Canine RetractionNCT07752212
Comparative Assessment of Maxillary Canine Retraction With and Without Piezocision
A study testing Piezocision and Conventional canine retraction in people with Canine Retraction and Piezocision, run by Foundation University Islamabad at 1 site in Pakistan.
Trial summary
Intraoral impressions with alginate will be taken at the start of treatment and plaster casts will be obtained by using ortho plaster. Separators will be passed mesial and distal to first molars to create space for band placement. After 7-10 days bands will be cemented on first molars. Read more about this study
- Who is it for?
- Ages 15 to 35 years
- Conditions the study is for
- Canine Retraction, Piezocision
- What is being tested?
- Piezocision and Conventional canine retraction
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 30 participants
- Where
- 1 sitePakistan
- Study dates
- 1 Jul 2022to 1 Jul 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 15 to 35 years
- All sexes
- No healthy volunteers
- Child, Adult
Who may be able to join
- Patients between the age of 15-35 years
- Both male and female patients
- Treatment plan with extraction of maxillary first premolars or both maxillary and mandibular first premolars.
- Space for canine retraction of at least 3mm after levelling and alignment
Who cannot join
- Craniofacial syndromes
- Previous Orthodontic treatment
- Systemic disease
- Periodontal bone loss
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Foundation University College of Dentistry and Hospital
Islamabad, Federal, 44000
About this study
Official title: Comparative Assessment of Maxillary Canine Retraction With and Without Piezocision - A Randomized Clinical Trial"
Intraoral impressions with alginate will be taken at the start of treatment and plaster casts will be obtained by using ortho plaster. Separators will be passed mesial and distal to first molars to create space for band placement. After 7-10 days bands will be cemented on first molars. Pre- adjusted edgewise brackets with 0.022 in-slot Roth appliance will be bonded on teeth according to the treatment plan. Extractions will be done according to the treatment plan and piezocision will be carried out after levelling and alignment.
This will be a split mouth study with one side receiving piezocision (experimental) and the other side acting as control, after random allocation. Randomization will be done by simple randomization method in which experimental side will be randomly allocated to the patient and opposite side of the same patient will act as control. First patient will have piezocision on right side and 2nd patient will have piezocision on left side, 3rd patient will have piezocision on right side and 4th patient will have piezocision on left side and so on.
After extraction of maxillary first premolars, piezocision will be performed on experimental side whereas the opposite side will be taken as control. Piezocision will be performed under local anesthesia by giving two vertical interproximal incisions on mesiobuccal \& distobuccal line angles of canine on experimental side 2mm below the interdental papilla with piezo electrical knife without flap reflection. Piezoelectric incisions of the cortical alveolar bone will then be made with piezotome. The incisions will be sutured with non resorbable 4-0 black silk with the interrupted suture technique. After piezocision canine retraction will be carried out by either continuous mechanics, sectional mechanics or sliding mechanics depending on the treatment plan. Mechanics will be same on left and right side of the patient and mean retraction will be measured at four time intervals. T0 at the start of canine retraction, T1 at 4 weeks, T2 at 8 weeks and T3 at 12 weeks after piezocision
Read the detailed description
Intraoral impressions with alginate will be taken at the start of treatment and plaster casts will be obtained by using ortho plaster. Separators will be passed mesial and distal to first molars to create space for band placement. After 7-10 days bands will be cemented on first molars. Pre- adjusted edgewise brackets with 0.022 in-slot Roth appliance will be bonded on teeth according to the treatment plan. Extractions will be done according to the treatment plan and piezocision will be carried out after levelling and alignment.
This will be a split mouth study with one side receiving piezocision (experimental) and the other side acting as control, after random allocation. Randomization will be done by simple randomization method in which experimental side will be randomly allocated to the patient and opposite side of the same patient will act as control. First patient will have piezocision on right side and 2nd patient will have piezocision on left side, 3rd patient will have piezocision on right side and 4th patient will have piezocision on left side and so on. After extraction of maxillary first premolars, piezocision will be performed on experimental side whereas the opposite side will be taken as control. Piezocision will be performed under local anesthesia by giving two vertical interproximal incisions on mesiobuccal \& distobuccal line angles of canine on experimental side 2mm below the interdental papilla with piezo electrical knife without flap reflection. Piezoelectric incisions of the cortical alveolar bone will then be made with piezotome. The incisions will be sutured with non resorbable 4-0 black silk with the interrupted suture technique. After piezocision canine retraction will be carried out by either continuous mechanics, sectional mechanics or sliding mechanics depending on the treatment plan. Mechanics will be same on left and right side of the patient and mean retraction will be measured at four time intervals. T0 at the start of canine retraction, T1 at 4 weeks, T2 at 8 weeks and T3 at 12 weeks after piezocision.
Alginate impressions will be taken at T0, T1, T2 and T3. The anteroposterior crown tip movements of the canines will be assessed on scanned cast at 4 time points (T0-T3). A cast showing the reference lines, the midpalatine raphe (MPR) and the rugae line (RL) formed by a projection from the most medial point on the third right rugae. The distance between the cusp tip of the canine and the rugae line used to measure the anteroposterior canine movement is dc.
- Conditions
- Canine Retraction, Piezocision
- Being tested
- Piezocision, Conventional canine retraction
- Keywords
- Canine retraction, Accelerated Orthodontics, Piezocison, Tooth movement techniques, Split-mouth design
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
PiezocisionProcedure or surgery
After extraction of maxillary first premolars, piezocision will be performed on experimental side whereas the opposite side will be taken as control. Piezocision will be performed under local anesthesia by giving two vertical interproximal incisions on mesiobuccal \& distobuccal line angles
Conventional canine retractionProcedure or surgery
Conventional canine retraction will be carried out by NiTi coil spring with 150g force
| Study group | Role | What they receive |
|---|---|---|
| Piezocision Group | Active comparator | Canine retraction with piezocision Receives: Procedure: Piezocision |
| Conventional retraction group | Placebo comparator | Canine retraction via conventional orthodontic traction Receives: Procedure: Conventional canine retraction |
What is being measured
The primary outcome is the main question the study is designed to answer.
Distance measured in millimeters
To compare the mean difference in millimeters, canine retraction with and without piezocision.
Measured: 4Week, 8Week and 12Week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Aug 2026
- Study start1 Jul 2022
- Primary completion1 Jan 2024
- Study completion1 Jul 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Canine RetractionStudies of the same condition, open and under way.
- More trials run by Foundation University IslamabadThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Foundation University Islamabad
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Shoaib Rahim, Foundation University Islamabad
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07752212
- Sponsor's protocol ID
- FUCD-Ortho- 2604
- Status last verified
- Aug 2026
- First submitted
- 27 Jul 2026
- Last updated
- 11 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Privacy Concerns
Publications
Figueiredo DS, Houara RG, Pinto LM, Diniz AR, de Araujo VE, Thabane L, Soares RV, Oliveira DD. Effects of piezocision in orthodontic tooth movement: A systematic review of comparative studies. J Clin Exp Dent. 2019 Nov 1;11(11):e1078-e1092. doi: 10.4317/jced.56328. eCollection 2019 Nov.
PubMed 31700581Raj SC, Praharaj K, Barik AK, Patnaik K, Mahapatra A, Mohanty D, Katti N, Mishra D, Panda SM. Retraction With and Without Piezocision-Facilitated Orthodontics: A Randomized Controlled Trial. Int J Periodontics Restorative Dent. 2020 Jan/Feb;40(1):e19-e26. doi: 10.11607/prd.3968.
PubMed 31815981Mheissen S, Khan H, Samawi S. Is Piezocision effective in accelerating orthodontic tooth movement: A systematic review and meta-analysis. PLoS One. 2020 Apr 22;15(4):e0231492. doi: 10.1371/journal.pone.0231492. eCollection 2020.
