Clinical trials: Total Knee Replacement
Blood Loss
Tranexamic Acid for Unilateral Total Knee Arthroplasty
Total knee arthroplasty is often associated with excessive postoperative bleeding due to increased fibrinolysis. Hence, the objective of the proposed of this multicentre study is to determine the peri-operative bleeding comparing…
- Trial name
- TRANEXTOP (NCT01594671)
- Testing
- Tranexamic Acid, haemostasia
- Where
- 2 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Total Knee Anthroplasty
Comparison of Ultrasound-Guided Lumbar ESPB and ACB for Knee Arthroplasty
Total knee arthroplasty (TKA) is a surgical procedure frequently associated with moderate-to-severe postoperative pain. While Adductor Canal Block (ACB) has demonstrated analgesic efficacy in TKA, the Erector Spinae Plane Block…
- Trial name
- NCT07115771
- Testing
- Postoperative analgesia management
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bursa City Hospital
Pain, Total Knee Replacement
Analysis of Postoperative Analgesic of Different Nerve Blocks for Total Knee Replacement Surgery
This study is a retrospective analysis using the accumulated clinical database from 2017/09-2023/12 to analyze patients who underwent total knee arthroplasty and received nerve blocks.
- Conditions
- Pain, Total Knee Replacement, Motor Function
- Trial name
- NCT06521619
- Testing
- Femoral and sciatic nerve blocks
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- Fu Jen Catholic University Hospital
Pain
Evaluation of Pain Treatment After Total Knee Arthroplasty
The purpose of the study is to characterize opioid use after total knee arthroplasty (TKA).
- Trial name
- NCT07538570
- Testing
- Suzetrigine
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Arthroplasty
Preoperative Pain, Function, and Activity for Total Hip and Knee Arthroplasty Patients
This study wish to show if the preoperative level of pain, function or activity for hip and knee arthroplasty patients has any predictive value of the time it takes to fulfill the well-defined discharge criteria.
- Trial name
- NCT01248039
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Hvidovre University Hospital
Postsurgical Pain
Study of CA-008 (Vocacapsaicin) in Total Knee Arthroplasty
This is a two-part, Phase 2, multi-center, randomized, double-blind, placebo-controlled, parallel design study of CA-008 (vocacapsaicin) vs. placebo injected/instilled during an elective TKA.
- Trial name
- NCT03731364
- Testing
- CA-008
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Concentric Analgesics
Knee Arthritis Osteoarthritis
Condylar Offset and Outcomes in Primary Total Knee Arthroplasty
This prospective cohort study aims to evaluate the effect of posterior condylar offset (PCO) and anterior condylar offset (ACO) changes on functional outcomes after primary total knee arthroplasty (TKA).
- Trial name
- OFFSET-TKA (NCT07517614)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- SB Istanbul Education and Research Hospital
Postoperative Pain
Daily Single Shot Adductor Canal Block Versus Continuous Adductor Canal Block After Total Knee Arthroplasty
This study will compare the analgesic efficacy of daily single-shot adductor canal block(ABC) versus continuous ACB after total knee arthroplasty (TKA).
- Trial name
- NCT05727137
- Testing
- Single shot adductor canal block, Continuous adductor canal block
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Osteoarthritis
"Score Infectivity" During Reoperation on Total Hip or Knee Prosthesis
The hip or knee is a validated treatment of end-stage osteoarthritis, and these interventions commonly make a significant improvement in the quality of life of patients. Infection can occur in 1-5% of cases.
- Trial name
- NCT02467764
- Testing
- Retrospective study
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis
The goal of this study is to create a prospective registry (<100 patients) to show the effectiveness of the genicular artery embolization procedure overtime in reducing bilateral or unilateral osteoarthritic knee pain as measured…
- Conditions
- Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)
- Trial name
- GAE (NCT06781463)
- Testing
- Registry (N/A)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Osteoarthritis, Total Knee Arthroplasty
Use of Cold and Compression Therapy With Total Knee Replacement Patients
The purpose of the study is to evaluate the effectiveness of a device that delivers cold and intermittent compression as compared to ice and compressive wraps on patients who have undergone knee replacement.
- Trial name
- NCT00712816
- Testing
- Game Ready Injury Treatment System (CoolSystems Inc.), Ice with compressive bandages
- Where
- 11 sites in United States, Australia
- Volunteers
- 224 people
- Sponsor
- CoolSystems, Inc.
