord Diseases
NG004 in Incomplete Spinal Cord Injury Patients
This is a randomized, double-blind, placebo controlled, multicenter trial of NG004 in patients with acute traumatic incomplete cervical SCI.
- Conditions
- Acute Spinal Cord Injury (SCI), Spinal Cord Diseases, Spinal Cord Injuries, Trauma Nervous System
- Trial name
- SPROUT-2 (NCT07840196)
- Testing
- NG004
- Where
- 10 sites in Germany, Switzerland
- Volunteers
- 120 people
- Sponsor
- NovaGo Therapeutics AG
Hemorrhage, Trauma
Evaluation of Transthoracic Echocardiography Parameters and Their Changes in Blood Donor Volunteers
This study investigates the impact of blood donation on transthoracic echocardiography (TTE) parameters in healthy volunteers, aiming to enhance the understanding of hemodynamic changes associated with mild blood loss and assess…
- Conditions
- Hemorrhage, Trauma, Shock Hypovolemic
- Trial name
- EDoS (NCT07207629)
- Testing
- Transthoracic Echocardiography measurements
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Stress Disorders, Post-Traumatic, Mental Disorders
Group-based Stabilization and Skill Training for Patients With Lasting Posttraumatic Reactions in Mental Health Care
This study evaluates the addition of a group based stabilization and skill-training intervention to individual out-patient treatment for long lasting post-traumatic reactions.
- Conditions
- Stress Disorders, Post-Traumatic, Mental Disorders, Trauma and Stressor Related Disorders
- Trial name
- NCT03887559
- Testing
- Group-based stabilization and skill training in addition to individual treatment, Treatment as usual
- Where
- Norway
- Volunteers
- 160 people
- Sponsor
- St. Olavs Hospital
Burnout, Secondary Trauma
PATH to Reducing Burnout Among Peers Who Deliver Overdose Prevention Services (R33 Phase Clinical Trial)
The investigators propose to test the effectiveness of PATH (Peer Advanced Training for total Health) as an educational workforce intervention for improving peer recovery support specialists' (PRSS) overdose prevention (OP)…
- Conditions
- Burnout, Secondary Trauma, Compassion Fatigue, Opioid Use Disorder
- Trial name
- NCT07886944
- Testing
- PATH (Peer Advanced Training for total Health)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Chestnut Health Systems
Ocular Trauma
Corneal Trauma Diagnostic Study
Tear fluid will be collected from patients diagnosed with ocular trauma at the University of Pittsburgh Medical Center to evaluate biomarkers.
- Trial name
- NCT07887425
- Testing
- Tear fluid collection with mass spec analysis.
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- InnSight Technology, Inc.
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Severe Chest Trauma
EffecT of eARly analGesia With Erector Spinae Plane Block to Reduce Ventilation After Severe Chest Trauma
Blunt chest trauma is commonly associated with rib fractures and early pain management is a key goal after chest trauma. In spontaneous breathing patients, pain limits coughing efficiency and secretion clearance, thereby…
- Trial name
- TARGET (NCT05920109)
- Testing
- ESP block
- Where
- 14 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Grenoble
Head Injury Trauma, Traumatic Brain Injury, Mild
The PIONEER Comparative Effectiveness Study - Project 2
This is a pragmatic, open-label, multicenter, stepped-wedge, Type II hybrid effectiveness-implementation study. It is designed to evaluate both the comparative effectiveness and implementation feasibility of a…
- Trial name
- NCT07829107
- Testing
- Clinical pathway 1: Guidelines plus biomarkers, Clinical guidelines only
- Where
- 6 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- University of Michigan
Trauma Associated Hemorrhage
Prehospital Transfusion Outcomes in Traumatic Hemorrhage: a Prospective Cohort Study
Traumatic injuries can cause severe bleeding, which causes a lot of deaths worldwide that could be prevented. Starting treatment as early as possible has been shown to improve survival, which makes fast care very important.
- Trial name
- PRONTO (NCT07883252)
- Where
- Netherlands
- Volunteers
- 750 people
- Sponsor
- Erasmus Medical Center
Intergenerational Trauma
Child Cognitive-Affective Resilience Following 13-11 Event : A Pluridisciplinary Study of Intergenerational Transmission of a Traumatic Event
CARE 13-11 study explores the transmission of trauma within families. Exposure to a traumatic event can have an impact on those directly exposed, but also on their family.
