Clinical trials: Sternotomy, open to volunteers
Median Sternotomy, Pain Management
Effect of Parasternal Plane Block on Intraoperative Nociception
Effective pain control during pediatric cardiac surgery remains a major clinical challenge, particularly in procedures involving median sternotomy, which is associated with intense nociceptive stimulation.
- Trial name
- NCT07354750
- Testing
- Parasternal Plane Block, Group without peripheral nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Ascending Aortic Aneurysm
Full Sternotomy vs Mini-sternotomy for Ascending Aortic Pathology
This study investigates outcomes after hemiarch repair in patients with chronic ascending aortic disease. The patients will be divided into two groups according to surgical approach: 100 patients will undergo hemiarch repair via…
- Trial name
- NCT07386028
- Testing
- Full sternotomy, J-shaped mini-sternotomy
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Tomsk Cardiology Research Institute
Sternotomy
SuperCable vs. Conventional Steel Wire for Closure After a Median Sternotomy
During certain heart surgeries, the sternum is opened and must then be closed securely. The study compares two closure methods - steel wires and SuperCable - in terms of stability, healing, and patient satisfaction.
- Trial name
- SURE (NCT07251881)
- Testing
- SuperCable®, Steel Wires
- Where
- Switzerland
- Volunteers
- 86 people
- Sponsor
- University of Zurich
Complete Revascularization, Coronary Artery Bypass Grafting
Complete Revascularization Via Inferior Part-sternotomy
To verify the effectiveness and safety of minimally invasive coronary artery bypass grafting for complete revascularization of multivessel coronary artery disease via inferior part-sternotomy, We aim to randomize 260 patients…
- Conditions
- Complete Revascularization, Coronary Artery Bypass Grafting, Multivessel Coronary Artery Disease
- Trial name
- NCT05835167
- Testing
- Inferior part-sternotomy, Full median sternotomy
- Volunteers
- 260 people
- Sponsor
- China National Center for Cardiovascular Diseases
Bariatric Surgery, Cardiac Surgery With Sternotomy
Suzetrigine-enhanced MultimOdal Opioid-sparing THerapy in Cardiac and Bariatric SURGery
This is prospective, randomized study. The purpose of this study is to evaluate whether the addition of Suzetrigine to well established multimodal pain regimen for participants undergoing bariatric patients undergoing weight-loss…
- Conditions
- Bariatric Surgery, Cardiac Surgery With Sternotomy, Post-operative Pain
- Trial name
- SMOOTH-SURG (NCT07539623)
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 235 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Bypass Surgery, Arrythmia
Parasternal Intercostal Plane Catheter for Pain Control After CABG Surgery
Coronary artery bypass graft (CABG) surgery performed via sternotomy (incision of the breastbone) can cause severe pain after surgery; this can slow recovery and increase the need for opioid pain relievers.
- Conditions
- Bypass Surgery, Arrythmia, Postoperative Pain
- Trial name
- PIP-PAIN (NCT07759570)
- Testing
- Parasternal blocks
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Koc University Hospital
Chronic Pain, Postoperative, Sternotomy Pain
Early Screening of Chronic Post-sternotomy Pain Using the DN4-i Questionnaire
Chronic post-sternotomy pain (CPSP) is a common complication after cardiac surgery, with a reported prevalence between 30% and 50%.
- Trial name
- DEPDN4i (NCT07603271)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Institute Arnault Tzanck, France
Postoperative Pain, Cardiac Surgery
Comparison of Paravertebral Block and Deep Parasternal Intercostal Plane Block in Cardiac Surgery
Median sternotomy is commonly used in cardiac surgery and is often associated with significant postoperative pain. Poor pain control after sternotomy may increase opioid use, delay mobilization, prolong extubation time, and…
- Conditions
- Postoperative Pain, Cardiac Surgery, Postoperative Pain After Cardiac Surgery Via Median Sternotomy
- Trial name
- SPARE-CABG (NCT07498946)
- Testing
- Thoracic paravertebral block (TPVB), Bilateral Deep Parasternal Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Gaziantep City Hospital
Sternotomy Closure,Open Heart Surgery
Adjustable Carbon Fiber Sternal Plates for Sternotomy Closure
The goal of this clinical trial is to learn if a new medical device (SC03 plates) to close the sternum after a sternotomy in patients that have been operated of a cardiac surgery, is safe and effective.
- Trial name
- FIX IT ALL (NCT07366203)
- Testing
- SC03 Plating system, Stainless steel wires
- Volunteers
- 190 people
- Sponsor
- NEOS Surgery
Frailty, Coronary Artery Disease
Funcional Recovery After Minithoracotomy or Sternotomy for CABG in Frail Patients
Frailty is a major predictor of adverse outcomes following coronary artery bypass grafting (CABG), being associated with increased postoperative complications, prolonged hospitalization, delayed functional recovery, and reduced…
- Conditions
- Frailty, Coronary Artery Disease, Coronary Artery Bypass Graft (CABG)
- Trial name
- MINIFRAGILE (NCT07742475)
- Testing
- Minimally Invasive Coronary Artery Bypass Grafting (MICS-CABG), Conventional Coronary Artery Bypass Grafting (Median Sternotomy)
- Volunteers
- 194 people
- Sponsor
- University of Sao Paulo General Hospital
Sternotomy, Cardiovascular Diseases
RCT on T-REX Twente Regimen Effects on Quality of Life and Mobilisation for Cardiac Surgery Patients After Sternotomy
The goal of this study is whether the T-REX Twente precautions have a positive impact on the quality of life (MAcNew QLMI), level of physical activity, and reduction of fear of movement in heart patients after a total median…
- Conditions
- Sternotomy, Cardiovascular Diseases, Physical Inactivity, Quality of Life
- Trial name
- T-REX Twente (NCT06115759)
- Testing
- T-REX Twente precautions, Usual (restrictive) sternal precautions
- Where
- Netherlands
- Volunteers
- 154 people
- Sponsor
- Medisch Spectrum Twente
Chronic Poststernotomy Pain
Bilateral Pecto-Intercostal Fascial Plane Block for Prevention of Chronic Poststernotomy Pain After CABG
This single-center, prospective, parallel-group randomized controlled trial will evaluate whether adding ultrasound-guided bilateral single-shot pecto-intercostal fascial plane block (PIFB) to standard multimodal systemic…
- Trial name
- NCT07882836
- Testing
- Pecto-Intercostal Fascial Plane Block, Standardized Multimodal Systemic Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Izmir Katip Celebi University
Pain, Postoperative
Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children
The primary objective of this study is to determine if the peri and post operative use of gabapentin in children reduces the need for narcotics after thoracic surgery.
