Clinical trials: Thrombectomy
Ischemic Stroke
Total Posterior-circulation Infarct Volume in Basilar Artery Stroke
Preprocedural predictors of outcome in patients with acute basilar artery occlusion (ABAO) who underwent endovascular treatment (EVT) remain controversial.
- Trial name
- TPCIV-ABAO (NCT04650022)
- Testing
- Mechanical thrombectomy
- Where
- France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Montpellier
Ischemic Stroke, Acute Disease
Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy (ALLY) II Trial
The study objective is to evaluate the safety and efficacy of Intra arterial (IA) Tenecteplase (TNK) as an adjunctive therapy in acute ischemic stroke (AIS) patients with large vessel occlusions (LVO) in the anterior circulation…
- Trial name
- ALLY II TNK (NCT06949228)
- Testing
- tenecteplase
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- ProMedica Health System
Stroke, Hemorrhage
Cone Beam Computed Tomography Following Thrombectomy
Cerebral haemorrhages following reperfusion treatments involve not only rupture of the blood-brain barrier, but also direct damage to vessels related to the equipment used and secondary toxicity to thrombolytics.
- Trial name
- Hemathromb (NCT03869567)
- Testing
- cone beam CT
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Stroke, Acute, Cerebrovascular Disorders
Therapy Evaluation in Patients With Minor Stroke and Large Vessel Occlusion
This multicenter registry study, which record the therapy strategy and follows up these acute ischemic stroke (AIS) patients with low NIHSS and large vessel occlusion (LVO), is intended to provide the important data for therapy…
- Conditions
- Stroke, Acute, Cerebrovascular Disorders, Brain Diseases, Central Nervous System Diseases
- Trial name
- TEMPOS (NCT06633809)
- Testing
- Immediate endovascular therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sir Run Run Shaw Hospital
Ischemic Stroke
Selection Criteria in Endovascular Thrombectomy and Thrombolytic Therapy (SECRET) Study: Development of Patient Selection Criteria Using CT Images and Accompanying Diseases for Efficient Intravenous Thrombolytic and Intra-arterial Recanalization Therapy in Acute Ischemic Stroke
Use of intravenous (IV) thrombolysis and intra-arterial (IA) recanalization treatment has been rapidly increasing, However, despite of the treatment, recanalization rates are 22.6 - 70% and only 30-50% of patients show meaningful…
- Trial name
- NCT02964052
- Testing
- Brain CT imaging
- Where
- South Korea
- Volunteers
- 1,359 people
- Sponsor
- Yonsei University
Ischemic Stroke
A Study to Monitor Safety and Effectiveness of Approved J&J MedTech Devices in the Treatment of Participants With Ischemic Stroke
The purpose of this study is to collect medical information to monitor the ongoing safety of the J\&J MedTech devices and to understand how well they work when routinely used to treat participants with acute ischemic stroke (a…
- Trial name
- POSEIDON (NCT07760649)
- Volunteers
- 5,000 people
- Sponsor
- Neuravi Limited
Ischemic Stroke
Boosting REcanalization of Thrombectomy for Ischemic Stroke by Intra-arterial TNK (BRETIS-TNK)
Thrombolysis and endovascular thrombectomy are the most efficient treatments for acute ischemic stroke patients in time window. However, sufficient recanalization (mTICI2b-3) can 't be acquired in all patients under thrombectomy.
- Trial name
- NCT04202458
- Testing
- intra-arterial tenecteplase administration
- Where
- China
- Volunteers
- 30 people
- Sponsor
- General Hospital of Shenyang Military Region
Acute Ischemic Stroke
Methylprednisolone With Endovascular Thrombectomy for Large Ischemic Stroke
It is uncertain whether intravenous methylprednisolone improves outcomes for acute anterior circulation large vascular occlusion (LVO) patients with a large infarct core.
- Trial name
- MATCH (NCT06870448)
- Testing
- Methyprednisolone sodium succinate
- Where
- China
- Volunteers
- 1,614 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Stroke, Ischemic, Thrombectomy
Prognostic Value of Isolated and Combined Score Aspects in Acute Ischemic Stroke
This study, called TARGET-ASPECT, looks at patients who had a type of stroke called acute ischemic stroke and were treated with clot-busting medicine and a procedure to remove the clot.
- Conditions
- Stroke, Ischemic, Thrombectomy, Thrombolytic Therapy, Brain Ischemia
- Trial name
- NCT07069452
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Centre Hospitalier de Gonesse
Stroke, Ischemic
Randomization of Endovascular Treatment in Acute Ischemic Stroke in the Extended Time Window
A phase III, randomized, multi-center, open label clinical trial that will examine whether endovascular treatment is superior to standard medical therapy alone in patients who suffer a large vessel anterior circulation ischemic…
- Trial name
- RESILIENTExt (NCT04256096)
- Testing
- Thrombectomy
- Where
- 14 sites in Brazil
- Volunteers
- 376 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Stroke, Neuroprotection
Regional Hypothermia in Combination With Endovascular Thrombectomy in Acute Ischemic Stroke
The investigators have previous shown that regional hypothermia by the intra-arterial infusion of cold saline combined with mechanical thrombectomy in acute ischemic stroke is feasible and safe.
