Clinical trials: Tooth Erosion
Non-carious Cervical Lesions
Evaluation of Double Layer Application Using a Universal Adhesive in the Quality of Cervical Lesions Restorations
The aim of this study will be to evaluate the effect of a double layer application of a universal adhesive system used as etch-and-rinse application mode in non-carious cervical lesions (NCCLs), on the 6- and 12-months clinical…
- Trial name
- NCT06474494
- Testing
- Application of one layer, Application of double layer, Etch-and-rinse application mode
- Where
- Chile
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Tooth Erosion
In Situ Erosion Study to Investigate the Effectiveness of an Experimental Toothpaste
This will be a randomized, controlled, single center, single- blind, 3 period, 3 treatment, cross-over, in situ design which consists of placing pre-eroded bovine enamel specimens intra orally using a palatal appliance and…
- Trial name
- NCT03296072
- Testing
- 0.254% w/w sodium fluoride and 5% KNO3, 0.454% w/w stannous fluoride, 5% KNO3
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Erosion
Dental Erosion in Patients With Gastro-oesophageal Reflux
Not only caries but also exposure to acids can lead to loss of tooth structure. This acid-related tooth structure loss is defined as dental erosion.
- Trial name
- NCT02775149
- Testing
- Collection of saliva samples, Visual detection of BEWE-index
- Volunteers
- 30 people
- Sponsor
- University of Göttingen
Obesity, Dental Erosion
Salivary Function and Dental Changes During GLP-1 Therapy
People who use glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide and tirzepatide, may experience changes in their oral health.
- Conditions
- Obesity, Dental Erosion, Saliva Collection, Saliva Altered
- Trial name
- NCT07720466
- Testing
- Unstimulated Whole Saliva Collection, Salivary Analysis, Oral Examination and BEWE Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bilecik Seyh Edebali Universitesi
Gastroesophageal Reflux, Dental Erosion
Relationship and Pathophysiology of Gastroesophageal Reflux and Dental/Periodontal Disease
This study investigates the prevalence and pathophysiology of dental and periodontal involvement in pediatric patients with symptomatic or asymptomatic gastroesophageal reflux (GER) or gastroesophageal reflux disease (GERD).
- Trial name
- NCT01167543
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Obesity, Water; Lack of
Preventing Early Childhood Obesity, Part 1: Family Spirit Nurture, 3-9 Months
This study aims to assess the impact of a brief home-visiting module, called "Family Spirit Nurture" (FSN), on American Indian (AI) parent feeding practices associated with increased risk for early childhood obesity, with a…
- Conditions
- Obesity, Water; Lack of, Breast Feeding, Tooth Erosion
- Trial name
- NCT03101943
- Testing
- Family Spirit Nurture (FSN), Control Program, Water Delivery
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Non-carious Cervical Lesions
Evaluation of the Solvent Evaporation Time of Universal Adhesives in the Quality of Cervical Lesions Restorations
The aim of this study will be to evaluate the effect of prolonging solvent evaporation time on the 6- and 12-months clinical performance of two universal adhesive systems used as selective enamel etch (SEE).
- Trial name
- NCT05945173
- Testing
- Evaporation time for 5 seconds, Evaporation time for 25 seconds, alcohol/water-based universal adhesive
- Where
- Chile
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Dentin Hypersensitivity, Erosive Tooth Wear
Multi-site Study to Look at Tooth Wear and Tooth Sensitivity and the Risk Factors Associated.
The goal of this observational study is to learn about tooth wear and tooth sensistivity and reasons for these conditions in five locations throughout the United States.
- Trial name
- NCT07195357
- Testing
- epidemiological
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- Indiana University
Dentine Hypersensitivity, Tooth Erosion
The Effects of Mouthguard and Desensitizing Toothpaste in Reducing Dental Hypersensitivity
Tooth hypersensitivity due to dental erosion is one of the most common problem related to swimming in improper pH chlorinated pools.
- Trial name
- NCT03515902
- Testing
- mouthguard, mouthguard with desensitizing toothpaste
- Where
- Thailand
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Dental Erosion
12 Months Clinical Follow-up of Non-Carious Cervical Lesions Restored With New Injectable Composite
Non-carious cervical lesions are defined as loss of pathological material not associated with caries in the enamel-cement junction of the tooth.
- Trial name
- NCT04095520
- Testing
- Laser Etching, Phosphoric acid etching
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Dental Erosion, Acid Wear
Evaluation of Efficacy of Experimental Gel to Foam Dentifrices in Dental Erosion
The purpose of this study is to compare and evaluate the ability of two European Union (EU) regulated gel to foam toothpaste formulations versus a non-fluoride toothpaste using a modified in-situ model of dental erosion and…
- Trial name
- NCT01657903
- Testing
- Sodium Fluoride, Potassium nitrate
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Esophagogastric Cancer
A Study of Tooth Erosion in People With Esophagogastric Cancer
The researchers are doing this study to find out more about what may lead to the loss of tooth enamel (the thin outer covering of the tooth) and how often it happens in people with esophagogastric cancer, colorectal cancer…
- Trial name
- NCT05612048
- Testing
- Survey, Intra-oral camera, Optional Salvia sample
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Tooth Erosion, Tooth Wear
Association Between Erosive Tooth Wear Progression and Dietary Risk Factors.
Study to determine if whether or not exist an association between the tissue loss (ETW progression) and the frequency of an acidic diet.
- Conditions
- Tooth Erosion, Tooth Wear, Erosion, Dental Erosion
- Trial name
- NCT04586322
- Testing
- No intervention, (observational study).
- Where
- Belgium
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University Ghent
Tooth Erosion
In Vivo Investigation of Initial Stages of Enamel Erosion
This exploratory study is designed to help develop a clinical model to measure the earlier stages of dietary acid medicated enamel loss. The study will use fluoride as positive control to explore the validity of this design.
- Trial name
- NCT02533466
- Testing
- Sodium fluoride + potassium nitrate, Potassium nitrate
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Non-carious Cervical Lesions
Effect of Wet and Overwet Dentin on the Clinical Performance of Two Universal Adhesive Systems
The aim of this study will be to evaluate the effect of wet and overwet dentin on the long-term clinical performance of two universal adhesive systems used as etch-and-rinse application mode in non-carious cervical lesions…
- Trial name
- NCT07034235
- Testing
- Dentin Wet, Dentin Overwet, Ambar Universal APS Plus; FGM
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Obesity, Obesity, Childhood
Associations Between Obesity, Dental Caries, Erosive Tooth Wear and Periodontal Disease in Adolescents: A Case Control-study
Objectives To compare oral health (dental caries, periodontal status, and erosive tooth wear (ETW)), diet and oral hygiene habits between obese and normal weight adolescents, and to explore possible risk associations.
- Conditions
- Obesity, Obesity, Childhood, Tooth Wear, Tooth Erosion
- Trial name
- NCT05146557
- Testing
- Dental examination
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University Ghent
Dental Erosion
The Effect of Nitrate Supplement on the Oral Microbiome and Saliva in Dental Erosion
Dental erosion happens when teeth lose some of their parts because of acid from the things people eat and/or drink or even from their stomach. It can make their teeth hurt and become sensitive.
- Trial name
- NCT06156618
- Testing
- Nitrate
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Dentine Hypersensitivity
Meta-analysis of Stannous Fluoride Dentifrice and the Effects on Dentine Hypersensitivity
The aim of this 11 study analysis was to compare the effect of bioavailable stannous fluoride (SnF2) on dentine hypersensitivity versus a positive or negative control dentifrice.
- Trial name
- NCT04005417
- Testing
- Stannous fluoride dentifrice, Positive control dentifrice, Negative control dentifrice
- Where
- United States
- Volunteers
- 1,036 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Tooth Erosion
Investigate a Varnish to Protect From Erosive Toothwear
This in-situ study will investigate on extracted teeth the protection of a re-formulated varnish containing fluoride in the same concentration as an existing approved varnish used to treat caries and erosion.
- Trial name
- NCT06136754
- Testing
- Varnishes, Fluoride
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Erosion, Erosive Tooth Wear
Quantitative In Vivo Monitoring of Early Erosion-Associated Enamel Optical Changes Using Swept-Source Optical Coherence Tomography.
This study aims to evaluate the ability of swept-source optical coherence tomography (SS-OCT) to detect early enamel optical changes associated with erosive tooth wear under clinically relevant in vivo conditions.
- Trial name
- NCT07690644
- Testing
- Swept-Source Optical Coherence Tomography (SS-OCT), Orange Juice Erosive Challenge, Sugar-Free Chewing Gum Stimulation
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Malaya