Clinical trials: Stomatitis, active
Ebola Virus Disease
Immunology of Ebola Vaccine
In this study 30 healthy adult participants will receive a single dose of an Ebola vaccine. Blood samples, fine needle aspirates, core biopsies, and bone marrow aspirates will be collected prior to and following vaccination to…
- Trial name
- NCT06100913
- Testing
- Recombinant Vesicular Stomatitis Vaccine for Ebola (rVSV∆G-ZEBOV-GP), Deuterium Labeled Water
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Emory University
Nasopharyngeal Cancinoma (NPC)
Sodium Bicarbonate for Reducing Radiation-Induced Oral Mucositis in Nasopharyngeal Carcinoma.
To evaluate whether the use of 2.5% sodium bicarbonate mouthwash throughout the entire course of radiotherapy for nasopharyngeal carcinoma reduces the severity of radiation-induced oral mucositis and improves patient adherence to…
- Trial name
- NCT06854510
- Testing
- Gargle with 2.5% sodium bicarbonate solution during radiotherapy, Gargle with 0.9% sodium chloride solution during radiotherapy
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Sun Yat-sen University
Oral Mucositis (Ulcerative) Due to Radiation, Nasopharyngeal Carcinoma (NPC)
Taurine for the Prevention and Treatment of Radiation-induced Oral Mucositis in Patients With Nasopharyngeal Carcinoma
This clinical trial aims to understand whether taurine can prevent and reduce severe radiation-induced oral mucositis in patients with nasopharyngeal carcinoma undergoing radiotherapy.
- Trial name
- NCT07567742
- Testing
- Taurine
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Sun Yat-sen University
Swallowing-induced Pain
Doxepin Solution for Alleviation of Stubborn Breakthrough Pain Induced by Swallowing in Patients Receiving Radiotherapy for Nasopharyngeal Carcinoma
The goal of this clinical trial is to explore the effectiveness and adverse reactions of doxepin solution spray for alleviation of stubborn breakthrough pain induced by swallowing in patients receiving radiotherapy for…
- Trial name
- NCT06017895
- Testing
- doxepin solution
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Nasopharyngeal Cancinoma (NPC), Radiation-induced Oral Mucositis
Prevention and Treatment of Radiation-Induced Oral Mucositis in NPC With Houyanqing Oral Liquid
To explore the efficacy of Houyanqing Oral Liquid combined with conventional treatment in preventing and treating radiation-induced oral mucositis, so as to improve the quality of life of nasopharyngeal carcinoma patients…
- Trial name
- NCT07311772
- Testing
- Houyanqing Oral Liquid, Conventional Treatment for Radiation-Induced Oral Mucositis
- Where
- 16 sites in China
- Volunteers
- 386 people
- Sponsor
- Sun Yat-sen University
Oral Lichen Planus, Recurrent Aphthous Stomatitis
Improving Prescribing Quality for Oral Mucosal Disorders Using a Pharmacist-Led Model
This study aims to improve how oral mucosal disorders-such as oral lichen planus, recurrent aphthous stomatitis, burning mouth syndrome, herpes viral infection and oral candidiasis-are treated in dental settings.
- Conditions
- Oral Lichen Planus, Recurrent Aphthous Stomatitis, Burning Mouth Syndrome, Oral Candidiasis
- Trial name
- NCT07721090
- Testing
- Pharmacist-Led Prescribing Optimization and Patient Counselling
- Volunteers
- 336 people
- Sponsor
- University of Fujairah
Oral Mucositis, Quality of Life
Effect of a Novel Topical Composition on the Incidence of Severe Oral Mucositis in Head & Neck Cancer Radiated Patients and Quality of Life Assessed by PROMs.
The use of a novel topical mucosa composition (XCM-OM118) comprising 2-(trimethylazaniumyl) acetate; (2R,3R,4S)-pentane-1,2,3,4,5-pentol; Hexadecanoic acid; (9Z, 12Z)-octadeca-9,12-dienoic acid; octadecanoic acid…
- Conditions
- Oral Mucositis, Quality of Life, Mucositis, Pain
- Trial name
- STOPOMP (NCT05635929)
- Testing
- XCM-OM118 Composition comprising olive oil, betaine and xylitol
- Where
- Spain
- Volunteers
- 63 people
- Sponsor
- Mucosa Innovations, S.L.
Cancer
Cryotherapy vs Lidocaine Spray for Oral Mucositis
The goal of this clinical trial is to evaluate the effectiveness of oral cryotherapy compared with topical lidocaine spray in preventing and reducing the severity of chemotherapy-induced oral mucositis among adult patients with…
- Trial name
- Cryotherapy vs (NCT07727031)
- Testing
- Oral Cryotherapy, Topical Lidocaine Spray
- Volunteers
- 60 people
- Sponsor
- Hanady Jabbar Mahmood
Head and Neck Cancer
Head and Neck Cancer Patients With Oral Mucositis Treated With Ketamine Oral Rinse
This 2-arm phase II study proposes to determine the efficacy of ketamine oral rinse in pain relief from mucositis in head and neck cancer patients undergoing radiation treatment.
- Trial name
- NCT06660017
- Testing
- Ketamine Topical
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Oklahoma
Oral Mucositis, Periodontal Diseases
F.L.O.S.S. Project (Facilitated Lessons on Oral and Systemic Health in Survivors)
The investigators will conduct a 2-arm 6-month randomized clinical controlled trial to evaluate the effectiveness of an oral Telehealth Intervention (THI) in preventing cancer-related oral complications, improving oral health…
- Conditions
- Oral Mucositis, Periodontal Diseases, Cancer
- Trial name
- NCT06315855
- Testing
- Telehealth Intervention (THI)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Georgetown University
Ebola Virus Disease
REVIVE (Response to the Ebola Virus Vaccine)
This study is a vaccine-related clinical trial which will be conducted by our study team at Kenema Government Hospital (KGH)'s Viral Hemorrhagic Fever Program in collaboration with Tulane University School of Medicine.