- Conditions
- Stroke, Neuroprotection, Hypothermia
- Trial name
- RE-HIBER (NCT04554797)
- Testing
- Regional Hypothermia
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Ischemic Stroke
Bridging Thrombolysis Versus Direct Mechanical Thrombectomy in Acute Ischemic Stroke
Intravenous thrombolysis with recombinant tissue-type plasminogen activator (IV t-PA) has been the only proven therapy for acute ischemic stroke (AIS) for almost 20 years.
- Trial name
- SWIFT DIRECT (NCT03192332)
- Testing
- Stent-retriever thrombectomy with revascularization device of the Solitaire™ type, Intravenous thrombolysis with recombinant tissue-type plasminogen activator (IV t-PA)
- Where
- 48 sites in Austria, Canada and 6 more
- Volunteers
- 410 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Ischemic Stroke
Permanent Intracranial Stenting for Acute Ischemic Stroke Related to a Refractory Large Vessel Occlusion
Clot extraction failure during mechanical thrombectomy is a major concern in the management of acute ischemic stroke related to large vessel occlusions.
- Trial name
- PISTAR (NCT06071091)
- Testing
- Intracranial stenting, Optimal medical care, without additional endovascular procedures
- Where
- 13 sites in France
- Volunteers
- 346 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke, Acute
Delay AvoIding Primary Evaluation for ThRombectomy of Acute StrokE Patients With Large Vessel OCclusion in the Angiography SuiTe
The purpose of this study is to compare two strategies for treating adults with suspected large vessel occlusion stroke within 7 hours of symptom onset.
- Trial name
- DIRECT (NCT06825897)
- Testing
- Conventional Triage for Mechanical Thrombectomy, Direct Transfer to Angiography Suite (DTAS
- Where
- 15 sites in United States
- Volunteers
- 2,039 people
- Sponsor
- Santiago Ortega Gutierrez
Peripheral Vascular Diseases, Thrombosis
A Prospective Observational Registry of Peripheral Use of AngioJet Rheolytic Thrombectomy With Mid-Length Catheters
This registry collects observational data about how mid-length AngioJet catheters (ie XPEEDIOR and DVX models) are used in routine clinical practice.
- Conditions
- Peripheral Vascular Diseases, Thrombosis, Venous Thrombosis
- Trial name
- NCT00778336
- Volunteers
- 452 people
- Sponsor
- Boston Scientific Corporation
Dialysis Access Malfunction, Dialysis; Complications
Balloon Assisted Maceration Versus Rotational Thrombectomy in Dialysis Access Salvage
The purpose of this research study is to compare how well a wire like device disrupts and removes blood clot in your blocked dialysis graft/fistula in comparison to inflating a balloon in your access for the same purpose.
- Trial name
- BART (NCT05782062)
- Testing
- Cleaner XT, Balloon
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Acute Ischemic Stroke
Feasibility Study of RapidPulseTM Aspiration System as Frontline Approach for Patients With Acute Ischemic Stroke
A feasibility study to evaluate the initial safety and performance of the RapidPulseTM Aspiration System in the treatment of patients with Acute Ischemic Stroke (AIS) due to Large Vessel Occlusion (LVO) in the intracranial ICA…
- Trial name
- PULSE-F (NCT05577351)
- Testing
- RapidPulseTM Aspiration System
- Where
- 2 sites in Georgia
- Volunteers
- 5 people
- Sponsor
- RapidPulse, Inc
PE - Pulmonary Embolism, PE - Pulmonary Thromboembolism
FlowTriever for Acute Massive Pulmonary Embolism (FLAME)
To evaluate treatment outcomes of patients diagnosed with high-risk (massive) pulmonary embolism
- Trial name
- FLAME (NCT04795167)
- Where
- 11 sites in United States
- Volunteers
- 115 people
- Sponsor
- Inari Medical
Cerebrovascular Disorders, Acute Cerebrovascular Disease
Inhaled Nitric Oxide in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy
The purpose of this study is to determine the safety and feasibility of using inhaled nitric oxide (iNO) in patients undergoing intra-arterial mechanical thrombectomy (blood clot extraction or IAMT) for treatment of acute…
- Trial name
- iNO (NCT05871606)
- Testing
- iNO
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Wake Forest University Health Sciences
Time, Benefit of in Situ Simulation for This Kind of Training
Formation of Health Professionals Through in Situ Simulation to Improve Performances During the Initial Step of Thrombectomy for Ischemic Strokes
The thrombectomy is an emergency care provided as soon as possible to selected patients suffering from ischemic strokes. Many steps are necessary to prepare this specialized procedure of interventional neuroradiology, including…
- Conditions
- Time, Benefit of in Situ Simulation for This Kind of Training, Installation of the Patient Until the Percutaneous
- Trial name
- OPTISS (NCT03738371)
- Testing
- In situ simulation
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon