Clinical trials: Split-mouth Design
Dental Caries
Comparison Between Biodentine and Calcium Hydroxide in the Indirect Pulp Treatment on Primary Teeth
Objective: The study's main purpose is to evaluate and compare the clinical and radiographic outcomes of Biodentine and a light-activated calcium hydroxide based-liner (Ultra-Blend plus®) as indirect pulp treatment (IPT) liners…
- Trial name
- IPT (NCT02799927)
- Testing
- Indirect Pulp Treatment with Bioactive Dentin Substitute, Indirect Pulp treatment with Calcium hydroxide
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- José Arturo Garrocho Rangel
Surgical Extraction of Impacted Third Molars
The Use of Manuka Honey to Improve Healing After Third Molars Surgery
Since there is an evidence that Manuka honey is an antibacterial agent, the present study aims to confirm this characteristic and assess its effect in improving healing and reducing postsurgical symptoms, if topically applied…
- Trial name
- NCT02483741
- Testing
- Manuka Honey
- Where
- Syria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Damascus University
Gingival Health, Metal Ceramic Restorations
The Effect of Fixed Dentures on Periodontal Tissues in Long-term.
The goal of this observational study is to to evaluate the periodontal condition around metal-ceramic crown. The main question to be answered is: whether the metal-ceramic crown is the cause of gum changes? The study offers to…
- Trial name
- NCT07611461
- Where
- Latvia
- Volunteers
- 75 people
- Sponsor
- Riga Stradins University
Edentulism
Success Rate of Immediately Loaded Implants With Platform Switched Design Placed in Anterior Part of Mandible and Restored With Fixed Prostheses
Change in crestal bone level implants at 5% significance level.
- Trial name
- NCT00780273
- Testing
- Ankylos Implants, Biomet 3i Prevail Implants
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Dentsply International
White Spot Lesion, Enamel Hypomineralization
Evaluation of CPP-ACP Prophylactic Effect on Enamel Surface During Orthodontic Treatment
This study is aiming in preventing the formation of WSL associated with orthodontic treatment which occurs to more than 50% of orthodontically treated patients through applying CPP-ACP on the enamel surface once every 2 weeks for…
- Trial name
- NCT03187548
- Testing
- Casein Phosphopeptide-Amorphous Calcium Phosphate Dental Paste
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Patient Comfort, Malocclusion
Comparison of Patient-Reported Comfort Between Two Clear Aligner Trimming-Line Designs: A Split-Mouth Study
The trimming-line design of clear aligners (supragingival versus juxtagingival) is a routine clinical decision whose influence on patient-reported comfort has not been established; available evidence on aligner comfort derives…
- Conditions
- Patient Comfort, Malocclusion, Oral Health
- Trial name
- COMFORT-ALIGN (NCT07660809)
- Testing
- Supragingival trimming-line design, Juxtagingival festooned trimming-line design
- Where
- Romania
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Suture Materials, Wound Healing
Patient-Reported Outcomes of Four Intraoral Suture Materials
When patients undergo minor oral surgery, dentists use various types of stitches (sutures) to help the gums heal. These stitches can be made of different materials, and some might feel more comfortable, cause less pain, or…
- Conditions
- Suture Materials, Wound Healing, Patient Comfort, Oral Health-Related Quality of Life
- Trial name
- NCT07569237
- Testing
- Silk Suture (Braided, Non-absorbable), Polyglactin 910 Suture (Braided, Absorbable), Polyamide Suture (Monofilament, Non-absorbable)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Canine Retraction, Piezocision
Comparative Assessment of Maxillary Canine Retraction With and Without Piezocision
Intraoral impressions with alginate will be taken at the start of treatment and plaster casts will be obtained by using ortho plaster.
- Trial name
- NCT07752212
- Testing
- Piezocision, Conventional canine retraction
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Foundation University Islamabad
Class II Div 1 Malocclusion
The Rate of Space Closure With Piezocision-based Corticotomy in Different Facial Types: A Split-mouth Design
23 female participants with class II div I will have extraction of bilateral first bicuspids 10 weeks after bond- up appointment. The extracted teeth will be preserved in special containers for subsequent microscopic analysis.
- Trial name
- RCT (NCT04202016)
- Testing
- Piezocision Surgery
- Where
- Jordan
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Dental Disorders Hard Tissues of Teeth, Tooth Discoloration
Effect of Preparation Design on the Functional and Esthetic Outcome of CAD/CAM Lithium Disilicate Laminate Veneers
Conservatism is considered the main concern in any treatment plan, the feather edge preparation design of laminate veneers have been introduced yet clinical studies are lacking to evaluate their clinical performance.The aim of…
- Trial name
- NCT04840524
- Testing
- Laminate veneers preparation
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Malocclusion, Esthetics, Dental
Effect of Finishing Clear Aligner Marginal Termination Design (Supragingival vs Juxtagingival) on Aligner Color Stability After 14 Days of Wear: A Split-Mouth Study
The goal of this clinical study is to learn whether the gumline edge design of a finishing orthodontic clear aligner affects how much the aligner's color changes after 14 days of wear.
