Clinical trials: Substance Use Disorder (SUD), open to volunteers
Substance Use Disorder (SUD), Drug Overdose
Justice Community Overdose Innovation Network II TCU Hub
The current study proposes to use a Hybrid Type 3 implementation research strategy to: 1) Significantly enhance our understanding of public health outcomes [e.g., overdose incidents and substance-use (SU)-related Emergency…
- Conditions
- Substance Use Disorder (SUD), Drug Overdose, Criminal Behavior
- Trial name
- JCOIN II TCU (NCT07528846)
- Testing
- Core-interagency community engagement approach, Enhanced-Core plus community engagement specialist
- Where
- United States
- Volunteers
- 1,620 people, healthy volunteers welcome
- Sponsor
- Texas Christian University
Addiction, Addiction Disorders
Evaluation of the ADD'Pro Vocational Reintegration Program (ADD-PRO-EVAL)
The goal of this clinical trial is to evaluate whether an integrated medico-psychosocial vocational support program (ADD'Pro) can improve employment outcomes in adults with substance use disorders receiving care at a specialized…
- Conditions
- Addiction, Addiction Disorders, Substance Use Recovery, Return to Work
- Trial name
- ADD-PRO-EVAL (NCT07520617)
- Testing
- ADD'Pro Program, Standard Care (in control arm)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
HIV Prevention, Sexually Transmitted Infections (STI)
California MEPS Hub
The California Hub for HIV/SUD Prevention Research with Reentry Populations addresses the question: "Can the evidence-based MEPS intervention be adapted and implemented at a range of organizations to effectively serve a wider…
- Conditions
- HIV Prevention, Sexually Transmitted Infections (STI), Preexposure Prophylaxis (PrEP), Incarceration
- Trial name
- NCT07433985
- Testing
- Mobile Enhanced Prevention Support (MEPS), Control
- Where
- 3 sites in United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Substance Use Disorder (SUD)
Identifying Substance Use Consequences
The goal of this study is to develop a new tool for measuring substance use disorder treatment outcome. We will start by interviewing people and gathering advisory groups to develop the items for this new tool.
- Trial name
- NCT07503067
- Testing
- none, there is no intervention in this study
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mclean Hospital
HIV, Substance Use Disorder (SUD)
Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs
The goal of this study is to determine the feasibility and impact of delivering long-acting injectable cabotegravir HIV pre-exposure prophylaxis and suite of support services to adults who inject non-prescription drugs who are…
- Conditions
- HIV, Substance Use Disorder (SUD), Injection Drug Use
- Trial name
- ASCEND (NCT07199335)
- Testing
- APRETUDE (cabotegravir)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Prisoners, Substance Use History
Calls and Coordination for Transitions of Care at Re-entry
The goal of this clinical trial is to learn if a short program for people being released from prison can help connect them to medical care.
- Conditions
- Prisoners, Substance Use History, Chronic Medical Conditions, Psychiatric Condition
- Trial name
- Call2Care (NCT06794983)
- Testing
- In-person visit with study team member, In-person visit with NCM, Phone calls and texts
- Where
- United States
- Volunteers
- 488 people
- Sponsor
- University of Wisconsin, Madison
Substance Use Disorder (SUD)
Correctional Service of Canada Pilot Trial of Digital Substance Use Disorder Interventions (PROCESS)
Problems with substance use are common in prisoners. Since most substances are still illegal in Canada, substance use problems can increase the risk for re-incarceration.
- Trial name
- PROCESS (NCT07342218)
- Testing
- Breaking Free Online (BFO), Computer-Based Training for Cognitive Behavioural Therapy (CBT4CBT)
- Where
- 4 sites in Canada
- Volunteers
- 20 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Transdiagnostic, Depression - Major Depressive Disorder
Open-Label Psilocybin Study in Transdiagnostic Population
The primary objective of this study is to investigate the safety, feasibility, and tolerability of psilocybin treatment in individuals with functional impairment due to psychiatric symptoms.
- Conditions
- Transdiagnostic, Depression - Major Depressive Disorder, Anxiety, PTSD Symptoms
- Trial name
- NCT06442423
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yale University
Major Depressive Episode (MDE), Major Depressive Disorder (MDD)
LHC-CIDI-5 in Hong Kong
The World Health Organization Composite International Diagnostic Interview-5th (CIDI-5) is a standardized diagnostic tool used to assess the prevalence of mental and substance use disorders over varying time frames (30 days, 12…
- Conditions
- Major Depressive Episode (MDE), Major Depressive Disorder (MDD), Persistent Depressive Disorder (PDD), Suicidal Ideation
- Trial name
- NCT06804525
- Testing
- CIDI-5, LHC-CIDI-5
- Where
- Hong Kong
- Volunteers
- 2,500 people
- Sponsor
- The University of Hong Kong
Alcohol Use Disorder (AUD), Cocaine Use Disorder (CUD)
Web-based Alcohol- or Cocaine-specific Inhibition Training in Adolescents and Young Adults With Substance Use Disorder
Substance misuse is one of the most common risk factors for health problems and premature death among adolescents and young adults worldwide.