- Trial name
- NCT05992480
- Testing
- rVSVDG-ZEBOV-GP Ebola Virus Vaccine (ERVEBO)
- Where
- Sierra Leone
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tulane University
Nasopharyngeal Carcinoma (NPC)
Sapylin Versus Dexamethasone Inhalation for CCRT-Induced Oral Mucositis in Nasopharyngeal Carcinoma
Radiation therapy is the main treatment for nasopharyngeal carcinoma (NPC), and standard care for advanced NPC often includes combination chemotherapy and radiation (CCRT).
- Trial name
- NCT07327216
- Testing
- Sapylin, Dexamethasone, CCRT with Cisplatin
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Affiliated Hospital of Guangdong Medical University
Mucositis Oral, Head & Neck Cancer
Photobiomodulation Alone Versus Photobiomodulation Combined With Topical Oral Oxygen Therapy for Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients: A Randomized Clinical Trial
Oral mucositis is the inflammation and ulceration of the mucous membranes within the oral cavity, characterized by atrophy, edema, and erythema (1), and it occurs in nearly all patients with advanced head and neck cancer (HNC)…
- Trial name
- NCT07865780
- Testing
- sirolase xtent laser, blue m gel
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Assiut University
Oral Mucositis, Stomatitis
Amimestrocel Injection for Preventing Severe Oral Mucositis in HSCT Patients
This study aims to see if a single intravenous infusion of a cell therapy called Amimestrocel injection can help prevent severe mouth sores (oral mucositis) in patients receiving a stem cell transplant.
- Conditions
- Oral Mucositis, Stomatitis, Gastrointestinal Mucositis, Hematopoietic Stem Cell Transplantation
- Trial name
- NCT07400328
- Testing
- Amimestrocel injection
- Where
- China
- Volunteers
- 22 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Oral Mucositis
Photobiomodulation for the Prevention of Oral Mucositis
The goal of this clinical trial is to learn if photobiomodulation works to prevent severe oral mucositis in patients who are undergoing allogeneic hematopoietic cell transplantation.
- Trial name
- NCT07290413
- Testing
- Photobiomodulation - INTRAORAL, Photobiomodulation - EXTRAORAL, Photobiomodulation - INTRAORAL and EXTRAORAL
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Brigham and Women's Hospital
Colorectal Cancer
Protective Role of Alpha-Lipoic Acid in Chemotherapy-Induced Mucositis
Colorectal cancer (CRC) represents one of the most common cancers worldwide and 5-Fluorouracil (5-FU) is still the mainstay of treatment.
- Trial name
- NCT07736495
- Testing
- alpha lipoic acid 600 mg twice daily
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
B-Cell Non-Hodgkin Lymphoma, Histiocytic and Dendritic Cell Neoplasm
A Vaccine (VSV-hIFNβ-NIS) With or Without Cyclophosphamide and Combinations of Ipilimumab, Nivolumab, and Cemiplimab in Treating Relapsed or Refractory Multiple Myeloma, Acute Myeloid Leukemia or Lymphoma
This phase I trial studies the best dose and side effects of the VSV-hIFNβ-NIS vaccine with or without cyclophosphamide and combinations of ipilimumab, nivolumab, and cemiplimab in treating patients with multiple myeloma, acute…
- Conditions
- B-Cell Non-Hodgkin Lymphoma, Histiocytic and Dendritic Cell Neoplasm, Myelodysplastic Syndrome, Previously Treated Myelodysplastic Syndrome
- Trial name
- NCT03017820
- Testing
- Biopsy Procedure, Biospecimen Collection, Bone Marrow Biopsy
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- Mayo Clinic
Head and Neck Tumors, Breathomics
Breathomics in the Diagnosis and Prediction of Radiotherapy-Induced Oropharyngeal Mucositis in Head and Neck Tumors
Radiotherapy-Induced Oropharyngeal Mucositis (RIOM) is one of the most distressing side effects for patients with head and neck tumors during radiotherapy, requiring clinical physicians to manage it according to the severity of…
- Conditions
- Head and Neck Tumors, Breathomics, Volatile Organic Compounds, Radiotherapy-induced Oral Mucositis
- Trial name
- NCT06767488
- Where
- China
- Volunteers
- 375 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Advanced or Metastatic Breast Cancer
The Efficacy of Oral Cryotherapy in Preventing TROP2-ADC-Induced Oral Mucositis in Patients With Advanced Breast Cancer
The incidence of oral mucositis associated with TROP2-ADC therapy in patients with advanced breast cancer is notably high. Identifying effective preventive and therapeutic strategies is essential for enhancing patient quality of…
- Trial name
- NCT06934733
- Testing
- Oral cryotherapy, Routine oral care
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Henan Cancer Hospital
Recurrent Aphtous Stomatitis
Randomized Double Blind Controlled Trial Comparing the Safety and Efficacy of Apremilast Versus Placebo in Severe Forms of Recurrent Aphthous Stomatitis
The objective of the study is to assess the superiority of apremilast in comparison with placebo to achieve Complete Remission (CR) of oral ulcers at Week 12, in patients with severe Recurrent aphtous stomatitis resistant or…
- Trial name
- PREMS (NCT04227314)
- Testing
- Apremilast
- Where
- 21 sites in France
- Volunteers
- 134 people
- Sponsor
- University Hospital, Rouen