Tooth LossPHOTOHANCT07700732
Photofunctionalization and Hyaluronic Acid for Posterior Maxillary Implants
A study testing Delayed dental implant placement without photofunctionalization., Delayed dental Implant photofunctionalization before placement and Delayed dental Implant photofunctionalization and hyaluronic acid application before placement. in people with Tooth Loss and Surface Treatment, run by Mansoura University at 1 site in Egypt.
Trial summary
This randomized clinical trial evaluates the effect of UV photofunctionalization and hyaluronic acid on dental implants placed in the posterior maxilla. Clinical and radiographic outcomes will be assessed during follow-up Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Tooth Loss, Surface Treatment, Delayed Implant
- What is being tested?
- Delayed dental implant placement without photofunctionalization., Delayed dental Implant photofunctionalization before placement and Delayed dental Implant photofunctionalization and hyaluronic acid application before placement.
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Oct 2025to Aug 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patients with missed single tooth or multiple teeth in posterior maxilla.
- Patients Free from any para-functional habits.
- Patient with Adequate inter-arch relation and inter-occlusal space to accommodate the prosthetic restoration.
- Patient with good oral hygiene.
- Patients Willing to participate in the study's follow-up intervals.
Who cannot join
- Patients with any local or systemic disease that absolute contraindicate implant placement or surgery.
- Pregnancy.
- Patients with any pathological lesion or aggressive periodontal disease at the planned surgical site.
- Patients on drugs that could affect bone healing process such as bisphosphonate.
- Heavy Smokers for more than 10 cigarettes a day.
- Uncooperative patients.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Enhancing Implant Success in the Posterior Maxilla: The Impact of Photofunctionalization and Hyaluronic Acid
This randomized clinical trial evaluates the effect of UV photofunctionalization and hyaluronic acid on dental implants placed in the posterior maxilla. Clinical and radiographic outcomes will be assessed during follow-up
Read the detailed description
The study compares conventional implants, UV-photofunctionalized implants, and UV-photofunctionalized implants with hyaluronic acid application in the posterior maxilla. Implant stability and peri-implant tissue changes will be evaluated clinically and radiographically during follow-up.
- Conditions
- Tooth Loss, Surface Treatment, Delayed Implant, Implant Placement, UV Dental Implant, Hyaluronic Acid (HA)
- Being tested
- Delayed dental implant placement without photofunctionalization., Delayed dental Implant photofunctionalization before placement, Delayed dental Implant photofunctionalization and hyaluronic acid application before placement.
- Keywords
- Photofunctionalization, Ultraviolet (UV) treatment, Hyaluronic acid, Dental implants, Posterior maxilla, Osseointegration, Implant stability
- Medical subject headings
- Tooth Loss
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Delayed dental implant placement without photofunctionalization.Procedure or surgery
Delayed dental implants placed without photofunctionalization or hyaluronic acid in the posterior maxilla.
Delayed dental Implant photofunctionalization before placementProcedure or surgery
Delayed dental implants photofunctionalized with UV light before placement in the posterior maxilla.
Delayed dental Implant photofunctionalization and hyaluronic acid application before placement.Procedure or surgery
Delayed dental implants photofunctionalized with UV light and treated with hyaluronic acid before placement in the posterior maxilla.
| Study group | Role | What they receive |
|---|---|---|
| Study Group 1 | Experimental | 20 non-UV activated implants were inserted into the prepared osteotomy site in posterior maxilla. Receives: Procedure: Delayed dental implant placement without photofunctionalization. |
| Study group 2 | Experimental | 20 UV activated implants were inserted into the prepared osteotomy site in posterior maxilla. Receives: Procedure: Delayed dental Implant photofunctionalization before placement |
| Study Group 3 | Experimental | 20 UV activated implants with Hyaluronic acid applied topically on implants surface and into the prepared osteotomy sites in posterior maxilla. Receives: Procedure: Delayed dental Implant photofunctionalization and hyaluronic acid application before placement. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Hard Tissue (peri-implant bone)
Marginal bone loss will be assessed using CBCT measured in mm.
Measured: - Immediately postoperative - 3 months after implant placement - 9 months after implant placement.
Implant Stability
Implant stability will be evaluated using Osstell device based on resonance frequency analysis (ISQ values).
Measured: -immediately after implant placement -2 weeks postoperatively -4 weeks postoperatively - 3 months postoperatively - 9 months postoperatively
Secondary outcomes (2)
Soft Tissue
The peri-implant mucosa will be evaluated for signs of inflammation using the Modified Sulcus Bleeding Index (mSBI).
Measured: -After 3 months postoperatively. -After 9 months postoperatively.
Peri-implant probing depth
Probing depth will be assessed using a calibrated periodontal probe and measured in mm.