- Conditions
- Alcohol Use Disorder (AUD), Cocaine Use Disorder (CUD), Substance Use Disorder (SUD)
- Trial name
- WAIT-AYA (NCT07071779)
- Testing
- Substance-specific inhibition training, Control training
- Where
- Switzerland
- Volunteers
- 210 people
- Sponsor
- University of Bern
PTSD - Post Traumatic Stress Disorder, Substance Use Disorder (SUD)
Mechanisms of Written Exposure Therapy in Residential SUD Treatment
The goal of this clinical trial is to learn how Written Exposure Therapy (WET), a brief treatment for PTSD, works among individuals with substance use disorders (SUD) engaged in residential SUD treatment and how biology may…
- Trial name
- NCT07397507
- Testing
- Written Exposure Therapy, Neutral Writing
- Volunteers
- 108 people
- Sponsor
- Mclean Hospital
Substance Use Disorder (SUD)
Effect of Person-Centered Occupational Therapy Interventions for Substance Use Disorder
This study investigates the impact of person-centered occupational therapy interventions on individuals diagnosed with substance use disorder.
- Trial name
- NCT07364240
- Testing
- Awareness Training, Person-Centered Occupational Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Hacettepe University
Substance Use Disorder (SUD)
Study to Confirm the AuthenTicity of Point of Care Urine samplEs Using Oral fluoreScein Sodium in adulTs With substancE Use Disorder (ATTESTED)
The purpose of this phase III, randomized, double-blind, placebo-controlled study is to confirm the authenticity of point-of-care urine samples in adult persons with substance use disorder using fluorescein sodium as a marker.
- Trial name
- ATTESTED (NCT07356349)
- Testing
- Fluorescein
- Volunteers
- 114 people
- Sponsor
- UpTru Inc.
PTSD - Post Traumatic Stress Disorder, PTSD and Alcohol Use Disorder
Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons
Addiction and trauma exposure are common among the 5.5 million people (1 in 47 adults) in the U.S. who are in prison or under supervision.
- Conditions
- PTSD - Post Traumatic Stress Disorder, PTSD and Alcohol Use Disorder, PTSD and Trauma-related Symptoms, Substance Use Disorder (SUD)
- Trial name
- STRIDES2 (NCT06923423)
- Testing
- Group Cognitive Processing Therapy (CPT), Control Group Individual trauma focused self-help via workbook
- Where
- 6 sites in United States
- Volunteers
- 640 people
- Sponsor
- University of Arkansas
Substance Use Disorder (SUD)
The Effect of Cognitive Behavioral Model-Based Psychoeducation on Social Exclusion, Hopelessness, and Relapse Levels in Individuals Diagnosed With Substance Use Disorder
This research was planned to measure the effect of cognitive behavioral model-based psychoeducation on the level of social exclusion and hope in individuals diagnosed with substance use disorder, as well as teaching them to cope…
- Trial name
- NCT07316335
- Testing
- Cognitive Behavioral Therapy (CBT) Theoretical Basic Training Group
- Volunteers
- 44 people
- Sponsor
- Ataturk University
Substance Use Disorder (SUD)
Peer Support Workers Feasibility Study
Many people with high-risk opioid use visit emergency departments (EDs), facing a high risk of death if they leave before completing care.
- Trial name
- NCT07030192
- Testing
- Peer support service
- Where
- Canada
- Volunteers
- 3,181 people
- Sponsor
- University of British Columbia
Substance Use Disorder (SUD), Opioid Use Disorder (OUD)
Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder
The purpose of this study is to determine if personalized (adaptive) Deep Brain Stimulation (DBS) based upon invasive brain mapping is safe and can lead to better outcomes like reductions in craving and opioid use.
- Trial name
- aDBS OUD (NCT07214467)
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, San Francisco
Posttraumatic Stress Disorder (PTSD), Substance Use Disorders (SUD)
Project COMET: Massed Prolonged Exposure for PTSD and SUD
The goal of this clinical trial is to learn if Massed Prolonged Exposure Therapy (M-PE) can improve PTSD symptoms and reduce substance use in adults receiving intensive outpatient (IOP) treatment for substance use disorder (SUD).
- Conditions
- Posttraumatic Stress Disorder (PTSD), Substance Use Disorders (SUD), Comorbidity, Trauma and Stressor Related Disorders
- Trial name
- PROJECT COMET (NCT06968832)
- Testing
- Massed Prolonged Exposure Therapy (M-PE), Standard outpatient SUD care
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Rutgers, The State University of New Jersey
Substance Use Disorder (SUD)
Evaluating Pain Control Strategies in Postpartum Patients on Opioid Use Disorder Medications.
The purpose of this study is to investigate the efficacy of three different modalities of post-operative pain control in parturient with opioid use disorders.
- Trial name
- NCT06617949
- Testing
- Regional Anesthesia, Hydromorphone Patient Controlled Analgelsic, Epidural local anesthetic infusion
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Substance Use Disorder (SUD)
Recovery Works - Facilitating Sustainable Recovery Through Workforce
The goal of this clinical trial is to determine whether an apprenticeship-based workforce model, the Community Restitution Apprenticeship-Focused Training (CRAFT), improves recovery outcomes for persons with substance use…
- Trial name
- NCT07216612
- Testing
- Community Restitution Apprenticeship-Focused Training (CRAFT), Standard Employment Model
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- West Virginia School of Osteopathic Medicine