Clinical trials: Total Knee Arthroplasty
Total Knee Arthroplasty (TKA)
VRAS (Velys Robot-Assisted Solution) Operational Excellence Study
The aim of this study is to investigate the differences in process set-up, efficiency, OR team workload, instrument trays and OR financial performance when using the VRAS (Velys Robotic Assisted Solution) of DePuy Synthes…
- Trial name
- NCT06563843
- Testing
- Robotic-assisted TKA, Conventional TKA
- Where
- 10 sites in Austria, Belgium and 6 more
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- DEO NV
Postoperative Pain After Total Knee Arthroplasty
Agreement Between Patient-Reported Pain, Observer-Rated Pain Behavior, and Analgesic Request After Total Knee Arthroplasty
The goal of this observational study is to learn how well patients' own pain ratings match what an observer sees and whether the patient asks for extra pain medicine after total knee replacement surgery.
- Trial name
- NCT07891221
- Volunteers
- 120 people
- Sponsor
- Gamze Kübra Zelyurt
Total Knee Arthroplasty
Smartphone Video-Based AI Gait Analysis Reports to Support Remote Follow-up After Total Knee Arthroplasty
This study evaluates whether an artificial intelligence (AI)-assisted gait report generated from smartphone walking videos can support remote follow-up after total knee arthroplasty (TKA).
- Trial name
- NCT07892248
- Testing
- Smartphone Video-Based AI Gait Analysis, video recorded on a mobile phone (assessed by doctors)
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Total Knee Arthroplasty
Oral Tranexamic Acid After Total Knee Arthroplasty
This is a prospective, double-blind, randomized controlled trial evaluating the efficacy of oral tranexamic acid (TXA) in total knee arthroplasty (TKA).
- Trial name
- NCT06894719
- Testing
- tranexamic acid Oral-Short Arm, tranexamic acid Oral-Long Arm
- Volunteers
- 351 people
- Sponsor
- Rush University Medical Center
Total Knee Arthroplasty
Virtual Reality During Passive Motion After Knee Surgery
The purpose of this study is to investigate the effects of virtual reality on pain, anxiety, and comfort during continuous passive motion following total knee arthroplasty
- Trial name
- NCT07177573
- Testing
- Virtual Reality
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Manisa Celal Bayar University
Total Knee Arthroplasty
The Effect of Mind Mapping-Based Education on Postoperative Pain, Kinesiophobia, and Discharge Readiness in Patients Undergoing Total Knee Arthroplasty
Total knee arthroplasty is a surgical procedure used to relieve pain and improve function in patients with severe knee joint problems.
- Trial name
- NCT07885449
- Testing
- Mind Mapping-Based Education
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Inonu University
Total Knee Arthroplasty (Postoperative Pain)
Phase 2B Study Assessing Pain Relief After Replacement of the Knee
The goal of the ATX101-TKA-004 clinical trial aims to evaluate the efficacy and safety of ATX101 1,500 mg in participants undergoing primary unilateral total knee arthroplasty.
- Trial name
- SPARK2 (NCT06799845)
- Testing
- ATX101, bupivacaine hydrochloride
- Where
- 11 sites in United States
- Volunteers
- 226 people
- Sponsor
- Allay Therapeutics, Inc.
Total Knee Arthroplasty, Venous Thromboembolism
Comparison of DOACs and LMWH for Thromboprophylaxis After Total Knee Arthroplasty
Yes. For these two fields, I would enter the following in English, based on your study protocol. 1. Brief Summary Copy and paste: This study aims to compare three thromboprophylaxis regimens in adults undergoing primary total…
- Trial name
- DOLOTHROK (NCT07869615)
- Testing
- Apixaban, Rivaroxaban, Enoxaparin (LMWH)
- Where
- Tunisia
- Volunteers
- 138 people
- Sponsor
- Military Hospital of Tunis
Knee Osteoarthritis, Total Knee Arthroplasty
Improvement of Total Knee Arthroplasty Effectiveness Using Preoperative Prehabilitation
Total knee arthroplasty (TKA) is the most effective treatment for stage III-IV knee osteoarthritis (OA). However, up to 30% of patients remain dissatisfied due to periarticular functional insufficiency, pain, and movement…
- Trial name
- TKA-PREHAB (NCT07790146)
- Testing
- Multimodal phenotype-based prehabilitation
- Where
- Russia
- Volunteers
- 64 people
- Sponsor
- Samara State Medical University
Total Knee Arthroplasty Recovery, Knee Osteoarthritis
Wearable Knee-Assisted Rehabilitation for Range of Motion and Muscle Strength After Total Knee Arthroplasty
This randomized controlled trial evaluates a wearable electrogoniometry-based telerehabilitation system designed to support recovery after total knee arthroplasty.
- Trial name
- NCT07875725
- Testing
- ReBK Wearable Telerehabilitation System, Standard Home-Based Rehabilitation
- Where
- 3 sites in Chile
- Volunteers
- 80 people
- Sponsor
- University of Chile
Knee Osteoarthritis, Total Knee Arthroplasty
Effect of AI-Assisted Anatomical Visualization on Anxiety and Kinesiophobia in Knee Arthroplasty Patients
Total knee arthroplasty (TDA) is an effective surgical method applied to reduce pain, improve joint function, and enhance quality of life in patients with advanced osteoarthritis or joint degeneration.
- Trial name
- AI-KNEE (NCT07545447)
- Testing
- Standard Clinical Education, Video-Supported Education, AI-Assisted Anatomical Visualization Training
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Munzur University
Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\)
Suzetrigine in TKA
Total knee replacements are among the most common and painful orthopedic procedures performed worldwide, often requiring intensive analgesia to support early ambulation and recovery.
- Conditions
- Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\), Total Knee Replacement, Total Knee Replacement Surgery
- Trial name
- NCT07864896
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Total Knee Arthroplasty
Improving Rehabilitation for Veterans After Total Knee Arthroplasty Using Individualized Recovery Trajectories
This study will examine the impact of a new clinical decision support tool for rehabilitation after total knee arthroplasty (TKA).
- Trial name
- NCT05288803
- Testing
- Clinical decision support tool (CDS tool)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development
Revision Total Hip Arthroplasty (RTHA), Revision Total Knee Arthroplasty
CLinical Evaluation of ANtiseptic Skin Preparation in Revision Total Joint Arthroplasty of the Hip and Knee
The goal of this clinical trial is to compare two types of skin preparation solutions (chlorhexidine gluconate-alcohol solution and povidone-iodine solution) that help eliminate harmful bacteria on the skin at the time of surgery…
- Trial name
- CLEANJoint (NCT05828810)
- Testing
- Chlorhexidne Gluconate-Alcohol Skin Preparation, Poviodine-iodine Skin Preparation
- Where
- 3 sites in Canada
- Volunteers
- 400 people
- Sponsor
- Sunnybrook Health Sciences Centre
Total Knee Arthroplasty
Personalized Information Before and After Total Knee Arthroplasty: PAK-study
Despite positive results following total knee arthroplasty (TKA), some patients are dissatisfied after recovery. Unfulfilled expectations is a key predictor of dissatisfaction.
- Trial name
- PAK (NCT05266482)
- Testing
- Personal report
- Where
- Netherlands
- Volunteers
- 461 people
- Sponsor
- Kliniek ViaSana
Total Knee Arthroplasty, Postmenopausal Women
Balance, Fall Risk, and Gait in Women With Total Knee Arthroplasty
Total knee arthroplasty (TKA) is a commonly performed surgical procedure aimed at reducing pain, restoring joint function, and improving quality of life, particularly among older women.
- Conditions
- Total Knee Arthroplasty, Postmenopausal Women, Quality of Life (QOL), Balance
- Trial name
- NCT07650175
- Testing
- TKA group
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Knee Osteoarthritis, Postoperative Pain Management
Effect of iPACK and BiFeS Blocks on Quality of Recovery After Total Knee Arthroplasty
This prospective, randomized, double-blind clinical trial aims to compare the effects of two different posterior knee analgesia techniques-iPACK block (Interspace Between the Popliteal Artery and the Capsule of the posterior…
- Conditions
- Knee Osteoarthritis, Postoperative Pain Management, Total Knee Arthroplasty
- Trial name
- BiFeS-TKA (NCT07248072)
- Testing
- Adductor Canal Block (ACB) Only, IPACK block, BiFeS Block
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Ataturk University
Pain After Total Knee Arthroplasty, Pain Management
Combined Distal Femoral Nerve Block for Pain Control After Knee Replacement
The goal of this clinical trial is to see whether a combined distal femoral nerve block improves pain relief after total knee replacement in adults having planned surgery.
- Trial name
- FEM-COMB (NCT07629388)
- Testing
- Combined distal femoral nerve block, Saphenous nerve block alone, Standard perioperative care in both groups
- Where
- France
- Volunteers
- 240 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Osteoarthitis, Knee Arthroplasty, Total
The Effect of Mindfulness Therapy on Anxiety, Pain, and Sleep Quality in Patients Undergoing Knee Arthroplasty Surgery: A Randomized Controlled Trial
This study was conducted as a randomized controlled trial to determine the effect of mindfulness therapy on anxiety, pain, and sleep quality in patients undergoing total knee arthroplasty surgery.
- Conditions
- Osteoarthitis, Knee Arthroplasty, Total, Postoperative Pain
- Trial name
- NCT07857876
- Testing
- Mindfulness Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Saglik Bilimleri Universitesi
Osteoarthritis, Unicompartmental Knee Arthroplasty
Post-op Prednisone and Glucose Monitoring in TKA
This study compares the efficacy of a 5-day post-operative oral prednisone regimen (40 mg daily) with the standard intraoperative steroid regimen, focusing on pain, swelling, range of motion, opioid use, and glucose levels…
- Conditions
- Osteoarthritis, Unicompartmental Knee Arthroplasty, Total Hip Arthroplasty (THA)
- Trial name
- NCT07630896
- Testing
- Prednisone, Continuous Glucose Monitor, InkWell Health Tattoos
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Columbia University