PubMed 32320408
Study at a glance
From the registry record, last updated by the sponsor on 11 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Assessment of Maxillary Canine Retraction With and Without Piezocision - A Randomized Clinical Trial"
- ClinicalTrials.gov ID
- NCT07752212
- Acronym / sponsor ID
- FUCD-Ortho- 2604
- Conditions
- Canine Retraction, Piezocision
- Keywords
- Canine retraction, Accelerated Orthodontics, Piezocison, Tooth movement techniques, Split-mouth design
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Foundation University IslamabadUniversity, hospital or other
- Study start
- 1 Jul 2022 (actual)
- Primary completion
- 1 Jan 2024 (actual)
- Study completion
- 1 Jul 2024 (actual)
- First posted
- 7 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Intraoral impressions with alginate will be taken at the start of treatment and plaster casts will be obtained by using ortho plaster. Separators will be passed mesial and distal to first molars to create space for band placement. After 7-10 days bands will be cemented on first molars. Pre- adjusted edgewise brackets with 0.022 in-slot Roth appliance will be bonded on teeth according to the treatment plan. Extractions will be done according to the treatment plan and piezocision will be carried out after levelling and alignment.
This will be a split mouth study with one side receiving piezocision (experimental) and the other side acting as control, after random allocation. Randomization will be done by simple randomization method in which experimental side will be randomly allocated to the patient and opposite side of the same patient will act as control. First patient will have piezocision on right side and 2nd patient will have piezocision on left side, 3rd patient will have piezocision on right side and 4th patient will have piezocision on left side and so on.
After extraction of maxillary first premolars, piezocision will be performed on experimental side whereas the opposite side will be taken as control. Piezocision will be performed under local anesthesia by giving two vertical interproximal incisions on mesiobuccal \& distobuccal line angles of canine on experimental side 2mm below the interdental papilla with piezo electrical knife without flap reflection. Piezoelectric incisions of the cortical alveolar bone will then be made with piezotome. The incisions will be sutured with non resorbable 4-0 black silk with the interrupted suture technique. After piezocision canine retraction will be carried out by either continuous mechanics, sectional mechanics or sliding mechanics depending on the treatment plan. Mechanics will be same on left and right side of the patient and mean retraction will be measured at four time intervals. T0 at the start of canine retraction, T1 at 4 weeks, T2 at 8 weeks and T3 at 12 weeks after piezocision
Detailed description
Intraoral impressions with alginate will be taken at the start of treatment and plaster casts will be obtained by using ortho plaster. Separators will be passed mesial and distal to first molars to create space for band placement. After 7-10 days bands will be cemented on first molars. Pre- adjusted edgewise brackets with 0.022 in-slot Roth appliance will be bonded on teeth according to the treatment plan. Extractions will be done according to the treatment plan and piezocision will be carried out after levelling and alignment.
This will be a split mouth study with one side receiving piezocision (experimental) and the other side acting as control, after random allocation. Randomization will be done by simple randomization method in which experimental side will be randomly allocated to the patient and opposite side of the same patient will act as control. First patient will have piezocision on right side and 2nd patient will have piezocision on left side, 3rd patient will have piezocision on right side and 4th patient will have piezocision on left side and so on. After extraction of maxillary first premolars, piezocision will be performed on experimental side whereas the opposite side will be taken as control. Piezocision will be performed under local anesthesia by giving two vertical interproximal incisions on mesiobuccal \& distobuccal line angles of canine on experimental side 2mm below the interdental papilla with piezo electrical knife without flap reflection. Piezoelectric incisions of the cortical alveolar bone will then be made with piezotome. The incisions will be sutured with non resorbable 4-0 black silk with the interrupted suture technique. After piezocision canine retraction will be carried out by either continuous mechanics, sectional mechanics or sliding mechanics depending on the treatment plan. Mechanics will be same on left and right side of the patient and mean retraction will be measured at four time intervals. T0 at the start of canine retraction, T1 at 4 weeks, T2 at 8 weeks and T3 at 12 weeks after piezocision.
