Clinical trials: T1D
Type 1 Diabetes (T1D), Type 1 Diabetes Mellitus
A Study of GNTI-122 in Adults Recently Diagnosed With T1D
This is a 78-week single arm, multi-center, Phase 1 study to evaluate the safety, tolerability, cellular kinetics, and biomarker changes in C-peptide over time of GNTI-122, an investigational cell therapy manufactured from a…
- Trial name
- POLARIS (NCT06919354)
- Testing
- GNTI-122
- Where
- 10 sites in United States
- Volunteers
- 16 people
- Sponsor
- GentiBio, Inc
Type 1 Diabetes (T1D)
Universal Type 1 Diabetes Screening in Pediatrics
This study examines how population-based screening for type 1 diabetes (T1D) using islet autoantibodies (i.e., immune system proteins) can be incorporated into pediatric primary care during routine well-child visits.
- Trial name
- NCT07612475
- Testing
- Set of implementation strategies
- Where
- 8 sites in United States
- Volunteers
- 9,500 people
- Sponsor
- Northwestern University
Type 1 Diabetes (T1D)
Diactive-1: Scaled-up Personalized mHealth Program for Youth With Type 1 Diabetes
The Diactive-1 project aims to establish the Diactive-1 mobile application as a clinical tool for managing type 1 diabetes in children and adolescents in several hospitals from Spain.
- Trial name
- Diactive-1v2 (NCT07290868)
- Testing
- Diactive-1
- Where
- Spain
- Volunteers
- 158 people
- Sponsor
- Fundacion Miguel Servet
Type 1 Diabetes (T1D)
Clinical Trial for the Study of Stress and Exercise Impact on Glucose Levels and Additional Physiological Signals. Stress, Insulin and Exercise Study: a Trial in Argentina
The study lasted 28 days. During the study period, participants completed two structured aerobic exercise sessions (days 4 and 18), two structured resistance exercise sessions (days 11 and 25), and four structured stress tests…
- Trial name
- SIESTA (NCT07865923)
- Testing
- Structured Aerobic Exercise, Structured Resistance Exercise, Stress Test
- Where
- Argentina
- Volunteers
- 5 people
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Type 1 Diabetes (T1D), Healthy Subjects
Effect of Artificial Sweetener (AFS) on Glucose Metabolism in Patients With Type 1 Diabetes (T1D)
The goal of this randomized crossover study is to test the prediction that consuming carbohydrates will affect insulin release differently depending on whether Non-Nutritive Sweeteners (NNSs) are consumed simultaneously.
- Trial name
- AFS_T1D (NCT06315725)
- Testing
- Sweet taste perception with/without sweet taste blockade
- Where
- Canada
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Type 1 Diabetes (T1D)
Food Prescription Among Youth With Type 1 Diabetes
The purpose of this study is to assess the feasibility and preliminary outcomes of a healthy eating program that consists of Food Rx combined with an evidence-based healthy eating family behavioral intervention refined for…
- Trial name
- NOURISH (NCT07860229)
- Testing
- Healthy Eating Program
- Volunteers
- 45 people
- Sponsor
- Baylor College of Medicine
Insulin Dependent Diabetes, Diabetes (DM)
Integrating New Skills Into Diabetes Education With CGM
This study is designed to test the preliminary efficacy of a three-stage continuous glucose monitor (CGM) integration program for older adults who are taking insulin.
- Conditions
- Insulin Dependent Diabetes, Diabetes (DM), Diabetes (Insulin-requiring, Type 1 or Type 2), Diabetes Education
- Trial name
- INSIDE-CGM (NCT07463209)
- Testing
- Three-stage CGM integration program, One-time clinic-based CGM training, Self-directed CGM training
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of North Carolina, Chapel Hill
Healthy Adult, Type 1 Diabetes (T1D)
Finding Immune Nascent Type 1 Diabetes
The goal of this clinical trial is to understand how many individuals who previously participated in the Indiana Biobank will return a type 1 diabetes home screening kit based upon different methods of recruitment communication.
- Trial name
- FIND T1D (NCT07663136)
- Testing
- phone call, email/mail
- Where
- United States
- Volunteers
- 3,800 people, healthy volunteers welcome
- Sponsor
- Indiana University
Type 1 Diabetes (T1D), Menopause
Functional Mobility and Resistance Exercise for Postmenopausal Females With Type 1 Diabetes
Improvements in diabetes care and technology have led to people with type 1 diabetes living longer. There are now more seniors than ever living with this complex health condition.
- Trial name
- FLEX-T1D (NCT07851662)
- Testing
- Resistance exercise
- Where
- 3 sites in Canada
- Volunteers
- 63 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Diabetes, Type1diabetes
Continuous Ketone Monitoring in People With Type 1 Diabetes Using SGLT2 Inhibitors
Type 1 diabetes is an autoimmune disease where the body attacks the insulin-producing cells in the pancreas. In the absence of insulin, the body is unable to effectively use glucose for energy, resulting in high blood sugar…
- Conditions
- Diabetes, Type1diabetes, T1D
- Trial name
- EmpaCKM (NCT06753994)
- Testing
- SGLT-2 inhibitor
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McGill University
Type 1 Diabetes (T1D)
Clinican BEAD-T1D: Building the Evidence to Address Disengagement in Type 1 Diabetes
Youth with public insurance underutilize diabetes care, particularly diabetes technology which is associated with improvement in diabetes-specific outcomes.