Knee Arthroplasty, Total
LEGION Hinge Safety and Efficacy Study
The purpose of the current investigation is to assess the safety and efficacy of a new hinged revision knee device. This device is designed to provide efficient, reproducible reconstructions with optimal limb and implant…
- Trial name
- LINKS (NCT02445443)
- Testing
- LEGION Hinge Knee System
- Where
- 7 sites in United States, Australia and 3 more
- Volunteers
- 47 people
- Sponsor
- Smith & Nephew, Inc.
Wear of Articular Bearing Surface of Prosthetic Joint, Migration of Implant
Migration of CS vs CR Insert in TKA Using RSA
Background: The choice whether or not to preserve the posterior cruciate ligament (PCL) in total knee arthroplasty (TKA) is coupled to the us of a PCL-retaining (CR) or a condylar (CS) insert.
- Trial name
- CS vs CR RSA (NCT05936593)
- Testing
- Condylar Stabilizing (CS) insert, Cruciate Retaining (CR) insert
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- Reinier Haga Orthopedisch Centrum
Total Knee Arthroplasty Recovery, Knee Osteoarthritis
Wearable Knee-Assisted Rehabilitation for Range of Motion and Muscle Strength After Total Knee Arthroplasty
This randomized controlled trial evaluates a wearable electrogoniometry-based telerehabilitation system designed to support recovery after total knee arthroplasty.
- Trial name
- NCT07875725
- Testing
- ReBK Wearable Telerehabilitation System, Standard Home-Based Rehabilitation
- Where
- 3 sites in Chile
- Volunteers
- 80 people
- Sponsor
- University of Chile
Postoperative Complications, Memory Disorders
A Study to Determine if Carbon Dioxide Lavage During Total Knee Surgery Reduces Intraoperative Embolic Events
The purpose of this study is to determine if the use of a carbon dioxide lavage device (CarboJet) to clean bone surfaces during total knee surgery decreases intraoperative embolic events when compared with standard orthopedic…
- Trial name
- NCT00736125
- Testing
- pulsatile saline lavage, carbon dioxide lavage
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kinamed Incorporated
Post-Operative Pain
A Multicenter, Randomized, Open-Label, Parallel-Group Trial to Compare the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™)to Intravenous Patient-Controlled Analgesia With Morphine for the Treatment of Acute Post-Operative Pain
The study is intended to show that the Sufentanil NanoTab PCA System is as effective as morphine intravenous patient-controlled analgesia (IV PCA) for treating pain after surgery.
- Trial name
- NCT01539538
- Testing
- Sufentanil NanoTab PCA System/15 mcg, morphine IV PCA
- Where
- 16 sites in United States
- Volunteers
- 357 people
- Sponsor
- Talphera, Inc
Osteoarthrosis Knee Arthroplasty Analgesia Pain Management
Comparison Ultrasound-Guided Adductor Canal Block and Surgeon-Performed Block for Pain Management After Total Knee Arthroplasty
Objective: Adductor canal block (ACB) is widely performed for postoperative analgesia for total knee arthroplasty (TKA). The aim of this study is to compare surgeon-assisted and anesthesiologist-assisted (ultrasound-guided)…
- Trial name
- ACB (NCT06533085)
- Testing
- Adductor canal block by surgeon
- Where
- Turkey (Türkiye)
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Total Knee Arthroplasty
Single-injection Modified 4 in 1 Block as Postoperative Analgesia in Total Knee Arthroplasty
Patients suffer from moderate to severe pain after TKA. Patients are asked to begin functional exercise as early as possible after surgery, and that requires adequate control of postoperative pain.
- Trial name
- NCT05447871
- Testing
- Ultrasound guided single injection modified 4 in 1 block technique, Ultrasound guided adductor canal block technique, Bupivacaine 0.25%
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Mansoura University
Total Knee Replacement
Evaluation of Patellar Crepitus Following Total Knee Arthroplasty
Analyze clinical data for a group of subjects implanted with a new surgical device designed to reduce the incidence of patellar crepitus following PCL-substituting TKA and compare that to a control group of subjects implanted…
- Trial name
- NCT01340144
- Volunteers
- 1,250 people
- Sponsor
- Colorado Joint Replacement
Osteoarthritis, Knee
Functional Knee Phenotypes of Patients Operated on for Total Knee Arthroplasty
The aim of this study was to analyze the coronal alignment of a large population of patients undergoing total knee arthroplasty using a modern classification of the knee phenotypes found in a population of non-osteoarthritic…
- Trial name
- FP-Knee (NCT05380206)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
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