MalocclusionBMU/2026/8506NCT07879066

Evaluation of Corticotomy-Assisted Canine Retraction Rate

A study testing Experimental: Corticotomy¬-Assisted Canine Retraction in people with Malocclusion and Corticotomy, run by Tanzila Rafique at 1 site in Bangladesh.

Enrolling by invitation

Enrolling by invitation. The study team selects and invites participants, usually from an existing group of patients.

Sites and contacts

Official record

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Trial summary

Who is it for?: Ages 16 to 25 yearsHealthy volunteers can take part
Conditions the study is for: Malocclusion, Corticotomy, Canine Retraction
What is being tested?: Experimental: Corticotomy¬-Assisted Canine Retraction
Type of treatment: Surgery or procedure
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 24 participants
Where: 1 siteBangladesh
Study dates: 8 Aug 2026to 8 Aug 2027
Phase: Interventional

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 16 to 25 years
All sexes
Healthy volunteers accepted
Child, Adult

Who may be able to join

Participants who need both maxillary first molar extractions for orthodontic treatment.
Class Ⅰ (Bimaxillary proclination), Class Ⅱ division 1 malocclusion.
Participants with full permanent dentition present (excluding 3rd molar).
Participants with good general health conditions and oral hygiene status.
The age range of the patients will be 16 years to 25 years.
Sex of the participants will be male, female, or third gender.
The treatment plan of maximum anchorage value preservation used mini-implant anchorage during retraction of teeth to obtain good esthetics and correct the molar relationship.
No previous orthodontic treatment.

Who cannot join

Medically compromised patients with uncontrolled diabetes mellitus and compromised immune systems.
Participants taking medications that alter bone metabolism like bisphosphonates, nonsteroidal anti-inflammatory drugs (NSAIDs), and on long-term corticosteroids.
Vitamin D deficiency.
Cleft lip /palate, craniofacial syndrome or facial asymmetry.
Severe class Ⅲ malocclusion.
Pregnant women.
Smoker.
Non-compliant patient.

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Bangladesh1 site

Bangladesh Medical University (BMU), Dhaka,1000
Dhaka, Bangladesh, 1000

Other trials in Bangladesh

About this study

Official title: Title: Evaluation of Corticotomy-Assisted Canine Retraction Rate: A Split-Mouth Randomized Clinical Trial.

The goal of this split-mouth randomized clinical trial is to evaluate the effectiveness of corticotomy on maxillary canine retraction rate compared to conventional orthodontic techniques. Each participant acts as their own control. After bilateral maxillary first premolar extractions, one quadrant is randomly assigned to receive corticotomy before retraction, while the contralateral quadrant undergoes standard orthodontic retraction without corticotomy.

Read the detailed description

The goal of this split-mouth randomized clinical trial is to evaluate the effectiveness of corticotomy on maxillary canine retraction rate compared to conventional orthodontic techniques. The main question it aims to answer is Does corticotomy-assisted canine retraction accelerate the rate of tooth movement compared to conventional canine retraction methods? Researchers will evaluate the rate of canine retraction, root resorption, bone density, and pocket depth after corticotomy during the canine retraction phase.

Participants will:

Receive fixed orthodontic treatment using a pre-adjusted edgewise appliance system (Roth, 0.018-inch slot).
Undergo bilateral maxillary first premolar extractions indicated for orthodontic space closure.
Undergo a corticotomy (vertical buccal cortical plate cuts distal to the canine root) at the extraction appointment on one randomly assigned maxillary side (Experimental side).
Receive conventional canine retraction with no corticotomy on the contralateral maxillary side (Control side).
Have titanium mini-implants (Vector TAS, 1.4 × 8.0 mm) placed bilaterally between the second premolar and first molar for anchorage.
Undergo bilateral canine retraction initiated with standardized force (150 gm elastomeric power chain) on a rigid 0.016 × 0.022-inch stainless steel working archwire.
Be evaluated at baseline and every 3 months over a 6-month follow-up period to measure canine retraction rate, root resorption, and bone density via CBCT.

Conditions: Malocclusion, Corticotomy, Canine Retraction, Orthodontic Tooth Movement, Split-mouth Design, Bilateral Maxillary 1st Premolar Extraction
Being tested: Experimental: Corticotomy¬-Assisted Canine Retraction, Active Comparator / Control: Conventional Canine Retraction
Keywords: Corticotomy, Canine retraction, Accelerating tooth movement, regional acceleratory phenomenon (RAP)
Medical subject headings: Malocclusion

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Experimental: Corticotomy¬-Assisted Canine RetractionProcedure or surgery
Corticotomy will be performed on one maxillary quadrant before initiating standardized canine distalization.
Active Comparator / Control: Conventional Canine RetractionProcedure or surgery
Conventional canine retraction will be performed on the contralateral quadrant without corticotomy under identical orthodontic mechanics.

Study groups in NCT07879066
Study group	Role	What they receive
Experimental: Corticotomy¬-Assisted Canine Retraction	Experimental	Corticotomy will be performed on one maxillary quadrant before initiating standardized canine distalization. Receives: Procedure: Experimental: Corticotomy¬-Assisted Canine Retraction; Procedure: Active Comparator / Control: Conventional Canine Retraction
Active Comparator / Control: Conventional Canine Retraction	Active comparator	Conventional canine retraction will be performed on the contralateral quadrant without corticotomy under identical orthodontic mechanics. Receives: Procedure: Experimental: Corticotomy¬-Assisted Canine Retraction; Procedure: Active Comparator / Control: Conventional Canine Retraction

What is being measured

The primary outcome is the main question the study is designed to answer.

Rate of maxillary canine retraction
Linear distal movement of the maxillary canine measured on CBCT scans relative to a fixed anatomical landmark (e.g., the cusp tip, the center of the tooth (midpoint of the line joining the cusp tip and root apex), and the root apex) to compare the corticotomy-assisted side with the conventional side.
Measured: 6 months

Secondary outcomes (5)

Overall rate of maxillary canine retraction
- A frontal reference plane (FP) was constructed to the mid-sagittal and horizontal planes, passing through the incisive foramen and the long axis of the canine.
- Three landmarks identified on each CBCT volume: the cusp tip, the center of the tooth, and the root apex.
- The perpendicular distance from each of these three landmarks to the FP measured at both experimental and control sides.
- The amount of retraction at the cusp tip, center, and root apex calculated as the difference in distdistance-to-FP between successive time point and across the full retraction period.
Measured: Baseline to Post-retraction (6months)
Comparison of amount of canine root resorption between the corticotomy- assisted side and the conventional side.
-Root resorption was calculated (in mm) as the difference in canine length, from cusp tip to root apex, between the pre- and post-retraction CBCTs.
Measured: Baseline to Post-retraction (6months)
The rate of retraction at each landmark
The rate of retraction at each landmark was calculated by dividing the amount of movement by the time elapsed (mm per month).
Measured: Baseline to Post-retraction (6months)
Measurement of bone density between the corticotomy-assisted side and the conventional side.
Bone density was measured between the corticotomy-assisted side and the conventional side over six months by sequential CBCT scans(with the same field of view and the same voxel resolution) taken at T0 (baseline), T1 (3 months), and T2 (6 months).
Measured: Baseline to Post-retraction (6months)
Measurement and comparison of the pocket depth of the canine(in mm) between the corticotomy-assisted and the conventional side.
Pocket depth of the canine was measured between the corticotomy-assisted side and the conventional side by periodontal probing at T0 (baseline), T1 (3 months), and T2 (6 months).
Measured: Baseline to Post-retraction (6months)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

8 Aug 20268 Aug 2027

First posted16 Oct 2026
Study start8 Aug 2026
Primary completion8 Aug 2027 (estimated)
Study completion8 Aug 2027 (estimated)

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Other trials for MalocclusionStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Model description: Each participant acts as their own control. After bilateral maxillary first premolar extractions, one quadrant is randomly assigned to receive corticotomy before retraction, while the contralateral quadrant undergoes standard orthodontic retraction without corticotomy.
Masking: None (open label)
Enrolment: 24 participants (estimated)

IDs, dates and publications

ClinicalTrials.gov ID: NCT07879066
Sponsor's protocol ID: BMU/2026/8506
Acronym: BMU/2026/8506
Status last verified: Oct 2026
First submitted: 3 Sep 2026
Last updated: 16 Oct 2026
Results posted: No
Data monitoring committee: Yes
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: No

Interested in taking part?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See sites and contacts

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