- Trial name
- CARE 13-11 (NCT07203443)
- Testing
- MRI, Psychological assessment, Cognitive assessment
- Where
- France
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Trauma Injury
The Effects of Footplate Stiffness on Foot Loading Within Carbon Fiber Custom Dynamic Orthoses
Carbon fiber custom dynamic orthoses (CDOs) improve function, reduce pain, and offload the foot and ankle. CDOs include a proximal cuff that wraps around the leg just below the knee, a posterior carbon fiber strut that bends to…
- Trial name
- CDOCFPlate (NCT07312032)
- Testing
- Carbon Fiber Custom Dynamic Orthosis, Carbon Fiber Footplate
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Jason Wilken
Nerve Block, Nerve Blocks
Blast-related Regional Anaesthesia and Peripheral nerVe Injury Evaluation
This randomized study will examine whether ultrasound-guided regional anaesthesia (a nerve block) contributes to new or worsening peripheral nerve problems after blast-related limb trauma.
- Conditions
- Nerve Block, Nerve Blocks, Nerve Injury, Blast Injury
- Trial name
- BRAVE (NCT07879508)
- Testing
- Standardized Multimodal Analgesia, Ultrasound-Guided Regional Anaesthesia
- Volunteers
- 150 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Trauma, Hemorrhage
Incidence of Trauma Induced Coagulopathy in Patients With Prehospital Administration of Fibrinogen
The purpose of the study is to find out the incidence of trauma induced coagulopathy in patients with severe trauma who received fibrinogen prior admission to emergency department during prehospital care.
- Conditions
- Trauma, Hemorrhage, Coagulopathy
- Trial name
- TICAF (NCT03572309)
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- Masaryk University
Polytrauma, Coagulation Disorder
Comparison of Viscoelastic Measurement by ROTEM® Delta and ClotPro® in Trauma Patients.
The purpose of the study is to describe the differences and interchangeability in measurements of viscoelastic tests of coagulation by two different devices in adult trauma patients.
- Trial name
- ROTCLOT (NCT04107818)
- Where
- Czechia
- Volunteers
- 108 people
- Sponsor
- Masaryk University
Spinal Cord Injuries, Neuropathic Pain
Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI
The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain.
- Conditions
- Spinal Cord Injuries, Neuropathic Pain, Neurological Injury, Pain
- Trial name
- NCT05492188
- Testing
- Operant Conditioning of Cutaneous Reflexes
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Medical University of South Carolina
PTSD, Stress Disorders, Traumatic
Psilocybin for the Treatment of Veterans With Post-Traumatic Stress Disorder
The primary aim of this study is to assess the safety and efficacy of psilocybin-assisted therapy in the treatment of post-traumatic stress disorder in United States military Veterans.
- Conditions
- PTSD, Stress Disorders, Traumatic, Stress Disorders, Post-Traumatic, Trauma and Stressor Related Disorders
- Trial name
- NCT05554094
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Ohio State University
Spinal Deformity, Spinal Infection
Analysis of Pedicle Screw Accuracy to Plan Using Medtronic Mazor Robotic System
The purpose of the study is to assess screw deviation from pre-planned trajectory using the Mazor X robotic system in patients undergoing posterior thoracolumbar arthrodesis procedures between T2-S1.
- Conditions
- Spinal Deformity, Spinal Infection, Trauma, Neoplastic Processes
- Trial name
- NCT05884593
- Testing
- Pedicle screw instrumentation using Mazor X robotic system
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Burnout, Compassion Satisfaction
PATH to Reducing Burnout Among Peers Who Deliver Overdose Prevention Services (R61 Phase Pilot)
The investigators propose to develop and test the effectiveness of PATH (Peer Advanced Training for total Health) as an educational workforce intervention for improving peer recovery support specialists' (PRSS) overdose…
- Conditions
- Burnout, Compassion Satisfaction, Secondary Trauma
- Trial name
- NCT07218562
- Testing
- PATH (Peer Advanced Training for total Health)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Chestnut Health Systems