Clinical trials: Tooth Disease
Caries,Dental
Clinical Trial Proximal Caries Infiltration and Detection
The purpose of this study is to investigate the clinical efficacy of resin infiltration (Icon, DMG, Germany) compared to fluoride varnish (Duraphat Fluoride Varnish, Colgate, USA) in the management of proximal early caries…
- Trial name
- NCT01796106
- Testing
- Resin infiltration, Fluoride varnish & Oral hygiene instruction
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- DMG Dental Material Gesellschaft mbH
Dentine Hypersensitivity
The Efficacy of a Dentifrice in Providing Relief From the Pain of Dentinal Hypersensitivity
A study to compare the efficacy of a test dentifrice against a control dentifrice in reducing dentinal hypersensitivity over an eight week treatment period.
- Trial name
- NCT01592864
- Testing
- Stannous Fluoride, Sodium Monofluorophosphate
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentin Sensitivity
A Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity
This study is for people with sensitive teeth and involves going to the dentist for 4 visits over 6 weeks. At each visit the dentist will look at the mouth, teeth, tongue and gums of subjects, and check for sensitive teeth.
- Trial name
- NCT01727258
- Testing
- Mouth Rinse, Fluoride Toothpaste, Potassium Nitrate Toothpaste
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Post-surgical Dental Pain
Post-operative Dental Pain Study Comparing Two Different Dosage of Analgesic Efficacy
GlaxoSmithKline will be conducting this trial to compare analgesic efficacy of paracetamol 1000 mg vs 650 mg. The post-surgical dental pain model will be used to evaluate the analgesic efficacy of paracetamol.
- Trial name
- NCT01075243
- Testing
- Paracetamol 1000 mg, Paracetamol 650 mg
- Where
- United States
- Volunteers
- 401 people
- Sponsor
- GlaxoSmithKline
Jaw, Edentulous, Jaw, Edentulous, Partially
Comparison of Synthetic Bone Substitute and a Bovine-derived Xenograft in Horizontal Bone Augmentation
The objective of the study is to test the efficacy on bone formation of Straumann Bone Ceramic as a grafting material applied in buccal bone dehiscences on simultaneously placed oral implants.
- Trial name
- NCT00901017
- Testing
- Straumann BoneCeramic, Bio-Oss
- Where
- Belgium
- Volunteers
- 14 people
- Sponsor
- Institut Straumann AG
Dental Plaque
Efficacy of Three Experimental Toothpastes to Remove Plaque
The Dose response of three experimental toothpastes (test product 1, test product 2 and test product 3) to remove plaque after a single brushing, compared to a positive control and negative control dentifrice will be evaluated.
- Trial name
- NCT02992691
- Testing
- 20% w/w sodium bicarbonate, 35% w/w sodium bicarbonate, 50% w/w sodium bicarbonate
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Erosion, Acid Wear
Evaluation of Efficacy of Experimental Gel to Foam Dentifrices in Dental Erosion
The purpose of this study is to compare and evaluate the ability of two European Union (EU) regulated gel to foam toothpaste formulations versus a non-fluoride toothpaste using a modified in-situ model of dental erosion and…
- Trial name
- NCT01657903
- Testing
- Sodium Fluoride, Potassium nitrate
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Jaw, Edentulous
Study on ASTRA TECH Implant System, OsseoSpeed™ Implants in Patients Missing All Teeth in the Upper Jaw, Restored With Provisional Teeth Within 24 Hours
The purpose of the study is to evaluate ASTRA TECH Implant System, OsseoSpeed™ implants, in patients with totally edentulous upper jaws and poor bone quality and quantity, when provisional artificial teeth are attached within 24…
- Trial name
- NCT00711022
- Testing
- ASTRA TECH Implant System, OsseoSpeed™, all dimensions.
- Where
- 2 sites in United States, Sweden
- Volunteers
- 51 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Dentine Hypersensitivity
The Efficacy of a Dentifrice in Providing Relief From Immediate and Short Term Relief From Dentinal Hypersensitivity
A randomised, examiner blind, two treatment arm, stratified, parallel design, single-site study in subjects with at least two sensitive teeth to compare the efficacy of a test dentifrice against that of a control dentifrice in…
- Trial name
- NCT03072719
- Testing
- Stannous Fluoride, Sodium Monofluorophosphate
- Where
- Ireland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentin Sensitivity
Clinical Study to Evaluate the Anti-sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers
The aim of this study is to confirm the clinical Dentin Hypersensitivity (DH) efficacy of a 0.454 percent (%) Stannous Fluoride (SnF2) toothpaste.