Alginate impressions will be taken at T0, T1, T2 and T3. The anteroposterior crown tip movements of the canines will be assessed on scanned cast at 4 time points (T0-T3). A cast showing the reference lines, the midpalatine raphe (MPR) and the rugae line (RL) formed by a projection from the most medial point on the third right rugae. The distance between the cusp tip of the canine and the rugae line used to measure the anteroposterior canine movement is dc.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Piezocision Group | Active comparator | Procedure: PiezocisionCanine retraction with piezocision |
| Conventional retraction group | Placebo comparator | Procedure: Conventional canine retractionCanine retraction via conventional orthodontic traction |
Who may qualify
- Ages
- 15 to 35 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
Key inclusion criteria (4 listed)
- Patients between the age of 15-35 years
- Both male and female patients
- Treatment plan with extraction of maxillary first premolars or both maxillary and mandibular first premolars.
- Space for canine retraction of at least 3mm after levelling and alignment
Key exclusion criteria (4 listed)
- Craniofacial syndromes
- Previous Orthodontic treatment
- Systemic disease
- Periodontal bone loss
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| PiezocisionAfter extraction of maxillary first premolars, piezocision will be performed on experimental side whereas the opposite side will be taken as control. Piezocision will be performed under local anesthesia by giving two vertical interproximal incisions on mesiobuccal \& distobuccal line angles | Procedure or surgery | Piezocision Group |
| Conventional canine retractionConventional canine retraction will be carried out by NiTi coil spring with 150g force | Procedure or surgery | Conventional retraction group |
Primary outcome
Distance measured in millimeters
Time frame: 4Week, 8Week and 12Week
To compare the mean difference in millimeters, canine retraction with and without piezocision.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Aug 2026.
- Background: PubMed 31700581Figueiredo DS, Houara RG, Pinto LM, Diniz AR, de Araujo VE, Thabane L, Soares RV, Oliveira DD. Effects of piezocision in orthodontic tooth movement: A systematic review of comparative studies. J Clin Exp Dent. 2019 Nov 1;11(11):e1078-e1092. doi: 10.4317/jced.56328. eCollection 2019 Nov.
- Background: PubMed 31815981Raj SC, Praharaj K, Barik AK, Patnaik K, Mahapatra A, Mohanty D, Katti N, Mishra D, Panda SM. Retraction With and Without Piezocision-Facilitated Orthodontics: A Randomized Controlled Trial. Int J Periodontics Restorative Dent. 2020 Jan/Feb;40(1):e19-e26. doi: 10.11607/prd.3968.
- Background: PubMed 32320408Mheissen S, Khan H, Samawi S. Is Piezocision effective in accelerating orthodontic tooth movement: A systematic review and meta-analysis. PLoS One. 2020 Apr 22;15(4):e0231492. doi: 10.1371/journal.pone.0231492. eCollection 2020.
- Individual participant dataSharing planned: No. Privacy Concerns
Related trials for Canine Retraction
Enrolling by invitation
Discision as Acceleration Method in Canine Retraction in Orthodontics With Aligner and Fixed Appliances in Young Adults a Split Mouth Study
Bimaxillary Protrusion, Class II Div 1 Malocclusion
Recruiting
Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine Retraction
Malocclusions, Canine Retraction
Enrolling by invitation
Evaluation of Corticotomy-Assisted Canine Retraction Rate
Malocclusion, Corticotomy
Recruiting
Accelerated Orthodontics With Alveolar Decortication Plus CGF Injection
Accelerate Tooth Movement
Enrolling by invitation
Comparison of Maxillary Canine Retraction Rate With and Without Power Arm
Orthodontic Anchorage, Power Arm Sliding
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Piezocision and Conventional canine retraction in people with Canine Retraction and Piezocision, run by Foundation University Islamabad at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 11 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Distance measured in millimeters (time frame: 4Week, 8Week and 12Week). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07752212, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Aug 2026.