- Trial name
- BEAD-T1D (NCT07491471)
- Testing
- Intervention to increase diabetes technology prescriptions
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stanford University
Type 1 Diabetes (T1D)
App-Based Certified Diabetes Education Therapy (AB-CDE)
The purpose of this study is to learn more about a smartphone application (app) called DailyDose, an investigational decision support tool that may help in managing your diabetes.
- Trial name
- AB-CDE (NCT07282639)
- Testing
- DailyDose
- Where
- 6 sites in United States
- Volunteers
- 99 people
- Sponsor
- Oregon Health and Science University
T1D, T1DM
Pre-Exercise Whey and Pea Protein in Adolescents With Type 1 Diabetes
The goal of this clinical trial is to learn whether drinking whey protein or pea protein before exercise affects blood sugar levels and appetite in adolescents with type 1 diabetes.
- Trial name
- NCT07836673
- Testing
- low whey protein, moderate whey protein, low Pea protein
- Volunteers
- 30 people
- Sponsor
- University of Jordan
Type 1 Diabetes (T1D)
Cadisegliatin as Adjunctive Therapy to Insulin in Participants With Type 1 Diabetes Who Are Using Hybrid Closed Loop (HCL) Systems
TTP399-206 is a Phase 2a multicenter double blind cross over randomized study of cadisegliatin in participants with T1D using hybrid closed loop systems to manage their diabetes.
- Trial name
- Hybrid CATT1 (NCT07616206)
- Testing
- Cadisegliatin 800 mg QD
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- vTv Therapeutics
Type 1 Diabetes Mellitus, T1DM
Type 1 Diabetes Extension Study
This is a multi-center, prospective, non-interventional study that focuses on the long- term effects following participation in selected ITN new-onset Type1 Diabetes Mellitus studies with immunomodulatory agents (T1DM, T1D).
- Conditions
- Type 1 Diabetes Mellitus, T1DM, T1D
- Trial name
- T1DES (NCT02734277)
- Where
- 12 sites in United States
- Volunteers
- 111 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes (Insulin-requiring, Type 1 or Type 2), Diabetes
Benefits of Retained Insulin for Good Health
The purpose of this research is to understand the impact of retained endogenous insulin (as measured by C-peptide) on quality of life and related outcomes in people living with insulin treated diabetes, and, in those living with…
- Conditions
- Diabetes (Insulin-requiring, Type 1 or Type 2), Diabetes, Diabetes (DM), Type 1 Diabetes (T1D)
- Trial name
- BRIGHT (NCT07828626)
- Testing
- Observational
- Where
- 4 sites in United Kingdom
- Volunteers
- 700 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Type 1 Diabetes (T1D), Metabolic Diseases
METabolic MODulation to Enhance Insulin Sensitivity and Mitochondrial Function in Type 1 Diabetes (MetMod-T1D)
The study is a randomized, double-blind, parallel-group clinical trial to examine the effects of 24 weeks of oral AMX0035 (sodium phenylbutyrate + taurursodiol) versus placebo in 60 adults with Type 1 Diabetes (T1D) (n=30 per…
- Conditions
- Type 1 Diabetes (T1D), Metabolic Diseases, Glucose Metabolism Disorders, Endocrine System Diseases
- Trial name
- MetMod-T1D (NCT07699380)
- Testing
- AMX0035
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 60 people
- Sponsor
- University of Washington
Type 1 Diabetes Mellitus, T1D
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
This study is a Phase 1b/2a First-in-Human (FIH) clinical trial to assess the safety, tolerability, pharmacodynamics (PD), and efficacy of multiple ascending doses of CNP-103.
- Conditions
- Type 1 Diabetes Mellitus, T1D, T1DM, T1DM - Type 1 Diabetes Mellitus
- Trial name
- NCT06783309
- Testing
- CNP-103
- Where
- 45 sites in United States
- Volunteers
- 72 people
- Sponsor
- COUR Pharmaceutical Development Company, Inc.
Type 1 Diabetes (T1D)
Extracellular Vesicle-based Strategy to Stratify Islets and Improve Their FItness Before Transplantation
Islet transplantation restores glucose tolerance in people living with diabetes characterised by high glycaemic variability: 90 per cent of patients were free from severe hypoglycaemia at 5 years, compared with 26 per cent prior…
- Trial name
- EVIFIT (NCT07812974)
- Testing
- beta2score
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Strasbourg, France
Type 1 Diabetes (T1D), Type 2 Diabetes (T2D)
Safety Evaluation of MODI, an Insulin Titration Algorithm, in Adults With Diabetes
A 13-week multi-center single-arm trial, preceded by a 2-week standard therapy phase, will be conducted to assess the safety of MODI, an insulin titration algorithm, in adults with type 1 diabetes (T1D) who use multiple daily…
- Trial name
- MODIUS (NCT07599982)
- Testing
- MODI Algorithm
- Where
- 6 sites in United States
- Volunteers
- 102 people
- Sponsor
- DreaMed Diabetes