Clinical trials: Stomatitis (Oral Mucositis)
Inflammation of Mouth, Acute Mucous Inflammation
Efficacy of Anthocyanin Mouthrinse for Oral Anti-inflammation From Orthodontic Treatment
The purpose of this study is to compare the oral inflammatory reduction effect caused from orthodontic treatment of anthocyanin and placebo mouthrinse.
- Trial name
- NCT02536781
- Testing
- Anthocyanin
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Khon Kaen University
Swallowing-induced Pain
Doxepin Solution for Alleviation of Stubborn Breakthrough Pain Induced by Swallowing in Patients Receiving Radiotherapy for Nasopharyngeal Carcinoma
The goal of this clinical trial is to explore the effectiveness and adverse reactions of doxepin solution spray for alleviation of stubborn breakthrough pain induced by swallowing in patients receiving radiotherapy for…
- Trial name
- NCT06017895
- Testing
- doxepin solution
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Oral Mucositis, Leukemia
Honey or Olive Oil for Treating Oral Mucositis in Children and Adults With Leukemia Receiving Intensive Chemotherapy
Background: Oral mucositis (OM) is a significant complication occurring in approximately 40% of patients on chemotherapy regimens.
- Trial name
- NCT03399331
- Testing
- Manuka honey, olive oil, Control group
- Where
- Lebanon
- Volunteers
- 45 people
- Sponsor
- American University of Beirut Medical Center
Limbal Stem Cell Deficiency, Stevens-johnson Syndrome
Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet Transplantation
To investigate the effect of ocular surface reconstruction and assess the safety in cultivated oral mucosal epithelial cell sheet transplantation (COMET) regarding patients with cicatricial change of ocular surface.
- Conditions
- Limbal Stem Cell Deficiency, Stevens-johnson Syndrome, Ocular Cicatricial Pemphigoid, Chemical Burn
- Trial name
- NCT02149732
- Testing
- cultivated oral mucosal epithelial sheet transplantation
- Where
- 2 sites in South Korea
- Sponsor
- Seoul National University Hospital
Radiation-induced Oral Mucositis
Effects of CKI for Oral Mucositis Caused by Radiotherapy for Head and Neck Cancer
Oral mucositis (OM) is an acute side effect of radiotherapy for head and neck cancer (HNC). OM associated pain affects oral functions and nutrition of the patient that may result in discontinuity of treatment.The purpose of this…
- Trial name
- NCT04204382
- Testing
- Levofloxacin Injection, Compound Kushen Injection（CKI）
- Where
- 12 sites in China
- Volunteers
- 144 people
- Sponsor
- Shanxi Zhendong Pharmacy Co., Ltd
Chemotherapy Induced Oral Mucositis
Low Level Diode Laser Versus Topical Chamomile in Management of Chemotherapy Induced Oral Mucositis
a three-arm head-to-head randomized clinical trial assessing two of the promising studied interventions, low-level diode laser and topical Chamomile, comparing them to each other's and to conventional therapy in the management of…
- Trial name
- NCT06214273
- Testing
- Low level diode laser, Chamomile, Ibuprofen analgesic and anti-inflammatory oral gel and miconazole anti fungal oral gel
- Volunteers
- 45 people
- Sponsor
- Cairo University
Candida Albicans Infection, Cigarette Smoking
Curcumin; Rose Bengal; Denture Stomatitis
Cigarette smoking in conjugation with bad oral hygiene is considered a typical predisposing factor for many oral diseases including denture stomatitis.
- Trial name
- NCT04837664
- Testing
- Curcumin, Rose Bengal, Nystatin
- Where
- Saudi Arabia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- King Saud University
Stomatitis
Morphine Mouthwash for Management of Oral Mucositis in Patients With Head and Neck Cancer
Oral mucositis is a debilitating side effects of cancer treatment for which there is not much successful treatments at yet. The investigators are going to evaluate the effectiveness of topical morphine compared with a routine…
- Trial name
- NCT01837446
- Testing
- 2% morphine solution, Magnesium aluminum hydroxide, 2% viscous lidocaine
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Isfahan University of Medical Sciences
Malignant Neoplasm
Dexamethasone in Reducing Everolimus-Induced Oral Stomatitis in Patients With Cancer
This phase III trial studies how well dexamethasone works in reducing everolimus-induced oral stomatitis in patients with cancer.
- Trial name
- MIST (NCT03839940)
- Testing
- Dexamethasone, Questionnaire, Quality-of-Life Assessment
- Where
- 319 sites in United States
- Volunteers
- 39 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Oral Ulcer, Oral Mucositis
A Study of Phenytoin Mucoadhesive Film for Oral Ulcers in Healthy Volunteers
The goal of this clinical trial is to learn if a new 1% Phenytoin mucoadhesive film is safe and works to treat oral ulcers in healthy adult volunteers and patients with oral ulcers.
