Clinical trials: Total Knee Replacements
Osteoarthrosis
Effect of Methylprednisolone on Quadriceps Muscle Function in Patients Undergoing Total Knee-arthroplasty
This study evaluates the pathophysiological effects of a single dose Methylprednisolone administered prior to total knee-arthroplasty (TKA).
- Trial name
- NCT02319343
- Testing
- Methylprednisolone, Isotonic Sodium Chloride
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Osteoarthritis, Knee, Osteoarthritis Knees Both
Astaxanthin for Management of Inflammation in Knee Osteoarthritis
Over 30 million Americans are currently affected by osteoarthritis (OA), with prevalence expected to increase 40% by 2025 as a result of the aging population and obesity epidemic.
- Conditions
- Osteoarthritis, Knee, Osteoarthritis Knees Both, Joint Inflammation
- Trial name
- NCT05138549
- Testing
- Astaxanthin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Prisma Health-Midlands
Postoperative Pain, Postoperative Nausea and Vomiting
Effects of Methylprednisolone After Total Knee Arthroplasty
The purpose of the study is to compare the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome after knee arthroplasty.
- Conditions
- Postoperative Pain, Postoperative Nausea and Vomiting, Sleeping Quality, Fatigue
- Trial name
- NCT00968578
- Testing
- Methylprednisolone
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Hvidovre University Hospital
Total Knee Arthroplasty, Edema
The Effects of Manual Lymphatic Drainage and Kinesiotaping on Lower Extremity Edema
Significant trauma and muscular tightness often result during Total Knee Arthroplasty (TKA) surgery and thus act to restrict tissue fluid movement resulting with lower extremity edema.
- Conditions
- Total Knee Arthroplasty, Edema, Exercise
- Trial name
- NCT04164927
- Testing
- Manual Lymphatic Drainage, Kinesio Taping, Control
- Volunteers
- 40 people
- Sponsor
- Hacettepe University
Post-operation Pain
A Feasibility Dose-escalating Study of MDT-10013 for Acute Postoperative Pain Following Total Knee Arthroplasty
This is an open-label dose-escalating study to evaluate the tolerability and systemic exposure of MDT-10013 in men and women at least 18 years of age who are undergoing primary unilateral TKA.
- Trial name
- NCT02263222
- Testing
- MDT-10013
- Where
- 3 sites in United States
- Sponsor
- Medtronic Spinal and Biologics
Post-surgical Pain
Study to Evaluate Safety/Efficacy of a Single Preop Dose of AYX1 Injection to Treat Pain After Knee Replacement Surgery
The objectives of this study are to evaluate the safety and analgesic efficacy of a single preoperative intrathecal administration of AYX1 Injection in patients undergoing unilateral total knee arthroplasty.
- Trial name
- NCT02807428
- Testing
- AYX1 Injection 660 mg/6 mL
- Where
- 9 sites in United States
- Volunteers
- 210 people
- Sponsor
- Adynxx, Inc.
Postoperative Pain
Effect of Dexamethasone as Analgesic Treatment After Total Knee Arthroplasty
Effect of Dexamethasone as Analgesic Treatment After Total Knee Arthroplasty: Subgroup Analyses of The DEX-2-TKA Randomized Clinical Trial This explorative post-hoc analysis is a substudy of the DEX-2-TKA-trial (NCT03506789)…
- Trial name
- NCT05008367
- Testing
- Dexamethasone, Isotonic saline
- Where
- 5 sites in Denmark
- Volunteers
- 485 people
- Sponsor
- Naestved Hospital
Osteoarthritis
A Multi-Center Bidirectional Cohort Study on Total Knee Arthroplasty for the Treatment of Knee Osteoarthritis
The purpose of this study is to evaluate the clinical benefits of different types of total knee arthroplasty (TKA) in osteoarthritis treatment.
- Trial name
- NCT06990594
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Knee Osteoarthritis, Arthroplasty
Effects of Sensorimotor and Core Stabilization Exercises After Total Knee Arthroplasty
Tha aim of the study is to investigate the effects of core stabilization and sensorimotor exercise program on range of motion, proprioception, balance and functional status in patients with total knee arthroplasty.
- Conditions
- Knee Osteoarthritis, Arthroplasty, Joint Replacement
- Trial name
- NCT05248854
- Testing
- Sensorimotor exercise training, Core stabilization exercise training
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Yeditepe University
Pain, Acute, Opioid Use
Femoral Triangle Block With Popliteal Plexus Block Versus Femoral Triangle Block Versus Adductor Canal Block for TKA
In this study we wish to investigate the analgesic effect 3 different nerve block regimes in patients following primary total knee arthroplasty (TKA).
