Clinical trials: Substance Use Disorders
Opioid-Related Disorders, NAS
MOms in REcovery (MORE) Study: Defining Optimal Care
Northern New England has among the highest rates of opioid dependence in the U.S. This region also has among the highest rates of opioid-related deaths in the U.S., with a disproportionate high rate among pregnant women with…
- Conditions
- Opioid-Related Disorders, NAS, Substance Use Disorders, Mental Health
- Trial name
- MORE (NCT04251208)
- Testing
- Observational Study
- Where
- 10 sites in United States
- Volunteers
- 2,510 people
- Sponsor
- Trustees of Dartmouth College
Substance Use Disorders (SUDs)
Development of an Interview-Informed Timeline Follow-Back (TLFB) for Opioid Use in the Era of Fentanyl
Background: A Timeline Follow-Back (TLFB) is a tool that helps researchers track how much of a substance a person uses. Different versions of the tool are used to track the use of alcohol, cigarettes, and cannabis.
- Trial name
- NCT06995885
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Use Disorder (SUD)
Fighting Addictions, Improving Lives: COmprehensive Drug Rehabilitation With Music
FALCO is a parallel pragmatic randomized control trial addressing long-term effects of music therapy (MT) on substance use disorder (SUD). 600 participants will be recruited from multiple European countries (see Locations).
- Trial name
- FALCO (NCT07028983)
- Testing
- Active Music Group (AMG), Music Listening Group (MLG), Treatment as Usual (TAU)
- Where
- 11 sites in Austria, Israel and 6 more
- Volunteers
- 600 people
- Sponsor
- NORCE Norwegian Research Centre AS
Schizophrenia Disorder, Schizoaffective Disorder
Incentives and Long-Acting Injectable Adherence After Involuntary Hospitalization
This study is a randomized controlled trial evaluating the impact of financial incentives on medication adherence among individuals with schizophrenia, schizoaffective disorder, or bipolar disorder and/or co-occurring substance…
- Conditions
- Schizophrenia Disorder, Schizoaffective Disorder, Bipolar Disorder (BD), Substance Use Disorder (SUD)
- Trial name
- NCT07130500
- Testing
- Financial incentives for adherence to long-acting injectable medication, Standard of care with monthly surveys
- Where
- 6 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Stanford University
Treatment Resistant Depression, Substance Use Disorders
Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder
The goal of this clinical trial is to learn if a single dose of psilocybin (5mg Vs 10mg Vs 25mg) alongside psychotherapy is safe and can help treat treatment resistant depression (TRD) with co-occurring substance use disorder…
- Trial name
- NCT07499583
- Testing
- Psilocybin
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Indiana University
HIV, Substance Use Disorder
Olfactory Function and Model-Based Behavior in People Living With HIV and SUD
Background: Human immunodeficiency virus (HIV) infection can affect areas of the brain that control thinking ability. These same areas of the brain also control the sense of smell.
- Trial name
- NCT07637669
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Use, HIV Infections
Expanding the Potential of Couples HIV Testing: Adjunct Modules to Reduce Drug Use Among Vulnerable Male Couples
This study utilizes a randomized controlled trial design to evaluate the efficacy of two intervention components for couples HIV testing and counseling (CHTC): a communication skills training video and a substance use module.
- Trial name
- 4Us (NCT05000866)
- Testing
- Communication skills training video, Drug use module
- Where
- 2 sites in United States
- Volunteers
- 484 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Cannabis Use, Substance Use Disorder (SUD)
Research Investigating Drug Effects-2 (RiDE-2)
The purpose of this study is to better understand how people's mood, behavior, and brains respond to different recreational drugs.
- Conditions
- Cannabis Use, Substance Use Disorder (SUD), Healthy
- Trial name
- RiDE-2 (NCT06758596)
- Testing
- THC
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Tobacco Use, Substance Use Disorders
STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking
The purpose of this study is to investigate whether non-cigarette tobacco products, namely e-cigarettes (nicotine vapes), can help people who smoke and are in treatment for substance use disorder quit smoking by switching…
- Trial name
- STEPS (NCT06922617)
- Testing
- Switching to E-Cigarette, Quitting using Medication, Counseling
- Where
- 4 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Substance Use
Home Visitation Enhancing Linkages Project in Kansas
The goal of this study is to learn about whether digital screening and brief intervention can help address substance use in postpartum mothers who are enrolled in home visiting programs.
- Trial name
- HELP (NCT06624332)
- Testing
- e-SBI main session, e-SBI Booster Session, Text messaging
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The National Center on Addiction and Substance Abuse at Columbia University
Opioid Use Disorder, Substance Use Disorder
Neurofeedback During Naturalistic Stimuli to Reduce Craving in Heroin Addiction
Support groups are an important component of addiction treatment, where individuals at more stable stages of their recovery help others by sharing personal experiences.
