Tooth Loss in the Anterior MaxillaNCT07544706

A Follow-Up Study of Straight and Tapered Dental Implants in the Front Upper Jaw

A study testing Neoss Implant System (ProActive Straight and Tapered) in people with Tooth Loss in the Anterior Maxilla and Partial Edentulism of the Maxilla, run by Branemarkkliniken at 1 site in Sweden.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record

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Trial summary

Who is it for?: Ages 18 years and older
Conditions the study is for: Tooth Loss in the Anterior Maxilla, Partial Edentulism of the Maxilla
What is being tested?: Neoss Implant System (ProActive Straight and Tapered)
Type of treatment: Medical device
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 51 participants
Where: 1 siteSweden
Study dates: 21 Mar 2021to 31 Jul 2030
Phase: Interventional

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 years and older
All sexes
No healthy volunteers
Adult, Older adult

Who may be able to join

Signed informed consent to participate in the study. Adults ≥18 years of age requiring an implant-supported crown or bridge in the anterior maxilla (region 13-23).
No prior bone augmentation required at the implant site. The implant site must be free from signs of infection.

Who cannot join

Individuals under 18 years of age. Individuals unable to provide informed consent due to disease, mental disorder, impaired health status, or similar conditions.
Presence of systemic or local disease/condition contraindicating implant treatment.
Lack of availability for follow-up visits over the 5-year study period. Previous radiotherapy to the head, neck, or jaw region. Untreated or uncontrolled periodontitis and/or peri-implantitis. Use of immunosuppressive medication. Uncontrolled diabetes mellitus. Severe alcohol and/or substance abuse.

Trial locations and contacts

1 site in 1 country.

Sweden1 site

Brånemark Clinic, Public Dental Health Care Service, Region of Västra Götaland, Gothenburg, Sweden
Gothenburg

Other trials in Sweden

About this study

Official title: A Prospective Clinical Follow-up Study of Straight and Tapered Dental Implants Placed in the Anterior Maxilla

This prospective study aims to evaluate 5-year clinical, radiographic, and patient-reported outcomes of implant-supported crowns and bridges placed on Neoss implants (ProActive Straight and Tapered) in the anterior maxilla (region 13 - 23). The study is conducted at Brånemarkkliniken, Public Dental Service, Västra Götalandsregionen, Sweden. While the treatment involves established methods and CE-marked devices, long-term data for this specific indication are limited.

Read the detailed description

The purpose of this study is to conduct a 5-year follow-up of implant-supported crowns and bridges placed on Neoss implants (ProActive Straight and Tapered) in the anterior maxilla (region 13 - 23).

This is a prospective, single-center clinical follow-up study evaluating implant-supported prosthetic restorations in the anterior maxilla. Eligible patients receiving crowns or bridges supported by Neoss implants (ProActive Straight and Tapered) will be followed for 5 years.

The treatment is based on established methods and CE-marked devices routinely used in clinical practice. However, long-term data for this specific indication are limited, and prospective follow-up is considered to be of clinical relevance.

Clinical, radiographic, digital, and patient-reported outcomes will be assessed at prosthetic delivery (baseline), and at 1-year and 5-year follow-ups. The study aims to evaluate the performance of Neoss implants (ProActive Straight and Tapered) as support for single crowns and bridges after 5 years, with respect to complications, function, aesthetics, and patient satisfaction.

Conditions: Tooth Loss in the Anterior Maxilla, Partial Edentulism of the Maxilla
Being tested: Neoss Implant System (ProActive Straight and Tapered)
Keywords: Neoss Dental Implants, Implant-Supported Prosthesis, Anterior Maxilla, Marginal Bone Loss, Aesthetic Outcome

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Neoss Implant System (ProActive Straight and Tapered)Device
Participants will receive implant-supported crowns or bridges supported by Neoss dental implants (ProActive Straight and Tapered) placed in the anterior maxilla. Implant placement and prosthetic rehabilitation will be performed according to standard clinical procedures using a commercially available CE-marked implant system. The implants serve as support for fixed prosthetic restorations, and participants will be followed for 5 years to evaluate clinical, radiographic, and patient-reported outcomes.

Study groups in NCT07544706
Study group	Role	What they receive
Implant-Supported Crowns and Bridges on Neoss Implants (ProActive Straight and Tapered)	Experimental	Participants will receive implant-supported crowns or bridges supported by Neoss implants (ProActive Straight and Tapered) placed in the anterior maxilla as part of routine clinical treatment. Prosthetic rehabilitation will be performed following standard clinical procedures, and participants will be followed for 5 years to assess clinical, radiographic, and patient-reported outcomes. Receives: Device: Neoss Implant System (ProActive Straight and Tapered)

What is being measured

The primary outcome is the main question the study is designed to answer.

Implant Survival
Absence of implant loss during the study period.
Measured: Baseline, 1 year, and 5 years
Change in marginal bone level around implants
Change in marginal bone level around implants as assessed by radiographic evaluation using standardized, anonymized radiographs. Measurements will be performed by an independent examiner.
Measured: Baseline, 1 year, and 5 years

Secondary outcomes (4)

Peri-implant Soft Tissue Status and change
Clinical assessment and evaluation of peri-implant soft tissue conditions using intraoral scanning and digital comparison over time.
Measured: Baseline, 1 year, and 5 years
Individual Tooth-Related Pink Esthetic Score (PES)
Evaluation of the peri-implant soft tissue aesthetics using the Pink Esthetic Score at the individual tooth level based on standardized photographic assessment.
Measured: Baseline, 1 year, and 5 years
Patient-Reported Outcomes
Patient satisfaction and perceived function/aesthetics assessed using a Visual analogue scale for rating (1-10).
Measured: Baseline, 1 year, and 5 years
Incidence of Adverse Events
Incidence of adverse events, including but not limited to implant loss, marginal bone loss, infection, swelling, and soft tissue complications.
Measured: Throughout the 5-year study period

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

21 Mar 202131 Jul 2030

First posted22 Apr 2026
Study start21 Mar 2021
Primary completion31 Mar 2030 (estimated)
Study completion31 Jul 2030 (estimated)

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Other trials for Tooth Loss in the Anterior MaxillaStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Treatment
Allocation: Not applicable
Intervention model: Single group
Masking: None (open label)
Enrolment: 51 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT07544706
Sponsor's protocol ID: 2020-04621
Status last verified: Apr 2026
First submitted: 16 Apr 2026
Last updated: 22 Apr 2026
Results posted: No
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: Undecided

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See locations

Not yet recruiting
Peri-Implant Hard and Soft Tissue Changes After Immediate Implant Placement With Socket Shield and Immediate Restoration Versus Early Implant Placement in the Esthetic Zone
Tooth Loss in the Anterior Maxilla, Alveolar Bone Resorption

All Tooth Loss in the Anterior Maxilla trials