- Trial name
- NCT04724252
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Davis
Cardiovascular Surgical Procedures, Pain, Postoperative
Fascial Plane Blocks and Quality of Recovery in Cardiac Surgery
In this randomized trial, the investigators will test the hypothesis that combining regional analgesia techniques-which have the potential to improve the quality of postoperative recovery following median sternotomy-with PIFB…
- Conditions
- Cardiovascular Surgical Procedures, Pain, Postoperative, Cardiovascular Diseases
- Trial name
- NCT07557108
- Testing
- Ultrasound-Guided Pectointercostal Fascial Plane Block, Ultrasound-Guided Rectus Sheath Block, Ultrasound-Guided Recto-Intercostal Fascial Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 123 people
- Sponsor
- Ordu University
Postoperative Pain, Sternotomy
Preoperative Deep Parasternal Intercostal Plane Block and Intraoperative Opioid Use in Cardiac Surgery
Median sternotomy is commonly used in cardiac surgery and is associated with significant intraoperative and postoperative pain, often requiring substantial opioid administration.
- Conditions
- Postoperative Pain, Sternotomy, Opioid Consumption, Intraoperative Pain Control
- Trial name
- NCT07315308
- Testing
- Deep Parasternal Intercostal Plane Block, Standard Multimodal Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Gaziantep City Hospital
Retrospective Review, Cerclage
Enhanced Sternal Closure With Montage or Montage-CT to Evaluate Post-Operative Opioid Use Following Median Sternotomy
This is a retrospective study based on analysis real world data obtained from hospitals that have adopted use of Montage or Montage-CT for use following sternotomy.
- Conditions
- Retrospective Review, Cerclage, Pain Management
- Trial name
- NCT07215546
- Testing
- Montage or Montage CT
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Abyrx, Inc.
Chronic Postsurgical Pain
Effectiveness of Myofascial Release in Patients With Chronic Post Sternotomy Pain Syndrome
The main aim of this study is to investigate the effectiveness of Myofascial release in patients with chronic sternotomy pain.
- Trial name
- NCT06630208
- Testing
- Myofascial release, Breathing exercises, Pharmacological treatment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Ultrasound, Pectoral Nerve Block
Ultrasound Guided Bilateral Pectoral Nerve Block Versus Bilateral Transverse Thoracic Plane Block In Pediatric Patients Undergoing Corrective Cardiac Surgeries Requiring Cardiopulmonary Bypass Via Median Sternotomy
This randomized, double-blinded, study aims to compare the efficacy of intraoperative and postoperative pain control while using bilateral ultrasound guided the pectoral nerves (PECS) versus transversus thoracic muscle plane…
- Conditions
- Ultrasound, Pectoral Nerve Block, Transverse Thoracic Plane Block, Pediatric Patients
- Trial name
- NCT06984276
- Testing
- Control, Pectoral nerves (PECS), Transversus thoracic muscle plane block (TTPB)
- Where
- Egypt
- Volunteers
- 81 people
- Sponsor
- Cairo University
Heart Valve Diseases or Prosthesis, Aortic Valve Stenosis
Comparison of Early Postoperative Outcomes Between Minimally Invasive Valve Surgery Via Right Thoracotomy and Conventional Valve Surgery Via Sternotomy.
This randomized controlled trial aims to compare early postoperative outcomes between Minimally Invasive Valve Surgery (MIVS) via right thoracotomy and Conventional Valve Surgery via median sternotomy in patients undergoing…
- Conditions
- Heart Valve Diseases or Prosthesis, Aortic Valve Stenosis, Aortic Valve Insufficiency, Valvular Heart Disease Stenosis and Regurgitation (Diagnosis)
- Trial name
- NCT07251660
- Testing
- Minimally Invasive Valve Surgery, Conventional Valve Surgery
- Volunteers
- 32 people
- Sponsor
- Chaudhry Pervaiz Elahi Institute of Cardiology
Coronary Artery Bypass, Off-Pump, Minimally Invasive Cardiac Surgery
MInithoraCotomy vs Sternotomy for Multivessel Coronary Artery Bypass Grafting: A Partially Randomized Patient Preference Trial Assessing Quality of Life and Patency Outcomes
This trial will address essential questions of the efficacy and safety of MICS-CABG in addition to the quality of life and patency rate of the grafts.
- Trial name
- NCT04795193
- Testing
- Minimal invasive coronary surgery, Off-pump coronary artery bypass surgery
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Peking University Third Hospital