- Trial name
- SPECTRO-ALIGN (NCT07628491)
- Testing
- Tri-layer thermoplastic finishing clear aligner
- Where
- Romania
- Volunteers
- 50 people
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Maxillary Sinus Augmentation, Posterior Maxillary Atrophy
Histologic and Histomorphometric Evaluation of Lateral Maxillary Sinus Augmentation With or Without Platelet-Rich Fibrin
This study evaluates bone healing after lateral maxillary sinus lift surgery performed prior to dental implant placement. This surgical procedure is commonly used when there is insufficient bone height in the upper jaw to support…
- Trial name
- NCT07348198
- Testing
- Lateral Maxillary Sinus Augmentation With DFDBA, Lateral Maxillary Sinus Augmentation With DFDBA and PRF
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Marmara University
Dental Caries, Reversible Pulpitis
Assessment of Pain and Anxiety During Infiltration Anesthesia Using Dental Anesthesia Injector Versus Conventional Syringe in Pediatric Patients
This randomized controlled trial is conducted on pediatric dental patients to compare the effectiveness of local anesthesia administered using a dental anesthesia injector device versus the traditional syringe method.
- Trial name
- NCT07101068
- Testing
- Dental Anesthesia Injector, conventional syringe
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anesthesia, Local
Efficiency of Single Buccal Infiltration Versus Buccal and Intrapapillary Infiltration
Everyday practice in dentistry is based on giving the painless injection and achieving adequate local anesthesia. Various techniques of reducing injection pain in children can be broadly categorized as psychological and physical.
- Trial name
- NCT04458142
- Testing
- Single buccal infiltration
- Volunteers
- 25 people
- Sponsor
- Cairo University
Partially Edentulous Maxilla, Mandible
Submerged vs. Nonsubmerged Single Laser-microgrooved Dental Implants.
Aim: to evaluate and compare radiographic marginal bone loss (MBL) and soft tissue parameters around submerged/two-stage and nonsubmerged/one-stage single implants with same tapered body design and surface, same thread design and…
- Trial name
- NCT03674762
- Testing
- Microgrooved dental implants
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Orthodontic Appliance Complication, Orthodontic Appliance Design
Periodontal and Orthodontic Outcomes of Straight vs. Looped Fixed Retainers
The goal of this split-mouth, head-to-head, randomized controlled trial is to compare the effects of a fixed straight retainer with the V- loop bonded retainer on periodontal health in patients with the requirement of continuous…
- Conditions
- Orthodontic Appliance Complication, Orthodontic Appliance Design, Orthodontic Treatment
- Trial name
- NCT05644119
- Testing
- V- loop Bonded Orthodontic Retainer, Straight Wire Retainer
- Where
- Saudi Arabia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Tooth, Impacted
Comparison Between the Lingually Based and the Buccally Based Triangular Flap Design in the Surgical Removal of Impacted Mandibular Third Molars
The primary objective of this study was to compare between the lingually based triangular flap with the buccally based triangular flap in the surgical removal of impacted mandibular third molars.
- Trial name
- NCT04192864
- Testing
- Lingually based triangular flap, Buccally based triangular flap
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Nourhan M.Aly
Periodontitis
Emdogain Minimally Invasive Surgical Technique
The aim of this controlled study is to assess the clinical outcomes and patient reported outcomes of using minimally invasive surgical procedure with Straumann Emdogain as an adjunct (test treatment) or without Straumann Emdogain…
- Trial name
- NCT02551770
- Testing
- Scaling and root planing, Scaling and root planing without Emdogain, Emdogain application
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Institut Straumann AG
Oral Health
Quaternary Ammonium Methacryloxy Silicate-containing Acrylic Resin
One of the major challenges in orthodontic treatment is long-term stability. Because removable retainers are worn for at least one year, bacteria and fungi may accumulate on the retainers in the form of multi-species plaque…
- Trial name
- NCT02525458
- Testing
- QAMS-containing PMMA, QAMS-free PMMA
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Frank Tay, BDSc (Hons), PhD
Gingival Recession, Generalized, Gingival Recession, Localized
Clinical and Histological Evaluation of Subepithelial Connective Tissue Graft Maturation at Different Healing Timepoints, With and Without Topical Application of a Polynucleotide- and Hyaluronic Acid-Based Gel
This study evaluates whether a 9-week healing interval is sufficient for subepithelial connective tissue graft (SCTG) maturation after palatal harvesting, and whether topical application of a polynucleotide and hyaluronic acid…
- Conditions
- Gingival Recession, Generalized, Gingival Recession, Localized, Wound Healing, Palate; Wound
- Trial name
- NCT07708051
- Testing
- polynucleotide and hyaluronic acid gel, subepithelial connective tissue graft harvesting
- Volunteers
- 15 people
- Sponsor
- University of Sao Paulo