- Conditions
- Pain, Acute, Opioid Use, Analgesia
- Trial name
- NCT04854395
- Testing
- Marcain 5 mg/ml
- Where
- Denmark
- Volunteers
- 165 people
- Sponsor
- Regionshospitalet Silkeborg
Arthroplasty, Replacement, Knee
Knee Connect: Measuring Range of Motion and Gait Metrics After Total Knee Arthroplasty
The main goals of total knee replacement (TKR) surgery are to relieve pain and to allow patients to remain active. Sunnybrook is working with Kineris Inc.to advance a wearable device, the Knee Connect, aimed at tracking the…
- Trial name
- NCT03651739
- Testing
- Knee Connect
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- Sunnybrook Health Sciences Centre
Knee Osteoarthristis
New Robotic Knee Surgery: Does Implant Type Affect Alignment Accuracy?
Total knee replacement is a common surgery for patients with severe knee arthritis. To improve surgical accuracy, surgeons now use robotic systems to help plan and perform the procedure.
- Trial name
- CAPTAIN (NCT07777757)
- Testing
- Attune Total Knee Implant, Persona Total Knee Implant
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Acute Pain, Regional Anesthesia Morbidity
A Trial Comparing Adductor Canal Catheter and Intraarticular Catheter Following Primary Total Knee Arthroplasty
The study is a prospective randomized controlled trial comparing intraarticular catheters and adductor canal catheters for postoperative analgesia following a primary Total Knee Arthroplasty (TKA).
- Trial name
- NCT02497911
- Testing
- Adductor Canal Catheter, Intraarticular Catheter, Ropivicaine
- Volunteers
- 110 people
- Sponsor
- Thomas Jefferson University
Osteoarthritis, Knee
Kinematics After Total Knee Arthroplasty
The purpose of this study is to evaluate and compare implant kinematics of conventional mechanically aligned and anatomically aligned total knee arthroplasties (TKA) at 1 year post-operatively.
- Trial name
- NCT03093077
- Testing
- DePuy ATTUNE total knee arthroplasty system
- Where
- United States
- Sponsor
- Kristin Zhao, PhD
Arthropathy of Knee, Analgesia
Fascia Iliaca Compartment Block and IPACK Block in Total Knee Arthroplasty
The investigators sought to compare the effectiveness of postoperative pain control between the standard intravenous multimodal analgesia procedure used in managing patients undergoing total knee surgery, who experience severe…
- Trial name
- NCT06125067
- Testing
- no peripheral block, Fascia Iliaca Compartment Block, iPACK Block
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Total Knee Arthoplasty
Antibiotic Loaded Cement After TKA
This study will provide us with clear information about the postoperative concentration of antibiotic reached in synovial fluid, thereby helping surgeons to determine if concentration could potentially prevent the growth and…
- Trial name
- NCT05429671
- Testing
- total knee arthroplasty, Tobramycin, Gentamicin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Sarcopenia, Knee Prosthesis
Knee Replacement and Sarcopenia
The presence of sarcopenia in patients planned to undergo knee prosthesis and the effect of knee prosthesis on sarcopenia will be investigated
- Conditions
- Sarcopenia, Knee Prosthesis, Knee Arthroplasty, Total
- Trial name
- NCT06635356
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Knee Disease
Measurement of the Quality of Life in Patients Operated With a Total Knee Prosthesis (TKA) From the FHK® Range.
As part of Medical Devices CE marking regulatory process, an appropriate post-market clinical follow-up (PMCF) is required. This PMCF study is in the framework of CE mark renew of FHK® total knee prosthesis, it aims to answer…
- Trial name
- NCT04578951
- Testing
- FHK® total knee prosthesis
- Where
- France
- Volunteers
- 50 people
- Sponsor
- FH ORTHO
Knee Pain, Chronic Osteoarthritis
ROSA Robot Used in Total Knee Replacement Post Market Study
This is a prospective, multicenter clinical study designed to facilitate the collection and evaluation of workflow efficiency, patient pain and function, and adverse event data.
- Conditions
- Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities
- Trial name
- NCT03969654
- Testing
- PERSONA Total Knee, Vanguard Total Knee, NexGen Total Knee
- Where
- 5 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Primary Total Knee Arthroplasty
Effects of Pregabalin on Pain After Total Knee Arthroplasty
Total knee arthroplasty can cause severe postoperative pain, and patients typically receive oral opioid analgesics for over 2 weeks.
- Trial name
- NCT01333956
- Testing
- Pregabalin 50mg, Pregabalin 100mg, Pregabalin 150mg
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Hospital for Special Surgery, New York