Measured: After 3 months postoperatively. -After 9 months postoperatively.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Jul 2026
- Study start1 Oct 2025
- Primary completionJul 2026 (estimated)
- Study completionAug 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Tooth LossStudies of the same condition, open and under way.
- More trials run by Mansoura UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mansoura University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07700732
- Sponsor's protocol ID
- R.26.02.107
- Acronym
- PHOTOHA
- Status last verified
- Jul 2026
- First submitted
- 8 Jul 2026
- Last updated
- 14 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 14 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Enhancing Implant Success in the Posterior Maxilla: The Impact of Photofunctionalization and Hyaluronic Acid
- ClinicalTrials.gov ID
- NCT07700732
- Acronym / sponsor ID
- PHOTOHA / R.26.02.107
- Conditions
- Tooth Loss, Surface Treatment, Delayed Implant, Implant Placement, UV Dental Implant, Hyaluronic Acid (HA)
- Keywords
- Photofunctionalization, Ultraviolet (UV) treatment, Hyaluronic acid, Dental implants, Posterior maxilla, Osseointegration, Implant stability
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Mansoura UniversityUniversity, hospital or other
- Study start
- 1 Oct 2025 (actual)
- Primary completion
- Jul 2026 (estimated)
- Study completion
- Aug 2026 (estimated)
- First posted
- 14 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized clinical trial evaluates the effect of UV photofunctionalization and hyaluronic acid on dental implants placed in the posterior maxilla. Clinical and radiographic outcomes will be assessed during follow-up
Detailed description
The study compares conventional implants, UV-photofunctionalized implants, and UV-photofunctionalized implants with hyaluronic acid application in the posterior maxilla. Implant stability and peri-implant tissue changes will be evaluated clinically and radiographically during follow-up.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Study Group 1 | Experimental | Procedure: Delayed dental implant placement without photofunctionalization.20 non-UV activated implants were inserted into the prepared osteotomy site in posterior maxilla. |
| Study group 2 | Experimental | Procedure: Delayed dental Implant photofunctionalization before placement20 UV activated implants were inserted into the prepared osteotomy site in posterior maxilla. |
| Study Group 3 | Experimental | Procedure: Delayed dental Implant photofunctionalization and hyaluronic acid application before placement.20 UV activated implants with Hyaluronic acid applied topically on implants surface and into the prepared osteotomy sites in posterior maxilla. |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Patients with missed single tooth or multiple teeth in posterior maxilla.
- Patients Free from any para-functional habits.
- Patient with Adequate inter-arch relation and inter-occlusal space to accommodate the prosthetic restoration.
- Patient with good oral hygiene.
- Patients Willing to participate in the study's follow-up intervals.
Key exclusion criteria (6 listed)
- Patients with any local or systemic disease that absolute contraindicate implant placement or surgery.
- Pregnancy.
- Patients with any pathological lesion or aggressive periodontal disease at the planned surgical site.
- Patients on drugs that could affect bone healing process such as bisphosphonate.
- Heavy Smokers for more than 10 cigarettes a day.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Delayed dental implant placement without photofunctionalization.Delayed dental implants placed without photofunctionalization or hyaluronic acid in the posterior maxilla. | Procedure or surgery | Study Group 1 |
| Delayed dental Implant photofunctionalization before placementDelayed dental implants photofunctionalized with UV light before placement in the posterior maxilla. | Procedure or surgery | Study group 2 |
| Delayed dental Implant photofunctionalization and hyaluronic acid application before placement.Delayed dental implants photofunctionalized with UV light and treated with hyaluronic acid before placement in the posterior maxilla. | Procedure or surgery | Study Group 3 |
Primary outcome
Hard Tissue (peri-implant bone)
Time frame: - Immediately postoperative - 3 months after implant placement - 9 months after implant placement.
Marginal bone loss will be assessed using CBCT measured in mm.
Implant Stability
Time frame: -immediately after implant placement -2 weeks postoperatively -4 weeks postoperatively - 3 months postoperatively - 9 months postoperatively
Implant stability will be evaluated using Osstell device based on resonance frequency analysis (ISQ values).
2 secondary outcomes
Soft Tissue
Time frame: -After 3 months postoperatively. -After 9 months postoperatively.
Peri-implant probing depth
Time frame: After 3 months postoperatively. -After 9 months postoperatively.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Delayed dental implant placement without photofunctionalization., Delayed dental Implant photofunctionalization before placement and Delayed dental Implant photofunctionalization and hyaluronic acid application before placement. in people with Tooth Loss and Surface Treatment, run by Mansoura University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 14 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Hard Tissue (peri-implant bone) (time frame: - Immediately postoperative - 3 months after implant placement - 9 months after implant placement.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Jul 2026.