Clinical trials: Teeth Loss
Tooth Loss, Tooth Diseases
Autogenous Tooth Transplantation With Instrumentally Simulated Open Apex and Platelet-Rich Fibrin
Autogenous tooth transplantation (autotransplantation) represents a biologically valid alternative to implant therapy, particularly in young patients where implant placement is contraindicated due to ongoing skeletal growth.
- Conditions
- Tooth Loss, Tooth Diseases, Reimplant; Complications
- Trial name
- OpenApexT (NCT07393997)
- Testing
- Autogenous Tooth Transplantation, Alveolar Prf graft
- Where
- Italy
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Bari Aldo Moro
Alveolar Ridge Atrophy, Tooth Loss
Alveolar Ridge Splitting With Simvastatin/PRF Composite and Simultaneous Implant Placement
This randomized controlled clinical trial evaluated the effectiveness of platelet-rich fibrin (PRF) and a simvastatin/PRF composite combined with a xenogeneic bone graft during alveolar ridge splitting with simultaneous implant…
- Trial name
- ARS-SIMV (NCT07692620)
- Testing
- Alveolar Ridge Splitting with Simultaneous Implant Placement, Xenogeneic Bone Graft, Platelet-Rich Fibrin (PRF)
- Where
- Egypt
- Volunteers
- 21 people
- Sponsor
- Maruwan Ali Alteer
Alveolar Bone Loss, Tooth Loss
Changes of Soft and Hard Tissues After Alveolar Ridge Preservation: Freeze-dried Bone Allograft vs. L-PRF Clot
A Clinical Trial to study the effectiveness between two, tooth socket grafting materials namely, Freeze Dried Bone Allograft (human derived bone particles) and Leukocytic-Platelet Rich Fibrin (the patient's own centrifuged…
- Trial name
- NCT03331185
- Testing
- Freeze Dried Bone Allograft, L-PRF clot
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Dehiscence, Tooth Extraction
Effect of Collagen Membrane on Ridge Preservation
This study will evaluate whether adding a resorbable collagen membrane to an anorganic bone-collagen composite (ABCC) graft improves ridge preservation after tooth extraction.
- Conditions
- Dehiscence, Tooth Extraction, Alveolar Bone Loss
- Trial name
- NCT07580495
- Testing
- Minimally Invasive tooth extraction, Alveolar ridge preservation with ABCC, Resorbable collagen membrane (InterCollagen® Guide)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Debora Dias
Tooth Loss
A Clinical Study of the TSX Dental Implant System (Xpresso)
A prospective, observational, multicenter study where 62 patients needing implants in the maxilla or mandible will be enrolled. The patients will be restored with a final prosthesis no later than 4 months following implant…
- Trial name
- Xpresso (NCT06571812)
- Testing
- TSX
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- ZimVie
Maxillofacial Bone Defects, Alveolar Bone Atrophy
Gene-activated Matrix for Bone Tissue Repair in Maxillofacial Surgery
The purpose of this study is to evaluate safety and efficacy of gene-activated matrix ("Nucleostim") for regeneration of bone tissue in maxillofacial area.
- Conditions
- Maxillofacial Bone Defects, Alveolar Bone Atrophy, Jaw Fractures, Maxillofacial Bone Deformities
- Trial name
- NCT02293031
- Testing
- Gene-activated matrix "Nucleostim"
- Where
- 2 sites in Russia
- Volunteers
- 12 people
- Sponsor
- NextGen Company Limited
Tooth Loss in the Esthetic Zone Requiring Immediate Implant Placement, Immediate Dental Implant Placement
Influence of Provisional Restoration Type on Outcomes of Immediate Implant Placement and Loading
A randomized clinical trial comparing 3D-printed resin and CAD/CAM-milled PMMA provisional restorations used for immediate loading of fully digitally guided immediate implants.
- Conditions
- Tooth Loss in the Esthetic Zone Requiring Immediate Implant Placement, Immediate Dental Implant Placement, Immediate Loading, Provisional Restoration
- Trial name
- PRODIGI (NCT07700771)
- Testing
- 3D-Printed Resin Provisional Crown, CAD/CAM-Milled PMMA Provisional Crown
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Tooth Loss, Surface Treatment
Photofunctionalization and Hyaluronic Acid for Posterior Maxillary Implants
This randomized clinical trial evaluates the effect of UV photofunctionalization and hyaluronic acid on dental implants placed in the posterior maxilla. Clinical and radiographic outcomes will be assessed during follow-up
- Conditions
- Tooth Loss, Surface Treatment, Delayed Implant, Implant Placement
- Trial name
- PHOTOHA (NCT07700732)
- Testing
- Delayed dental implant placement without photofunctionalization., Delayed dental Implant photofunctionalization before placement, Delayed dental Implant photofunctionalization and hyaluronic acid application before placement.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Premature Loss of Primary Molars, Space Maintenance
Space Changes After Premature Loss of Lower First Primary Molars in Children Using Digital Scanning
This prospective split-mouth clinical study aims to evaluate space changes in the mandibular dental arch following premature extraction of the lower first primary molar in children aged 3 to 5.5 years.
- Conditions
- Premature Loss of Primary Molars, Space Maintenance, Dental Arch Development, Pediatric Tooth Extraction
- Trial name
- NCT06965777
- Where
- Egypt
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Cairo University
Jaw, Edentulous, Partially
Bacterial Microleakage and Bone Loss in Internal Connection Dental Implants Based on the Type of Abutment Used in Zirconia Partial Fixed Prosthesis: in Vivo Study
This clinical trial aims to observe if there are differences in bacterial micro-filtration on interfaces and to evaluate if there are differences in the occurrence of peri-implant diseases and bone loss in fixed partial…
- Trial name
- NCT06156111
- Testing
- Transepithelial abutment group, Direct to implant group
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Dental Crowding, Alveolar Bone Loss
Bone Level Changes Using Clear Aligners Compared to Fixed Appliances in Non-Extraction Treatment of Adults
This study compares two common ways of straightening teeth in adults who have mild-to-moderate crowding of the lower front teeth and do not need any teeth removed: clear aligners and traditional fixed braces.