- Trial name
- NCT06359028
- Testing
- Stannous fluoride toothpaste, Crest cavity protection toothpaste
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- HALEON
Pain
Naproxen Sodium/Acetaminophen Proof of Concept Dosing Study
Study assessing efficacy and safety of concomitantly dosed naproxen sodium with acetaminophen, compared with naproxen sodium, hydrocodone/acetaminophen and Placebo in a postoperative dental pain.
- Trial name
- NCT03879408
- Testing
- 440 mg naproxen sodium with 1000 mg acetaminophen, 220 mg naproxen sodium with 650 mg acetaminophen, 10 mg hydrocodone + 650 mg acetaminophen
- Where
- United States
- Volunteers
- 290 people
- Sponsor
- Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division
Dental Caries
A Clinical Study to Evaluate Experimental Children's Toothpastes in an In-Situ Caries Model
An in situ model will be used to evaluate and compare enamel remineralization of human enamel specimens after single use of experimental children's toothpastes.
- Trial name
- NCT01607411
- Testing
- Fluoride
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentin Sensitivity
A Study in Dentinal Hypersensitivity (DH) Participants to Assess the Efficacy of an Occluding Dentifrice.
This study will investigate the longitudinal efficacy of two experimental oral rinses, one containing 1.5% weight/weight (w/w) dipotassium oxalate monohydride (KOX) /0 Parts per Million (ppm fluoride) and the other 2.0% w/w KOX…
- Trial name
- NCT02753075
- Testing
- Experimental Oral Rinse 1, Experimental Oral Rinse 2, Fluoride toothpaste
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentin Sensitivity
Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity
This study is for people with sensitive teeth and involves going to the dentist for 4 visits over 6 weeks. At each visit the dentist will look at the mouth, teeth, tongue and gums of participants, and check for sensitive teeth.
- Trial name
- NCT02113579
- Testing
- Experimental Mouth Rinse 12027-033
- Where
- 2 sites in United States
- Volunteers
- 375 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Jaw, Edentulous
A Study to Treat Patients With Edentulous Mandibles With Two Straumann 3.3mm Diameter Bone Level Implants
The purpose of this study is to assess the change of crestal bone level at the Titanium Zirconium (TiZr) compared to Titanium (grade IV) implant between surgery and 6, 12, 24, and 36 month post surgery.
- Trial name
- NCT00905840
- Testing
- Titanium Zircon implant, Titanium Grade IV implant
- Where
- 8 sites in Belgium, Germany and 3 more
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Institut Straumann AG
Pain
Acetaminophen/Naproxen Sodium Dose Ranging Study
Study assessing the relative efficacy of five strengths of a fixed combination of acetaminophen and naproxen sodium is being investigated to help inform selection of dose(s) for further development and to evaluate the safety of a…
- Trial name
- NCT04447040
- Testing
- Acetaminophen/naproxen sodium Dose A, Acetaminophen/naproxen sodium Dose B, Acetaminophen/naproxen sodium Dose C
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division
Dental Caries
Stopping Cavities Study: Diammine Silver Fluoride
This study is being conducted to test whether the use of diammine silver fluoride (also called silver diamine fluoride) hardens the cavity sufficiently so that it arrests.
- Trial name
- NCT02536040
- Testing
- 38% diammine silver fluoride, Water
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Advantage Dental Services, LLC
Jaw, Edentulous, Partially
Clinical Study Comparing Submerged Versus Trans-mucosal Healing of P.004 Implants in the Anterior Mandible and Maxilla
The purpose of this study is To demonstrate that there is no difference in change in bone level around P.004 implants between 1st stage surgery and 6 months post surgery when transmucosal implant placement is compared to…
- Trial name
- NCT00906425
- Testing
- Straumann Bone Level Implant
- Where
- 11 sites in United States, Australia and 5 more
- Volunteers
- 145 people
- Sponsor
- Institut Straumann AG
Partial Edentulism, Tooth Disease
A Study of Certain Prevail Implants Used for the Preservation of Crestal Bone in Short Fixed Bridge Cases.
This prospective, randomized study will evaluate the performance of the Osseotite Certain Prevail implant when compared to that of the non-lateralized version of the implant.
- Trial name
- Cliffhanger (NCT00728754)
- Testing
- Dental implant Osseotite Prevail, Dental implant Osseotite
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- ZimVie
Dental Caries
Evaluation of Plaque Fluid Fluoride Retention From Fluoride Toothpastes
The purpose of this study is to investigate the efficacy of different sodium fluoride (NaF) containing toothpastes in prevention of dental caries.
- Trial name
- NCT00708305
- Testing
- Sodium Fluoride (NaF)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline