Clinical trials: Status Epilepticus
Epilepticus; Status, Focal Motor
Perampanel in Focal Status Epilepticus
Randomized controlled trial on focal motor status epilepticus (SE), studying the add-on efficacy of the enteral administration of perampanel (PER) to a conventional intravenous antiepileptic drug.
- Trial name
- PEPSI (NCT04309721)
- Testing
- Perampanel
- Where
- 10 sites in France
- Volunteers
- 1 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Epilepsy, Status Epilepticus
Training Program to Improve EEG Competence
The goal of this clinical trial is to investigate the extent to which a practice-oriented training program for intensive care nursing staff and non-physician treatment teams can contribute to the earlier detection of epileptic…
- Conditions
- Epilepsy, Status Epilepticus, Status Epilepticus, Electrographic, Status Epilepticus, Non-Convulsive
- Trial name
- EPI-Train (NCT07689084)
- Testing
- Training Program
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital Marburg
Status Epilepticus
Improving Status Epilepticus Treatment Times
This is a stepped-wedge cluster randomized effectiveness-implementation hybrid study aimed at determining the effect of dissemination of a QI bundle on the time to treatment of SE among hospitalized, non-critically ill children.
- Trial name
- QuITT-SE (NCT06194747)
- Testing
- Quality improvement bundle, Quality improvement bundle and local PDSA cycles with central support, Quality improvement bundle and local PDSA cycles without central support
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Nationwide Children's Hospital
Status Epilepticus
Prognosis Factors Associated With Convulsive Status Epilepticus in Adults
The aim of the study is to evaluate, prospectively, prognosis factors associated with convulsive status epilepticus (CSE) in adults hospitalized in intensive care units.
- Trial name
- NCT00318578
- Where
- 34 sites in France
- Volunteers
- 100 people
- Sponsor
- Versailles Hospital
Electrical Status Epilepticus of Slow-Wave Sleep
Efficacy of Epidiolex in Patients With Electrical Status Epilepticus of Sleep (ESES).
This study aims to assess the efficacy of Epidiolex in patients with ESES. ESES is characterized by sleep potentiated spikes with a spike index greater than 85% (conventional definition) and 50% (new definition)1.
- Trial name
- NCT04721691
- Testing
- Epidiolex 100 mg/mL Oral Solution
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Northwell Health
Status Epilepticus
Efficacy Comparison Between Levetiracetam and Valproic Acid in Pediatric Patients With Status Epilepticus
Since there is a significant degree of variability in the results of previous studies and there exists a thirst for local data regarding this topic, the current study was planned, with the objective of comparing the efficacy of…
- Trial name
- NCT07052136
- Testing
- Levetiracetam, Valproic acid
- Where
- Pakistan
- Volunteers
- 138 people
- Sponsor
- RESnTEC, Institute of Research
Status Epilepticus
Improving Emergency Management of Status Epilepticus
In the trial the effectiveness of pre-briefing physicians with the current guideline on Status epilepticus (SE) treatment or a consolidated "one page" guideline regarding quality enhancement of the physician's clinical…
- Trial name
- SESIM (NCT03883516)
- Testing
- Pre-briefing with the current SE treatment guidelines, Pre-briefing with a consolidated "one page" SE treatment guide, No Pre-briefing
- Where
- Switzerland
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Generalized Convulsive Status Epilepticus
Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus
Although generalized convulsive status epilepticus (GCSE) is a life-threatening emergency, evidence-based data to guide initial drug treatment choices are lacking in the Chinese population.
- Trial name
- NCT03025906
- Testing
- Phenobarbital, Valproate
- Where
- 6 sites in China
- Volunteers
- 120 people
- Sponsor
- Xuanwu Hospital, Beijing
Refractory Status Epilepticus
Efficacy and Safety of Perampanel in the Treatment of Refractory Status Epilepticus
This project is aiming to better understand the use of perampanel as an appropriate standard-of-care therapy for treatment refractory status epilepticus (RSE), to identify determinants of outcomes, and establish safety.
- Trial name
- NCT05684978
- Testing
- Perampanel
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Wayne State University
Psychomotor Status, Muscle Strain, Lower Leg
The Effect of Dance Training on Psychomotor, Biomechanical and Biochemical Parameters in Adults
Clinical Trial, repeated-measures design, pilot study. 81 young adults, male (30) and female (51) underwent research protocol. The aim of the research will be to assess the impact of long-term dance training on psychomotor…
- Conditions
- Psychomotor Status, Muscle Strain, Lower Leg, Muscle Strain Back, Balanced
- Trial name
- Dance (NCT06600594)
- Testing
- Beginners dance training, Experience dance training
- Where
- Poland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Józef Piłsudski University of Physical Education
Status Epilepticus
Paramedic Treatment of Prolonged Seizures by Intramuscular Versus Intravenous Anticonvulsant Medications
The goal of this non-inferiority trial is to determine which type of routine care is the best for paramedics to stop someone from seizing.
- Trial name
- RAMPART (NCT00809146)
- Testing
- Intramuscular route of active treatment, Intravenous route of active treatment
- Where
- 17 sites in United States
- Volunteers
- 1,023 people
- Sponsor
- Robert Silbergleit
Seizure
Levetiracetam Versus Phenobarbital in Benzodiazepines Unresponsive Paediatric Prolonged Seizures
Convulsive prolonged seizures in children are the most common life-threatening neurological emergencies. The aim of active management of seizure control is to prevent irreversible neuronal damage as early as possible.
- Trial name
- NCT07098728
- Testing
- Levetiracetam IV, Phenobarbital
- Where
- 2 sites in Burma
- Volunteers
- 180 people
- Sponsor
- Ministry of Health and Sports, Myanmar
Status Epilepticus, Convulsive Status Epilepticus
Predictors of Outcomes of Convulsive Status Epilepticus
Status epilepticus is a life-threatening neurological emergency characterized by prolonged seizures or multiple seizures occurring without the patient regaining consciousness between episodes.
- Trial name
- NCT07853391
- Volunteers
- 100 people
- Sponsor
- Assiut University
Epilepsy
Possible Immuno-Modulatory Effect of Tocilizumab in Patients With Refractory Status Epilepticus.
Recently, the pathogenesis of epilepsy is immuno-modulatory and neuro-inflammatory which is commonly activated in epileptogenic brain regions in humans and is clearly involved in animal models of epilepsy.
- Trial name
- NCT05346666
- Testing
- Tocilizumab Prefilled Syringe [Actemra]. propofole, phenobarbital, midazolam
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Damanhour University
Coma, Electrographic Status Epilepticus
Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation-2 (TELSTAR-2)
The goal of this comparative effectiveness trial is to study electrographic status epilepticus (ESE) treatment in comatose patients after cardiac arrest.
- Trial name
- TELSTAR-2 (NCT06549426)
- Testing
- anti-seizure medication + sedative agent(s)
- Where
- 21 sites in Belgium, Netherlands
- Volunteers
- 150 people
- Sponsor
- University of Twente
Status Epilepticus
A Clinical Study of Children With Status Epilepticus in China
Phase 1: The first part of study is a multi-center, retrospect study involving 38 hospitals. The program is a national epidemiological study on status epilepticus in Chinese children.The aims of the epidemiological study include…
- Trial name
- NCT03378687
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Fudan University
Epilepsia Partialis Continua, Status Epilepticus
Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Epilepsy
The purpose of this study is to assess the effects of repetitive transcranial magnetic stimulation (rTMS) as a treatment for Epilepsia Partialis Continua (EPC) or refractory Status Epilepticus (SE), when standard clinical…
- Trial name
- NCT02560597
- Testing
- repetitive transcranial magnetic stimulation
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- University Hospital, Ghent
Super-Refractory Status Epilepticus
An Open Label, Expanded Access Protocol With SAGE-547 for Super-Refractory Status Epilepticus
This is an open-label, expanded access protocol, designed to offer treatment with SAGE-547 to subjects in SRSE, and to evaluate the efficacy and safety of SAGE-547 administered as a continuous intravenous infusion to these…
- Trial name
- NCT02433314
- Testing
- SAGE-547
- Sponsor
- Supernus Pharmaceuticals, Inc.
Status Epilepticus, Generalized Convulsive Status Epilepticus
Effectiveness of Combined Levetiracetam and Midazolam in Generalized Convulsive Status Epilepticus in Children
Generalized status epilepticus is a common pediatric neurological emergency with significant mortality and morbidity. Benzodiazepines remain the first anticonvulsive line but benzo-diazepines don't control seizures in about 30%…
- Conditions
- Status Epilepticus, Generalized Convulsive Status Epilepticus, Status Epilepticus, Generalized, Status Epilepticus, Generalized Convulsive
- Trial name
- NCT04926844
- Testing
- Levetiracetam, Midazolam
- Where
- Egypt
- Volunteers
- 144 people
- Sponsor
- Sohag University
Neonatal Encephalopathy
Remote EEG Device for Identification of Risk for Neonatal Seizures
The purpose of this study is to see if the use of wireless brain wave monitoring can be helpful for newborns and help their medical providers identify seizures earlier and to monitor for the risk for seizures.
- Trial name
- NCT05239585
- Testing
- Epilog device
- Where
- United States
- Sponsor
- Mayo Clinic