- Conditions
- Dental Crowding, Alveolar Bone Loss, Malocclusion
- Trial name
- NCT07716007
- Testing
- Fixed orthodontic appliance, Clear aligners
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Tooth Loss in the Anterior Maxilla, Partial Edentulism of the Maxilla
A Follow-Up Study of Straight and Tapered Dental Implants in the Front Upper Jaw
This prospective study aims to evaluate 5-year clinical, radiographic, and patient-reported outcomes of implant-supported crowns and bridges placed on Neoss implants (ProActive Straight and Tapered) in the anterior maxilla…
- Trial name
- NCT07544706
- Testing
- Neoss Implant System (ProActive Straight and Tapered)
- Where
- Sweden
- Volunteers
- 51 people
- Sponsor
- Branemarkkliniken
Tooth Movement
Alignment Efficiency and Coating Durability of Aesthetic Archwires
This study investigates the efficiency of orthodontic aesthetic archwires which are coated with tooth-colored materials and the durability of the coatings after being used.
- Trial name
- RCT (NCT03876184)
- Testing
- Aesthetic archwires, Control group
- Where
- 3 sites in Malaysia
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Substance Use Disorder (SUD), Decayed Teeth
Oral and Dental Health in Substance Dependent Individuals
The goal of this cross-sectional clinical study is to compare the oral health status of individuals with Methamphetamine (MA), Cannabis (THC), and Polysubstance (PSU) use disorders to healthy controls.
- Conditions
- Substance Use Disorder (SUD), Decayed Teeth, Teeth Loss, Teeth Missing
- Trial name
- ODH_SUD (NCT06640712)
- Testing
- Dental caries was assessed using the DMFT index (Decayed, Missing, and Filled Teeth) according to the World Health Organization's caries diagnostic criteria., Substance Use Disorder Diagnosis
- Where
- Turkey (Türkiye)
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Alveolar Bone Loss
Treatment of Alveolar Bone Defects Using Aastrom Biosciences Autologous Tissue Repair Cell Therapy
The purpose of this research is to determine if a subject's own bone marrow tissue can help regenerate bone in the area of his/her jaw where a tooth has been removed using Tissue Repair Cell (TRC) Therapy.
- Trial name
- NCT00755911
- Testing
- Tissue Repair Cells (TRC), Control
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Michigan
Alveolar Bone Loss, Alveolar Ridge Resorption After Extraction
THBC/CGF for Alveolar Bone Regeneration: A Real-World Study
This study aims to combine real-world research with relevant bone repair materials and techniques to improve alveolar bone resorption in extraction sockets following impacted wisdom tooth removal, while achieving effective bone…
- Conditions
- Alveolar Bone Loss, Alveolar Ridge Resorption After Extraction, Tooth, Impacted
- Trial name
- NCT07779421
- Testing
- Temperature-sensitive hydroxybutyl chitosan-loaded concentrated growth factor, Temperature-sensitive hydroxybutyl chitosan, Autologous Concentrated Growth Factor
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Stomatological Hospital Affiliated with Fujian Medical University
Loss of Teeth Due to Extraction, Alveolar Bone Loss
Regeneration of Alveolar Sockets With rhBMP-2-loaded Bovine Bone Mineral
Aim of the present investigation will be to evaluate the efficacy and safety of a granulate of rhBMP-2- loaded bovine bone mineral (rhBMP-2-BBM) as alveolar bone regeneration procedure following tooth extraction.
- Conditions
- Loss of Teeth Due to Extraction, Alveolar Bone Loss, Edentulous Alveolar Ridge
- Trial name
- PROTEOGRAFT (NCT05717478)
- Testing
- rhBMP-2-BBM, Bio-Oss+Bio-Gide
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad Complutense de Madrid
Tooth Extraction, Periapical Infections
Cortical Lamina for Alveolar Ridge Preservation
This randomized controlled clinical trial aims to evaluate the efficacy of placing a cortical lamina between the elevated flap and buccal bone plate following tooth extraction for preserving alveolar ridge dimensions.
- Conditions
- Tooth Extraction, Periapical Infections, Tooth Fracture, Periodontal Disease, AVDC Stage 4
- Trial name
- Lamina (NCT07231874)
- Testing
- Cortical Lamina Technique, Natural Healing (Control)
- Where
- Cuba
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- ARDEC Academy
Alveolar Bone Loss
Mineralized Dentin Graft Versus Beta-Tricalcium Phosphate for Alveolar Ridge Preservation
The goal of this clinical trial was to compare three ways of helping the jawbone heal after removal of a tooth. The jawbone that supports a tooth is called the alveolar ridge.
- Trial name
- NCT07812610
- Testing
- Alveolar Ridge Preservation With Autogenous Mineralized Dentin Graft, Alveolar Ridge Preservation With Beta-Tricalcium Phosphate, Extraction Socket Healing Without Bone Graft
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Soaad Tolba Mohammed Tolba Badawi
Tooth Loss, Tooth Mobility
Clinical Follow-up of Direct/Indirect Bridge, Orthodontic and Periodontal Splint by Using Fibre-reinforced Composite
The purpose of this study is to determine whether fibre-reinforced composite resin restorations are effective for single tooth replacement, elimination of tooth mobility following periodontal treatment and as an orthodontic…
- Trial name
- NCT02343796
- Testing
- Fibreglass reinforced composite restoration-everStick, everStick
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Ege University