- Conditions
- Opioid Use Disorder, Substance Use Disorder, Heroin Use Disorder
- Trial name
- NCT07344233
- Testing
- Real-time fMRI Neurofeedback
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Burnout, Secondary Trauma
PATH to Reducing Burnout Among Peers Who Deliver Overdose Prevention Services (R33 Phase Clinical Trial)
The investigators propose to test the effectiveness of PATH (Peer Advanced Training for total Health) as an educational workforce intervention for improving peer recovery support specialists' (PRSS) overdose prevention (OP)…
- Conditions
- Burnout, Secondary Trauma, Compassion Fatigue, Opioid Use Disorder
- Trial name
- NCT07886944
- Testing
- PATH (Peer Advanced Training for total Health)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Chestnut Health Systems
Mental Health Issue, Substance Use Disorders
Improving Maternal Mental Health & SUD Screening and Treatment
The purpose of the study is to compare a text message-based mental health and substance use screening and referral to a treatment program, called Listening to Women and Pregnant and Postpartum People (LTWP), to standard of care…
- Conditions
- Mental Health Issue, Substance Use Disorders, Postpartum Depression, Postpartum Anxiety
- Trial name
- NCT05764213
- Testing
- Listening to Women & Pregnant and Postpartum People
- Where
- United States
- Volunteers
- 10,469 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Substance Use Disorders, HIV Infections
Development and Evaluation of a Virtual Reality Tool for At-Risk Trauma-Exposed Young People
This is a multi-phased study, funded through a National Institute on Drug Abuse (NIDA) K24 grant that aims to ultimately refine a virtual reality tool through qualitative and quantitative research targeting HIV and substance…
- Trial name
- NCT05816083
- Testing
- Virtual Reality Tool
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Substance Use Disorders
Shared Decision Making to Treat Or Prevent (STOP) HIV in Criminal Legal Involved Populations (R33)
This study seeks to compare the effectiveness of two Patient Navigation models of care to evaluate the proportion who initiate PrEP/ART and substance use/substance use disorder (SU/SUD) treatment.
- Trial name
- NCT07223398
- Testing
- Standard PN, Patient Choice
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- Yale University
HIV Prevention, Substance Use
mHealth Service Linkage for Young Adults Impacted by the Criminal Legal System
This study is designed to test Project LYNX, a program designed to help young adults (ages 18-29) with recent criminal legal system involvement can find and get connected to substance use and HIV-prevention services in the…
- Trial name
- LYNX (NCT07599722)
- Testing
- LYNX, Standard of Care
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Substance Use Behavior
Cognitive Behavioral Therapy for Substance Use and Mental Health in University Students
This study examined changes in substance use frequency, psychological well-being, and psychological symptoms among university students participating in a cognitive-behavioral therapy (CBT)-based group intervention.
- Trial name
- NCT07884422
- Testing
- Cognitive-Behavioral Therapy (CBT)-Based Group Intervention, Group Counseling Program
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mehmet Akif Ersoy University
Drug Abuse, Nicotine Dependence
Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging
Background: Functional and structural magnetic resonance imaging (MRI) techniques have allowed researchers to map and study how the brain works when at rest and when engaged in specific tasks.
- Trial name
- NCT01036581
- Testing
- MagPro X100 Magnetic Stimulator, Transcranial Rotating Magnetic Stimulator, Magnetom Prisma Fit 3T Scanner
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Post Traumatic Stress Disorder, Obstructive Sleep Apnea
OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
Substance use disorder (SUD) and posttraumatic stress disorder (PTSD) frequently co-occur and having both disorders is associated with greater psychological and functional impairment than having either disorder alone.
- Conditions
- Post Traumatic Stress Disorder, Obstructive Sleep Apnea, Substance Use Disorder, Residential Treatment Program
- Trial name
- NCT05156112
- Testing
- Positive Airway Pressure Device
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- VA Office of Research and Development
Alcohol Abuse, Alcohol Use Disorder
A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners
The purpose of this study is to evaluate the efficacy of an adaptive web intervention (Partners Connect) on military spouse drinking behaviors (CPs) and service member help-seeking (SMs).
- Conditions
- Alcohol Abuse, Alcohol Use Disorder, Alcohol Drinking, Relations, Interpersonal
- Trial name
- NCT05619185
- Testing
- CRAFT Web-Based Intervention, Phone-Based CRAFT, CRAFT Workbook
- Where
- United States
- Volunteers
- 744 people, healthy volunteers welcome
- Sponsor
- Stanford University