- Conditions
- Oral Ulcer, Oral Mucositis, Aphthous Stomatitis
- Trial name
- PHENO-FILM (NCT07890428)
- Testing
- 1% Phenytoin Mucoadhesive Film, Blank Mucoadhesive Film
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Oral Mucositis
Honey and a Mixture of Honey, Beeswax and Olive Oil-propolis Extract in Treatment of Chemotherapy-induced Oral Mucositis
Although, oral mucositis has been studied for many years, no available treatment has been shown to be effective in preventing or treating mucositis.
- Trial name
- NCT01431729
- Testing
- honey, hope,mucositis
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- mamdouh abdulmaksoud abdulrhman
Oral Mucositis
Efficacy of Aleo Vera Use in Prevention and Treatment of Chemotherapy-Induced Oral Mucositis in a Group of Egyptian Children with Acute Leukemia
evaluatation the efficacy of Aleovera in prevention and treatment of chemotherapy-induced oral mucositis in children suffering from acute leukemia in terms of appearance and severity
- Trial name
- NCT06757270
- Testing
- Second arm: Using aleovera for Prevention and Treatment of Chemotherapy-Induced Oral Mucositis
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Oral Mucositis
Oral Mucositis and Laser Therapy Associated With Photodynamic Therapy
The aim of the study was to evaluate the therapeutic action through the diameter of the lesion, of low level laser (LLL) associated to photodynamic therapy (PDT) in oral mucositis (OM) lesions, in young patients.
- Trial name
- OMLTPT (NCT02555501)
- Testing
- PDT + Low level laser, Low level laser
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Universidade Ceuma
Recurrent Aphthous Stomatitis
A Study on Sumac Mouth Rinse for Treating Recurrent Aphthous Stomatitis
This randomized controlled clinical study aims to evaluate the effectiveness of a Sumac mouth rinse in the management of recurrent aphthous stomatitis (RAS).
- Trial name
- SUMAC-RAS (NCT07229469)
- Testing
- Sumac mouth rinse, Tantum Verde mouth rinse
- Where
- Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Chemotherapy Induced Oral Mucositis
Effect of Oral Ice Chips to Prevent Chemotherapy-Induced Oral Mucositis in Patient With Solid Tumor Treated With 5 Fluorouracil and Methotrexate
The goal of this randomized controlled clinical trial is to determine whether oral cryotherapy using ice chips can prevent and reduce the incidence and severity of chemotherapy-induced oral mucositis in adult cancer patients…
- Trial name
- NCT07327476
- Testing
- Oral Cryotherapy (Ice Chips), Standard Oral Care (Mouthwash)
- Where
- Pakistan
- Volunteers
- 102 people
- Sponsor
- University of Health Sciences Lahore
Toxic Epidermal Necrolysis, Stevens-Johnson Syndrome
Study to Evaluate the Use of Palifermin to Treat Toxic Epidermal Necrolysis
To test the ability of palifermin (a recombinant human keratinocyte growth factor) to decrease mucocutaneous injury and to promote epithelial repair in Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome-Toxic Epidermal…
- Trial name
- NCT02037347
- Testing
- Palifermin
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Brett King
Radiation Induced Oral Mucositis
Appaconitine Patch for Oral Mucositis Pain Caused by Chemoradiotherapy in Patients With Nasopharyngeal Cancer
The purpose of this clinical study is to evaluate the efficacy of lappaconitine adhesive patch in alleviation radiation induced mucositis pain and the improvements in QOL of patients with nasopharyngeal carcinoma .
- Trial name
- NCT03518489
- Testing
- Lappaconitine Adhesive Patch, standard care
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Fujian Cancer Hospital
Head and Neck Cancer
A Study of Palifermin for the Reduction of Oral Mucositis in Subjects With Advanced Head and Neck Cancer
The purpose of this study is to evaluate the efficacy and safety of palifermin (recombinant human keratinocyte growth factor, rHuKGF) in reducing the incidence of severe oral mucositis in subjects with locally advanced head and…
- Trial name
- NCT00131638
- Testing
- Palifermin
- Volunteers
- 241 people
- Sponsor
- Amgen
Radiation Induced Oral Mucositis, Radiodermatitis
Taurine's Therapeutic Effect on Acute Radiation-induced Oral Mucositis and Dermatitis
This is a single-center, double-blind, randomized controlled study. The patients were divided into control group and experimental group, 80 cases each.
- Trial name
- NCT07029178
- Testing
- Taurine granule
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Head-and-neck Squamous Cell Carcinoma, Oral Mucositis
Role of SAMITAL® in the Relief of Chemo-radiation (CT-RT) Induced Oral Mucositis in Head and Neck Cancer Patients
The purpose of this study is to: evaluate the activity of SAMITAL in reducing the incidence of severe mucositis in head-and-neck cancer patients undergoing chemo-radiotherapy.
- Trial name
- ROSAM (NCT01941992)
- Testing
- SAMITAL®
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Istituto Oncologico Veneto IRCCS